Unveiling the influences of prenatal and maternal factors on the journey of an autistic child.

Background: Autism Spectrum Disorder (ASD) is a complex lifelong neurodevelopmental disorder with a high and increasing global prevalence. Although the precise causes are unknown, both genetic and environmental factors, including maternal ones during pregnancy, significantly influence its development. Therefore, this study endeavors to explore the potential causes of autism, including maternal and paternal prenatal risk factors, as well as antenatal and natal maternal risk factors, and their associations with the severity of ASD in mothers of children with ASD, from February to May 2024.

Allogenic Cultured Limbal Epithelial Transplantation and Cultivated Oral Mucosal Epithelial Transplantation in Limbal Stem Cells Deficiency: A Comparative Study.

Introduction: This study compared the clinical outcomes of allogenic cultured limbal epithelial transplantation (ACLET) and cultivated oral mucosal epithelial transplantation (COMET) in the management of limbal stem cell deficiency (LSCD).

Methods: Forty-one COMET procedures in 40 eyes and 69 ACLET procedures in 54 eyes were performed in the Corneoplastic Unit of Queen Victoria Hospital, East Grinstead. Data were examined for demographics, indications, ocular surface stability, absence of epithelial defect, ocular surface inflammation, visual outcomes, and intra- and postoperative complications.

Histological and radiographic assessment of the regenerative potential of sodium hexametaphosphate (SHMP) as a novel direct pulp capping material in an animal model.

Background: This study aimed to assess the histological and radiographic effects of sodium hexametaphosphate (SHMP) as a direct pulp capping (DPC) agent in immature permanent dog premolars.

Methods: A split-mouth design was employed with three healthy 4-month-old Mongrel dogs, each having 36 premolars. The premolars were randomly assigned to either SHMP or MTA.

Ramadan fasting in adolescents with epilepsy: Seizure control and behavioral outcome.

Data about the effect of Ramadan fasting on seizure control among adolescents with epilepsy (AWE) is scarce. Several psycho-behavioral problems have also been encountered in this teenage group. This study aimed to assess seizure frequency and behavioral outcomes after Ramadan fasting in a sample of AWE METHODS: In this prospective study, AWE who completed fasting during Ramadan 2024 were evaluated regarding the seizure frequency of each type during Shaban (the month immediately preceding Ramadan) and Ramadan.

Discriminative features of immunoglobulin G4-related disease (IgG4-RD) and associated autoimmune rheumatic diseases (ARDs) in a nationwide observational cohort: study from the Egyptian College of Rheumatology.

Objective: The objective of this study is to present the clinical characteristics of immunoglobulin G4-related diseases (IgG4-RD) patients and describe associated overlap with autoimmune rheumatic diseases (ARDs).

Patients And Methods: This cross-sectional study included 81 patients with IgG4-RD who were recruited from 13 specialized rheumatology departments and centers across the country in collaboration with the Egyptian College of Rheumatology (ECR). Patients underwent a thorough history-taking and clinical examination.

A novel deep synthesis-based insider intrusion detection (DS-IID) model for malicious insiders and AI-generated threats.

Insider threats pose a significant challenge to IT security, particularly with the rise of generative AI technologies, which can create convincing fake user profiles and mimic legitimate behaviors. Traditional intrusion detection systems struggle to differentiate between real and AI-generated activities, creating vulnerabilities in detecting malicious insiders. To address this challenge, this paper introduces a novel Deep Synthesis Insider Intrusion Detection (DS-IID) model.

Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals.

Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability.

Green synthesis and characterization of CuO/PANI nanocomposite for efficient Pb (II) adsorption from contaminated water.

This study presents the synthesis of a green polymer-based nanocomposite by incorporating green CuO nanoparticles into polyaniline (PANI) for the adsorption of Pb (II) ions from contaminated water. The nanocomposite was extensively characterized using FTIR, XRD, BET, SEM-EDX, XPS, and Raman spectroscopy, both before and after Pb(II) adsorption. Optimization studies were performed to assess the effects of key parameters, including pH, adsorbent dosage, and initial ion concentration on the adsorption process.

Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life.

: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. : This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals.

Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management.

Chronic wounds in diabetic patients experience significant clinical challenges due to compromised healing processes. Hypoxia-inducible factor-1 alpha (HIF-1α) is a critical regulator in the cellular response to hypoxia, enhancing angiogenesis and tissue restoration. Nevertheless, the cellular response to the developed chronic hypoxia within diabetes is impaired, likely due to the destabilization of HIF-1α via degradation by prolyl hydroxylase domain (PHD) enzymes.

Drug toxicity prediction model based on enhanced graph neural network.

Prediction of drug toxicity remains a significant challenge and an essential process in drug discovery. Traditional machine learning algorithms struggle to capture the full scope of molecular structure features, limiting their effectiveness in toxicity prediction. Graph Neural Network offers a promising solution by effectively extracting drug features from their molecular graphs.

Laboratory safety and immunogenicity evaluation of live attenuated avian infectious bronchitis GI-23 virus vaccine.

Avian infectious bronchitis virus (IBV) is responsible for a highly contagious disease that poses a significant threat to the poultry industry due to its high rates of evolution. The occurrence of vaccination failure can frequently be attributed to the emergence of novel strains that exhibit antigenic divergence from conventional vaccine strains. This study aims to evaluate the safety and efficacy of the Eg/1212B-based live attenuated virus vaccine indicated for immunization of chickens against nephropathogenic GI-23 variant strains reported globally.

Impact of Anemia on Clinical Outcomes in Atrial Fibrillation Patients on Oral Anticoagulants: A Prognostic Meta-Analysis.

Background: Anemia is frequently observed as a comorbidity in atrial fibrillation (AF), especially in elderly patients and in those on anticoagulation. This has been associated with poor clinical outcomes. We aim to investigate the impact of anemia on clinical outcomes in patients with AF on oral anticoagulation.

