9,165 results match your criteria: "Beijing Tiantan Hospital[Affiliation]"

Article Synopsis
  • A multicenter study was conducted to assess the effects of self-crosslinked hyaluronic acid (SCH) gel on endometrial recovery in 382 women post-artificial abortion, comparing SCH treatment with a control group.
  • Results showed that the SCH group had significantly greater endometrial thickness and fewer cases of reduced menstrual volume compared to the control group, indicating potential benefits of the gel for recovery.
  • While SCH gel also appeared to reduce dysmenorrhea, this difference was not statistically significant, and overall safety was affirmed with no serious adverse events associated with the treatment.
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Aims: Clonal hematopoiesis of indeterminate potential (CHIP), which has recently been shown to be an age-related phenomenon, is associated with cardiovascular diseases, including atherosclerosis and stroke. This study focused on the association between CHIP and short- and long-term stroke recurrence in patients with acute ischemic stroke and intracranial atherosclerotic stenosis (ICAS).

Methods: This study included 4,699 patients with acute ischemic stroke based on data from the Third China National Stroke Registry (CNSR-III), a nationwide prospective hospital-based registry.

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Article Synopsis
  • * A randomized trial in China involved 269 patients who were assigned to start antiplatelet therapy early (3 days post-surgery) or late (30 days post-surgery) to evaluate safety and effectiveness on major cardiovascular events.
  • * The study, which involved patients mostly around 60 years old, aimed to measure occurrences of new major ischaemic events and intracranial bleeding within 90 days after surgery, and is officially registered under ClinicalTrials.gov number NCT04820972.
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Surgical treatment for chronic subdural haematoma.

Lancet Neurol

December 2024

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 10050, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address:

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Objective: To present a global overview of the current research landscape and emerging trends in mechanical thrombectomy for acute ischemic stroke (AIS) over the past decade.

Methods: A thorough search was conducted on the Web of Science on May 20, 2024, focusing on original articles and reviews in English. Bibliometric tools were employed to make a network analysis and visual representation.

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Brain lesion characteristics in Chinese multiple sclerosis patients: A 7-T MRI cohort study.

Ann Clin Transl Neurol

November 2024

Departments of Neurology, Radiology, Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objective: Prevalence, susceptibility genes, and clinical and radiological features may differ across different ethnic groups of multiple sclerosis (MS). We aim to characterize brain lesions in Chinese patients with MS by use of 7-T MRI.

Methods: MS participants were enrolled from the ongoing China National Registry of Neuro-Inflammatory Diseases (CNRID) cohort.

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Pathways from insulin resistance to incident cardiovascular disease: a Bayesian network analysis.

Cardiovasc Diabetol

November 2024

Department of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

Background: Insulin resistance coexist with many metabolic disorders, whether these disorders were promotors or pathway-factors for the association of insulin resistance and cardiovascular disease (CVD) remained unclear. We aimed to investigate the pathways related to elevated the triglyceride-glucose (TyG) index and pathways through elevated TyG index to the occurrence of CVD in Chinese adults.

Methods: A total of 96,506 participants were enrolled from the Kailuan study.

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SAKit: An all-in-one analysis pipeline for identifying novel proteins resulting from variant events at both large and small scales.

J Bioinform Comput Biol

October 2024

Department of AI and Bioinformatics, Nanjing Chengshi Biopharmaceutical (TheraRNA) Co., Ltd., Nanjing, P. R. China.

Article Synopsis
  • Genetic mutations can disrupt cellular signaling pathways and lead to cancer by creating abnormal proteins not found in the normal human body, which could serve as potential drug targets.
  • Current sequencing tools mainly focus on point mutations and struggle to detect larger, more complex mutations and don't provide protein-level insights.
  • The Sequencing Analysis Kit (SAKit) is a new bioinformatics tool that combines long-read and short-read RNA sequencing data to effectively identify and validate both large and small genetic variations in human and mouse studies.
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Background And Purpose: The low-field MRI is a promising tool to accurately diagnose strokes. We here report our study on the accuracy of a 0.23-Tesla (0.

