PRC1 and PRC2 proximal interactome in mouse embryonic stem cells.

Polycomb repressive complexes PRC1 and PRC2 control lineage-specific gene silencing during early embryogenesis. To better understand Polycomb biology, we profile the proximal interactome (proxeome) of multiple PRC1 and PRC2 subunits in mouse embryonic stem cells (mESCs). This analysis identifies >100 proteins proximal to PRC1 and PRC2, including transcription factors and RNA-binding proteins.

Fast face-selective responses in prefrontal face patches of the macaque.

Face processing models propose gradually more complex receptive field properties culminating in invariant representations in anterior inferotemporal cortex (aITC), leading to late socio-emotionally relevant encoding in pre- and orbitofrontal cortex (POC). Top-down facilitation models, however, predict that some lower-level POC neurons respond faster than aITC. To resolve this discrepancy, we recorded from 2,459 neurons in fMRI-defined POC and aITC face patches.

Factors Associated with Response to Intravenous Glucocorticoids in Active Moderate-to-Severe Thyroid Eye Disease.

Intravenous glucocorticoids (IVGCs) are the first-line treatment for active moderate-to-severe thyroid eye disease (TED) in many countries worldwide, mainly because of their anti-inflammatory efficacy. Retrospective cohort study of 64 patients with active moderate-to-severe TED, without dysthyroid optic neuropathy, treated between 2003 and 2023 at a single tertiary centre with the 12 weeks IVGC EUGOGO (European Group on Graves Orbitopathy) protocol. All patients were evaluated for response to IVGC according to the clinical judgment (CL) and 44/64 (69%) patients were also evaluated with the EUGOGO 2021 revised composite index (CI).

Interleukin 6 inhibition in refractory antisynthetase syndrome: case-based literature review.

Introduction: Antisynthetase syndrome (ASyS) is a rare idiopathic inflammatory myopathy (IIM), characterised by the presence of anti-aminoacyl tRNA synthetase antibodies. Significant clinical heterogeneity often results in delayed or missed diagnoses. While corticosteroids are the primary treatment for ASyS, immunosuppressants are frequently added as steroid-sparing agents.

[The future of the Belgian psychiatric patient according to the WPA-Lancet Commission].

Background: In 2017, the World Psychiatric Association-Lancet Psychiatry Commission on the future of psychiatry identified several priority areas for the next decade. Six major domains were distinguished, namely the patient and his treatment, psychiatry and healthcare systems, psychiatry and society, the future of mental health legislation, digital psychiatry and training the psychiatrist of the future. This essay examines the state of affairs in Belgium seven years after the publication of the above-mentioned document.

[The organization of psychiatry in the Netherlands and Belgium: who is an example for whom?].

Background: The medical profession such as that of a psychiatrist is a profession with three essential characteristics (specialist care, autonomy and formal recognition, and professional ethics). The 21st century is characterized by bureaucratization and marketization of healthcare. Medical sociologist Friedson described three forms of logic: the logic of the professional, the logic of bureaucracy and the logic of the market.

Developing a Measure for the Accuracy of Symptom Perception: The Congruence Between Self-reported Dyspnea and Physiological Parameters in the Dutch Lifelines Cohort Study.

Objective: We aimed to assess whether a symptom perception accuracy measure can be derived from routinely collected general population cohort data.

Methods: We combined information on self-reported dyspnea and physiological parameters (FEV1%pred, body weight) from the Lifelines Cohort Study (N=138,594; 59.0% female; mean age=42.

Validation of a questionnaire to screen chronic obstructive respiratory diseases.

Spirometry is the gold standard for diagnosing chronic obstructive respiratory diseases (CORD), but it is not widely available in primary healthcare in Vietnam. We aimed to validate a simple CORD Screening Questionnaire (CORD-SQ) for the Vietnamese population to screen subjects requiring spirometry.In a cross-sectional study, 589 volunteers seen in a primary healthcare unit were submitted to the CORD-SQ.

