Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by glycerophospholipid metabolism and PI3K/Akt signaling pathway.

Background And Purpose: Chuanxiong Qingnao Granles (CQG), has been used to treat migraine headache (MH) for many years. However, current investigation of CQG have primarily focused on clinical studies, and the potential mechanisms underlying of its effects on MH have not been fully elucidated. In the present study, we applied an integrated approach of transcriptomics and metabolomics to elucidate the therapeutic mechanisms of CQG in nitroglycerin (NTG)-induced MH injury.

Time-Frequency functional connectivity alterations in Alzheimer's disease and frontotemporal dementia: An EEG analysis using machine learning.

Objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.

Methods: Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics.

Insight into the effect of GSH curing treatment on the flavor formation of chicken meat.

Glutathione (GSH) is an important precursor of meat flavor. This study aimed to evaluate the effect of GSH-curing on the flavor of cooked chicken. GSH-cured chicken with different concentrations and uncured chicken (blank) were roasted separately and comprehensively analyzed in terms of flavors, odor-active compounds, free amino acids, and fatty acids profile.

DCSENets: Interpretable deep learning for patient-independent seizure classification using enhanced EEG-based spectrogram visualization.

Neurologists often face challenges in identifying epileptic activities within multichannel EEG recordings, requiring extensive hours of analysis. Computer-aided diagnosis systems have been proposed to reduce manual inspection of EEG signals by neurologists. However, direct analysis of EEG signals is difficult due to their complex and dynamic nature, with variation across multiple patients.

Cadmium sulfide (CdS) nanoparticles and Cd accumulated by Portulaca oleracea L. using a hydroponic system: Constructed wetland perspective.

To identify cadmium sulfide nanoparticles (CdS NPs) and Cd hyperaccumulators for Cd-contaminated waters. A potential species of constructed wetland plants (P. oleracea) was examined for their CdS NPs and Cd ions tolerance and accumulation.

Enhanced electron transfer for the improvement of nitrogen removal efficiency and NO reduction at low temperatures.

Low temperature generally restricts biological activity, slowing down electron transfer in biogeochemical cycles and causing a series of environmental problems such as nitrogen pollution. We present a strategy to boost electron transfer in microbial cell at low temperatures via stimulation with low current. It is demonstrated by establishing a constructed wetland system coupled with solar powered microbial electrolysis cell, which enhances microbial activity through external micro currents (18.

Tracking the nitrogen transformation in saline wastewater by marine anammox bacteria-based Fe(II)-driven autotrophic denitratation and anammox.

Marine anammox bacteria-based Fe(II)-driven autotrophic denitratation and anammox (MFeADA) was investigated for nitrogen removal from saline wastewater for the first time. The study demonstrated that varying influent doses of Fe(II), which participate in the Fe cycle, significantly influenced nitrogen removal performance by altering the fate of nitrite. When 50 mg/L Fe(II) was added, the nitrogen removal was mainly performed by the anammox and Fe(II)-driven autotrophic denitratation (FeAD).

Protocol for in vitro generation of innate lymphoid cells from human embryonic tissues.

Deciphering the origins of innate lymphoid cells (ILCs) is critical for a deeper understanding of innate immunity. Here, we present a protocol for assessing ILC potential of human embryonic resources. We describe steps for identifying lymphoid progenitors in human embryonic tissues, then culturing mature ILCs in vitro, and identifying characteristics and functions of different cultured ILC subsets using cellular indexing of transcriptomes and epitopes (CITE)-sequencing and flow cytometry analysis.

Field-Induced Polarization Rotation in Order-Disorder (K,Na)NbO-Based Ferroelectrics.

Phase boundary is highly recognized for its capability in engineering various physical properties of ferroelectrics. Here, field-induced polarization rotation is reported in a high-performance (K, Na)NbO-based ferroelectric system at the rhombohedral-tetragonal phase boundary. First, the lattice structure is examined from both macroscopic and local scales, implementing Rietveld refinement and pair distribution function analysis, respectively.

Real-Time Detection of Dynamic Restructuring in KNiFe F Perovskite Fluorides for Enhanced Water Oxidation.

Mechanistic understanding of how electrode-electrolyte interfaces evolve dynamically is crucial for advancing water-electrolysis technology, especially the restructuring of catalyst surface during complex electrocatalytic reactions. However, for perovskite fluorides, the mechanistic exploration for the influence of the dynamic restructuring on their chemical property and catalytic mechanism is unclear due to their poor conductivity that makes the definition of electrocatalyst structure difficult. Herein, for oxygen evolution reaction (OER), various operando characterizations are employed to investigate the structure-activity relationships of the KNiFe F@NF.

Orbital Current Pumping From Ultrafast Light-driven Antiferromagnetic Insulator.

The orbital Hall effect originating from light materials with weak spin-orbit coupling, has attracted considerable interest in spintronic applications. Recent studies demonstrate that orbital currents can be generated from charge currents through the orbital Hall effect in ferromagnetic materials. However, the generation of orbital currents in antiferromagnets has so far been elusive.

Interface-aware molecular generative framework for protein-protein interaction modulators.

Protein-protein interactions (PPIs) play a crucial role in numerous biochemical and biological processes. Although several structure-based molecular generative models have been developed, PPI interfaces and compounds targeting PPIs exhibit distinct physicochemical properties compared to traditional binding pockets and small-molecule drugs. As a result, generating compounds that effectively target PPIs, particularly by considering PPI complexes or interface hotspot residues, remains a significant challenge.

Association of Preoperative Oxygen Saturation and McGoon Ratio With Early Prognosis of Tetralogy of Fallot: A Propensity Score-Matched Analysis.

