Effect of Curing Temperature on Volume Changes of Alkali-Activated Slag Pastes.

This study investigates the influence of curing temperature (explored at 10 °C, 20 °C, and 30 °C) on the volume changes of alkali-activated slag (AAS) pastes with the aim of expanding existing knowledge on alkali-activated materials (AAMs). The focus was on autogenous and thermal strains, internal relative humidity (IRH), heat flow and cumulative heat, setting times, and workability. The results indicate that increasing the curing temperature to 30 °C reduces autogenous shrinkage, likely due to changes in the elastic modulus and viscoelastic properties, while promoting swelling, especially for higher molarities.

General Practitioners' Mental Well-Being During Crises: Results of the PRICOV-19 Study Pilot in Serbia.

Background/aims: This study was conducted with the aim of assessing the mental well-being of general practitioners (GPs) amidst the COVID-19 pandemic in Serbia. These findings are intended to provide valuable insights to primary care stakeholders about the potential need for support interventions.

Materials And Methods: In the context of the international cross-sectional survey on primary health care during the COVID-19 pandemic (PRICOV-19), our initial focus was on evaluating the appropriateness of employing the Mayo Clinic Well-Being Index (MWBI) for Serbian GPs.

Footwear Choice and Locomotor Health Throughout the Life Course: A Critical Review.

In this paper, we review and discuss epidemiological and experimental evidence on the effects of daily footwear on gait and life-long health. We consider different types of footwear, including "minimal shoes", and their design features, comparing them to barefoot walking, with a focus on overall gait and the function of the heel pad. Narrative review.

Assessment of Muscular Strength and Functional Capacity in Smoker Population Without Any Diagnosed Respiratory Disease: A Cross-Sectional Study.

: Smoking is a risk factor for chronic obstructive pulmonary disease (COPD) and lung cancer. In addition to pulmonary damages, peripheral muscle impairments are present in this population. Pulmonary limitation is observed in smokers before disease diagnosis, but functional capacity limitations are uncertain, contrary to patients who have already been diagnosed.

Bimekizumab in the Treatment of Axial Spondyloarthritis and Psoriatic Arthritis: A New Kid on the Block.

The interleukin (IL)-17 family encompasses six structurally related pro-inflammatory cystine knot proteins, designated as IL-17A to IL-17F. Over the last decades, evidence has pointed to its role as a critical player in the development of inflammatory diseases such as psoriasis (PsO), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA). More specifically, IL-17A and IL-17F are overexpressed in the skin and synovial tissues of patients with these diseases, and recent studies suggest their involvement in promoting inflammation and tissue damage in axSpA and PsA.

Functional Interactions Between Recombinant Serum Amyloid A1 (SAA1) and Chemokines in Leukocyte Recruitment.

The acute phase response is a hallmark of all inflammatory reactions and acute phase reactants, such as C-reactive protein (CRP) and serum amyloid A (SAA) proteins, are among the most useful plasma and serum markers of inflammation in clinical medicine. Although it is well established that inflammatory cytokines, mainly interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) induce SAA in the liver, the biological functions of elicited SAA remain an enigma. By the classical multi-step protein purification studies of chemotactic factors present in plasma or serum, we discovered novel chemokines and SAA1 fragments, which are induced during inflammatory reactions.

Spatial Transcriptomic Analysis of Surgical Resection Specimens of Primary Head and Neck Squamous Cell Carcinoma Treated with Afatinib in a Window-of-Opportunity Study (EORTC90111-24111).

Afatinib-induced tumor and microenvironment modifications in head and neck squamous cell carcinoma were evaluated by spatial transcriptomics in surgical specimens and RNA-sequencing in tumor biopsies of patients included in the EORTC-90111-24111 window-of-opportunity study. The aim was to explore tumor evolution and composition under anti-HER therapy. Based on our previous investigations by RNA-seq on tumor biopsies, surgical slides of ID08 and ID15 from the epithelial-to-mesenchymal (EMT) cluster and ID30 from the non-EMT cluster were investigated with spatial transcriptomics.

Free Radical Scavenging Activity and Inhibition of Enzyme-Catalyzed Oxidation by -aryl-Palladium Complexes.

