Premolar Autotransplantation to the Anterior Maxilla Region-Aesthetic Outcome and Patient Satisfaction.

Aim: The aim of this study was to assess the aesthetic results and patient satisfaction of premolars transplanted to the maxillary incisor region.

Material And Methods: In this multicenter study, 192 patients were included, with a minimum follow-up of 3 years. The aesthetic evaluation comprised two parts: Assessment of the PES/WES score using standardized intraoral photographs.

Why, how and when to look for occult giant cell arteritis in patients with polymyalgia rheumatica.

In this article, the author explains the relationship between GCA and PMR, based on historical studies, his own experience with a large group of patients and recent publications. Searching for occult vasculitis in patients with pure PMR is recommended and the author explains why PET is well suited for this purpose.

Highlights from the breakout session: imaging in disease assessment.

The breakout session "Imaging in Disease Assessment" featured six abstracts on imaging advancements for vasculitis. Disease extent on cranial MRI and its association with visual complications in giant cell arteritis (GCA) was evaluated, introducing the Propensity for Enhancement for GCA (P EG) score to assess inflammation. Predictors of remission and relapse in chronic periaortitis were analyzed, suggesting the potential for tailored treatment approaches.

Discovery of the Novel HLA-B*27:284 Allele Identified by Next Generation Sequencing.

HLA-B*27:284 differs from HLA-B*27:07:01 by one nucleotide substitution in exon 4, at gDNA position 1614 (G>A).

An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress.

Background: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.

ERS Congress 2024: highlights from the Allied Respiratory Professionals Assembly.

https://bit.ly/3ZPrlZw.

Design and evaluation of AE4W: An active and flexible shaft-driven shoulder exoskeleton for workers.

The wide adoption of occupational shoulder exoskeletons in industrial settings remains limited. Passive exoskeletons were proved effective in a limited amount of application scenarios, such as (quasi-)static overhead handling tasks. Quasi-active devices, albeit representing an improved version of their passive predecessors, do not allow full modulation of the amount of assistance delivered to the user, lacking versatility and adaptability in assisting various dynamic tasks.

Data altruism and the "consent" question: a study into the "consent" models used under the GDPR and how the data altruism mechanism can act as a potential solution for the research community in the reuse of health data.

Introduction: The General Data Protection Regulation ("GDPR") legal basis for obtaining consent for the processing of personal data for research purposes, where those purposes cannot be fully specified in advance, is provided for in Articles 6, 7 and Recital 33. However, GDPR's requirements for obtaining consent, as to the secondary use and sharing of data in research, have been argued to have generated confusion, whilst the conflicts between the Regulation itself, its practical application and research ethics are well-documented (1). The requirements for "informed consent", as defined within the GDPR, have not been well defined in the context of genome research or clinical trials (2), which has in turn led to the implementation and interpretation of the lawful basis to span into different idiosyncratic models.

Aspirin-triggered DHA metabolites inhibit angiogenesis.

Background And Aim: Blood vessels supply oxygen, nutrients and provide gateways for immune surveillance. Since this network nourishes all tissues, vessel abnormalities contribute to many diseases, such as cancer. One of the potential targets for Docosahexaenoic Acid (DHA) in cancer is suppressing angiogenesis, a process of new blood vessel formation within tumors.

Dissemination strategies of clinical practice guidelines-mixed methods evidence synthesis protocol.

Clinical practice guidelines (CPGs) are shared through various dissemination strategies using a range of dissemination products and channels. However, users may have different needs for accessing and understanding them. Patients and carers from low- and middle-income countries might face challenges in accessing CPGs such as inadequate systems for printed book distribution and insufficient and substandard photocopies.

Correction: Single crystal formation in core-shell capsules.

Correction for 'Single crystal formation in core-shell capsules' by Marie Mettler , , 2023, , 12739-12742, https://doi.org/10.1039/D3CC03727D.

Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.

Objective: Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of the c.911G>A; p.

Boosting the Pixel Acquisition Rate of Elemental Mapping with Laser Ablation-ICP-Mass Spectrometry to 1000 Hz.

