Anti-LSSDS pharmacological components identification of YuHuangLian based on the combination of spectrum-effect analysis and network pharmacology as well as molecular docking.

This research aimed to investigate the pharmacological components for liver stagnation and spleen deficiency syndrome (LSSDS) of Evodia rutaecarpa (also called Yu HuangLian [YHL]) by exploring the spectrum-effect relationship between fingerprints and pharmacological actions. The fingerprints of 17 batches of YHL with different preparation conditions according to Box-Behnken Design were generated and analyzed to identify the common peaks by HPLC and FT-IR. Vasoactive intestinal peptide (vip), substance P, and 5-HT levels in colon sample were measured by ELISA.

The crosstalk between LINC01089 and hippo pathway inhibits osteosarcoma progression.

Introduction: Osteosarcoma is the most common malignancy in children, with high morbidity worldwide. Researches indicated that long non-coding RNAs (lncRNAs) played crucial roles in various cancers. Nevertheless, study investigating lncRNA long intergenic non-protein coding RNA 1089 (LINC01089) in osteosarcoma is extremely rare.

Myelin and lymphocyte protein 2 regulates cell proliferation and metastasis through the Notch pathway in prostate adenocarcinoma.

Background: Myelin and lymphocyte protein 2 (MAL2) is a proven oncogene in some human tumors. However, currently, little is known about the function of MAL2 in prostate adenocarcinoma (PRAD). This study sought to investigate the role of MAL2 on PRAD progression.

Impact of self-designed Ningxin Anshen Decoction on the resting-state network functional connectivity in patients with mild to moderate generalized anxiety disorders.

Background: Generalized anxiety disorder (GAD) is a persistent chronic excessive anxiety that is hard to control. Our previous study indicated that self-designed Ningxin Anshen Formula (NXAS) was effective to treat mild to moderate GAD patients. This study is a randomized controlled clinical trial and aimed to investigate the imapct of self-designed NXAS on the resting-state functional connectivity (rsFC) in patients with mild to moderate GAD and explore the potential mechanisms.

Traditional Chinese medicine versus regular therapy in Henoch-Schönlein purpura nephritis in children: study protocol for a randomized controlled trial.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common secondary glomerular disease in children. Currently, the treatment for HSPN is always selected based on the Kidney Disease Improving Global Outcomes guidelines; however, this approach may lead to undertreatment, especially in patients with persistent proteinuria that does not reach nephrotic levels and/or hematuria and those with a pathological classification between grades 1 and 3 according to the International Study of Kidney Disease in Children. This study was performed to evaluate the curative effect and safety of a traditional Chinese medicine (TCM) integrated treatment program in this type of HSPN.

Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: A nonrandomized controlled pilot study.

Background: Depression presents a significant burden to both patients and society. One treatment that has emerged is vagus nerve stimulation (VNS), an FDA-approved physical treatment for depressive disorders. However, the application of this intervention has been limited by the involvement of surgery and potential side effects.

The cost-effectiveness analysis of JinQi Jiangtang tablets for the treatment on prediabetes: a randomized, double-blind, placebo-controlled, multicenter design.

Background: At present, diabetes is a chronic disease of great cost and heavy burdens. The International Diabetes Federation has repeatedly warned that by 2025, the global number of diabetics would rise to 333 million from 194 million in 2003. Although the occurrence of diabetes in developing countries is lower, China has a large population, so that the number of cases is increased.

[The path of creating TCM female periodicals in the Republican period].

A"special issue of female physicians" was included in the 1934 Kunghwa Medical Journal. In 1939, Qian Bao-hua, together with a batch of female TCM professional medical workers, inaugurated a "Chinese Feminine Physicians" included in the "Journal of Column of Traditional Chinese Medicine". The former one was published independently in 1941, only for 8 issues and was suspended in the same year.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was conducted to develop an emulgel formulation for Cyclosporin A (CsA) employing polycarbophil as the gelling agent for ocular delivery. The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, stability, precorneal clearance and irritation.

Chinese herbal medicine banxiaxiexin decoction treating diabetic gastroparesis: a systematic review of randomized controlled trials.

Objective. To assess the current clinical evidence of Banxiaxiexin decoction for diabetic gastroparesis (DGP). Methods.

The in situ and in vivo study on enhancing effect of borneol in nasal absorption of Geniposide in rats.

The objective of this research was to study the in situ and in vivo nasal absorption of Geniposide (Ge) co-administered with borneol. A rat in situ nasal perfusion technique with a novel volumeadjusted calculation was used to examine the absorption rate and extent of Ge. The influence of different experimental conditions such as purity of extract, drug concentration, co-administration with synthetic borneol or natural borneol were also investigated.

