998 results match your criteria: "Beijing Institute of Biotechnology[Affiliation]"
Biochim Biophys Acta Mol Basis Dis
December 2024
Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China.
Background: Type 2 diabetes mellitus (T2D) is a significant health concern. Research using non-human primates, which develop T2D with similar symptoms and pancreatic changes as humans, is crucial but limited by long timelines and low success rates.
Results: We targeted capture sequenced 61 normal and 81 T2D cynomolgus monkeys using a primer panel that captured 269 potential regulatory regions potentially associated with T2D in the cynomolgus monkey genome.
Curr Microbiol
December 2024
Medical School of Chinese PLA, Beijing, China.
Tigecycline is one of the last-resort treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae (KP). Unfortunately, tigecycline resistance is increasingly reported and causes an unprecedented public health crisis worldwide. Although studies on tigecycline resistance are expanding, the underlying mechanisms are not fully understood.
View Article and Find Full Text PDFMol Biomed
December 2024
School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Signal Transduct Target Ther
December 2024
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors, protein kinases and transcription factors. However, it remains poorly understood how these components interact to regulate aerobic glycolysis coordinately. Here, we show that sine oculis homeobox 1 (SIX1) phosphorylation integrates growth factors (e.
View Article and Find Full Text PDFJ Transl Med
November 2024
Department of Cardiology, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing, 100037, People's Republic of China.
Adv Mater
November 2024
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Nat Commun
November 2024
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Emerg Microbes Infect
December 2024
Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, People's Republic of China.
is a genus of hazardous pathogens that has caused over 30 outbreaks. However, currently approved therapies are limited in scope, as they are only effective against the Ebola virus and lack cross-protection against other orthoebolaviruses. Here, we demonstrate that a previously isolated human-derived antibody, 2G1, can recognize the glycoprotein (GP) of every orthoebolavirus species.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
November 2024
Department of Anesthesiology, The Third Center of PLA General Hospital, Beijing, China.
Bone cancer pain remains a significant clinical challenge, often refractory to conventional treatments. The upregulation of the P2X3 receptor in the dorsal root ganglia has been implicated in the pathogenesis of bone cancer pain. This study aimed to elucidate the role of the P2X3 receptor in this context and assess the therapeutic potential of receptor silencing.
View Article and Find Full Text PDFBiomaterials
April 2025
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China. Electronic address:
Modular self-assembling nanoparticle vaccines, represent a cutting-edge approach in immunology with the potential to revolutionize vaccine design and efficacy. Although many innovative efficient modular self-assembling nanoparticles have been designed for vaccination, the immune activation characteristics underlying such strong protection remain poorly understood, limiting the further expansion of such nanocarrier. Here, we prepared a novel modular nanovaccine, which self-assembled via a pentamer cholera toxin B subunit (CTB) domain and an unnatural trimer domain, presenting S.
View Article and Find Full Text PDFNat Commun
November 2024
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
NPJ Vaccines
October 2024
Centre for Clinical Trial, Institute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia.
Cancer Biol Med
October 2024
Senior Department of Oncology, Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
Front Cell Infect Microbiol
October 2024
Faculty of Medicine, School of Basic Medical Sciences, Dalian University of Technology, Dalian, China.
Int J Mol Sci
September 2024
Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms, such as rhinitis and asthma, in humans. With the increasing popularity of and care provided to these companion animals, the allergens they produce pose a growing threat to susceptible patients' health. Allergens from cats and dogs have emerged as significant risk factors for triggering asthma and allergic rhinitis worldwide; however, there remains a lack of systematic measures aimed at assisting individuals in recognizing and preventing allergies caused by these animals.
View Article and Find Full Text PDFCell Death Discov
October 2024
Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, 10 TIEYI Road, Beijing, 10038, China.
Palbociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer by suppressing cell proliferation. However, monotherapy with palbociclib was discouraging in prostate cancer, calling for a mechanism-based effective therapy. In this study, we reported in prostate cancer that palbociclib is a potent sensitizer of ferroptosis, which is worked out by downregulating the expression of TRIB3, a gene highly expressed in prostate cancer.
View Article and Find Full Text PDFImmunology
January 2025
Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China.
Botulinum neurotoxins (BoNTs), including serotypes A and E, are potent biotoxins known to cause human poisoning. In addition to the critical protective antigen found in the full BoNT molecule, the receptor binding domain (Hc domain), BoNTs also harbour another essential protective antigen-the light chain-translocation domain (L-HN domain). Leveraging these pivotal protective antigens, we genetically engineered a series of inactivated chimeric molecules incorporating L-HN and Hc domains of BoNT/A and E.
View Article and Find Full Text PDFNature
October 2024
Frontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Academy of Military Medical Science; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.
Vaccine
December 2024
Department of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China. Electronic address:
Front Immunol
September 2024
School of Biotechnology, Dublin City University, Dublin, Ireland.
Botulinum neurotoxin (BoNT), produced by , is the most toxic protein known, capable of causing severe paralysis and posing a significant bioterrorism threat due to its extreme lethality even in minute quantities. Despite this, there are currently no FDA-approved vaccines for widespread public use. To address this urgent need, we have developed an innovative vaccine platform by fusing the neuronal binding domain of BoNT/E (Hc/E) with core-streptavidin (CS), resulting in a stable CS-Hc/E vaccine.
View Article and Find Full Text PDFArch Toxicol
December 2024
Institute of Materia Medica, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism agent. After poisoning, the only effective treatment is injection of antitoxin. However, neutralizing nanoantibodies are safer and more effective, representing a promising therapeutic approach.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is characterized by a lack of obvious clinical features in the early stages and is likely to progress to advanced HCC. Advanced HCC is a highly malignant tumor. However, there are few treatment options for advanced HCC.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
Department of Genetic Engineering, Beijing Institute of Biotechnology, Beijing, 100071, China. Electronic address:
Extracellular vesicles (EVs) are considered as promising candidates for predicting patients who respond to immunotherapy. Nevertheless, simultaneous detection of multiple EVs markers still presents significant technical challenges. In this work, we developed a high-throughput microdroplet-enhanced chip (MEC) platform, which utilizes thousands of individual microchambers (∼pL) as reactors, accelerating the detection efficiency of the CRISPR/Cas systems and increasing the sensitivity by up to 100-fold (aM level).
View Article and Find Full Text PDFAdv Sci (Weinh)
November 2024
Beijing Institute of Biotechnology, Beijing, 100071, China.
De novo lipogenesis (DNL), a hallmark of cancer, facilitates tumor growth and metastasis. Therapeutic drugs targeting DNL are being developed. However, how DNL is directly regulated in cancer remains largely unknown.
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