Comparison of single-visit versus multiple-visit root canal therapy for chronic anterior apical periodontitis.

Objective: To compare the efficacy of single-visit root canal therapy (RCT) and traditional multi-visit RCT for chronic apical periodontitis in anterior teeth.

Methods: A retrospective analysis was conducted on 106 patients with sinus-type anterior chronic apical periodontitis who underwent root canal treatment during March 2020 and April 2023 at Beijing Hospital of Integrated traditional Chinese and Western Medicine. The patients were divided into an observation group (55 cases, single-visit RCT) and a control group (51 cases, traditional multi-visit RCT) according to different treatment methods.

Icariin stimulates the proliferation of rat bone mesenchymal stem cells via ERK and p38 MAPK signaling.

Bone mesenchymal stem cells (BMSCs) are able to differentiate into multi types of lineages, so they have been widely applied in the stem cell transplantation. The BMSCs are usually needed to be expanded before transplantation due to their limited content in bone marrow. It has recently been reported that Icariin (ICA), a major constituent of flavonoids from the Chinese medical herb Epimedium brevicornum Maxim, promotes the proliferation of various types of differentiated cells.