Case Report: Winkelmann hip rotationplasty as a last-resort solution.

Background: Rotationplasty, an invasive surgery, serves as an alternative to amputation in pediatric orthopedic oncology. It is currently applied in broader cases (e.g.

Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study.

Objectives: Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneous manifestations. First-line treatment is based on colchicine, hydroxychloroquine, dapsone or low-dose glucocorticoids. In refractory forms, the use of biologics has been anecdotally described as potentially effective.

An Instrument for Evaluating the Self: The Self-Discrepancies Scale in Non-Clinical Participants.

Objective: The Self-Discrepancies Scale (S-DS) is a multiple-subscore instrument designed to assess discrepancies between mental representations of the self: the actual self on one hand, and the ideal and socially prescribed selves on the other. Its idiographic subscores rely on the endorsement of self-descriptive traits, while its abstract subscores form an overall judgement of felt self-discrepancies. The objectives of the present study were to (i) evaluate the S-DS in a new non-clinical population, (ii) expand the body of data on the S-DS's convergent validity, (iii) study the idiographic data for the S-DS, and (iv) establish a nomothetic list of traits with a better choice of unwanted traits.

[Elexacaftor, Tezacaftor and Ivacaftor: immediate efficacy evaluation using home spirometry].

Introduction: Following two weeks of application of the triple combination therapy of Elexacaftor (E), Tezacaftor (T), and Ivacaftor (I) known as ETI, substantial pulmonary improvement in patients with cystic fibrosis is well-documented. However, few detailed data are available on the action of this treatment over the course of these first 14 days.

Methods: In this prospective study (NCT05599230), 20 patients aged≥12 years, all of them eligible for ETI, were recruited at the initiation of treatment.

Development of an easy non-destructive particle isolation protocol for quality control of red blood cell concentrates.

The extracellular vesicle release in red blood cell concentrates reflects progressive accumulation of storage lesions and could represent a new measure to be implemented routinely in blood centres in addition to haemolysis. Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation-based protocol (20,000 ×  protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level.

[Patient with type 2 diabetes and progressive chronic kidney disease].

Chronic kidney disease (CKD) is a common and severe complication in patients with type 2 diabetes (T2D). While inhibitors of the renin-angiotensin system remained for a long time the only medications that had proven nephroprotective effects, several other pharmacological classes also recently showed such a benefit : sodium-glucose cotransporter type 2 (SGLT2) inhibitors (gliflozins), glucagon-like peptide-1 receptor agonists (semaglutide), and mineralocorticoid receptor antagonists (MRA, finerenone). This clinical vignette aims at explaining the pharmacotherapy strategy for a patient with T2D who presents a progressive CKD.

[Addison's disease: looking to the past and the future].

In 1849, Thomas Addison discovered alterations in the adrenal glands at autopsy of three patients who had died with idiopathic anemia. Struck by Addison's work, Charles-Edouard Brown-Séquard demonstrated in 1851 that bilateral adrenalectomy in dogs was fatal. It was not until 1950 that the discovery of the hormones of the adrenal cortex, their structure and their biological effects allowed Kendall, Reichstein and Hench to win the Nobel Prize in Physiology or Medicine.

[Molecular biomarkers in breast cancer : advances in precision medicine].

Breast cancer is a complex disease influenced by genetic and environmental factors. Molecular profiling research has revealed significant diversity within the disease, including among tumours with similar morphological features. This diversity can lead to significant differences in tumour behaviour.

[The place of invasive approaches to the treatment of low back pain].

The prevalence of chronic low back pain is high and rising. Chronic low back pain is «non-specific» in approximately 90 % of cases. In addition to age, risk factors include smoking, obesity, physical and psychological stress, as well as demographic factors.

[Bronchiectasis in patients with severe asthma : a narrative literature review].

Asthma is a common respiratory disease, accounting for 3 to 10 % of severe cases. Among these, bronchiectasis is more frequent (prevalence between 15.5 % and 67.

[Out-of-hospital cardiac arrests : year 2023 review of the CHC - Bcar registry in Liege area (Belgium)].

Out-of-hospital cardiac arrests represent impactful events. Despite the evolution of care, they are still associated with high morbidity and mortality. We present the analysis of our activity included in the 2023 CHC - Bcar registry in Liege area (Belgium).

[Idiopathic pulmonary arterial hypertension revealed by right ventricular dysfunction].

