Predicting drug combination side effects based on a metapath-based heterogeneous graph neural network.

In recent years, combined drug screening has played a very important role in modern drug discovery. Generally, synergistic drug combinations are crucial in treatment for many diseases. However, the toxic side effects of drug combinations are probably increased with the increase of drugs numbers, so the accurate prediction of toxic side effects of drug combinations is equally important.

Vacancy-Enhanced Self-Reduction of Eu in Pyrophosphate Phosphor.

The self-reduction mechanism in pyrophosphate phosphors is currently explained through nonequivalent substitution for charge compensation. Nevertheless, the impact of oxygen vacancies on the self-reduction enhancement requires further investigation. Herein, heterovalent BaZnPO:Eu, Mg phosphors with rigid structures were prepared through conventional solid-phase technology in air.

Cerebral malaria induced by : clinical features, pathogenesis, diagnosis, and treatment.

Cerebral malaria (CM) caused by is a fatal neurological complication of malaria, resulting in coma and death, and even survivors may suffer long-term neurological sequelae. In sub-Saharan Africa, CM occurs mainly in children under five years of age. Although intravenous artesunate is considered the preferred treatment for CM, the clinical efficacy is still far from satisfactory.

Effects of Dopamine-Modified and Organic Intercalation on the Thermophysical Properties of Octadecane/Expanded Vermiculite Composite Phase Change Materials.

For phase change materials (PCMs) confined in porous structure, the interface interaction between the PCM and the porous skeleton is the key factor to determine the thermal storage performance of PCM. In this study, the modified expanded vermiculite (EVM) was prepared by dopamine modification and DTA intercalation method and a series of EVM-based composite phase change materials with form shape (fs-CPCMs) were prepared by physical impregnation using -octadecane as PCMs. The heat storage performance of the composite phase change materials were improved obviously, and the encapsulation ratio is increased to 84.

An efficient factor for fast screening of high-performance two-dimensional metal-organic frameworks towards catalyzing the oxygen evolution reaction.

Two-dimensional (2D) metal-organic frameworks (MOFs) are promising materials for catalyzing the oxygen evolution reaction (OER) due to their abundant exposed active sites and high specific surface area. However, how to rapidly screen out highly-active 2D MOFs from numerous candidates is still a great challenge. Herein, based on the high-throughput density functional theory (DFT) calculations for 20 kinds of different transition metal-based MOFs, we propose a factor for fast screening of 2D MOFs for the OER under alkaline conditions (pH = 14.

Fast and quantitative analysis of level 3 details for latent fingerprints.

Level 3 details play essential roles in practical latent fingerprint (LFP) identification. To reliably extract reproducible and identifiable level 3 features, high-resolution images of fingerprints with adequate quality are required. Conventional methods for acquiring level 3 details often involve specific pretreatment, intricate peripheral, leading to time-consuming analysis.

The dual role of RFX6 in directing β cell development and insulin production.

RFX6 transcription factor is believed to play a central role in directing cell development of insulin-producing pancreatic islet. RFX6 homozygous mutations cause syndromic neonatal diabetes with hypoplastic pancreas. However, RFX6 heterozygous mutations cause maturity-onset diabetes of the young (MODY) with normal pancreas development.

Activation of six lipocalins genes' transcription under PCB18 stress in OsTIL-silenced Oryza sativa L.

The lipocalins genes have been assigned for involving in the responses of organisms to various stress factors. The function of lipocalins under PCB18 stress was addressed by pathway complementation in the Oryza sativa L. OsTIL-silenced mutant.

Diagnostic performance of magnetic resonance technology in detecting steatosis or fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis.

Background: The aim of this study was to evaluate the diagnostic accuracy of magnetic resonance (MR) imaging-based methods for detecting steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD).

Methods: Data were extracted from research articles obtained after a literature search from multiple electronic databases. Random-effects meta-analyses were performed to obtain overall effect size of the area of operator receiver curve (AUROC), sensitivity and specificity of MR imaging, MR elastography, and MR spectroscopy in detecting or grading steatosis/fibrosis.

The improvement of dry eye after cataract surgery by intraoperative using ophthalmic viscosurgical devices on the surface of cornea: The results of a consort-compliant randomized controlled trial.

Backgroud: This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery.

Methods: A total of 149 eyes (149 patients) diagnosed with age-related cataract, age 69.19 ± 9.

Clinicopathological and prognostic significance of homeobox transcript antisense RNA expression in various cancers: A meta-analysis.

Background: Increased expression of the homeobox (HOX) transcript antisense RNA (HOTAIR) has been reported in multiple types of malignancies and enhances the proliferation and migration of cancer cells. However, the association between HOTAIR expression and tumor progression and prognosis remains controversial. We performed a meta-analysis to clarify the association between the expression of HOTAIR and the clinicopathological features and prognosis in different cancers.

Landscape response to progressive tectonic and climatic forcing in NW Borneo: Implications for geological and geomorphic controls on flood hazard.

Empirical models have simulated the consequences of uplift and orographic-precipitation on the evolution of orogens whereas the effects of these forcings on ridgelines and consequent topography of natural landscapes remain equivocal. Here we demonstrate the feedback of a terrestrial landscape in NW Borneo subject to uplift and precipitation gradient owing to orographic effect, and leading to less-predictable flooding and irreversible damages to life and property. Disequilibrium in a large catchment recording the lowest rainfall rates in Borneo, and adjacent drainage basins as determined through χ, a proxy for steady-state channel elevation, is shown to result in dynamic migration of water divide from the windward-side of the orogen towards the leeward-side to attain equilibrium.

Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism.

Background: Previous studies support an association between elevated total homocysteine (tHcy) levels and increased all-cause mortality. However, few prospective studies have examined this association in hypertensive patients, and/or tested any effect modification by the methylene tetrahydrofolate reductase (MTHFR) C677T genotype.

Methods: This was a post hoc analysis of the China Stroke Primary Prevention Trial.

Prevalence and correlates of airflow obstruction in ∼317,000 never-smokers in China.

In China, the burden of chronic obstructive disease (COPD) is high in never-smokers but little is known about its causes in this group. We analysed data on 287 000 female and 30 000 male never-smokers aged 30-79 years from 10 regions in China, who participated in the China Kadoorie Biobank baseline survey (2004-2008). Prevalence of airflow obstruction (AFO) (pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.