A meta-analysis of the efficacy of physical exercise interventions on activities of daily living in patients with Alzheimer's disease.

Objective: This study aimed to systematically review published randomized controlled trials on the effects of physical exercise on activities of daily living (ADL) in Alzheimer's patients through meta-analysis, thereby synthesizing existing evidence to provide scientific intervention recommendations for exercise prescriptions in Alzheimer's patients.

Methods: Based on strict literature inclusion and exclusion criteria, a systematic search was conducted in databases including PubMed and Web of Science from their inception to July 1, 2024. The Cochrane risk assessment tool was used to evaluate the design of randomized controlled trials.

Feasibility and potential of intraoperative ultrasound in arthroscopy of femoroacetabular impingement.

This study aimed to evaluate the feasibility of using ultrasound for monitoring osteochondroplasty intraoperatively, determine the factors that interfere with ultrasound imaging and assess its influence on surgeon performance. Intraoperative ultrasonography was performed during osteochondroplasty in 39 cases of arthroscopy. The femoral head-neck junction (FHNJ) was evaluated using ultrasonography.

Scalable Preparation of Superdurable, Self-Healing, and Biocompatible Superhydrophobic Poly(ethylene terephthalate) Fabrics.

The chemical inertness of poly(ethylene terephthalate) (PET) fabrics poses challenges in achieving superhydrophobic coatings with durable adhesion on their surfaces. Conventional surface modification methods such as alkali etching and plasma etching typically compromise the favorable mechanical properties of PET. In this study, polydopamine (PDA) was utilized to functionalize the PET fabric nondestructively by creating robust and reactive hydroxyl and amine groups on its surface, which were subsequently used as a binder of superhydrophobic modifiers such as fluorine-free octadecyltrichlorosilane (OTS).

Effect of bariatric surgery on mitochondrial remodeling in human skeletal muscle: a narrative review.

In the context of obesity epidemic as a major global public health challenge, bariatric surgery stands out for its significant and long-lasting effectiveness in addressing severe obesity and its associated comorbidities. Skeletal muscle mitochondrial function, which is crucial for maintaining metabolic health, tends to deteriorate with obesity. This review summarized current evidence on the effects of bariatric surgery on skeletal muscle mitochondrial function, with a focus on mitochondrial content, mitochondrial dynamics, mitochondrial respiration and mitochondrial markers in glucolipid metabolism.

Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.

In this study, we explore the cartilage defect repair mechanism by phosphocreatine-grafted chitosan hydrogels loaded with berberine-treated ATDC5 cells (CSMP@BBR@ATDC5). Under the optimal concentrations of LPS and BBR ideal conditions, ATDC5 cell toxicity and proliferation were detected with AM/PI and EdU staining. Additionally, qPCR and Western blot were employed to detect the expression of the SIRT1/BMP4 signaling pathway and chondrogenic-related factors in ATDC5 cells.

Effect of neuroticism on Chinese athletes' vigor: serial mediating roles of pre-competition anxiety and mind wandering.

Introduction: Vigor plays an important role in mental health, and it is closely related to sporting performance. Neuroticism can affect individual vigor, but its internal mechanism remains unclear. This study aims to examine the relationship between neuroticism and vigor, and the role of anxiety and mind wandering between the two.

The application of different biotechnologies in detecting the changes in MAM and their classic discoveries.

Mitochondria-associated membrane (MAM) has been studied as a novel target for explaining the mechanisms underlying the changes in cellular function and the process of multiple diseases. This structure is a complex of proteins, it tethers mitochondria to the endoplasmic/sarcoplasmic reticulum (ER/SR) and mediates the crosstalk of ions, lipids and metabolites between the two organelles. Different component proteins play distinctive ways in influencing the structure of MAM or the cellular signal transduction.

A demonstration of superior judgement? Exploring league of legends players' performance in risky and ambiguous decision-making tasks.

In three studies, we investigated how League of Legends (LOL) game experience and game skill relate to players' performance in the Iowa Gambling Task (IGT), Balloon Analogue Risk Task (BART), and Probability Discounting Task (PDT). Additionally, the present study examined the relationship between players' in-game risk preferences and their performance in three types of decision-making tasks. To achieve this, we utilized a self-developed League of Legends Risk Propensity Scale (LRPS) to characterize LOL players' in-game risk preferences.

Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease.

Background: Sequential working memory refers to the cognitive ability to maintain and/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD).

Objectives: The aim of this study is to evaluate the sequential working memory in patients with YOPD.

Effect of exercise for patients with advanced lung cancer and cancer-related fatigue: A systematic review and meta-analysis.

Background: Cancer-related fatigue (CRF) is a significant burden for patients with advanced lung cancer. While exercise is recommended for managing CRF during pre- and active treatment phases, evidence supporting its efficacy in advanced stage remains limited. This systematic review and meta-analysis aimed to quantify the effects of exercise on CRF and its common complications in patients with advanced lung cancer.

Visualized trends and bibliometric analysis in ankle cartilage repair from 2004 to 2024.

Ankle cartilage injuries are a common sports-related condition that significantly impairs patients' daily activities and imposes substantial economic burdens on both families and society. Effective cartilage repair strategies are crucial to addressing this pathological condition. Current conservative treatments include muscle strengthening, use of ankle braces, physical therapy, and the administration of NSAIDs.

Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling.

Background: Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for 3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite effective local treatments, metastasis remains a significant challenge, with more than half of patients developing metastatic disease within ten years. Conventional therapies often yield poor outcomes, highlighting the urgent need for novel therapeutic strategies to enhance survival and prognosis for UM patients.

Aerobic exercise attenuates insulin resistance via restoring branched chain amino acids homeostasis in obese mice.

Introduction: Emerging evidences suggests that the disrupted branched-chain amino acids (BCAAs) homeostasis and elevated BCAAs promote obesity-related insulin resistance (IR). Exercise improves insulin sensitivity. However, whether BCAAs plays a role in the exercise-attenuated IR remains to be fully investigated.

Dynamic Imine Chemistry Enables Paintable Biogel Electrolytes to Shield On-Body Zinc-Ion Batteries from Interfacial Interference.

On-body batteries with hydrogel electrolytes are a pivotal enabling technology to drive bioelectronics for healthcare and sports, yet they are prone to failure due to dynamic interfacial interference, accompanied by e-waste production. Here, dynamic imine chemistry is proposed to design on-electrode paintable biogel electrolytes that feature temperature-controlled reversible phase transition (gelling within 1.5 min) and ultrafast self-healing capability (6 s), establishing a dynamically self-adaptive interface on cyclically deforming electrodes for shielding on-body Zn-ion batteries from interfacial interference.

Evaluating the efficacy of the SENO decision framework in managing metastatic spinal disease: a comparative study.

Background Context: The management of metastatic spinal disease presents a complex challenge, with no universally accepted guidelines currently available. A new treatment approach, termed the "SENO" (Systemic Conditions, Effectiveness of Systemic Treatment, Neurology, and Oncology) decision framework, was developed, incorporating a 12-point grading system for epidural spinal cord compression.

Purpose: This study aims to assess the clinical efficacy of the SENO decision framework and compare its outcomes with those from traditional treatment frameworks.