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Pituitary tumors contain a side population with tumor stem cell-associated characteristics.
Endocr Relat Cancer
August 2015
Department of Development and RegenerationCluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, BelgiumDepartment of Hand SurgeryTongji Medical College, Union Hospital, Huazhong University of Science and Technology (HUST), Jiefang Avenue #1277, Wuhan, Hubei 430022, ChinaZhejiang Provincial Key Laboratory of OphthalmologyHangzhou, ChinaEye Center of the 2nd Affiliated HospitalMedical College of Zhejiang University, Hangzhou, ChinaDepartment of Imaging and PathologyKU Leuven, Leuven, BelgiumCITNOBA (National Research Council of Argentina)National University of the Northwest of Buenos Aires (CONICET-UNNOBA), Pergamino, Buenos Aires, ArgentinaLaboratory of Pituitary RegulationInstituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, ArgentinaUnit Head and Neck OncologyUniversity Hospitals Leuven, Leuven, BelgiumResearch Group Experimental Oto-Rhino-LaryngologyUniversity Hospitals Leuven, Leuven, BelgiumUnit Clinical and Experimental EndocrinologyUniversity Hospitals Leuven, Leuven, BelgiumResearch Group Experimental Neurosurgery and NeuroanatomyUniversity Hospitals Leuven, Leuven, Belgium
Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor stem cells (TSCs).
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