Programmable Wrinkled MXene-Based Soft Actuators with Moisture- and Light-Responsive Deformation and Water-Surface Locomotion Capabilities.

Soft actuators are limited by single-mode driving technology, which poses challenges in dealing with complex and multidimensional movements. In this study, a multiresponsive soft actuator was fabricated by integrating a microwrinkling structure into an MXene-based film, enabling programmable motions. To achieve this, we introduced -hexane into the film preparation process and utilized its rapid volatilization to accelerate the shrinkage difference between the film and the substrate.

Migraine and cognitive dysfunction: a narrative review.

The association between migraine and cognitive function has been studied during the last decade, however, this relationship is not well established. As migraine prevalence is highest between the ages of 30-40, aligning with some of our most productive years, we must understand cognitive changes within this disorder. Cognitive impairment potentially limits social and professional interactions, thus negatively impacting quality of life.

Analysis of bioactive compounds of hen egg components at the first half of incubation.

A comparative analysis of mass-volume characteristics of structural and morphological components of hen eggs before incubation and on the fifth (HH25-HH27) and 10th (HH36) days of incubation was carried out. During incubation, egg weight decreased by 9.25% (10 days), mainly due to a decrease in albumen weight (35.

Recent advances in asymmetric synthesis cyclopropanol intermediates.

Cyclopropanols have attracted significant attention in organic synthesis as versatile three-carbon synthons, as this readily available class of donor-activated cyclopropanes undergoes miscellaneous transformations, either ring-opening or with retention of the cyclopropane ring. This review summarizes stereoselective and stereoretentive transformations suitable for asymmetric synthesis. The utility of cyclopropanols is discussed for two main strategies: (i) substrate-controlled transformations using enantiomerically enriched cyclopropanol intermediates through a traditional approach, and (ii) the use of nonchiral or racemic cyclopropanols, where asymmetric induction is achieved through a chiral catalyst, representing a direction that has recently emerged.

Mental healthcare for older adults among countries in World Psychiatric Association Zone 10.

Objectives: This study aimed to compare mental healthcare services for older adults aged ≥65 years among countries in World Psychiatric Association (WPA) Zone 10.

Methods: A culturally sensitive questionnaire was developed and sent to the presidents of national psychiatric associations of the eight countries in WPA Zone 10 (Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Russia, and Uzbekistan).

Results: Psychiatric associations of six countries responded to the questionnaire (Armenia and Moldova did not respond).

Efficacy of p62-expressing plasmid in treatment of canine osteoarthritis.

Introduction: Osteoarthritis (OA) is a progressive degenerative disease of synovial joints which is highly prevalent in dogs and results in lameness, loss of joint function and mobility, chronic pain, and reduced quality of life. Traditional OA management consist of non-steroidal anti-inflammatory drugs and remains challenging because of significant side effects, thus there is an urgent need for new effective and safe therapeutics for OA.

Methods: Here we present the results of our one-arm open-label pilot clinical study of our novel biologics, a DNA plasmid encoding SQSTM/p62, in 17 companion dogs suffering from OA.

Catechol-derived Mannich bases: radical regulatory properties, cytotoxicity and interaction with biomolecules.

Free radicals are ubiquitous in biological systems, being responsible for pathogenesis of degenerative diseases and participating in vitally important biochemical processes, which are mediated by radical regulatory agents. The effects of the aliphatic amine substituents in the catechol-derived Mannich bases on their antioxidant and pro-oxidant activity were investigated. It has been found that the presence of catechol moiety in the structure of Mannich bases allows them to act as Cu(II) reductants, efficient Fe(II) chelators and potent DPPH radical scavengers.

Wear Resistance Design of Laser Cladding Ni-Based Self-Fluxing Alloy Coating Using Machine Learning.

To improve the collaborative design of laser cladding Ni-based self-fluxing alloy (SFA) wear-resistant coatings, machine learning methods were applied. A comprehensive database was constructed from the literature, linking alloy composition, processing parameters, testing conditions, and the wear properties of Ni-based SFA coatings. Feature correlation analysis using Pearson's correlation coefficient and feature importance assessment via the random forest (RF) model highlighted the significant impact of C and B elements.

Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents.

Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide.

Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured.

