Numerical study on the back slope effect of trapezoidal canyon slope under oblique incidence of P-SV waves.

The incident angle of seismic waves influences the dynamic response of rock slopes. However, the relationship between the back-slope effect in strong earthquake areas and the incident angle has not been well-explained. Based on the equivalent nodal force method and the viscoelastic artificial boundary theory, the oblique incidence of seismic P-wave and SV-wave are carried out in FLAC3D software.

Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening.

The abnormal expression of acetylcholinesterase (AChE) is linked to the development of various diseases. Accurate determination of AChE activity as well as screening AChE inhibitors (AChEIs) holds paramount importance for early diagnosis and treatment of AChE-related diseases. Herein, a fluorescent and colorimetric dual-channel probe based on gold nanoclusters (AuNCs) and manganese dioxide nanosheets (MnO NSs) was developed.

Soil application of dazomet combined with 1,3-dichloropropene against soilborne pests for tomato production.

There is a growing problem in China, whereby tomato replant disease is being affected by Fusarium spp., Meloidogyne spp., and Phytophthora spp.

Thrust-dominated unilateral rupture of a blind listric fault associated with the 2024 Hualien earthquake.

The 2024 Hualien M 7.4 earthquake struck the Longitudinal Valley, which accommodates the partial collision between the Eurasian and Philippine Sea plates. As the most significant event in Taiwan since the 1999 Chi-Chi M 7.

Predictive value of system immune-inflammation index for the severity of coronary stenosis in patients with coronary heart disease and diabetes mellitus.

Coronary heart disease (CHD) has been recognized as a chronic progressive inflammatory disorder, and Diabetes mellitus (DM) is an independent risk factor for the pathogenesis of CHD. Recent research has underscored the systemic immune-inflammation index (SII) as a potent prognostic indicator for individuals suffering from acute coronary syndrome (ACS). This study aimed to delve into the relationship between SII and the degree of coronary atherosclerotic stenosis in non-acute myocardial infarction patients with or without DM.

Event co-occurrences for prompt-based generative event argument extraction.

Recent works have introduced prompt learning for Event Argument Extraction (EAE) since prompt-based approaches transform downstream tasks into a more consistent format with the training task of Pre-trained Language Model (PLM). This helps bridge the gap between downstream tasks and model training. However, these previous works overlooked the complex number of events and their relationships within sentences.

Temperature alters bacterial community structure in sediment of mountain stream.

Temperature and nutrients are known as crucial drivers for the variations of bacterial community structure and functions in oceans and lakes. However, their significance and mechanisms in influencing the bacterial community structure and function in mountain stream remain unclear. In this study, we investigated the spatiotemporal patterns of the bacterial communities and the main environmental factors in the Taizicheng River, a high-latitude mountainous stream, to reveal the main driving factors for sedimental bacterial communities.

Dual-objective optimization of prefabricated component logistics based on JIT strategy.

Prefabricated construction involves manufacturing components in a factory and then transporting them to a construction site for assembly, yielding resource savings and improved efficiency. However, the large size and weight of prefabricated components, along with strict delivery requirements, introduce logistical challenges, such as increased carbon emissions during transport and site congestion. This study addresses the dual-objective vehicle scheduling problem for prefabricated components.

Re-evaluation of the relationship between PrPc expression and patient prognosis in primary esophageal squamous cell carcinoma and primary hepatocellular carcinoma.

PrPc is expressed in various tumors and is associated with cancer progression, but previous studies have shown conflicting results regarding its relationship with patient prognosis-potentially due to differences in the antibodies used. This study aimed to clarify the relationship between PrPc expression and primary esophageal squamous cell carcinoma (ESCC) and primary hepatocellular carcinoma (HCC) using a novel anti-PrPc antibody, 4AA-m, noted for its high specificity and sensitivity. We used flow cytometry to detect PrPc expression in ESCC and HCC cell lines.

