Role of copy number variation analysis in prenatally diagnosed Blake's pouch cyst.

Background: Blake's pouch cyst (BPC) is a midline cystic anomaly of the posterior fossa. BPC has been shown to have a risk of aneuploidy prenatally. Copy number variation (CNV) and/or genetic syndromes have been reported in a few prenatal/postnatal cases with BPC.

Outdoor light at night exposure was associated with hypothyroidism in pregnant women: A national study in China.

Background: Evidence on the influence of outdoor artificial light at night (ALAN) on hypothyroidism in pregnant women is scarce. We aimed to investigate the association between outdoor ALAN exposure and hypothyroidism in pregnancy.

Methods: 81,120 pregnant women from the China Birth Cohort Study (CBCS) were analyzed, which recruited from 18 provinces and autonomous regions in China between February 2018 and December 2020.

Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study.

Background: The role of inflammation in the development of gestational diabetes mellitus (GDM) has recently become a focus of research. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), novel indices, reflect the body's chronic immune-inflammatory state. This study aimed to investigate the associations between the SII or SIRI and GDM.

Engrailed-2 (EN2) protein in cervical mucus: a novel biomarker for endometrial carcinoma.

Objective: This study aims to demonstrate that the EN2 protein in cervical mucus may serve as a novel biomarker for screening endometrial cancer.

Materials And Methods: This study included 133 patients who were treated at Beijing Obstetrics and Gynecology Hospital. According to the pathological results of hysteroscopy endometrial biopsy, the patients were divided into endometrial cancer group (n = 55), endometrial atypical hyperplasia group (n = 16), benign lesion group (n = 28), and control group (n = 34).

A novel homozygous mutation in the NLRP2 gene causes early embryonic arrest.

Purpose: Successful reproduction in humans requires maturation and fertilization of gametes as well as early embryonic development. Any deviation from these processes leads to infertility. Early embryonic arrest (EEA) is common in female infertility and is primarily attributed to genetic factors.

Assisted reproductive technology and the risk of birth defects mediated by multifetal pregnancy: evidence from the China Birth Cohort Study.

Background: Both assisted reproductive technology and multifetal pregnancy have been reported to be associated with an increased risk of birth defects. However, it is unclear whether multifetal pregnancy is a mediator that increases the risk of birth defects in assisted reproductive technology-conceived pregnancies.

Objective: To investigate the risk of birth defects associated with assisted reproductive technology, and to quantify the mediating effect of multifetal pregnancy between assisted reproductive technology and birth defects.

Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis.

Mitophagy serves as a mitochondrial quality control mechanism to maintain the homeostasis of mitochondria and the intracellular environment. Studies have shown that there is a close relationship between mitophagy and apoptosis. Sestrin2 (Sesn2) is a highly conserved class of stress-inducible proteins that play important roles in reducing oxidative stress damage, inflammation, and apoptosis.

Retraction Note: MiR-299-3p inhibits proliferation and invasion of cervical cancer cell via targeting TCF4.

The article "MiR-299-3p inhibits proliferation and invasion of cervical cancer cell via targeting TCF4" by Y. Yu, J.-D.

Association of body roundness index with female infertility: 2013-2018 NHANES.

Aim: This study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals' well-being and rights.

Methods: All individuals who completed the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2018 were initially included in this cross-sectional study.

[The role and research progress of gut microbiota in placenta-derived diseases].

Gut microbiota plays an important role in maintaining the normal function of intestinal tract, regulating the body's immunity, metabolism and other physiological processes. In recent years, the theory that gut microbiota dysbiosis affects the disease occurrence of various organ systems through the gut-organ axis has been gradually confirmed. Placental diseases of pregnancy includes early onset preeclampsia, fetal growth restriction, etc.

Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers.

Background And Aims: There have been limited studies on the application of a diabetes-specific formula in gestational diabetes mellitus (GDM), the role of which has not been well studied. We explored the effect of a diabetes-specific formula on blood glucose levels, insulin use and pregnancy outcomes in GDM patients.

Methods: In this randomized controlled study, 112 GDM patients were randomly assigned to the intervention group (56) and the control group (56).

Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys.

The ovary is crucial for female reproduction and health, as it generates oocytes and secretes sex hormones. Transplantation of mesenchymal stem cells (MSCs) has been shown to alleviate pathological ovarian aging. However, it is unclear whether MSCs could benefit the naturally aging ovary.

Immune Subtypes and Characteristics of Endometrial Cancer Based on Immunogenes.

Purpose: The aim of this study was to explore the immune subtypes of endometrial cancer (EC) and its characteristics by immunogenes from the perspective of multidimensional genomics (multi-omics).

Patients And Methods: Immune subtypes were carried out using an unsupervised non-negative matrix factorization clustering (NMF) method and their characteristics were analysed. Key genes were identified using random forest analysis.

Trace elements exposure affects the outcomes of in vitro fertilization embryo transfer, a cohort study in Northern China.

Purpose: With urbanization and industrialization process accelerated, humans are exposed more and more trace elements. This study aimed to explore the potential associations of trace elements with the outcomes of in vitro fertilization embryo transfer (IVF-ET).

Methods: Total 181 women who underwent IVF-ET were enrolled, among which 89 women underwent fresh ET after IVF.

Identification of a disulfidptosis-related genes signature for diagnostic and immune infiltration characteristics in endometriosis.

Endometriosis (EMs) is the prevalent gynecological disease with the typical features of intricate pathogenesis and immune-related factors. Currently, there is no effective therapeutic intervention for EMs. Disulfidptosis, the cell death pattern discovered recently, may show close relationships to immunity and EMs.