Multi-analytical study for the art historical science: The mystery of the "Portrait of a young man in a wide-brimmed hat with a feather".

In this work, we performed a comprehensive spectroscopic analysis of the "Portrait of a Young Man in a Wide-Brimmed Hat with a Feather" authored by an unknown artist and housed in the National Art Museum of the Republic of Belarus. Previously this portrait was a part of the Myatlev collection (St. Petersburg, Russia).

How symmetry helps to improve the estimation of the hyperfine splitting of torsional levels due to tunneling. The case of the HSSSH molecule.

In this study, we analyze a series of molecules belonging to the C(M) molecular symmetry group which are characterized by several conformers. The use of molecular symmetry at each stage of calculating the energy of stationary torsional states is demonstrated. In particular, the importance is shown of preliminary symmetrization of physical characteristics of the molecules obtained by quantum chemical calculations.

Empirical Modal Decomposition Combined with Deep Learning for Photoacoustic Spectroscopy Detection of Mixture Gas Concentrations.

In photoacoustic spectroscopy based multicomponent gas analysis, the overlap of the absorption spectra among different gases can affect the measurement accuracy of gas concentrations. We report a multicomponent gas analysis method based on empirical modal decomposition (EMD), convolutional neural networks (CNN), and long short-term memory (LSTM) networks that can extract the exact concentrations of mixed gases from the overlapping wavelength-modulated spectroscopy with second harmonic (WMS-2f) detection. The WMS-2f signals of 25 different concentration combinations of acetylene-ammonia mixtures are detected using a single distributed feedback laser (DFB) at 1531.

Extracorporeal membrane oxygenation in obstetrical patients: a meta-analysis.

Critically acute and ill and Obstetrical patients constitute a unique clinical population with a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is gradually being used in obstetrical acute and critically ill patients and has shown great advantages. PubMed, Embase, Web of Science, Chinese CNKI Database, and Cochrane Library databases were systematically searched from the earliest available date to March 15, 2024, to obtain relevant studies on extracorporeal membrane oxygenation in obstetric patients.

Platelet Membrane-Camouflaged Copper Doped CaO Biomimetic Nanomedicines for Breast Cancer Combination Treatment.

Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide. Chemodynamic therapy (CDT), photothermal therapy (PTT), and ion interference therapy (IIT), used in combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO biomimetic nanomedicines have been developed for breast cancer treatments.

Diverse roles of Primary Health Care in COVID-19 vaccination across 28 European countries - Insights from the Eurodata study.

Background: The COVID-19 vaccination campaign in several European countries involved collaboration between public health and Primary Health Care (PHC).

Objective: To highlight the role of PHC professionals in the COVID-19 vaccination rollout, specifically in terms of vaccine administration, communication and contributing to vaccination population coverage.

Methods: A descriptive retrospective study of the COVID-19 vaccination campaign across 28 European countries was conducted, covering data from December 2020 to November 2021.

Controlled Fabrication of Wafer-Scale, Flexible Ag-TiO Nanoparticle-Film Hybrid Surface-Enhanced Raman Scattering Substrates for Sub-Micrometer Plastics Detection.

As an important trace molecular detection technique, surface-enhanced Raman scattering (SERS) has been extensively investigated, while the realization of simple, low-cost, and controllable fabrication of wafer-scale, flexible SERS-active substrates remains challenging. Here, we report a facile, low-cost strategy for fabricating wafer-scale SERS substrates based on Ag-TiO nanoparticle-film hybrids by combining dip-coating and UV light array photo-deposition. The results show that a centimeter-scale Ag nanoparticle (AgNP) film (~20 cm × 20 cm) could be uniformly photo-deposited on both non-flexible and flexible TiO substrates, with a relative standard deviation in particle size of only 5.

A near-infrared superoxide generator based on a biocompatible indene-bearing heptamethine cyanine dye.

One of the most significant limitations of photodynamic therapy is its reduced efficacy in hypoxic microenvironments, which are typical of the majority of tumors. This work demonstrates that indolenine heptamethine cyanines with different substituents in the polymethine chain and at the terminal heterocycles are effective superoxide generators that can be activated in the near-infrared range. The introduction of an indene moiety into the polymethine chain results in a significant enhancement in photostability compared to dyes with a cyclohexene moiety or an unsubstituted polymethine chain.