The attitudes of transgender and gender-diverse adolescents and their parents regarding fertility, parenthood, and fertility preservation before the start of puberty suppression or gender-affirming hormone therapy.

Background: Gender-affirming treatment for transgender and gender-diverse (TGD) adolescents can consist of puberty suppression (PS) and gender-affirming hormone treatment (GAHT), which may affect fertility.

Aim: This study aims to evaluate the attitudes and decision-making regarding parenthood and fertility preservation from TGD adolescents and their parents and analyze the fertility preservation use and outcome before the start of treatment.

Methods: Adolescents under 18 starting PS or GAHT between November 2021 and March 2024 were enrolled in a multicenter prospective cohort study "ENIGI adolescents," conducted at Amsterdam University Medical Centre, Ghent University Hospital, and Florence University Hospital.

Mapping Memories: Enhancing Retrospective Data with the Life History Calendar.

Retrospective data collection methods provide a practical and cost-effective alternative to traditional longitudinal studies, particularly when time and resource constraints hinder long-term follow-up. While conventional retrospective questionnaires are widely used, their susceptibility to recall errors often compromises data reliability and accuracy. The Life History Calendar (LHC) has emerged as a solution to these limitations by incorporating visual prompts and contextual cues to enhance recall and improve data quality.

Menopause has a beneficial influence on the evolution of prolactinomas. A study of 99 patients.

Context: Menopause is thought to have beneficial effects in women with prolactinoma, potentially offering a higher chance for successful dopamine agonist (DA) withdrawal. However, strong evidence supporting this remains limited.

Objective: To assess the impact of menopause on prolactinoma evolution and recurrence after DA withdrawal.

Expert opinion on the integration of combination therapy into the treatment algorithm for the management of dyslipidaemia.

The clinically important link between low-density lipoprotein cholesterol (LDL-C) lowering and cardiovascular (CV) risk reduction is well-established and reflected in the 2019 European Society of Cardiology/European Atherosclerosis Society guidelines for the management of dyslipidaemia. They recommend a stepwise approach to reaching LDL-C goals, beginning with statin monotherapy at the highest tolerated dose. However, real-world data shows a large gap between guideline LDL-C goal recommendations and their achievement in clinical practice.

Robotic parastomal hernia repair: an updated systematic review.

Introduction: Parastomal hernias (PSH) are a frequent complication following ostomy surgery, often requiring surgical intervention. Robotic surgery offers potential advantages in PSH repair, but evidence on its efficacy remains limited. This systematic review evaluates the outcomes of different robotic PSH repair techniques.

Combating the rising tide of kidney advocacy in Europe: the seminal role of the European Kidney Health Alliance (EKHA).

Chronic kidney disease (CKD) is one of the most prevalent and fatal chronic diseases. However, the political attention CKD receives is not proportional to its significant human, economic and ecological burden. One major reason is the lack of awareness among the general population and policymakers.

Real-world treatment and retreatment patterns and outcomes in patients with advanced or metastatic non-small cell lung cancer following nivolumab monotherapy in second line or later in France: an I-O Optimise analysis.

Introduction: This study describes treatment and retreatment patterns and outcomes in patients in France following nivolumab as a second-line or later (2L+) treatment in locally advanced or metastatic non-small cell lung cancer (LAM NSCLC).

Materials And Methods: This analysis included adults with tumor, node, metastasis stage IIIB-IV NSCLC (as defined in the 7th or 8th edition American Joint Committee on Cancer/Union for International Cancer Control) treated with nivolumab monotherapy in 2L+ using data from the retrospective Epidemiological-Strategy and Medical Economics Lung Cancer database. The inclusion period was from January 1, 2015, to September 30, 2020, with a follow-up until September 30, 2021.

Just the tip of the iceberg: uncovering a hyperdiverse clade of African (, , ) species with signs of evolutionary habitat adaptations.

