Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma.

Purpose: Immune checkpoint inhibitors (ICIs) and target therapy have provided the clinical efficacy for improving the clinical progression-free survival (PFS) and overall survival (OS) for patients with renal cell carcinoma (RCC). There has been little report of an surrogate salvage treatment for those failure of both ICIs and target. An innovation therapeutic model named SHAPE-T (synchronized hyperthermia with autologous progenitor expanded T cells) was applied to previously heavily treated metastatic RCC (mRCC).

Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial.

Importance: The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) is unknown.

Objective: To determine whether the use of high-intensity NPPV vs low-intensity NPPV reduces the need for endotracheal intubation in patients with an acute exacerbation of COPD and hypercapnia.

Design, Setting, And Participants: Randomized clinical trial conducted at 30 general respiratory non-intensive care unit wards of Chinese hospitals from January 3, 2019, to January 31, 2022; the last 90-day follow-up was on April 22, 2022.

Single-cell RNA-sequencing Analysis Reveals the Promoting Role of the Hedgehog Pathway in Epithelial Cells during Cervical Cancer Progression.

Aim: This study explored the role of the Hedgehog pathway in epithelial cells during cervical cancer [CC] progression, providing new insights for improving current CC treatment.

Background: Abnormal activation of the Hedgehog signaling pathway is associated with the malignant transformation of CC epithelial cells. Single-cell atlas of CC and the role of Hedgehog pathway in epithelial cells during CC progression remain to be explored.

Does the internal surface treatment technique for enhanced bonding affect the color, transparency, and surface roughness of ultra-transparent zirconia?

Purpose: To investigate the effects of different surface treatments and thicknesses on the color, transparency, and surface roughness of ultra-transparent zirconia.

Methods: A total of 120 Katana ultra-translucent multi-layered zirconia specimens were divided into 12 groups according to the thickness (0.3, 0.

Compared to exercise, the effects of exercise combined with cognitive training in people with mild cognitive impairment: a network meta-analysis.

Objectives: The study aimed to evaluate the relative effectiveness of exercise combined with cognitive training (E&CT) in improving cognitive function compared to exercise alone.

Method: PubMed, Embase, Cochrane Central Register of Controlled Trials, SPORTDiscus, and OpenGrey were systematically searched. Additional screenings were performed by reviewing citations of relevant articles.

A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy.

Unlabelled: The integration of predictive, preventive, personalized, and participatory (P4) healthcare advocates proactive intervention, including dietary supplements and lifestyle interventions for chronic disease. Personal profiles include deep phenotypic data and genetic information, which are associated with chronic diseases, can guide proactive intervention. However, little is known about how to design an appropriate intervention mode to precisely intervene with personalized phenome-based data.

Segment anything with inception module for automated segmentation of endometrium in ultrasound images.

Purpose: Accurate segmentation of the endometrium in ultrasound images is essential for gynecological diagnostics and treatment planning. Manual segmentation methods are time-consuming and subjective, prompting the exploration of automated solutions. We introduce "segment anything with inception module" (SAIM), a specialized adaptation of the segment anything model, tailored specifically for the segmentation of endometrium structures in ultrasound images.

Timing of early correction of mandibular hypoplasia in skeletal class II malocclusion: a review.

Skeletal Class II malocclusion is a common malocclusion seen in clinics. It is characterized by maxillary protrusion and mandibular retrognathia and has a high incidence in adolescent mixed dentition and early permanent dentition. The early functional correction has achieved some clinical results in treating skeletal Class II malocclusion with mandibular hypoplasia.

Prefrontal activation in response to a plantar contact task under open and closed eye conditions in patients with cerebral infarction.

Objective: This study investigates the effect of a bilateral (paralyzed side, healthy side) plantar contact task on dorsolateral prefrontal activation in patients recovering from cerebral infarction under open and closed eye conditions.

Methods: We selected 10 patients with cerebral infarction, admitted to the neurorehabilitation center of Beijing Rehabilitation Hospital, affiliated with Capital Medical University, from January 2019 to July 2020, who met our established criteria. Under open-eye and closed-eye conditions, the paralyzed and healthy sides performed the plantar contact tasks separately.

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial.

There has been a lack of treatments available to lower the frequency of recurrent aphthous ulcers (RAUs) until now. Total glucosides of paeony (TGP) is a botanical drug extracted from the dried roots of Pall. [Ranunculaceae; Paeoniae Radix Alba].

[Acupuncture with method by stages for menstrual headache based on syndrome differentiation: a randomized controlled trial].

Objective: To compare the clinical efficacy between acupuncture with method by stages based on syndrome differentiation and oral administration of ibuprofen sustained-release capsule in patients with menstrual headache.

Methods: A total of 90 cases with menstrual headache were randomly divided into an acupuncture group (45 cases, 1 case excluded, 3 cases dropped off) and a medication group (45 cases, 3 cases dropped off). The patients in the acupuncture group were treated with acupuncture with method by stages based on syndrome differentiation; during period of pain attacks, Ganshu (BL 18), Qimen (LR 14), Hegu (LI 4), Taichong (LR 3), Sizhukong (TE 23) through Shuaigu (GB 8) were selected, once a day; during period of pain relief, Qichong (ST 30), Dahe (KI 12), Guanyuan (CV 4), Taixi (KI 3) were selected, once every 1-2 days.