[Application of exercise therapy on rehabilitation after selective posterior rhizotomy (SPR) in children with cerebral palsy].

Objective: To observe the clinical effect of exercise therapy on rehabilitation after selective posterior rhizotomy (SPR) in children with cerebral palsy, so as to provide reliable rehabilitation method for children with cerebral palsy.

Methods: Two hundred and twenty-six children with cerebral palsy were treated in the study during September 2003 to April 2007. All the patients were randomly divided into the training and control groups.

[Ilizarov external fixator for the treatment of severe genuflex deformity in spastic cerebral palsy patients].

Objective: To explore the application and efficacy of Ilizarov external fixator in the treatment of severe genuflex deformity in spastic cerebral palsy patients.

Methods: The individualized Ilizarov external fixtor was designed to have two hinges posteriorly and one hinges anteriorly based on the tension-stress law. Distraction posteriorly and simutaneously compression anteriorly started 3 to 5 days after surgery.

[Study on orthopaedic causes of acute gastric dilatation (with 9 cases report)].

Objective: To analyzes the major cause of acute gastric dilatation in orthopaedic patients.

Methods: There are nine confirmed cases of acute gastric dilatation from Aug. 2006 to Mar.

[Effects on rats' bone mineral density and bone biomechanics by suspensory simulated weightlessness and removing suspension].

Objective: To study the effects on rats' bone mineral density and bone biomechanics by suspensory simulated weightlessness and removing suspension.

Methods: Twenty Wistar rats were divided into two groups randomly as control group and model group. Suspend the model group rats for 14 days, then remove suspension and continue to feed for another 14 days.

[Study on pharmacokinetics of glycyrrhetic acid in rats by RP-HPLC].

Objective: To develop a HPLC for the determination of plasma concentration of glycyrrhetic acid (GA) and study the pharmacokinetics of GA in rats.

Method: To sample blood from rat which were injected GA by 1.0 mg x kg(-1) at 0.

[Advances of studies on acupuncture reinforcing-reducing of twirling-rotating the needle].

The theories and clinical and experimental studies about reinforcing-reducing manipulation of twirling rotating the needle in recent 15 years are reviewed and a brief account of manipulation methods, mechanisms and effects of reinforcing-reducing manipulation of twirling-rotating the needle is given, and it is indicated that the following several aspects in the studies at present need to be completed. Standardization and establishment of national standard of acupuncture manipulation must be enforced; quantitative parameters of acupuncture manipulation and mechanisms of acupuncture reinforcing-reducing of twirling-rotating the needle need to be further studied.

[Discussion on the national standard, the Name and Location of Acupoints].

Location of a part of acupoints in the national standard, The Name and Location of Acupoints, are studied. In combination with anatomy, record of ancient literature and teaching experience, the location of Naohui (TE 13), Chengshan (BL 57), Fengshi (GB 31), Zhongdu (GB 32), Toulinqi (GB 15), Yinbao (LR 9) and Shaoshang (LU 11) in the national standard are analyzed and the relative location methods are raised.

[Brief introduction of professor Yang Jia-san's academic thought].

The present paper introduces Prof. YANG's academic thought from acupoint theory, acupoint selection method, filiform needle needling methods, reinforcing and reducing manipulation, clinical acupoint association, syndrome differentiation treatment thought, etc. Essence of acupoints is "Shenqi" freely flowing out and in, and is not local tissues of "skin, muscle, tendon and hone".

[Study on the mechanism of acupuncture at Daling (PC 7) for mental diseases by fMRI].

Objective: To probe into the central nervous mechanism of acupuncture at Daling (PC 7) treating mental diseases by fMRI.

Methods: Eight healthy volunteers were enrolled in the study. Acupuncture stimulation was given at Daling (PC 7) in each subject with a stimulating pattern, "rest-stimulation-rest-stimulation-rest".

[Professor Yang Jia-san, a famous acupuncture and moxibustion specialist of China in the present age].

Professor YANG Jia-san was a famous acupuncture and moxibustion specialist of China in the present age. He had studied medicine since early youth and practiced medicine on his own at age of 17 years. He devoted himself to the development of acupuncture and moxibustion sciences.

[Effects of electroacupuncture at Fenglong (ST 40) on SOD and MDA in different organs of the hyperlipemia rat].

Objective: To probe into the target organ of Fenglong (ST 40) and the mechanism in resolving phlegm.

Methods: Thirty SD rats were randomly divided into 3 groups, a blank control group, a model group and a Fenglong group, 10 rats in each group. The hyperlipemia rat model was prepared by feeding high fat forage.