Herein, nine square planar -arylbis(triphenylphosphine)palladium halides (PdX(PPh)Ar) were synthesized and fully characterized. The molecular structure of two complexes ( and ) have been determined by both X-ray diffraction and described thanks to Hirshfeld surface analysis. Investigation of the antioxidant activities showed that most of the complexes exhibit a strong dose-dependent radical scavenging activity towards DPPH radical as well as in the ABTS radical scavenging test.

Correction: Sherstneva et al. Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application. 2022, , 1314.

Acknowledgments were not included in the original publication [...

Advancing Textile Waste Recycling: Challenges and Opportunities Across Polymer and Non-Polymer Fiber Types.

The growing environmental impact of textile waste, fueled by the rapid rise in global fiber production, underscores the urgent need for sustainable end-of-life solutions. This review explores cutting-edge pathways for textile waste management, spotlighting innovations that reduce reliance on incineration and landfilling while driving material circularity. It highlights advancements in collection, sorting, and pretreatment technologies, as well as both established and emerging recycling methods.

Important Diseases of Small Ruminants in Sub-Saharan Africa: A Review with a Focus on Current Strategies for Treatment and Control in Smallholder Systems.

Sheep and goats are an important source of livelihood for smallholder farmers in sub-Saharan Africa (SSA). These livestock are almost entirely managed by resource-poor, smallholder farmers and pastoralists. Despite the large number of sheep and goats in SSA, their productivity is low, mainly due to diseases, poor feed, and inferior breeds.

A Novel Biplex Rapid Diagnostic Test Evaluated Among 3- to 9-Year-Old Children in Maridi, South Sudan.

: Point-of-care diagnostic tests are essential for confirming transmission in remote, resource-limited, onchocerciasis-endemic communities. In Maridi, South Sudan, we field-tested a novel "biplex A" rapid diagnostic test (RDT) developed by Drugs & Diagnostics for Tropical Diseases (DDTD), San Diego, California. : In February 2023, children aged 3-9 years were recruited from study sites at different distances from the Maridi Dam, a known blackfly breeding site.

Exploring MRI and Mammography Lesion Features for Breast Cancer Detection in PTEN Hamartoma Tumor Syndrome.

(1) Background/Objectives: Women with hamartoma tumor syndrome (PHTS) face a significantly increased risk of breast cancer (up to 66%) and a high prevalence of benign breast lesions (30-75%), which can complicate cancer detection and underscore the need for effective surveillance strategies. This study aimed to evaluate the imaging characteristics of breast cancers and benign breast lesions using magnetic resonance imaging (MRI) and mammography, with the goal of improving early cancer detection, reducing unnecessary biopsies, and guiding future surveillance protocols. (2) Methods: This retrospective single-institution study included 65 PHTS women aged ≥18 years (2001-2021), 39 of whom participated in a high-risk breast cancer surveillance program.

Line-Field Confocal Optical Coherence Tomography: Is One Hour of Training Sufficient for Diagnosing Basal Cell Carcinoma?

Basal cell carcinoma (BCC) is the most common malignancy, characterised by local invasiveness and the potential for tissue destruction. Diagnosing BCC can be challenging, particularly for less experienced dermatologists. Line-field confocal optical coherence tomography (LC-OCT), a new noninvasive optical technique, has become increasingly useful in clinical practice, allowing in vivo imaging at cellular resolution.

Scientific highlights of the 8th world one health Congress, Cape Town, South Africa 2024.

The 8th World One Health Congress took place in Cape Town, South Africa on 20-23 September 2024 to address all cross-sectoral and transdisciplinary aspects of the One Health paradigm, integrating human, animal, and environmental health. It brought together more than 1400 participants from 87 countries, and 400 speakers across 70 sessions. We summarize here the fourteen keynote lectures, which emphasized the need for a One Health approach to better integrate plant and agricultural health against food insecurity; the continuing challenges posed by antimicrobial resistance and emerging infectious threats; a paradigm shift towards health risk prevention; and approaches to further strengthen and expand the impact of the One Health movement.

Model development to assess the impact of a preventive treatment with sarolaner and moxidectin on Dirofilaria immitis infection dynamics in dogs.

Background: Dirofilaria immitis is a mosquito-transmitted filarial parasite causing heartworm disease in dogs. The parasite may cause a significant disease burden to the dog population in high prevalence areas and is mainly managed through prophylactic treatments.