Twenty-four-hour ambulatory blood pressure variability and association with ischemic stroke subtypes in the subacute stage.

Background And Purpose: Blood pressure (BP) variability (BPV) increases the risk of cerebral disease in both hemorrhagic and ischemic strokes. However, whether BPV is associated with different types of ischemic stroke remains unclear. In this study, we explored the relationship between BPV and ischemic stroke subtypes.

[Effect of dexamethasone combined with oxybuprocaine hydrochloride gel on prevention of postoperative sore throat after nasal endoscopy].

Objective: To explore the effectiveness and feasibility of dexamethasone combined with oxybuprocaine hydrochloride gel on the prevention of postoperative sore throat after nasal endoscopy.

Methods: In the study, 60 patients with American Society of Anesthesiologist (ASA) physical statuses Ⅰ to Ⅱ, aged 18 to 72 years, scheduled for elective nasal endoscope surgery under general anesthesia requiring endotracheal intubation were randomly divided into dexamethasone combined with oxybuprocaine hydrochloride gel group (G group, =30) and control group (C group, =30). The patients in the G group received dexamethasone 0.

Cognitive Domain Impairment and All-Cause Mortality in Older Patients Undergoing Hemodialysis.

The highly prevalent cognitive impairment in hemodialysis patients is associated with all-cause mortality; however, the role of different cognitive domain impairments in this association is still not clarified. Our objective was to determine the association between cognitive domain impairment and all-cause mortality in elderly adult patients undergoing hemodialysis. We conducted a prospective cohort study including patients from 11 hemodialysis centers in Beijing.

CTBP1 strengthens the cisplatin resistance of gastric cancer cells by upregulating RAD51 expression.

Drug resistance is a key factor affecting the treatment of gastric cancer. The resistance of gastric cancer cells to anticancer drugs, such as cisplatin (DDP), remains a major challenge to patient recovery. The present study aimed to investigate the roles of C-terminal-binding protein 1 (CTBP1) in the DDP resistance of gastric cancer cells and to determine its regulatory effect on DNA repair protein RAD51 homolog 1 (RAD51).

A new comprehensive oral health literacy scale: development and psychometric evaluation.

Background: It has been widely accepted that oral health status is related to oral health literacy. The need to measure oral health literacy has led to the development of measurement instruments. This study aimed to develop a comprehensive instrument for adults and to examine its reliability and validity in China.

Circ_0074027 binds to EIF4A3 and promotes gastric cancer progression.

Circular RNAs (circRNAs) have been reported to play an important role in the progression of numerous types of human cancer. The aim of the present study was to determine the effects of circRNA_0074027 (circ_0074027) in gastric cancer (GC), and to elucidate the underlying mechanisms of action. For this purpose, the expression of circ_0074027 in GC cell lines was detected using reverse transcription-quantitative PCR.

[Recognition system of acupuncture manipulations based on an array PVDF tactile sensor and machine learning].

In learning and evaluation of acupuncture manipulations, there are lack of quantitative physical parameters on exertion strength, duration and direction of acupuncture technique at present. Based on the tactile parameters collected during "twirling" and "lifting-thrusting" of needling, a kind of array polyvinylidene fluoride (PVDF) tactile sensor was designed. Followed by, a window segmentation method for tactile signal was proposed and the time domain features of the window were extracted.

[Development and application of computer vision-based acupuncture manipulation classification system].

Objective: To improve the accuracy of acupuncture manipulation modeling and inheritance, this article explores the feasibility of automatically classifying "twirling" and "lifting and thrusting", two basic acupuncture manipulations in science of acupuncture and moxibustion, with the computer vision technology.

Methods: A hybrid deep learning network model was designed based on 3D convolutional neural network and long-short term memory neural network to extract the spatial-temporal features of video frame sequences, which were then input into the classifier for classification.

Results: The model discriminated between "twirling" and "lifting and thrusting" manipulations in 200 videos, with the training and verification accuracy reaching up to 95.

Adsorptivity of cationic cellulose nanocrystals for phosphate and its application in hyperphosphatemia therapy.

Nanocellulose has gained much attention because of its excellent properties. Cationic cellulose nanocrystals (cCNC) shows good adsorptivity toward negative ions and molecules. Phosphate binders are most used to treat hyperphosphatemia and it is significant to develop its alternatives with high specific and low cost in the clinic.

Cognitive impairment and associated risk factors in older adult hemodialysis patients: a cross-sectional survey.

The clinical epidemiological features of cognitive impairment in Chinese older adult patients undergoing hemodialysis are not clear, we aimed to identify the extent and patterns of cognitive impairment among those patients. We conducted a cross-sectional study of 613 hemodialysis patients aged 50 to 80 from 11 centers in Beijing. A neuropsychological battery of 11 tests covering domains of attention/processing speed, executive function, memory, language, and visuospatial function was applied, patients were classified as none, mild, or major cognitive impairment according to the fifth version of the Diagnostic and Statistical Manual of Mental Disorders criteria for cognitive impairment.