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Neurodegenerative diseases, particularly Alzheimer's disease and other dementias as well as Parkinson's disease, are emerging as profoundly significant challenges and burdens to global health, a trend highlighted by the most recent Global Burden of Disease (GBD) 2021 studies. This growing impact is closely linked to the demographic shift toward an aging population and the potential long-term repercussions of the COVID-19 pandemic, both of which have intensified the prevalence and severity of these conditions. In this review, we explore several critical aspects of this complex issue, including the increasing global burden of neurodegenerative diseases, unmet medical and social needs within current care systems, the unique and amplified challenges posed by the COVID-19 pandemic, and potential strategies for enhancing healthcare policy and practice.

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Evaluation of Soluble Colony Stimulating Factor 1 Receptor (CSF1R) in Peripheral Blood as a Diagnostic Marker of CSF1R-Related Disorder (CSF1R-RD) in a Murine Model and CSF1R-RD Patients.

Ann Neurol

February 2025

Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.

Article Synopsis
  • Mutations in the colony stimulating factor 1 receptor (CSF1R) lead to a condition known as CSF1R-related disorder (CSF1R-RD).
  • Previous research showed that a soluble form of CSF1R (sCSF1R) might be a useful diagnostic tool for this disorder.
  • This study indicates that lower levels of sCSF1R in serum can accurately differentiate patients with CSF1R-RD from healthy individuals, suggesting its potential as a biomarker.
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Background: Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes. The role of endovascular therapy (EVT) in the management of CVT remains controversial and variations in practice patterns are not well known.

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Extubation timing and risk of extubation failure in aneurysmal subarachnoid hemorrhage patients.

Chin Neurosurg J

November 2024

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

Background: The extubation time is critical during the intensive care unit stay in aneurysmal subarachnoid hemorrhage (aSAH) patients. The current conventional parameters for predicting extubation failure (EF) and extubation time may not be suitable for this population. Here, we aimed to identify factors associated with EF in aSAH patients.

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Local progression of primary skull base chordoma (PSBC) is a sign of treatment failure. Predicting the postoperative progression of PSBC can aid in the development of individualized treatment plans to improve patients' progression-free survival (PFS) after surgery. This study aimed to develop a multiparametric MRI-based fusion radiomic model (FRM) and clinicoradiomic model (CRM) via radiomic and clinical analysis and to explore their validity in predicting postoperative progression in PSBC patients before surgery.

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Background: Sepsis-induced neurodegeneration and cognitive dysfunction remain critical challenges worldwide. Vitamin D was reported to reduce neuronal injury and neurotoxicity and its deficiency was associated with neurocognitive disorders. This study investigates the mechanisms by which vitamin D exerts neuroprotective potential against damage-associated molecular patterns (DAMPs), specifically extracellular histones, in sepsis-related brain dysfunction.

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Constructing protein-functionalized DNA origami nanodevices for biological applications.

Nanoscale

December 2024

Engineering Research Center of Advanced Rare Earth Materials, (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.

In living systems, proteins participate in various physiological processes and the clustering of multiple proteins is essential for efficient signaling. Therefore, understanding the effects of the number, distance and orientation of proteins is of great significance. With programmability and addressability, DNA origami technology has enabled fabrication of sophisticated nanostructures with precise arrangement and orientation control of proteins to investigate the effects of these parameters on protein-involved cellular processes.

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Unraveling the complexities of adolescent depression: A call for action.

World J Psychiatry

November 2024

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

The adolescent years are a period of profound change, both physically and psychologically. For many, these years are marked by excitement and exploration, but for others, they are fraught with challenges that can lead to significant mental health issues. Depression, in particular, has become an increasingly prevalent concern among adolescents worldwide, and its multifaceted etiology requires a comprehensive approach to understanding and intervention.

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Background: Orthostatic hypotension (OH) is associated with different cardiovascular diseases, however, the association between OH and coronary slow flow (CSF) has never been evaluated before.

