295 results match your criteria: "Beijing University of Chinese Medicine Beijing 100029[Affiliation]"
Zhongguo Zhong Yao Za Zhi
November 2024
School of Life Sciences, Beijing University of Chinese Medicine Beijing 100029, China.
Based on the differences in the protective effects of fresh Panax ginseng and its processed products on myocardial ischemia in mice, this study identified the advantageous aspects of fresh P. ginseng. By using network pharmacology combined with cell model validation, the molecular mechanisms of fresh P.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2024
Wangjing Hospital, China Academy of Chinese Medical Sciences Beijing 100102, China Beijing Key Laboratory of Orthopedics of Traditional Chinese Medicine Beijing 100102, China.
This study aims to assess the methodological and reporting quality of animal experimental studies on the treatment of cervical radiculopathy(CR) with traditional Chinese medicine(TCM), analyze the deficiencies during the experimental process, and develop the methods to enhance the quality of such studies. The related articles were retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science. The methodological quality and reporting quality of the included studies were evaluated according to the risk of bias tool of the Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE) and the Animal Research: Reporting of in vivo Experiments(ARRIVE) 2.
View Article and Find Full Text PDFTo investigate the effect of Buzhong Yiqi Decoction on regulatory T cells(Treg) in experimental rats with autoimmune thyroiditis(EAT) through the transforming growth factor-β(TGF-β)/Smad signaling pathway. Female SD rats were immunized with iodine-rich drinking water combined with Freund's adjuvant and porcine thyroglobulin(pTG) to establish the EAT model of rats, and the levels of serum thyroperoxidase antibody(TPOAb) and thyroglobulin antibody(TGAb) were detected. Pathological sections by hematoxylin-eosin(HE) staining were observed.
View Article and Find Full Text PDFThe evaluation of the effectiveness of traditional Chinese medicine(TCM) has long been a "bottleneck" issue that restricts the healthy development and internationalization of TCM. This article systematically analyzes the differences in diagnostic and treatment principles, material composition, new drug development pathways, efficacy cognition, and evaluation methodology between Chinese and Western medicine from the underlying logic of medical perspective. On this basis, it integrates the evidence elements of clinical experience, experimental research, and clinical trials, and for the first time proposes and establishes a new strategy and methodology for the evaluation of the effectiveness of TCM: the integrated evidence chain-based effectiveness evaluation of traditional Chinese medicine(iEC-Eff), forming an integrated evaluation and confirmation model of "clinical experience-experimental research-clinical trial" for the effectiveness of TCM.
View Article and Find Full Text PDFEvidence mapping was performed to review the clinical trials and systematic reviews about the treatment of hyperlipidemia with Chinese patent medicines in recent ten years. A total of 387 clinical studies and 18 systematic reviews/Meta-analysis involving 45 Chinese patent medicines commonly used in the treatment of hyperlipidemia in recent ten years were retrieved from Chinese and English academic publication databases. The article information was extracted by reading the abstract and full text, and the evidence of publication trend, combined medication, intervention course, complications, and outcome indicators was sorted out.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2024
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
Bayesian network Meta-analysis was conducted to assess the efficacy and safety of different Chinese medicine injections for dilated cardiomyopathy(DCM). CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, EMbase, Cochrane Library, ProQuest, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov were searched for the randomized controlled trial(RCT) from the inception to January 2024.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
Graduate School, China Academy of Chinese Medical Sciences Beijing 100700,China.
This study aims to investigate the therapeutic effect of Wangbi Tablets(WBT) on the inflammation in the rat model of collagen-induced arthritis(CIA) with the syndrome of kidney deficiency based on the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING) signaling pathway. Eighteen rats were randomly chosen from 24 SPF-grade rats for the modeling of CIA with the syndrome of kidney deficiency. The 24 SPF-grade rats were randomized into 4 groups: control(normal rats), model(CIA with syndrome of kidney deficiency), model+WBT(M+WBT), and model+methotrexate(M+MTX).
View Article and Find Full Text PDFAm J Transl Res
November 2024
Department of Neurology, China-Japan Friendship Hospital Beijing 100029, China.
Objectives: To evaluate the clinical efficacy of the combination of acupuncture and medicine for vascular dementia (VD) treatment, and to analyze and summarize the relevant association rules.
Methods: A systematic search of Chinese and English databases such as CNKI, VIP, Wanfang, Embase, PubMed, Cochrane Library, and Web of Science was performed along with a manual search to screen for randomized controlled trials that met the inclusion and exclusion criteria that were published over a period from January 1, 2000, to July 31, 2023. Literature quality assessment and meta-analysis were performed using the and RevMan 5.
Zhongguo Zhong Yao Za Zhi
September 2024
Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi
September 2024
China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi
August 2024
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi
August 2024
Department of Pharmacy & Institute of Clinical Medical Sciences, China-Japan Friendship Hospital Beijing 100029, China.
