760 results match your criteria: "Belgrade University.[Affiliation]"

Introduction: In many countries, hemodialysis is still the most common method of renal replacement. Significant regional variations exist in creating and maintaining vascular access for hemodialysis. Therefore, analyzing national registries with vascular access data is essential for developing effective national treatment strategies.

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  • Cardiac amyloidosis (CA) is an often overlooked cause of heart failure (HF), highlighting the importance of early detection and timely therapy for better patient outcomes.
  • A global survey with 1,460 physicians revealed that while many have experience diagnosing CA in patients with preserved ejection fraction (HFpEF), systematic screening is not widely practiced, with only 10% conducting routine checks.
  • There is significant variability in screening and management strategies for CA, indicating a need for better education and access to disease-modifying therapies within the HF community.
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  • Bismuth quadruple therapies (BQTs) have been effective in treating Helicobacter pylori infections in Europe, particularly in the face of antibiotic resistance, with notable use increasing from 8.6% in 2013 to 39% in 2021.
  • An analysis of data from nearly 50,000 patients indicated that the single-capsule BQT was the most common regimen and achieved over 90% effectiveness with certain combinations.
  • Key factors that improved treatment success included adherence to the regimen, use of high-dose proton pump inhibitors, and implementing the therapy as a first-line treatment.
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This study presents a comparative analysis of molecular docking data, focusing on the binding interactions of the natural compounds apigenin and luteolin with the proteins TP-53, pRb, and APOBEC, in comparison to conventional pharmacological ligands. Advanced bioinformatics techniques were employed to evaluate and contrast binding energies, showing that apigenin and luteolin demonstrate significantly higher affinities for TP-53, pRb, and APOBEC, with binding energies of -6.9 kcal/mol and -6.

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Extraction, Characterization, and In Vitro Biological Activity of Polyphenols from Discarded Young Fig Fruits Based on Deep Eutectic Solvents.

Antioxidants (Basel)

September 2024

Sichuan Key Laboratory of Fruit and Vegetable Postharvest Physiology, College of Food Science, Sichuan Agricultural University, Ya'an 625014, China.

(1) Background: Discarded young fig fruits (DYFFs) result in a waste of resources, such as sparse fruits and residual fruits, and there has been no research on the relationship between phenolic compounds and biological activity in DYFFs (2) Methods: Different deep eutectic solvents (DESs) and 80% ethanol were used to prepare DYFF extracts, and polyphenol extraction efficiency and bioactivities in the DYFFs extracts were compared. (3) Results: More than 1700 phytochemicals were identified in DYFFs, and thirteen of these typical phenolic compounds were analyzed quantitatively; chlorogenic acid, rutin, luteolin 8-C-glucoside, and epicatechin are the main polyphenols in DYFFs, especially chlorogenic acid with 2720-7980 mg/kg. Ferulic acid, caffeic acid, epicatechin, (+)-catechin, luteolin 8-C-glucoside, rutin, hesperetin, and chlorogenic acid showed different degrees of correlation with in vitro antioxidant activity.

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Diagnostic and therapeutic practice for Heart Failure with preserved ejection fraction around the world: An international survey.

Curr Probl Cardiol

December 2024

Heart Failure Department and Clinical Investigation Center Inserm1407, Louis Pradel Cardiovascular Hospital, Hospices Civils de Lyon, Claude Bernard University, Lyon, France.

Article Synopsis
  • A survey was conducted among physicians globally to evaluate the real-world practices for diagnosing and treating heart failure with preserved ejection fraction (HFpEF), highlighting a knowledge gap in clinical implementation.
  • 1,460 physicians from 95 countries participated, primarily cardiologists, with most using a 50% ejection fraction cut-off for HFpEF diagnosis; however, only 47.2% utilized formal diagnostic scores.
  • The results showed that while natriuretic peptides were commonly used (87.4%), SGLT2 inhibitors led as the preferred first treatment (54.4%), indicating a need for better education on HFpEF management.
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Wave propagation in tailored metastructures consisting of elastic beams and rigid bodies.