Combining Water-Soluble Porphyrin and Phthalocyanine Photosensitizers With Doxorubicin Improves the Efficacy of Chemo-Photodynamic Therapy Against DMBA-Induced Breast Carcinoma.

Breast cancer ranks as the second most widespread form of cancer globally. Currently, combination therapy is being actively employed in clinical practice to augment the efficiency of anticancer treatment. Hence, the objective of this study was to assess the therapeutic efficacy of a combination of femtosecond laser-based photodynamic therapy (PDT) utilizing two distinct photosensitizers (PSs), zinc phthalocyanine tetrasulfonate (ZnPcS) and α,β,χ,δ porphyrin-Tetrakis (1-methylpyridinium-4-yl) p-Toluenesulfonate porphyrin (TMPyP) in conjunction with doxorubicin chemotherapeutic agent, on mammary carcinomas experimentally induced in female mice using 7,12-dimethylbenz[a] anthracene (DMBA).

Camel milk extracellular vesicles/exosomes: a fascinating frontier in isolation and therapeutic potential.

Camel milk has a unique composition that sets it apart from other types of animal milk, which has captured the interest of medical and scientific communities. Extracellular vesicles (EVs) mainly contain exosomes (Exos, 30-200 nm) and microvesicles (MVs, 200-1000 nm). Camel milk EVs, particularly Exos, which we named EVs/Exos, have arisen as a fascinating area of scientific inquiry, holding enormous potential for the future of biomedicine due to their anticancer, antibacterial, antidiabetic nephropathy, and immunostimulatory impacts.

Comparing distal and proximal radial access for percutaneous coronary intervention and angiography: a comprehensive meta-analysis and systematic review of randomized controlled trials.

Background: Distal radial access (DRA) through the anatomical snuff-box is a novel technique for coronary procedures. Emerging evidence suggests that DRA is associated with a lower risk of certain complications compared to proximal radial access (PRA).

Methods: A systematic review was conducted to compare clinical and procedural outcomes between both access sites for coronary angiography and percutaneous coronary intervention.

Time-Related Voice and Swallowing Symptoms in Patients With Uncomplicated Thyroidectomy Versus Those With Other Laryngeal Disorders.

Objectives: This study conducted a subjective 6-month follow-up to evaluate voice and swallowing changes after thyroid surgery in patients without clinical evidence of recurrent nerve injury.

Methods: In this prospective cohort study, voice and swallowing alterations were assessed in 56 adult patients who underwent thyroidectomy, compared to 59 patients with laryngeal conditions and 60 controls. Voice and swallowing changes were measured using auditory perceptual assessment, laryngoscopy, the Arabic Thyroidectomy‑related voice and symptom questionnaire (A-TVSQ), the Arabic VHI (A-VHI), and Swallowing Impairment Scores (SIS-6).

Berberine and Cyperus rotundus extract nanoformulations protect the rats against Staphylococcus-induced mastitis via antioxidant and anti-inflammatory activities: role of MAPK signaling.

Berberine (BER) and Cyperus rotundus rhizomes extract (CRE) are phytochemicals characterized by broad-spectrum pharmacological activity that could tackle the side effects of conventional mastitis therapies, however, they undergo a modest bioavailability. In the current study, nanoformulations of BER and CRE chitosan hydrogel (BER/CH-NPs, CRE/CH-NPs) were investigated for their antibacterial, antioxidant, anti-inflammatory and anti-apoptotic effects against S. aureus-induced mastitis in a rat model.

Neuroprotective effect of red dragon fruit extract ameliorates oxidative stress and inflammation in D-galactose-induced aging rat model: biochemical, histological and immunohistochemical study.

Aging is a worldwide socioeconomic burden. Cerebellar aging is an enigma contributing to many behavioral aging disorders, hence is its hindering by prophylactic measurements is a crucial geriatric research target. Red dragon fruit (RDF) is a tropical fruit with antioxidant, anti-inflammatory and anti-apoptotic properties.

Bayesian and non-bayesian analysis for stress-strength model based on progressively first failure censoring with applications.

This article examines the estimate of ϑ = P [T < Q], using both Bayesian and non-Bayesian methods, utilizing progressively first-failure censored data. Assume that the stress (T) and strength (Q) are independent random variables that follow the Burr III distribution and the Burr XII distribution, respectively, with a common first-shape parameter. The Bayes estimator and maximum likelihood estimator of ϑ are obtained.

Effect of acetic acid shockwave phonophoresis on spur morphology, foot pain and function in patients with calcaneal spur: A randomised controlled trial.

Objective: To investigate the effect of acetic acid shockwave phonophoresis on spur morphology, foot pain, and function in patients with calcaneal spurs.

Design: A double-blinded, randomised clinical trial.

Setting: Outpatients physical therapy clinics.

Titanate-polyurethane-chitosan ternary nanocomposite as an efficient coating for steel against corrosion.

In this study, a titanate-polyurethane-chitosan ternary nanocomposite was prepared by physical mixing. Sodium titanate nanotubes (Na-TNTs) were prepared by the hydrothermal method, and chitosan was extracted from shrimp shell. Na-TNTs were mixed with polyurethane (PU) of different ratios by weight, and chitosan was added after optimization.

Assessment of molluscicidal activity of Syzygium aromaticum essential oil against Eobania vermiculata under laboratory and field conditions.

The present study focused on assessing the impact of clove oil on adult snails, specifically Eobania vermiculata, due to their detrimental effects on plants and crops. Our investigation aimed to explore both the lethal and sub-lethal toxicity of clove oil under laboratory and field conditions, with the goal of elucidating the mechanisms underlying its toxic effects on E. vermiculata.