[The role of MAPK signaling pathway in the repair of mucosal epithelium in chronic sinusitis with nasal polyps and without nasal polyps].

To evaluate the differences between CRS and normal subjects and between chronic rhinosinusitis without nasal polys(CRSsNP) and chronic rhinosinusitis with nasal polys(CRSwNP) in the regulation of EGF pathways and the regulating proliferative position of MAPK pathways. We evaluated the proliferation rates of ethmoidal mucosal cells before and after stimulation with EGF,epidermal growth factor receptor(EGFR) kinase inhibitor AG1478, and extracellular signalregulated kinase1/2(ERK1/2) inhibitorPD98059 using MTT assays.We also analyzed the sinonasal epithelial cells collected from control subjects and patients with CRS subtypes CRSsNP and CRSwNP for the expression of ERK1/2,phosphorylated ERK1/2 using western blot analyses.