Holistic approaches in systemic lupus erythematosus: do physicians avoid addressing difficult-to-treat but highly relevant symptoms?

Despite advancements in the management of systemic lupus erythematosus (SLE), patients experience poor health-related quality of life (hrQoL) and premature death due to disease severity and treatment side effects. Achieving remission offers substantial benefits, including improved hrQoL and reduced mortality, yet the complexity of SLE, with its diverse underlying immune mechanisms and clinical manifestations, hampers progress. Involvement of the central nervous system with symptoms like fatigue, pain and brain fog often goes unaddressed due to limited evidence-based guidance and measurement tools.

Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols.

Immunotherapy of cancer is now an essential pillar of treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration of new treatment strategies incorporating immune agents in cancer clinical practice. Immunotherapies perturb a complex system of interactions among genomically unstable tumor cells, diverse cells within the tumor microenvironment including the systemic adaptive and innate immune cells.

Self-assembling peptide IEIK13 for intra-operative hemostasis in cranial neurosurgery: clinical trial on efficacy and safety.

Objective: This paper describes the results of the first-in-human prospective clinical trial of a hemostatic hydrogel of the self-assembling peptide IEIK13 for hemostasis in intracranial surgery. Both safety and efficacy of IEIK13 for intraoperative hemostasis of oozing bleeding were evaluated in this multicenter trial.

Methods: A total of 80 participants underwent a surgical intervention, during which 203 intradural bleeding sites were treated with IEIK13.

Performance of the EQ-5D-5L with skin irritation and self-confidence bolt-on items in patients with urticaria.

Objectives: This study aimed to validate the EQ-5D-5L with the addition of skin irritation and self-confidence bolt-on items in Chinese patients with urticaria.

Methods: The skin irritation and self-confidence bolt-on items were translated into Simplified Chinese and cognitively debriefed. A cross-sectional survey was subsequently conducted among patients diagnosed with urticaria in Guangdong Province, China.

Colon Cancer Screening, Surveillance, and Treatment: Novel AI driving strategies in the management of colon lesions.

Colonoscopy, a crucial procedure for detecting and removing colorectal polyps, has seen transformative advancements through the integration of Artificial Intelligence (AI), specifically in Computer-Aided Detection (CADe) and Diagnosis (CADx). These tools enhance real-time detection and characterization of lesions, potentially reducing human error, and standardizing the quality of colonoscopy across endoscopists. CADe has proven effective in increasing adenoma detection rate, potentially reducing long-term colorectal cancer incidence.

Clinical validation of the Roche cobas HPV test on the Roche cobas 6800 system for the purpose of cervical screening and qualification as a second-generation comparator test.

This study assessed the relative clinical sensitivity and specificity for cervical precancer of the Roche cobas HPV test when processed using the Roche cobas 6800 system using the Roche cobas 4800 HPV test as comparator. Intra- and inter-laboratory reproducibility were evaluated as well. The cobas HPV test run on the cobas 6800 platform demonstrated a relative clinical sensitivity of 1.

DIAGNOSTIC EVALUATION AND CLINICAL FINDINGS IN CHILDREN WITH PERSISTENT TACHYPNEA OF INFANCY/NEUROENDOCRINE CELL HYPERPLASIA OF INFANCY: A EUROPEAN MULTICENTER RETROSPECTIVE STUDY.

Background: Persistent tachypnea of infancy (PTI)/neuroendocrine cell hyperplasia of infancy (NEHI) is a form of childhood interstitial lung disease (chILD) that predominantly affects young children. Although it is one of the most common chILDs, there is no unified diagnostic approach specific to this condition.

Research Question: Is there a difference in the clinical presentation and the diagnostic approach in PTI/NEHI patients between the European countries?

Study Design And Methods: This was a European multicenter, retrospective, observational study.

The perceived environmental sustainability (PENSUS) scale for food and drinks: Development and validation among young consumers in Belgium.

The perceived sustainability of food plays a significant role in young consumers' eating behaviors. While it is highly relevant to investigate these sustainability perceptions, the available measures are limited. Previous research has mostly relied on single-item measurements that only allow a surface-level understanding of food sustainability perceptions.

Reliability and validity of instrumented timed up and go test in typical adults and elderly: a systematic review.

Objective: To summarize the available literature investigating the reliability and validity of the instrumented timed up and go (iTUG) in typical adults and elderly.

Data Sources: Data were collected from PubMed, Web of Science and hand searching up until July 15, 2024.

Study Selection: English-language studies investigating the reliability and validity for the 3-meter version of the iTUG in typical adults and elderly were included.

The health-economic burden of hip and knee periprosthetic joint infections in Europe : a comprehensive analysis following primary arthroplasty.

Aims: Periprosthetic joint infections (PJIs) pose significant challenges to patients and healthcare systems worldwide. The aim of this study was to estimate the health-economic burden of reimbursement payment in Europe for PJIs following primary hip and knee arthroplasty.

Methods: The calculation was based on health-economic modelling using data on primary hip and knee arthroplasties for the year 2019 from the Statistical Office of the European Union (Eurostat) and published infection rates to estimate the total number of hip and knee PJIs in 30 European countries.

Investigation and optimization of the extra-column band broadening in micro-flow capillary liquid chromatography.

We report on the examination of extra-column band broadening (ECBB) effects as they can be observed when using commercially available HPLC products for micro-LC, with the aim of proposing some general rules for a rational design of the instrument set-up. For this purpose, we systematically assessed the ECBB contribution of the different LC instrument parts under fixed isocratic measurement conditions, using coumarin compounds with a retention factor (k) of respectively ∼1.2 and ∼2.

