Key elements for designing effective second victim support interventions: a focus group study in European clinical settings.

Background: The second victim (SV) experience limits the performance of health and care workers and places patients at risk. Peer support is recognised as the most effective, feasible and acceptable intervention to mitigate its impact.

Objective: To define a set of success factors when designing interventions to support SVs in health and care facilities based on expertise in different European countries.

Cardiac arrhythmia assessment with patch electrocardiogram versus insertable cardiac monitor: a cohort study in endurance athletes with atrial fibrillation.

Objectives: The objective of this study was to assess the quality of ECG recordings and the concordance between the automatic detection of cardiac arrhythmia episodes by a patch ECG and an insertable cardiac monitor.

Design: Prospective cohort study.

Setting And Participants: Endurance athletes diagnosed with paroxysmal atrial fibrillation (AF) and no other relevant comorbidities participating in a randomised controlled trial on the effects of training adaption.

Laser-Induced Metal-Organic Framework-Derived Flexible Electrodes for Electrochemical Sensing.

The successful development of a metal-organic framework (MOF)-derived Co/CoO/C core-shell composite integrated into laser-induced graphitic (LIG) carbon electrodes for electrochemical sensing is reported. The sensors are fabricated via a direct laser scribing technique using a UV laser (355 nm wavelength) to induce the photothermolysis of rationally selected ZIF-67 into the LIG matrix. Electrochemical characterization reveals that the incorporation of the laser-scribed ZIF-67-derived composite on the electrode surface reduces the impedance more than 100 times compared with bare LIG sensors.

Past, present and future of injury prevalence in high-income countries: insights and projections up to 2030 from the Global Burden of Disease Study.

Background: Injury prevalence is a metric which can be used to understand healthcare utilisation and prioritise injuries based on the magnitude of the injury rate. Given the ageing population in high-income countries and subsequently ageing of the injured population, the probability of long-term or permanent consequences of injuries is also likely to increase. By understanding past trends and exploiting patterns of prevalence injury rates (PIRs), future PIRs can be predicted.

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study.

Gyrate atrophy of the choroid and retina (GACR, OMIM #258870) is a rare inherited metabolic disorder characterized by progressive chorioretinal degeneration and hyperornithinemia. Current therapeutic modalities potentially slow disease progression but are not successful in preventing blindness. To allow for trial development, increased knowledge of the clinical phenotype and current therapeutic outcomes is required.

Biome conservatism prevailed in repeated long-distance colonization of Madagascar's mountains by Helichrysum (Compositae, Gnaphalieae).

Colonization and diversification processes are responsible for the distinctiveness of island biotas, with Madagascar standing out as abiodiversity hotspot exceptionally rich in species and endemism. Regardless of its significance, the evolutionary history and diversification drivers of Madagascar's flora remain understudied. Here we focus on Helichrysum (Compositae, Gnaphalieae) to investigate the evolutionary and biogeographic origins of the Malagasy flora.

Baseline gray matter volume associates with working memory performance after prefrontal transcranial direct current stimulation.

Working memory is crucial for daily life and is often impaired in neuropsychiatric conditions. Attempts to enhance it using transcranial direct current stimulation (tDCS) have shown mixed results, possibly due to large inter-individual variability. This study assessed whether baseline regional brain volume was associated with working memory performance following tDCS.

Proximate cord insertion in monochorionic twins with selective fetal growth restriction.

Background: Monochorionic (MC) twins share a single placenta which can be unequally shared, leading to selective fetal growth restriction (sFGR). Limited data is available on the prevalence and clinical consequences of proximate cord insertion (PCI) in sFGR pregnancies.

Objective: We aimed to investigate the prevalence of PCI in MC placentas with and without sFGR and per type of sFGR, and study the placental characteristics and perinatal outcome of PCI in sFGR pregnancies.

Expression and purification of an activated Orexin receptor 1- G-protein complex.

Orexin receptors constitute a family of class A G-protein coupled receptors. There are two subtypes of orexin receptors, namely OX1R and OX2R. OX1R and OX2R are widely distributed in the central nervous system and are the targets for the peptide neurotransmitters orexin-A and orexin-B.

Towards faster quality control of personal radiation protective equipment using CT scout or a dedicated biplanar radiography device.

Quality control (QC) of personal radiation protective equipment (PRPE) is essential to detect tears and holes in the attenuating layers. Routinely, this QC is performed using fluoroscopy on a conventional X-ray table. However, such a QC procedure is laborious and time consuming.

