Dissemination strategies of clinical practice guidelines-mixed methods evidence synthesis protocol.

Clinical practice guidelines (CPGs) are shared through various dissemination strategies using a range of dissemination products and channels. However, users may have different needs for accessing and understanding them. Patients and carers from low- and middle-income countries might face challenges in accessing CPGs such as inadequate systems for printed book distribution and insufficient and substandard photocopies.

Correction: Single crystal formation in core-shell capsules.

Correction for 'Single crystal formation in core-shell capsules' by Marie Mettler , , 2023, , 12739-12742, https://doi.org/10.1039/D3CC03727D.

Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.

Objective: Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of the c.911G>A; p.

Boosting the Pixel Acquisition Rate of Elemental Mapping with Laser Ablation-ICP-Mass Spectrometry to 1000 Hz.

Novel low-dispersion ablation cell designs and highly efficient aerosol transport systems have enabled fast elemental mapping using laser ablation-ICP-mass spectrometry (LA-ICP-MS) at high spatial resolution and its application in various research fields. Nowadays, the fastest low-dispersion setups enable narrow single pulse responses (SPR, duration of the transient signal observed upon a single laser shot), which enhance the signal-to-noise ratio and boost the pixel acquisition rate attainable in elemental mapping applications. In this work, the analytical performance of a nanosecond 193 nm ArF* excimer-based kHz laser in combination with a low-dispersion tube-type ablation cell, coupled to an ICP-mass spectrometer equipped with a time-of-flight (ToF) analyzer, was evaluated.

Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma?

Vascular neoplasms with epithelioid cytomorphology encompass a wide spectrum of benign and malignant lesions, including epithelioid hemangioma (EH), cutaneous epithelioid angiomatous nodule (CEAN), epithelioid hemangioendothelioma (EHE), and epithelioid angiosarcoma (EAS). Recently, the first case of a cutaneous hemangioma with epithelioid features harboring a TPM3::ALK fusion was reported. Herein, we report 4 additional cases, including 1 case with an alternate TPM4::ALK fusion, and expand on the clinicopathologic and molecular genetic features of these unusual vascular lesions.

Elective uterine preservation: a novel concept to tackle reproductive ageing. Fertility preservation beyond ovaries.

With a growing number of women in developed countries having children later in life, it is time to rethink women's reproductive health. This trend of 'delayed parenthood' reflects a complex interplay of labour market rules, personal choices, rarefying social connections and the renowned possibilities of assisted reproductive technology (ART). While ART offers support, its success wanes with age, prompting a rise in additional strategies such as elective ovarian cryopreservation.

Profile of Chief Medical Officers and performance of health zones in crisis contexts: a cross-sectional study in three provinces of the Eastern Democratic Republic of Congo.

Context: In crisis-affected health systems, the performance of health zones (also known as health districts) is challenged by recurrent armed conflicts and state fragility. The profiles of health zone managers and contextual factors can significantly influence the zones' ability to effectively respond to population health needs. This study explores these interactions to identify key factors associated with health zones performances in three provinces of Eastern Democratic Republic of Congo (DRC), a region that has endured over three decades of conflict.

Compliance with transmission-based precautions, and associated factors among healthcare providers in Cameroon: a cross-sectional study.

Background: Transmission-based precautions (TBP) and the proper use of personal protective equipment (PPE) are essential in preventing hospital-acquired infections (HAIs) and in controlling the emergence and spread of antimicrobial resistance (AMR). This study, therefore, aimed to determine healthcare providers' compliance with TBP and its determinants in healthcare settings to help curb the burden of HAIs and AMR.

Method: This study was a cross-sectional, hospital-based research conducted among healthcare providers at four health facilities in the Fako division of Cameroon, from January 1 to May 31, 2024.

Establishing a European wastewater pathogen monitoring network employing aviation samples: a proof of concept.

Pathogens know no borders, and the COVID-19 pandemic highlighted the urgent need for comparable, globally accessible pathogen data. This paper proposes a European wastewater pathogen monitoring network using aircraft and airport samples as a proof of concept for an effective cross-national surveillance system. The study emphasizes the importance of genomic data collection from strategic sites to produce high-value data for disease surveillance and epidemiological analysis.

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness.

Background: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we investigated if the in vivo activity of the LC is related to the variability in the quality of Rapid Eye Movement (REM) sleep.

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

Background: Recent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers their implementation for the development and testing of medication that targets human microglia.

Impact of deep learning denoising on kinetic modelling for low-dose dynamic PET: application to single- and dual-tracer imaging protocols.

Purpose: Long-axial field-of-view PET scanners capture multi-organ tracer distribution with high sensitivity, enabling lower dose dynamic protocols and dual-tracer imaging for comprehensive disease characterization. However, reducing dose may compromise data quality and time-activity curve (TAC) fitting, leading to higher bias in kinetic parameters. Parametric imaging poses further challenges due to noise amplification in voxel-based modelling.

A patient first perspective of sleep disturbance across therapeutic areas: a systematic literature review of qualitative studies.