The diversity within the ectomycorrhizal genus Russula (Basidiomycota) in West Africa is largely unexplored. The study area was Benin, where only ten out of the 159 species endemic to tropical Africa have been previously reported. We focused on "", which is a monophyletic lineage within Russulasubgen.

Global phylogeny of the family (, ) sheds light on the origin, diversification and endemism in foliicolous lineages.

Foliicolous lichens grow on living leaves of vascular plants. They are mostly found in tropical to subtropical or temperate rainforests. Many phenotype-based species are considered as pantropical or even sub-cosmopolitan, either attributed to old ages, having existed prior to continental breakups or long-distance dispersal.

Characteristics and outcomes of auto-intoxicated patients admitted to the ICU: A retrospective cohort study.

Introduction: Auto-intoxication represents a considerable number of Intensive care unit (ICU) admissions. Literature focusing on characteristics and outcomes of ICU-admitted auto-intoxicated patients is limited.

Objectives: We aimed to identify the quantity of intensive care admissions attributable to auto-intoxication in a Belgian tertiary center, to examine characteristics and outcomes of these patients, and to assess the impact of the covid-19 pandemic on these variables.

The biocontrol agent subsp. tempers shifts in the wheat spicosphere microbiome induced by Fusarium Head Blight.

Introduction: Fusarium Head Blight (FHB) is a major fungal disease in wheat caused by , inducing severe yield losses. Biological control agents (BCAs) can be an effective and sustainable approach to mitigate this phytopathogen. In this study, subsp.

DROP app: A hydroclimate information service to deliver scientific rainfall, local rainfall, and soil moisture forecasts for agricultural decision-making.

Weather and Climate Information Services developed for agriculture often only provide scientific weather and climate forecasts on various timescales. Yet, local forecasts derived from indigenous knowledge and soil moisture information are still missing. In this study, we evaluate the implementation of the DROP app, a hydroclimate information service, offering both local (LF) and scientific rainfall forecasts (SF) and soil moisture forecasts, that was designed with and for smallholder farmers working on rainfed agriculture in northern Ghana.

Underutilized treatments for patients with refractory cancer pain: a qualitative study assessing the use of intrathecal drug delivery devices in the United Kingdom compared to alternative treatments in cancer pain management.

Objectives: This research aims to better delineate how intrathecal drug delivery systems (IDDS) are incorporated into the oncology care continuum and highlight the need for further awareness of interventional options for pain management of cancer patients in the United Kingdom. The study focuses on exploring the knowledge, perspectives, and experiences of healthcare professionals regarding IDDS as a treatment option for managing chronic refractory pain in cancer patients.

Methodology: A thematic coding using inductive analysis was employed to achieve the research objectives.

A Viral Comeback: Recurrent Varicella in A Young Adult Female.

Unlabelled: An otherwise healthy young adult female presented to our clinic with a second episode of varicella. Our patient had a diffuse vesicular rash, reminiscent of childhood varicella, accompanied by constitutional symptoms. This rare presentation of a common virus required careful diagnostic and therapeutic decision-making, with a targeted approach based on clinical presentation and risk factors.

Epidemiology of herpes zoster in National Guard Hospitals in Saudi Arabia: a 6-year retrospective chart review study.

Introduction: Incidence of herpes zoster (HZ) is increasing worldwide, imposing significant burden on healthcare resources. In Saudi Arabia, local epidemiological studies are limited, and HZ burden is unknown.

Methods: This multi-center, hospital-based, retrospective medical chart review was conducted at five National Guard hospitals and affiliated primary care centers.

Patterns and factors associated with healthcare utilisation in Cambodia: a cross-sectional study based on the World Health Survey Plus 2023.

Background: The Cambodian government aims to boost healthcare utilisation in public facilities and reduce the spending burden for disadvantaged households. This study aims to describe patterns of public and private outpatient and inpatient healthcare use and investigate the factors associated with public healthcare usage in Cambodia.

Method: A cross-sectional study was conducted in all provinces in Cambodia, including the capital, Phnom Penh.