[Comparison study for the proportion of underdiagnosed zonulopathy in angle closure glaucoma].

To analyze the proportion and clinical characteristics of underdiagnosed zonulopathy in angle closure glaucoma (ACG) patients and to explore the related risk factors. Case-control study. Continuous cases of ACG patients who underwent phacoemulsification combined with intraocular lens implantation and goniosynechialysis surgery [ACG group, including acute angle closure glaucoma (AACG) and chronic angle closure glaucoma (CACG)] from November 1, 2020 to October 31, 2021 and age-related cataract patients who underwent phacoemulsification combined with intraocular lens implantation surgery in the same period (control group) were included.

[An immunohistochemistry study on extracellular matrix of lamina cribrosa in optic nerve head of experimental glaucoma].

Objective: To observe the change of the macromolecular components of extracellular matrix of lamina cribrosa (LC) in experimental glaucoma.

Methods: Immunoperoxidase (ABC) staining method was used to investigate the changes of collagen type IV and laminin in the lamina cribrosa of 9 monkey eyes with experimental glaucoma.

Results: At the late stage of glaucoma, the labeling of collagen type IV and laminin were increased at pre-LC and LC area due to the accumulation of basement membrane-like materials.

[The extracellular matrix of optic nerve head in normal human adult].

Objective: To demonstrate the macromolecular components of extracellular matrix of lamina cribrosa from young human donors.

Methods: Immunoperoxidase (ABC) staining method was used to investigate the distribution of collagen type IV, laminin and fibronectin in the lamina cribrosa of 7 pairs of normal human eyes.

Results: There was a large amount of collagen type IV and laminin in the cribrosa plates, but no positive staining of fibronectin in them.