Single-cell transcriptome analysis of stem cells from human exfoliated deciduous teeth investigating functional heterogeneity in immunomodulation.

Mesenchymal stem cells (MSCs) have been widely used in the treatment of various inflammatory diseases. The inadequate understanding of MSCs and their heterogeneity can impact the immune environment, which may be the cause of the good outcomes of MSCs-based therapy that cannot always be achieved. Recently, stem cells from human exfoliated deciduous teeth (SHED) showed great potential in inflammatory and autoimmune diseases due to their immature properties compared with MSCs.

Experimental study on ultrasonic reduction of irreducible water saturation in low permeability reservoir.

Irreducible water saturation is an important factor affecting the development effect of low permeability reservoir. Using the self-developed ultrasonic generator, kerosene was used as simulated oil, the natural low-permeability siltstone cores with different physical properties in Zhongyuan Oilfield were selected for indoor oil displacement experiment, and the effect of ultrasonic action on the saturation of irreducible water in low-permeability reservoirs was evaluated. It was found that ultrasound can further reduce the saturation of irreducible water on the basis of oil flooding.

Onco-mNGS facilitates rapid and precise identification of the etiology of fever of unknown origin: a single-centre prospective study in North China.

Objectives: Delayed diagnosis of patients with Fever of Unknown Origin has long been a daunting clinical challenge. Onco-mNGS, which can accurately diagnose infectious agents and identify suspected tumor signatures by analyzing host chromosome copy number changes, has been widely used to assist identifying complex etiologies. However, the application of Onco-mNGS to improve FUO etiological screening has never been studied before.

Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma.

Background: Posttranslational modifications (PTMs) play critical roles in hepatocellular carcinoma (HCC). However, the locations of PTM-modified sites across protein secondary structures and regulatory patterns in HCC remain largely uncharacterized.

Methods: Total proteome and nine PTMs (phosphorylation, acetylation, crotonylation, ubiquitination, lactylation, N-glycosylation, succinylation, malonylation, and β-hydroxybutyrylation) in tumor sections and paired normal adjacent tissues derived from 18 HCC patients were systematically profiled by 4D-Label free proteomics analysis combined with PTM-based peptide enrichment.

Ecological effects of micro/nanoplastics on plant-associated food webs.

Micro/nanoplastics (MNPs) contamination is a potential threat to global biodiversity and ecosystem functions, with unclear ecological impacts on aboveground (AG) and belowground (BG) food webs in terrestrial ecosystems. Here, we discuss the uptake, ingestion, bioaccumulation, and ecotoxicological effects of MNPs in plants and associated AG-BG biota at various trophic levels. We propose key pathways for MNPs transfer between the AG-BG food webs and elaborate their impact on terrestrial ecosystem multifunctionality.

Simultaneous Determination of Vitamins A and E and Their Generated Metabolites in Human Serum by LC-MS/MS.

In the context of personalized and precision medicine, simultaneous monitoring of different forms of vitamins A and E and their metabolites could help us better understand the status of vitamins A and E in the body. The aim of this study was to establish a method for simultaneous determination of 13 kinds of vitamins A and E and their metabolites in human serum. Serum samples were directly detected by LC-MS/MS after deproteinization.

Tracking Cr(VI) removal with Spectral Induced Polarization under ZVI and AC Synergetic Remediation.

The structure and active components of the filling material play a critical role in the contamination remediation performance of permeable reactive barriers. However, current methods lack a comprehensive understanding of the structural evolution and long-term performance of these materials during remediation processes. This study utilizes column experiments combined with spectral induced polarization (SIP) monitoring to investigate the effectiveness of zero-valent iron (ZVI), activated carbon (AC), and their composite with sand in removing Cr(VI).

Zn adsorption in ferric-silicates microstructures in sulfidic tailings mediated through mineral weathering by Acidithiobacillus species.

