1 results match your criteria: "Belgium oCenter of Gastroenterology[Affiliation]"
Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia.
Eur J Gastroenterol Hepatol
June 2016
Institutes for aHuman Genetics bMedical Biometry, Informatics, and Epidemiology Departments of cGenomics, Life & Brain Center dInternal Medicine I eGeneral, Visceral, Thoracic and Vascular Surgery, University of Bonn, Bonn fDepartment of Medicine B, University Hospital Münster, Münster gDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg hDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig iDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz jDepartment of Gastroenterology, German Diagnostic Clinic, Wiesbaden kInstitute of Pathology, Klinikum Bayreuth, Bayreuth lDepartment of General, Visceral, Vascular and Pediatric Surgery, University of Würzburg, Würzburg mDepartment of General and Abdominal Surgery, Protestant Hospital Castrop-Rauxel, Castrop-Rauxel, Germany nTranslational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Leuven, Belgium oCenter of Gastroenterology, Klinik Hirslanden, Zürich, Switzerland.
Background And Aim: Although an eight-residue insertion in HLA-DQβ1 has been recently identified as a genetic risk factor for idiopathic achalasia, other risk factors are still unknown. In the present study, we carried out an epidemiological survey and a genotype-phenotype (G×P) analysis to gain further insights into the etiology of achalasia.
Methods: We obtained medical data from 696 achalasia patients and 410 controls, as well as their first-degree relatives (2543 of patients and 1497 of controls).