Comparison of two mechanical carotid baroreceptor stimulation techniques.

We compared two mechanical carotid baroreceptor stimulation techniques, the phase related external suction (PRES) method and the conventional neck suction techniques concerning their effects on blood pressure and heart rate responses in a group of 10 normotensive men. The cuff pressure using the PRES method was phase-locked in time to the R-wave of the ECG. During the conventional neck suction technique the cuff pressure changes were not related to the cardiac cycle, it was either negative or positive.

Baroreceptor stimulation: pain perception and sensory thresholds.

Baroreceptor activity has been implicated in the modulation of pain. Sensory detection thresholds and pain ratings were measured in a group of 28 men during carotid baroreceptor manipulation with the PRES (phase-related external suction) neck suction technique. Brief, cardiac phase-related electrical impulses were delivered intracutaneously to the finger.

Development of angina pectoris pain and cardiac events in asymptomatic patients with myocardial ischemia.

A total of 389 patients with angiographically determined coronary artery disease, who exhibited a complete absence of angina pectoris in the presence of reproducible myocardial ischemia, were studied in a follow-up investigation. After an initial coronary angiogram, anti-ischemic medication was prescribed as treatment. After a mean follow-up time of 4.

Experimental pain thresholds and plasma beta-endorphin levels during exercise.

Experimental pain thresholds (electrical intracutaneous finger and dental pulp stimulation) and plasma hormone levels (beta-endorphin, cortisol, and catecholamines) were measured in ten healthy sportive men before, during, and after progressively more strenuous physical exercise. In a double-blind study conducted on two different days, 20 mg of the opioid-antagonist naloxone or placebo was administered prior to exercise. A significant pain threshold elevation was found during exercise for finger (ANOVA, P less than 0.

A defective angina pectoris pain warning system: experimental findings of ischemic and electrical pain test.

Ischemic pain threshold and tolerance levels using the tourniquet pain technique and electrical cutaneous pain thresholds were measured in patients with asymptomatic ischemic heart disease. Thirty asymptomatic patients, who repeatedly exhibited no angina pectoris pain during the occurrence of exercise-induced coronary ischemia (greater than or equal to 0.1 mV ST segment depression in exercise ECG) were compared to 30 randomly selected symptomatic control patients.