Idiopathic pulmonary arterial hypertension (iPAH) is a rare, rapidly progressive disease associated with high morbidity and mortality. It is characterized by endothelial dysfunction within the pulmonary vascular bed and gradually leads to an increase in the pulmonary vascular resistances. Its non-specific symptomatology delays the diagnosis and brings the most severe forms to right ventricular failure.

[Clinical case : Prevascular mediastinal mass].

In the event of a prevascular mediastinal mass, knowledge of the anatomy and content of the mediastinum is an essential prerequisite to establish a differential diagnosis. The «4T» rule is applicable because it is a simple and effective mnemonic. It groups together; thyroid goiter, terrible lymphoma, teratoma and thymoma.

[How I treat… An open bite secondary to ankylosis of a primary molar tooth].

Infraclusion is a consequence of dentoalveolar ankylosis. Associated complications include extrusion of the opposing tooth, open bites, and tilts. Early detection and management are crucial to limit and/or correct these complications.

[Spontaneous cervical swelling syndrome].

Spontaneous cervical swelling syndrome is a rare, benign, and recurrent condition, most commonly affecting middle-aged women. Although its etiology is not fully understood, it is thought to be associated with intermittent occlusion of the thoracic duct, caused by increased pressure in the head and neck region. It occurs as an acute, limited swelling of the left supra-clavicular region and regresses, in most cases, spontaneously, in less than a week.

Adherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study.

Purpose: The American Clinical Neurophysiology Society has provided a set of recommendations on the use of critical care EEG monitoring (CEEG). However, these recommendations have not been prospectively validated. We aimed to assess the adherence to the American Clinical Neurophysiology Society recommendations for obtaining CEEG for different indications and the yield of obtained CEEG according to these different indications.

[Pseudoaneurysm of the mitro-aortic trigone: Clinical case and literature review].

Case Report: We report the case of a 63-year-old patient who underwent aortic valve replacement with a biological valve for a bicuspid aortic stenosis, and LIMA-IVA single-bypass surgery. Two weeks later, he presented with Enterococcus faecillis bacteremia, attributed to left pyelonephritis and successfully treated with Amoxicillin. Two months after his surgery, he had a new bacteremia due to Enterococcus faecalis and we discovered a pseudo-aneurysm of the mitro-aortic trigone.

The utility of parent's and teacher's concerns for the screening of speech sound disorders: A study on French-speaking preschool children.

Speech sound disorders (SSD) are associated with difficulties in communication, social participation, literacy, and learning. An early identification process is therefore necessary. Our study was aimed at determining the utility and accuracy of parent's and teacher's concerns in screening for SSD.

[Intraoperative iatrogenic thermal burn: case report and review of operating room fire prevention measures].

Combustion of surgical drapes during surgery is a rare event which can nonetheless lead to serious consequences. Iatrogenic burns caused by this complication are often deep and lead to functional and aesthetic sequelae. Nevertheless, awareness of the triggering factors and mechanisms, as well as knowledge of the proper use of various at-risk products such as alcohol-based antiseptic agents and compressed oxygen can reduce the incidence of these undesirable events.

Behavioral Determinants of Older Adults' and Caregivers' Willingness to Deprescribe: A Systematic Review.

Background: Deprescribing is a strategy to optimize medication use and to prevent medication harm. Despite the fact that behavioral theories have been shown to be useful in explaining health behaviors, the literature on deprescribing relies almost exclusively on attitudes as an explanatory factor for deprescribing behavior. This study systematically reviews the literature that made explicit use of the constructs included in health behavior theories (HBTs) to explain older adults' and informal caregivers' deprescribing behavior and outcomes.

Prevalence, Activity Limitations and Quality of Life in Patients with Non-Specific Neck Pain in Burundi: A Cross-Sectional Study.

Introduction: Non-specific neck pain (NSNP) causes a great deal of discomfort, impacting a person's functionality and quality of life. This study aimed to determine the prevalence, activity limitations, and quality of life in patients with NSNP in Burundi.

Patients And Methods: This was a cross-sectional study with descriptive and analytical aims, covering the period from September 2023 to February 2024.

Uterine rupture with induction using misoprostol for intrauterine foetal death in the second trimester: A case report.

Uterine rupture is a well-known, life-threatening complication of misoprostol use; the incidence is remarkably low. Herein, we report what seems to be the first documented case of uterine rupture following induction of labour for intrauterine foetal death in the second trimester without a uterine scar. A 40-year-old woman with no history of caesarean section or uterine surgery presented with mild lower abdominal pain and mild genital bleeding.