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3,701 results match your criteria: "Bellvitge Biomedical Research Institute (IDIBELL); L'Hospitalet de Llobregat[Affiliation]"
Open Respir Arch
November 2024
Respiratory Department, Bellvitge Biomedical Research Institute (IDIBELL), Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Orphanet J Rare Dis
December 2024
HHT Unit. Hospital Universitari Bellvitge, C/Feixa Llarga S/N. L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Background: Hereditary hemorrhagic telangiectasia (HHT) is characterized by telangiectasia and larger vascular malformations. Liver malformations are the most frequent visceral involvement including the presence of portosystemic malformations (PSM) that can cause hepatic encephalopathy. Minimal hepatic encephalopathy (mHE) is characterized by alterations of brain function in neuropsychological or neurophysiological tests and decreases quality of life.
View Article and Find Full Text PDFEndoscopy
December 2023
Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Catalonia, Spain.
Respir Res
December 2024
Interstitial Lung Disease Unit, Respiratory Department, Bellvitge University Hospital, University of Barcelona, L'Hospitalet de Llobregat, Spain.
Background: Patients with familial fibrotic interstitial lung disease (ILD) experience worse survival than patients with sporadic disease. Current guidelines do not consider family aggregation or genetic information in the diagnostic algorithm for idiopathic pulmonary fibrosis or other fibrotic ILDs. Better characterizing familial cases could help in diagnostic and treatment decision-making.
View Article and Find Full Text PDFEBioMedicine
December 2024
Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), 17190, Salt, Girona, Spain. Electronic address:
J Clin Med
November 2024
Interstitial Lung Disease Unit, Department of Pneumology, Hospital Universitario de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), 08907 Barcelona, Spain.
: Interstitial lung disease (ILD) is one of the most severe complications of rheumatoid arthritis (RA). Real-world data on antifibrotic treatment are needed. Our objective was to evaluate the real-world effectiveness and tolerability of antifibrotic agents in patients with progressive fibrosing RA-ILD.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
: Nutrimetabolomics may reveal novel insights into early metabolic alterations and the role of dietary exposures on prostate cancer (PCa) risk. We aimed to prospectively investigate the associations between plasma metabolite concentrations and PCa risk, including clinically relevant tumor subtypes. : We used a targeted and large-scale metabolomics approach to analyze plasma samples of 851 matched PCa case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
View Article and Find Full Text PDFPLoS One
December 2024
CRIG, Cancer Research Institute Ghent, Ghent, Belgium.
Hum Reprod Open
November 2024
Departamento de Genética e Instituto de Biotecnología, Centro de Investigación Biomédica (CIBM), Universidad de Granada, Granada, Spain.
Study Question: Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility?
Summary Answer: Our findings revealed a significant association between SPGF and the gene and identified three novel genes (, , and ) along with 32 potentially pathogenic rare variants in 30 genes that contribute to this condition.
What Is Known Already: SPGF is a major cause of male infertility, often with an unknown aetiology. SPGF can be due to either multifactorial causes, including both common genetic variants in multiple genes and environmental factors, or highly damaging rare variants.
Eur J Intern Med
December 2024
HHT Unit. Hospital Universitari Bellvitge, Barcelona, Spain; Internal Medicine Department. Hospital Universitari Bellvitge, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Clinical Sciences Department. Faculty of Medicine and Health Sciences. Universitat de Barcelona, Barcelona, Spain; Center for Biomedical Research in Obesity and Nutrition Physiopathology Network (CIBEROBN). Carlos III Health Institute, Madrid, Spain. Electronic address:
Objectives: To describe the incidence of pulmonary arteriovenous malformations (PAVM)-related complications, right-to-left shunt (RLS) progression at transthoracic contrast echocardiography (TTCE) and development of treatable PAVM during long-term follow-up in hereditary hemorrhagic telangiectasia (HHT) patients with RLS grades 0-1 at screening TTCE.
Methods: Observational prospective study including adult HHT patients with grades 0-1 RLS at screening TTCE. Those requiring previous embolization of PAVM were excluded.
Pain Rep
February 2025
Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, Universitat de Barcelona, Barcelona, Spain.
Introduction: Chronic pain is a debilitating disease that is usually comorbid to anxiety and depression. Current treatment approaches mainly rely on analgesics but often neglect emotional aspects. Nonpharmacological interventions, such as listening to music, have been incorporated into clinics to provide a more comprehensive management of chronic pain.
View Article and Find Full Text PDFAm J Psychiatry
December 2024
General Psychology-Cognition, Faculty of Computer Science, University of Duisburg-Essen, Germany (Brand, Antons, Wegmann); Center for Behavioral Addiction Research, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Germany (Brand, Antons, Wegmann); Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany (Brand, Antons); Department of Psychology, University of Montreal, Montreal (Bőthe); Interdisciplinary Research Center on Intimate Relationship Problems and Sexual Abuse (CRIPCAS), Montreal (Bőthe); College of Education, Psychology, and Social Work, Flinders University, Adelaide, Australia (Demetrovics, King); Institute of Psychology, ELTE Eötvös Loránd University, Budapest (Demetrovics); Center of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar (Demetrovics); School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK (Fineberg); Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, UK (Fineberg); University of Cambridge School of Clinical Medicine, Cambridge, UK (Fineberg); Department of Clinical Psychology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona (Jimenez-Murcia); Ciber Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Barcelona (Jimenez-Murcia); Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Program, IDIBELL, Barcelona (Jimenez-Murcia); Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona (Jimenez-Murcia); Psychology Services of the University of Barcelona, Barcelona (Jimenez-Murcia); Instituto de Investigación, Transferencia e Innovación, Universidad Internacional de La Rioja, La Rioja, Spain (Mestre-Bach); Department of General Psychology, University of Padova, Padua, Italy (Moretta); Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hanover, Germany (Müller); Departments of Psychiatry, Neuroscience, and Child Study and Wu Tsai Institute, Yale University School of Medicine, New Haven, CT (Potenza); Connecticut Council on Problem Gambling, Wethersfield, CT (Potenza); Connecticut Mental Health Center, New Haven, CT (Potenza).