Philos Trans A Math Phys Eng Sci

September 2024

Department of Mechanics, Faculty of Mechanical Engineering, Belgrade University, Kraljice Marije 16, Belgrade 11120, Serbia.

This paper presents a study of wave propagation through an infinite periodic structure that consists of elastic Timoshenko beams interconnected with rigid bodies. This is a generalized approach in which the beams are not coaxial and the centre of mass of each rigid body is placed away from the intersection of their neutral axes. An analytical approach is used by applying the transfer matrix method (TMM), along with the Floquet-Bloch theorem for elastic wave propagation.

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  • * Even those who recover may deal with long-term health issues like hypertension and arrhythmias, affecting not just their health but also their families' well-being and quality of life.
  • * A collaborative, multidisciplinary approach is essential for managing PPCM, involving various healthcare professionals to address both medical and psychosocial needs, along with informing women about the risks of future pregnancies.
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Atrial fibrillation (AF) is the most common long-term arrhythmia in adults. Rhythm control in patients with AF involves efforts to restore and maintain sinus rhythm and is accomplished by medication, catheter ablation, or electrical cardioversion. Amiodarone represents one of the most commonly used antiarrhythmic medications.

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Introduction: Patient-reported treatment burden (TBN) refers to the patient's time and effort invested in the management of their chronic health conditions. The aim of this research was to explore TBN in patients with coronary artery disease (CAD).

Methods: Consecutive patients with chronic medical condition(s) were invited to complete the study questionnaires (TBN and EQ-5D).

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  • Heart transplantation (HTx) has been around for over 50 years, yet there's a lack of guidelines for post-transplant prevention and rehabilitation practices.
  • The statement emphasizes the need for tailored prevention and rehabilitation programs that consider both modifiable and non-modifiable factors to enhance the physical capacity and quality of life for HTx recipients.
  • It advocates for a multidisciplinary approach involving all members of the HTx team to support patients throughout their recovery journey, highlighting the importance of starting these programs early after transplantation.
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Objectives: This study aimed to evaluate the intensity of the subacute local biological effects after implantation and osseoconductive potential of novel hydroxyapatite-based bone substitute coated with poly (lactide-co-glycolide), named ALBO-OS, in comparison to Bio-Oss.

Methods: Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss. Furthermore, artificially made bone defects on both rat's tibias were implanted with experimental materials.

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Aims: To update the European Society of Cardiology (ESC) quality indicators (QIs) for the evaluation of the care and outcomes of adults with heart failure.

Methods And Results: The Working Group comprised experts in heart failure including members of the ESC Clinical Practice Guidelines Task Force for heart failure, members of the Heart Failure Association, and a patient representative. We followed the ESC methodology for QI development.

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Konjac glucomannan/microcapsule of thymol edible coating reduces okra pericarp browning by regulating antioxidant activity and ROS synthesis.

Int J Biol Macromol

September 2024

Sichuan Key Laboratory of Fruit and Vegetable Postharvest Physiology, College of Food Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China. Electronic address:

Okra is susceptible to browning during storage. The effects of konjac glucomannan/microcapsule of thymol edible coating (TKL) on antioxidant activity and reactive oxygen (ROS) synthesis of okra during low-temperature storage were investigated. Thymol edible coating of thymol concentration 40 mg/mL (TKL40) had a regulatory effect on okra browning.

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Raloxifene, a selective oestrogen receptor modulator (SERM), has demonstrated efficacy in the prevention and therapy of oestrogen receptor-positive (ER+) breast cancer, with some degree of effectiveness against triple-negative forms. This suggests the presence of oestrogen receptor-independent pathways in raloxifene-mediated anticancer activity. To enhance the potential of raloxifene against the most aggressive breast cancer cells, hybrid molecules combining the drug with a metal chelator moiety have been developed.