C_(20)-diterpenoid alkaloids are mainly distributed in plants of genus Aconitum, Delphinium, and Consolida in the Ranunculaceae. Their chemical structures are mainly categorized into nine types such as atisines, denudatines, hetidines, and hetisines. Bioactivity studies have shown that C_(20)-diterpenoid alkaloids have exhibited superior anti-tumor, analgesic, antiarrhythmic, and anti-inflammatory effects.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
August 2024
Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
Isochlorogenic acid A(ICA) is the main active component of several TCMs, such as Artemisiae Scopariae Herba. This study aims to identify the metabolites of orally administered ICA in rat plasma, urine, and feces, and to speculate on its potential metabolic pathways. Rats were administered ICA orally, and samples of plasma, urine, and feces were collected at different time points.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
August 2024
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital Beijing 100029, China Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730, China.
The chemical constituents from Cornus officinalis were isolated and purified by various techniques such as macroporous adsorption resin, silica gel, octadecylsilyl(ODS), Sephadex LH-20 column chromatography and preparative high-performance liquid chromatography(HPLC). The structures of the isolates were determined by a combination of spectroscopic techniques such as high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), one-dimensional(1D) and two-dimensional(2D) nuclear magnetic resonance(NMR) spectroscopy. Ten compounds were isolated from the aqueous extract of C.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
August 2024
Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China Institute of Cardiovascular Disease, Beijing University of Chinese Medicine Beijing 100700, China.
In recent years, the incidence and mortality rates of cardiovascular diseases in China have kept rising, with no significant reduction in disease burden observed. Percutaneous coronary intervention(PCI) is an effective approach for treating coronary artery disease. Drug-eluting stents and drug-coated balloons are currently the most common PCI devices used in clinical practice.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
April 2024
Key Laboratory of Basic Research on Syndromes and Prescriptions, Ministry of Education, Beijing University of Chinese Medicine Beijing 100029, China Beijing Key Laboratory of Basic Research on Symptoms and Prescriptions Beijing 100029, China Research Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
This study aimed to explore the mechanism of Shexiang Tongxin Dropping Pills(STDP) in treating diabetic cardiomyopathy(DCM) based on network pharmacology, molecular docking, and animal experiments. BATMAN, TCMSP, and GeneCards were searched for the active ingredients and targets of STDP against DCM. STRING and Cytoscape were used to build the protein-protein interaction(PPI) network and "drug-active ingredient-target" network.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2024
Research Center of Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine Beijing 100029, China Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi
May 2024
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
Sinopodophylli Fructus is a traditional medicine used by the Tibetan people. It is known for its ability to regulate menstruation and promote blood circulation. Presently, bioactive constituents that have been isolated and identified from Sinopodophylli Fructus mainly include 15 lignans(e.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2024
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
This study employed evidence mapping to systematically sort out the clinical studies about the treatment of premature ventricular contractions with Chinese patent medicines and to reveal the distribution of evidence in this field. The articles about the treatment of premature ventricular contractions with Chinese patent medicines were searched against PubMed, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP with the time interval from January 2016 to December 2022. Evidence was analyzed and presented by charts and graphs combined with text.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi
March 2024
School of Chinese Medicine, Hong Kong Baptist University Hong Kong 00852, China.
Zhongguo Zhong Yao Za Zhi
February 2024
School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China Institute of Scientific Research, Beijing Tongrentang Company Limited by Shares Beijing 100079, China.
This paper aims to study the therapeutic effect of Massa Medicata Fermentata on hyperlipidemia model rats and investigate its mechanism of hypolipidemic effect with the help of non-targeted metabolomics. The mixed hyperlipidemia model rats were constructed by giving high-fat chow. After successful modeling, the rats were divided into the model group, pravastatin sodium group(4.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
December 2023
Beijing Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
In light of the liver injury risk associated with the oral administration of Xianlin Gubao oral preparation, this study compared the differences in liver injury induced by two different extraction processes in rats and explored the correlation between hepatotoxicity and extraction process from the perspective of the differences in the content of the relevant components. Thirty male Sprague-Dawley(SD) rats were randomly divided into a normal group, tablet extract groups of different doses, and capsule extract groups of different doses, with 6 rats in each group. Each group received continuous oral administration for 4 weeks.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2023
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.
This study aims to systematically review the efficacy and safety of Shufeng Jiedu Capsules in the treatment of influenza. The randomized controlled trial(RCT) of Shufeng Jiedu Capsules alone or in combination with conventional western medicine for treating influenza were retrieved from PubMed, EMbase, Cochrane Library, Web of Science, SinoMed, CNKI, VIP, Wanfang, and ClinicalTrails.gov.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2023
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
The approach combining disease, syndrome, and symptom was employed to investigate the characteristic changes of blood stasis syndrome in a rat model of steroid-induced osteonecrosis of the femoral head(SONFH) during disease onset and progression. Seventy-two male SD rats were randomized into a healthy control group and a model group. The rat model of SONFH was established by injection of lipopolysaccharide(LPS) in the tail vein at a dose of 20 μg·kg~(-1)·d~(-1) on days 1 and 2 and gluteal intramuscular injection of methylprednisolone sodium succinate(MPS) at a dose of 40 mg·kg~(-1)·d~(-1) on days 3-5, while the healthy control group received an equal volume of saline.
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