Materials And Methods: Chest pain patients who underwent coronary angiography (CAG) and with normal coronary arteries in our department from January 1st, 2022 to August 31st, 2023 were retrospectively enrolled. Patients were divided into the CSF group and the normal blood flow (NBF) group.

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The effects of reference selection methods on PROPELLER MRI.

Magn Reson Imaging

February 2025

Center for Biomedical Imaging Research, School of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.

PROPELLER MRI has been shown effective for rigid motion compensation, while the performance of existing PROPELLER reconstruction methods critically depend on selecting a proper reference blade. In this work, we proposed a robust implementation for PROPELLER reconstruction, which was incorporated with different reference selection methods, including single blade reference (SBR), combined blades reference (CBR), grouped blades reference (GBR) and Pipe et al.'s revised method, which requires no blade reference (NBR).

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Denoising complex-valued diffusion MR images using a two-step non-local principal component analysis approach.

bioRxiv

October 2024

Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota.

Purpose: to propose a two-step non-local principal component analysis (PCA) method and demonstrate its utility for denoising diffusion tensor MRI (DTI) with a few diffusion directions.

Methods: A two-step denoising pipeline was implemented to ensure accurate patch selection even with high noise levels and was coupled with data preprocessing for g-factor normalization and phase stabilization before data denoising with a non-local PCA algorithm. At the heart of our proposed pipeline was the use of a data-driven optimal shrinkage algorithm to manipulate the singular values in a way that would optimally estimate the noise-free signal.

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Aim: The interaction between inflammatory biomarkers (high-sensitivity C-reactive protein, hsCRP) and antioxidants (uric acid, UA) regarding prognosis after ischemic stroke or transient ischemic attack (TIA) remains inadequately explored. This study aimed to assess (1) the individual and joint effects of hsCRP and UA, and (2) the neuroprotective role of UA in patients with elevated hsCRP levels concerning poor functional outcomes at 90 days.

Methods: A prospective cohort study was conducted involving 2140 consecutive ischemic stroke or TIA patients with hsCRP and UA levels.

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Background: Reverse triggering (RT) is a ventilatory asynchrony characterized by the activation of respiratory muscles in response to passive mechanical insufflation. Although RT can potentially exacerbate lung injury, its characteristics in patients with acute brain injury remain under-explored. This study aims to elucidate the incidence and factors associated with RT in this patient population.

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Aims: Patients with glioblastoma multiforme (GBM) do not benefit from current cancer treatments, and their prognosis is dismal. This study aimed to investigate the potential synergistic effects of TS-2021, a third-generation oncolytic adenovirus, combined with the PARP inhibitor olaparib in GBM.

Methods: TS-2021's impact on p66shc-induced apoptosis, DNA damage response, and poly (ADP-ribose) polymerase (PARP) activation was evaluated in GBM cells.

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Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies.

Signal Transduct Target Ther

November 2024

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Article Synopsis
  • Parkinson's disease (PD) shows a variety of motor subtypes like tremor-dominant and gait difficulty-dominant, but the specific causes of this diversity and effective personalized treatments are still unclear.* -
  • A new rat model simulating these PD subtypes was created, revealing that changes in neurofilament light chain levels, uric acid, and metabolites in the serum closely mirror those in human patients.* -
  • Through RNA sequencing, researchers identified altered gene expressions linked to PD subtypes and discovered 25 potential drug candidates, with baicalein proving particularly effective in treating the mixed subtype, suggesting tailored therapies may be feasible.*
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A computational method to predict cerebral perfusion flow after endovascular treatment based on invasive pressure and resistance.

Comput Methods Programs Biomed

January 2025

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background And Objective: Predicting post-operative flow is essential for assessing the risk of adverse events in cerebrovascular stenosis patients following endovascular treatment (EVT). This study aimed to evaluate the accuracy of the CFD simulation model in predicting post-operative velocity, flow and pressure distal to a stenosis, based on cerebrovascular microcirculatory resistance.

Methods: The patient-specific models of the extracranial and intracranial arteries were reconstructed.

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