Background: Sleep, a vital pillar of health, impacts daily functioning and overall quality of life. Despite extensive research on sleep disturbances within specific therapeutic areas (TAs), there's limited understanding of how these disturbances affect patients across multiple TAs. This systematic literature review adopts a patient-centered approach to explore the meaningful aspects of health and concepts of interest relating to sleep and sleep disturbances across a variety of TAs, utilizing qualitative research to bridge the gap between patient experiences and clinical measures.

Emerging sensor technologies and physics-guided methods for monitoring automotive lithium-based batteries.

As the automotive industry undergoes a major shift to electric propulsion, reliable assessment of battery health and potential safety issues is critical. This review covers advances in sensor technology, from mechanical and gas sensors to ultrasonic imaging techniques that provide insight into the complex structures and dynamics of lithium-ion batteries. In addition, we explore the integration of physics-guided machine learning methods with multi-sensor systems to improve the accuracy of battery modeling and monitoring.

Enhancing fetal ultrasound image quality and anatomical plane recognition in low-resource settings using super-resolution models.

Super-resolution (SR) techniques present a suitable solution to increase the image resolution acquired using an ultrasound device characterized by a low image resolution. This can be particularly beneficial in low-resource imaging settings. This work surveys advanced SR techniques applied to enhance the resolution and quality of fetal ultrasound images, focusing Dual back-projection based internal learning (DBPISR) technique, which utilizes internal learning for blind super-resolution, as opposed to blind super-resolution generative adversarial network (BSRGAN), real-world enhanced super-resolution generative adversarial network (Real-ESRGAN), swin transformer for image restoration (SwinIR) and SwinIR-Large.

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity.

Allergic Contact Dermatitis Induced by Modern Wound Dressings: A Comprehensive Analysis of Risks and Allergenic Components.

Modern wound dressings have revolutionised wound care, offering optimal healing environments. However, their widespread use has led to a significant increase in allergic reactions, particularly among patients with chronic leg ulcers. The complex chemical compositions of these dressings can trigger allergic responses.

New thoughts on the gut-immune axis of arthritis.

Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the 'gut-joint axis hypothesis' in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have provided insights into potential mechanisms by uncovering microbial influences and immune pathways that either connect or uncouple gut and joint inflammation.

Saliva Samples as a Potential Tool for the Diagnosis and Monitoring of Cytomegalovirus Reactivation in Children Undergoing Transplantation.

Background: Regular monitoring of cytomegalovirus (CMV) reactivation in children who undergo transplantation is performed by molecular testing on blood samples. This highlights the need to explore noninvasive alternatives, such as saliva. The present study evaluated the usefulness of saliva samples for detecting and monitoring CMV reactivation in children undergoing transplantation at a referral center in Lima, Peru.

Dysbiosis Patterns in Glottic and Laryngeal Cancers: A Systematic Review of Microbiome Alterations.

Background: This systematic review summarized current evidence regarding the role of upper aerodigestive tract microbiomes (UAM) in laryngeal squamous cell carcinoma (LSCC) development, progression, clinical, and oncological outcomes.

Methods: Two investigators systematically search PubMed, Scopus, and Cochrane Library databases for studies investigating microbiome characteristics, mechanistic roles, and associations with clinical and oncological outcomes in LSCC according to the Preferred Reporting Items For A Systematic Review And Meta-analysis statements. The bias analysis was conducted with the methodological index for nonrandomized studies.

A survey on measurement and reporting of total testosterone, sex hormone-binding globulin and free testosterone in clinical laboratories in Europe.

Objectives: To compare clinical laboratory workflows for the assessment of androgens in men, focusing on total testosterone (T), sex hormone-binding globulin (SHBG) and free T, in clinical laboratories throughout Europe.

Methods: An internet-based survey that included questions related to pre-analytical, analytical and post-analytical phases of androgen measurements was distributed between December 2022 and December 2023 by clinical laboratory/chemistry and endocrine societies. A total of 124 unique records from clinical laboratories in 27 European countries were analyzed.

Phylogenomic conflict analyses of plastid and mitochondrial genomes of Impatiens (Balsaminaceae) reveal its complex evolutionary history.

Impatiens is among the most diverse angiosperm genera, comprising more than 1000 species. The phylogenetic relationship among sections of Impatiens remains unclear. Plastomes and mitogenomes are useful for resolving problematic relationships in plant phylogenetics; however, conflicts between the organellar genomes have been reported.

Does total hip arthroplasty benefit patients with minimal radiological osteoarthritis?

Aims: The effectiveness of total hip arthroplasty (THA) for patients with no or minimal radiological signs of osteoarthritis (OA) is unclear. In this study, we aimed to: 1) assess the outcome of such patients; 2) identify patient comorbidities and CT or MRI findings which predicted outcome; and 3) compare their outcome to the expected outcome of THA for hip OA.

Methods: Adult patients undergoing THA for hip pain, with no or minimal radiological features of OA (Tönnis grading scale ≤ 1), were identified from a consecutive series of 1,925 THAs.