Novel low-dispersion ablation cell designs and highly efficient aerosol transport systems have enabled fast elemental mapping using laser ablation-ICP-mass spectrometry (LA-ICP-MS) at high spatial resolution and its application in various research fields. Nowadays, the fastest low-dispersion setups enable narrow single pulse responses (SPR, duration of the transient signal observed upon a single laser shot), which enhance the signal-to-noise ratio and boost the pixel acquisition rate attainable in elemental mapping applications. In this work, the analytical performance of a nanosecond 193 nm ArF* excimer-based kHz laser in combination with a low-dispersion tube-type ablation cell, coupled to an ICP-mass spectrometer equipped with a time-of-flight (ToF) analyzer, was evaluated.

Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma?

Vascular neoplasms with epithelioid cytomorphology encompass a wide spectrum of benign and malignant lesions, including epithelioid hemangioma (EH), cutaneous epithelioid angiomatous nodule (CEAN), epithelioid hemangioendothelioma (EHE), and epithelioid angiosarcoma (EAS). Recently, the first case of a cutaneous hemangioma with epithelioid features harboring a TPM3::ALK fusion was reported. Herein, we report 4 additional cases, including 1 case with an alternate TPM4::ALK fusion, and expand on the clinicopathologic and molecular genetic features of these unusual vascular lesions.

Elective uterine preservation: a novel concept to tackle reproductive ageing. Fertility preservation beyond ovaries.

With a growing number of women in developed countries having children later in life, it is time to rethink women's reproductive health. This trend of 'delayed parenthood' reflects a complex interplay of labour market rules, personal choices, rarefying social connections and the renowned possibilities of assisted reproductive technology (ART). While ART offers support, its success wanes with age, prompting a rise in additional strategies such as elective ovarian cryopreservation.

Profile of Chief Medical Officers and performance of health zones in crisis contexts: a cross-sectional study in three provinces of the Eastern Democratic Republic of Congo.

Context: In crisis-affected health systems, the performance of health zones (also known as health districts) is challenged by recurrent armed conflicts and state fragility. The profiles of health zone managers and contextual factors can significantly influence the zones' ability to effectively respond to population health needs. This study explores these interactions to identify key factors associated with health zones performances in three provinces of Eastern Democratic Republic of Congo (DRC), a region that has endured over three decades of conflict.

Compliance with transmission-based precautions, and associated factors among healthcare providers in Cameroon: a cross-sectional study.

Background: Transmission-based precautions (TBP) and the proper use of personal protective equipment (PPE) are essential in preventing hospital-acquired infections (HAIs) and in controlling the emergence and spread of antimicrobial resistance (AMR). This study, therefore, aimed to determine healthcare providers' compliance with TBP and its determinants in healthcare settings to help curb the burden of HAIs and AMR.

Method: This study was a cross-sectional, hospital-based research conducted among healthcare providers at four health facilities in the Fako division of Cameroon, from January 1 to May 31, 2024.

Establishing a European wastewater pathogen monitoring network employing aviation samples: a proof of concept.

Pathogens know no borders, and the COVID-19 pandemic highlighted the urgent need for comparable, globally accessible pathogen data. This paper proposes a European wastewater pathogen monitoring network using aircraft and airport samples as a proof of concept for an effective cross-national surveillance system. The study emphasizes the importance of genomic data collection from strategic sites to produce high-value data for disease surveillance and epidemiological analysis.

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness.

Background: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we investigated if the in vivo activity of the LC is related to the variability in the quality of Rapid Eye Movement (REM) sleep.

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

Background: Recent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers their implementation for the development and testing of medication that targets human microglia.

Impact of deep learning denoising on kinetic modelling for low-dose dynamic PET: application to single- and dual-tracer imaging protocols.

Purpose: Long-axial field-of-view PET scanners capture multi-organ tracer distribution with high sensitivity, enabling lower dose dynamic protocols and dual-tracer imaging for comprehensive disease characterization. However, reducing dose may compromise data quality and time-activity curve (TAC) fitting, leading to higher bias in kinetic parameters. Parametric imaging poses further challenges due to noise amplification in voxel-based modelling.