Anatomy versus Shunt Fraction: Hemodynamic Consequences in Atrial Septal Defects and Partial Anomalous Pulmonary Venous Connection - A comprehensive CMR study.

Aims: Atrial septal defect (ASD) and partial abnormal pulmonary venous connection (PAPVC) are noncyanotic congenital heart defects (CHD) that produce a left-to-right shunt. This single-center retrospective study aimed to assess the hemodynamic impact of isolated ASD, isolated PAPVC, and ASD-associated PAPVC using cardiovascular magnetic resonance (CMR).

Methods And Results: From our CMR registry (2002-2024), 110 patients were included: isolated ASD (n=64), isolated PAPVC (n=18), ASD-associated PAPVC (n=28, mostly sinus venosus septal defects).

Proteomics- and metabolomics-based analysis of the regulation of germination in Norway maple and sycamore embryonic axes.

Norway maple and sycamore belong to the Acer genus and produce desiccation-tolerant and desiccation-sensitive seeds, respectively. We investigated the seed germination process at the imbibed and germinated stages using metabolomic and proteomic approaches to determine why sycamore seeds germinate earlier and are more successful at establishing seedlings than Norway maple seeds under controlled conditions. Embryonic axes and embryonic axes with protruded radicles were analyzed at the imbibed and germinated stages, respectively.

Revised method for constructing acoustic vulnerability curves in trees.

During drought, the formation of air bubbles known as embolisms in the water-conducting xylem reduces hydraulic conductivity, which can ultimately result in tree death. Accurately quantifying vulnerability to embolism formation is therefore essential for understanding tree hydraulics. Acoustic emission (AE) analysis offers a non-destructive method to monitor this process, yet the interpretation of captured signals remains debated.

Radiation exposure in patients with inflammatory bowel disease.

Background And Aims: Radiological imaging is crucial for diagnosing and monitoring patients with inflammatory bowel diseases (IBD). With increasing awareness of radiation risks, imaging doses should be 'as low as reasonably achievable', with a risk level that one should try to stay underneath 75 mSv. However, real-world data on cumulative exposure are limited.

Human mobility and malaria risk in peri-urban and rural communities in the Peruvian Amazon.

Background: While the global burden of malaria cases has decreased over the last two decades, the disease remains a major international threat, even on the rise in many regions. More than 85% of Peruvian malaria cases are in the Amazonian region of Loreto. Internal mobility primarily related to occupation is thought to be primarily responsible for maintaining endemicity and introducing and reintroducing malaria parasites into areas of anophelism, a challenge for malaria eradication.

The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons.

The MAPT gene encodes Tau protein, a member of the large family of microtubule-associated proteins. Tau forms large insoluble aggregates that are toxic to neurons in several neurological disorders, and neurofibrillary Tau tangles represent a key pathological hallmark of Alzheimer's disease (AD) and other tauopathies. Lowering Tau expression levels constitutes a potential treatment for AD but the mechanisms that regulate Tau expression at the transcriptional or translational level are not well understood.

Short-Term Effects of Semi-Occluded Vocal Tract Therapy on the Phonation of Children With Vocal Fold Nodules: A Randomized Controlled Trial.

Purpose: The aim was to determine and compare the short-term effects of two intensive semi-occluded vocal tract (SOVT) programs, "straw phonation" (SP) and "resonant voice therapy" (RVT), on the phonation of children with vocal fold nodules.

Method: A pretest-posttest randomized controlled study design was used. Thirty children aged 6-12 years were randomly assigned to the SP group ( = 11), RVT group ( = 11), or control group receiving indirect treatment ( = 8) for their voice problems.

Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis.

Purpose: Overlapping genes are involved with rheumatoid arthritis (RA) and DNA repair pathways. Therefore, we hypothesised that patients with a high polygenic risk score (PRS) for RA will have an increased risk of radiotherapy (RT) toxicity given the involvement of DNA repair.

Methods: Primary analysis was performed on 1494 prostate cancer, 483 lung cancer and 1820 breast cancer patients assessed for development of RT toxicity in the REQUITE study.

Rapidly spreading with OXA-48-like carbapenemases.

(mostly , ) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy.

The peri-articular muscle envelope of the hip (PAME) shows atrophy in patients with refractory groin pain after iliopsoas tenotomy.

Background: Iliopsoas tenotomy is commonly used to address refractory groin pain resulting from iliopsoas tendinopathy. However, consensus and high-level research on its effectiveness are lacking, with concerns about poor outcomes and complications. Little is known of the effects of iliopsoas tenotomy on the peri-articular muscle envelope of the hip.