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  • The text highlights a lack of knowledge and guidelines on physical activity and lifestyle measures for heart transplantation (HTx) recipients, despite the procedure's long history.
  • It emphasizes the need for tailored prevention and rehabilitation strategies to enhance physical capacity, quality of life, and survival for these patients.
  • The statement calls for a multidisciplinary approach to care, starting early post-transplant and continuing throughout the patients' journey, as HTx recipients have unique rehabilitation needs compared to other heart-related patients.
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  • Limited information exists on the physical activity and lifestyle measures for heart transplantation (HTx) recipients, despite the history of HTx spanning over 50 years without established guidelines for prevention and rehabilitation.
  • The scientific statement aims to highlight the significance of prevention and rehabilitation post-HTx and identify both modifiable and non-modifiable factors that can enhance physical capacity, quality of life, and survival for these patients.
  • A multidisciplinary approach is essential for developing tailored prevention and rehabilitation programs that begin early after HTx and continue throughout the patient's recovery journey.
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Psychometric validation of the short version of the Information Needs in Cardiac Rehabilitation scale through a first global assessment.

Eur J Prev Cardiol

November 2024

KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, University of Toronto, 347 Rumsey Road, Room 250, Toronto, ON, M4G1R7, Canada.

Article Synopsis
  • This study investigates the information needs of cardiac patients using the Information Needs in Cardiac Rehabilitation short version (INCR-S) scale across different global regions.
  • It involved 1,601 patients from 19 countries and found that while knowledge of cardiac health topics was rated highly important, knowledge sufficiency varied significantly, especially between high- and middle-income countries.
  • The INCR-S scale proved to be a valid and reliable tool, revealing crucial gaps in patients’ knowledge regarding topics like medications, nutrition, and support resources.
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Triple-negative breast cancer (TNBC) poses challenges in therapy due to the absence of target expression such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Frequently, the treatment of TNBC involves the combination of several therapeutics. However, an enhanced therapeutic effect can be also achieved within a single molecule.

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A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.

Eur J Heart Fail

April 2024

Department of Translational Medical Sciences, Interdepartmental Center for Clinical and Translational Research (CIRCET), and Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.

Article Synopsis
  • Pulmonary hypertension (PH) linked to left heart failure (PH-LHF) is a common condition that worsens symptoms, reduces physical ability, and harms right heart function, leading to a poor outlook for patients.
  • Despite various drugs being tested, there are currently no specific treatments for PH-LHF, highlighting significant gaps in understanding its pathophysiology and clinical management.
  • The document calls for improved research on pulmonary venous changes, patient categorization for tailored therapies, and rigorous pre-clinical studies to enhance clinical trials and expand treatment options beyond current methods used for pulmonary arterial hypertension.
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Background And Aims: Contemporary multicentre data on clinical and diagnostic spectrum and outcome in myocarditis are limited. Study aims were to describe baseline features, 1-year follow-up, and baseline predictors of outcome in clinically suspected or biopsy-proven myocarditis (2013 European Society of Cardiology criteria) in adult and paediatric patients from the EURObservational Research Programme Cardiomyopathy and Myocarditis Long-Term Registry.

Methods: Five hundred eighty-one (68.

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Introduction: Metabolic Dysfunction-associated Liver Disease (MASLD) represents a spectrum of conditions from simple fat accumulation to non-alcoholic steatohepatitis. The possible role of the intestinal microbiome on MASLD development has been in focus. Our study aimed to examine the effects of synbiotics on the liver steatosis, inflammation, and stool microbiome.

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Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment-resistant anxiety disorders (TR-AD) informing such trials is currently lacking. We used a Delphi method-based consensus approach to provide internationally agreed, consistent and clinically useful operational criteria for TR-AD in adults.

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Aims: Data regarding the treatment of hip osteoarthritis (OA) with collagen-based extracellular bio-scaffolds are lacking. We evaluated the treatment of hip OA with ultrasound guided intraarticular injections of Collagen-based Medical Device (CMD).

Material And Methods: Forty-four patients with Kellgren-Lawrence grade (KLG) I or II were selected, and 20/44 randomly selected patients (CMD group), were treated with 2 weekly consecutive ultrasound guided intraarticular injections of CMD (MD-HIP, Guna S.

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