Methods: In this modelling study, the effect of a prophylactic treatment with moxidectin and sarolaner on heartworm disease dynamics was investigated in dogs.

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.

Background: Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood glial fibrillary acidic protein (GFAP) has garnered attention as a FTD biomarker. However, investigations of GFAP in FTD have been hampered by symptomatic and histopathologic heterogeneity and small cohort sizes contributing to inconsistent findings.

Surgical long-term outcomes of Hirschsprung Disease in the Democratic Republic of Congo: a case series of 31 patients in a resource-limited setting.

Background: Hirschsprung disease (HD) contributes significantly to the burden of disease related to conditions amenable to pediatric surgery within the Democratic Republic of Congo (DRC). However, it has received less clinical attention due to limited resources. We aimed at assessing the long-term follow-up outcomes following an innovate resection approach in South Kivu, eastern DRC.

Unlocking the geography of Azobé timber (Lophira alata): revealing spatial genetic structure beyond species boundaries.

Background: The illegal trade of tropical timber constitutes a major and persistent environmental problem. Since the detection of fraud in trade documents remains challenging, forensic tools that can independently trace timber origin are needed. In this study, we evaluated the potential of the chloroplast genome (plastome) as a genetic tool to verify the claimed species and geographic origin of timber from Azobé (Lophira alata), an intensively exploited and threatened tropical tree species.

Asynchronous xylogenesis among and within tree species in the central Congo Basin.

Background: Xylogenesis is synchronous among trees in regions with a distinct growing season, leading to a forest-wide time lag between growth and carbon uptake. In contrast, little is known about interspecific or even intraspecific variability of xylogenesis in tropical forests. Yet an understanding of xylogenesis patterns is key to successfully combine bottom-up (e.

Short-distance seed and pollen dispersal in both hunted and intact forests in the lower canopy African rainforest tree, Coula edulis Baill. (Coulaceae).

Background: Mammal-dispersed tropical trees can face regeneration problems due to increasing hunting pressure. We studied the case of Coula edulis Baill. (Coulaceae), an African rainforest tree that produces the 'African walnut', an essential food and income resource for rural communities.

Optimizing ethanol-modified supercritical CO₂ extraction for enhanced bioactive compound recovery in hemp seed oil.

This work aimed to extract hemp seed oil using modified supercritical CO with ethanol, while optimizing the overall process through response surface methodology. The effects of extraction temperature (30-60 °C), pressure (10-20 MPa), and time (120-300 min) on oil yield, total phenols (TPC), total tocopherols, oxidative stability index (OSI), total chlorophylls, total carotenoids, quality indices, and color were assessed. For a maximum yield of 28.

First-Line Tislelizumab Plus Chemotherapy for Esophageal Squamous Cell Carcinoma with Programmed Death-Ligand 1 Expression ≥ 1%: A Retrospective Analysis of RATIONALE-306.

Introduction: The United States Food and Drug Administration Oncologic Drugs Advisory Committee voted (September 2024) against the use of programmed cell death protein-1 inhibitors for first-line treatment of advanced or metastatic unresectable esophageal squamous cell carcinoma (ESCC) with a programmed death-ligand 1 (PD-L1) expression Tumor Area Positivity (TAP) score < 1% or combined positive score < 1 due to an unfavorable benefit-risk profile observed across the phase 3 CheckMate 648, KEYNOTE-590, and RATIONALE-306 trials. Therefore, we conducted a retrospective analysis of RATIONALE-306 to evaluate the efficacy and safety of tislelizumab plus investigator-chosen chemotherapy (ICC) versus placebo plus ICC in patients with advanced or metastatic unresectable ESCC and a PD-L1 TAP score ≥ 1%.

Methods: Adult patients with advanced or metastatic unresectable ESCC enrolled in the global, randomized, phase 3 RATIONALE-306 trial randomly received tislelizumab 200 mg every 3 weeks plus ICC or matched placebo plus ICC.

Association of medication adherence with treatment preferences: incentivizing truthful self-reporting.

Objective: Self-reported medication adherence may be influenced by socially desirable answers and untruthful reporting. Misreporting of adherence behavior can bias estimations of treatment (cost)effectiveness. This study investigated how to induce truthful self-reported medication adherence and evaluated how self-reported (truth-induced vs.