Stakeholders' practices in the pork value chain: Potential risks for Taenia solium and Toxoplasma gondii transmission in Burundi.

Pork is one of the most consumed meats in the world, including in Burundi. This study aimed to describe the pork value chain (PVC), stakeholders' practices, and the implications for the transmission of T. solium and T.

Co-MOF-derived CoO sensors for efficient 3-octanone biomarker monitoring in wheat mildew.

3-octanone has been widely identified as a primary biomarker for mold and insect infestation in wheat. Nevertheless, to date, no chemiresistive sensor based on a metal oxide semiconductor with excellent sensing properties for 3-octanone has been developed. In light of the extensively reported superior efficacy of CoO-based sensors for ketone detection, we designed CoO samples with various hierarchical morphologies (hollow sphere, multi-wall sphere, flower-like, and urchin-like), which were determined by regulating solvent and organic ligand.

Ahmedabad declaration: A framework to combat growing epidemic of young-onset type 2 diabetes in Asia.

Aim: Rising prevalence of Type 2 Diabetes (T2D) among young Asians has emerged as a public health crisis that threatens the long-term health, economic stability, and productivity of nations across Asia (1). Early-onset T2D poses unique challenges, including higher rates of undiagnosed cases, more aggressive disease progression, an increased risk of chronic complications and higher mortality (2). Hyperglycemia during the reproductive age especially among the female population can potentially have transgenerational impact through epigenetic changes.

Time-dependency of test-retest reliability and measurement error of center-of-pressure synchronization and symmetry during quiet standing within specific frequencies in early sub-acute stroke.

Background: People with unilateral sensorimotor impairments after a stroke exhibit poor between-limb synchronization and asymmetries in balance control by relying on their less-affected side to maintain stability during standing. Therefore, there is a growing consensus to include center-of-pressure metrics as between-limb synchronization and dynamic control asymmetry when investigating balance improvements poststroke. However, the test-retest reliability of these metrics remains under-investigated, hindering uptake of these assessments in future stroke rehabilitation and recovery studies.

Extracting the Luttinger Parameter from a Single Wave Function.

The low-energy physics of Tomonaga-Luttinger liquids (TLLs) is controlled by the Luttinger parameter. We demonstrate that this parameter can be extracted from a single wave function for one-component TLLs with periodic boundary condition. This method relies on the fact that TLLs are described by conformal field theory in which crosscap states can be constructed.

Empowering Health Care Actors to Contribute to the Implementation of Health Data Integration Platforms: Retrospective of the medEmotion Project.

Health data integration platforms are vital to drive collaborative, interdisciplinary medical research projects. Developing such a platform requires input from different stakeholders. Managing these stakeholders and steering platform development is challenging, and misaligning the platform to the partners' strategies might lead to a low acceptance of the final platform.

Long-Term Experiences of Health Care Providers Using Iris Scanning as an Identification Tool in a Vaccine Trial in the Democratic Republic of the Congo: Qualitative Study.

Background: Iris scanning has increasingly been used for biometric identification over the past decade, with continuous advancements and expanding applications. To better understand the acceptability of this technology, we report the long-term experiences of health care providers and frontline worker participants with iris scanning as an identification tool in the EBL2007 Ebola vaccine trial conducted in the Democratic Republic of the Congo.

Objective: This study aims to document the long-term experiences of using iris scanning for identity verification throughout the vaccine trial.

A Self-Adaptive Serious Game to Improve Motor Learning Among Older Adults in Immersive Virtual Reality: Short-Term Longitudinal Pre-Post Study on Retention and Transfer.

Background: Despite their potential, the use of serious games within immersive virtual reality (iVR) for enhancing motor skills in older adults remains relatively unexplored. In this study, we developed a self-adaptive serious game in iVR called REAsmash-iVR. This game involves swiftly locating and striking a digital mole presented with various distractors.

Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding.

Small molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acquired resistance, often causing therapy discontinuation, is frequently caused by mutations in the kinase therapeutic target. The advent of clinical tumor sequencing has opened additional opportunities for precision oncology to improve patient outcomes by pairing optimal therapies with tumor mutation profiles.

PathoSeq-QC: a decision support bioinformatics workflow for robust genomic surveillance.

Motivation: Recommendations on the use of genomics for pathogens surveillance are evidence that high-throughput genomic sequencing plays a key role to fight global health threats. Coupled with bioinformatics and other data types (e.g.

Multicentric prospective evaluation of Pneumocystis jirovecii fungal load in bronchoalveolar lavage fluid fractions using qPCR.

Bronchoalveolar lavage fluid (BALF) is the key sample type for diagnosing Pneumocystis jirovecii pneumonia, with quantitative PCR (qPCR) providing high sensitivity and specificity. However, sample processing varies considerably between laboratories, and optimal nucleic acid extraction method for BALF remains undetermined. This retrospective multicenter study, conducted in 12 centers as part of the Fungal PCR Initiative, assessed the efficacy of P.

Rationale and design of the Renal Lifecycle Trial assessing the Effect of Dapagliflozin on Cardiorenal Outcomes in Severe Chronic Kidney Disease.

Background: Several clinical trials have shown beneficial effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) with and without type 2 diabetes mellitus. However, some subgroups of patients with CKD have been excluded from participation in these trials, such as patients with severely impaired kidney function, patients on dialysis, and kidney transplant recipients.

Methods: The Renal Lifecycle trial (NCT05374291) is a pragmatic, international, multicenter, investigator-initiated, randomized, placebo-controlled, clinical trial planned to enroll approximately 1500 patients with 1) an estimated glomerular filtration rate (eGFR) ≤25 ml/min/1.