Heavy metals released from metallic sulfidic tailings pose significant environmental threats by contaminating surface and groundwater in mining areas. Sustainable rehabilitation methods are essential to remove or stabilize these metals, improving the quality of acid mine drainage and minimizing pollution. This study examines the adsorption capacity of zinc ions (Zn) by different iron-silicate mineral groups under natural weathering and bacteria-regulated weathered conditions.

Validation and evaluation of the performance of QIAstat-Dx gastrointestinal panel in pooled stool samples.

In the current study, the analytical sensitivity, analytical specificity, reproducibility, anti-interferences ability, and clinical performance of the QIAstat-Dx Gastrointestinal Panel (GIP) system were evaluated using pooled stool samples. Results showed that the pooled sample test detected the selected ten targets exclusively, with no cross reaction with any other targets of common enteropathogens. The analytical sensitivity of the pooled sample test on QIAstat-Dx GIP system was 10 CFU/ml for Shigella spp.

Constructing a green modifier by using glyoxal-urea resin and chitosan to obtain a modified soy protein adhesive with high bonding strength and excellent water resistance.

The manufacturing of soy-based adhesives with high bonding strength, excellent water resistance, and exceptional environmental performance still faces difficulties. In this work, using glyoxal-urea (GU) resin, chitosan (CS), and soy protein isolate (SPI) as the primary raw materials in order to effectively mitigate the release of free formaldehyde commonly found in traditional wood-based panels. Obtaining an adhesive with high strength, excellent water resistance, and a stable cross-linking structure of GU/CS/SPI (CS represents different mass fractions of chitosan solution).

Enhanced flame retardancy and accelerated degradation of polylactic acid using a chitosan-based additive with phosphorus and zinc.

Polylactic acid (PLA) is a bio-recyclable plastic, but its high flammability limits broader applications. Here, a novel flame retardant (Zn-CHP) is synthesized from chitosan (CH), diethylenetriaminepenta (methylenephosphonic) acid (DTPMP), and ZnCl₂ using a simple, solvent-free process. The Zn-CHP additive is melt-blended with PLA, achieving excellent flame retardancy at just 2 wt% loading.

Functional effects of BMPR1B in porcine endometrium provides novel insights into the high fecundity of Taihu pigs.

Litter size in pigs is affected by factors such as ovulation number, embryonic survival, and uterine environment conditions. Endometrial epithelial and stromal cells represent the first site of contact between the embryo and sows; therefore, dynamic changes in the growth and development of these cells are among the major factors affecting the intrauterine environment and implantation. Bone morphogenetic protein receptor type-1B (BMPR1B) is a receptor of the bone morphogenetic protein (BMP) family that has been identified as a candidate gene for reproductive traits in pigs.

Development of plantaricin RX-8 loaded pectin/4-carboxyphenylboric acid/carboxymethyl chitosan hydrogel microbead: A potential targeted oral delivery system.

Bacteriocin can effectively improve the gut inflammation for their superior antibacterial activity. However, its inherent attributes, such as easily degraded and off-target effect in the gastrointestinal environment, make bacteriocins' efficient oral delivery a great challenge. Herein, a pectin/4-carboxyphenylboric acid/carboxymethyl chitosan (PEC/CPBA/CMCS) hydrogel microbead targeted oral delivery system was innovatively developed for the plantaricin RX-8 protective delivery, precisely targeted inflammatory microenvironment (IME) and sustained released plantaricin RX-8 by pH/ROS dual stimulation response.

Identification and mechanistic study of piceatannol as a natural xanthine oxidase inhibitor.

Natural Xanthine oxidase (XOD) inhibitors represent promising therapeutic agents for hyperuricemia (HUA) treatment due to their potent efficacy and favorable safety profiles. This study involved the construction of a comprehensive database of 315 XOD inhibitors and development of 28 machine learning-based QSAR models. The ChemoPy light gradient boosting machine model exhibited the best performance (AUC = 0.