Sci Rep
December 2024
Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute - IDIBELL], L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
Soc Sci Med
November 2024
Health Policy and Health Services Research Group, Health Policy Research Unit, Consortium for Health Care and Social Services of Catalonia, Avinguda Tibidabo, 21, 08022, Barcelona, Spain. Electronic address:
Although the greatest delays in cancer diagnosis in Latin America occur in the provider interval little is known about the related factors. This study aims to analyze factors influencing access to cancer diagnosis -from initial contact with health services to confirmation- from institutional stakeholders' perspective in public healthcare networks of Chile, Colombia, and Ecuador. A qualitative, descriptive-interpretative study was conducted in two networks per country, using semi-structured individual interviews (n = 118; 23 to 58, per country) with a criterion sample of health professionals and administrative personnel from primary care (PC) (n = 41) and secondary/tertiary care hospitals (n = 47), network managers and policymakers (n = 30).
View Article and Find Full Text PDFSci Rep
December 2024
Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of Seville, Seville, Spain.
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C.
View Article and Find Full Text PDFJ Dent
November 2024
Department of Odontostomatology. Oral Surgery and Implantology. Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Objective: To evaluate the accuracy of immediate implant placement in fresh extraction sockets in the maxillary aesthetic zone using a dynamic computer-assisted implant surgery system (dCAIS), with the evaluation of possible deviations versus freehand placement.
Methods: A total of 18 implants were placed by an experienced surgeon in fresh extraction sockets of anterior teeth in 6 maxillary models. Nine implants were placed using the dCAIS system and 9 implants were placed using the conventional freehand technique.
J Clin Med
November 2024
Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), 08907 L'Hospitalet de Llobregat, Spain.
: Sinonasal exophytic papillomas (SNEP) are benign tumours arising from nasal mucosa. Human papillomavirus (HPV) infection seems to be related to the aetiology of a fraction of SNEP cases. SNEP presentation can be focal (FSNEP) or diffuse (DSNEP), but factors related to focal or diffuse presentation have not yet been well ascertained.
View Article and Find Full Text PDFMicroorganisms
November 2024
Infectious Diseases Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), 08907 Barcelona, Spain.
Febrile neutropenia is a very common complication in cancer patients, especially in hematologic patients and hematopoietic stem cell transplant (HSCT) recipients, and is associated with increased morbidity and mortality [...
View Article and Find Full Text PDFMedicina (Kaunas)
November 2024
Faculty of Medicine and Health Sciences, Department of Prosthodontics, School of Dentistry, University of Barcelona, 08907 Barcelona, Spain.
: Oral rehabilitation seeks to enhance mastication, a vital component of oral function that is compromised by tooth loss. This study aimed to assess the degree of improvement of masticatory performance in partially edentulous patients rehabilitated with removable partial dentures (RPD) or fixed partial dental prosthesis (FPDP). Changes in the occlusal contact area (OCA) and satisfaction with their chewing ability during the adaptation period were also evaluated.
View Article and Find Full Text PDFBiomedicines
November 2024
Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
Inherited arrhythmogenic syndromes comprise a heterogenic group of genetic entities that lead to malignant arrhythmias and sudden cardiac death. Genetic testing has become crucial to understand the disease etiology and allow for the early identification of relatives at risk; however, it requires an accurate interpretation of the data to achieve a clinically actionable outcome. This is particularly challenging for the large number of rare variants obtained by current high-throughput techniques, which are mostly classified as of unknown significance.
View Article and Find Full Text PDFRheumatology (Oxford)
November 2024
Department of Rheumatology. Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Objetive: To evaluate the frequency and timing of sustained drug-free remission (SDFR) in patients with giant cell arteritis (GCA) and to identify potential predictive factors of this outcome.
Methods: Retrospective review of all patients included in the large Spanish multicentre registry for GCA (ARTESER) with at least two years of follow-up. SDFR was defined as the absence of typical signs, symptoms, or other features of active GCA for ≥12 months after discontinuation of treatment.
Am J Gastroenterol
November 2024
Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
Background: Real-world data on the effectiveness of upadacitinib for inflammatory bowel disease (IBD) are limited.
Aims: To assess upadacitinib persistence, effectiveness, and safety in a real-world scenario.
Methods: Retrospective multicentre study of IBD patients who received upadacitinib before 31st December 2022 and at least 12 weeks before the recruitment date.
Pediatr Obes
November 2024
Molecular Epidemiology of Cancer Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Background: Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.
View Article and Find Full Text PDFJ Pathol
January 2025
Institute for Surgical Pathology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Transl Oncol
January 2025
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908, Barcelona, Spain.
Prostate cancer (PCa) is one of the leading causes of cancer-related deaths among men. The heterogeneous nature of this disease presents challenges in its diagnosis, prognosis, and treatment. Numerous potential predictive, diagnostic, prognostic, and risk assessment biomarkers have been proposed through various population studies.
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