Aim: Tetralogy of Fallot (TOF) is the most common cyanotic heart disease. This study aimed to demonstrate the effects of preoperative oxygen saturation on the early prognosis of TOF and identify risk factors associated with early complications.

Method: A cohort of 1,138 patients who were diagnosed and underwent one-stage surgical repair in this hospital were retrospectively included in this study.

Encapsulation of fluorescent carbon dots into mesoporous SiO colloidal spheres by surface functionalization-assisted cooperative assembly for high-contrast latent fingerprint development.

Exploiting solid powder fluorescence holds significant potential in diverse domains including medicine and forensics. Conventional fingerprint detection methods often fall short due to low contrast, sensitivity, and high toxicity. To addressing these challenges, we present a novel method for latent fingerprint detection using fluorescent carbon dots (CDs) encapsulated into mesoporous SiO colloidal spheres through a surface functionalization-assisted cooperative assembly.

Understanding the protein conformation transition within polymer hydrogels using a near-infrared water spectroscopy probe.

For understanding the behavior of the active substance in vivo, the near-infrared (NIR) spectral variations of ovalbumin (OVA) loaded in poly(N, N-dimethyl acrylamide) (PDMAA) hydrogel with temperature were investigated. Analyzing the spectra with improved resolution by continuous wavelet transform (CWT), the absorption variation of the peak at 4851 cm arising from the α-helix of OVA with temperature was studied. The results show that a sharp decrease occurs at a lower temperature in PDMAA hydrogel, indicating that the unfolding of OVA in PDMAA hydrogel is facilitated.

Development and evaluation of pH-sensitive Euryale ferox starch-based films containing nano-SiO and Chinese rose (Rosa chinensis) extract for freshness monitoring of chicken breast meat.

In this study, smart films of EFS, EFS-SiO and EFS-SiO-CRE were successfully developed by using Euryale ferox starch (EFS), nano-SiO and Chinese rose extract (CRE). The Chinese rose flower had a high content of anthocyanins (1.73 mg/g) and CRE exhibited different colors in varying pH buffers (2-13).

Long-term antioxidant and ultraviolet light shielding gelatin films for the preservation of leather artifacts.

In this study, CA-Gel complexes were prepared by crosslinking gelatin with chlorogenic acid (CA) by EDC/NHS chemistry, and incorporated into gelatin to produce CA-Gel/Gel films for leather artifact preservation. The synthesized CA-Gel complex had a total phenolic content of 139.62 ± 1.

Methacrylated silk fibroin based composite hydrogel with ROS-scavenging and osteogenic ability to orchestrate diabetic bone regeneration.

The repair of diabetic bone defects is still filled with enormous challenges. Excessive reactive oxygen species (ROS) are regenerated in diabetic bone defect sites which is harmful to bone regeneration. Therefore, it's to a good strategy to scavenge the excess ROS to provide a friendly environment for diabetic bone defects repair.

Dietary Bacillus subtilis HGcc-1 improves the growth performance, α-amylase and lipase activities, immunity and antioxidant capacity, intestinal microbiota, and heat stress resistance in Pacific white shrimp (Litopenaeus vannamei).

This study aimed to investigate the effects of B. subtilis HGcc-1 supplementation on the growth performance, immunity response, antioxidant capacity, intestinal microbiota and heat stress resistance of Litopenaeus vannamei. The results showed that B.

Adaptation of Left Ventricular Function and Myocardial Microstructure in Fetuses with Right Ventricular Hypoplasia.

Background: This study aimed to evaluate changes in left ventricular (LV) function and myocardial microstructure in fetuses with right ventricular hypoplasia (RVH) using two-dimensional speckle tracking echocardiography (2D-STE), diffusion tensor cardiovascular magnetic resonance imaging (DT-CMR) and proteomics analysis.

Methods: 51 singleton fetuses diagnosed with RVH and 51 normal fetuses were retrospectively included. LV global longitudinal strain (GLS) and global circumferential strain (GCS) were acquired by 2D-STE.

Exploring the molecular mechanisms for renoprotective effects of Huangkui capsule on diabetic nephropathy mice by comprehensive serum metabolomics analysis.

Ethnopharmacological Relevance: Huangkui capsule (HKC), a patent traditional Chinese medicine, has shown significant efficacy in managing chronic kidney disease (CKD), particularly diabetic nephropathy (DN). Previous studies have shown that HKC can alleviate kidney damage in DN. However, the exact mechanisms through which it exerts its effects remain unclear.

The effects and mechanisms of Chai Shao Jie Yu Granules on chronic unpredictable mild stress (CUMS)-induced depressive rats based on network pharmacology.

Ethnopharmacological Relevance: Chai Shao Jie Yu Granules (CSJY) is a renowned and time-honored formula employed in clinical practice for the management of various conditions, notably depression. Depression, a prevalent psychiatric disorder, poses challenges with limited effective treatment options. Traditional herbal medicines have garnered increasing attention in the realm of combating depression, being perceived as safer alternatives to pharmacotherapy.

Effect of an Endoscopy Screening on Upper Gastrointestinal Cancer Mortality: A Community-based Multicenter Cluster Randomized Clinical Trial.

Background And Aims: Population-based observational studies suggest that endoscopic screening may reduce upper gastrointestinal cancer mortality. We aimed to quantify the effect of endoscopy screening.

Methods: This is a community-based, multicenter, cluster randomized clinical trial conducted in both high-risk and non-high-risk areas of China.

Associations of Preconception Air Pollution Exposure with Growth Trajectory in Young Children: A Prospective Cohort Study.

Gestational air pollution exposure was associated with childhood obesity. However, little is known about the effect of air pollution exposure during the preconception period, a critical window when environmental exposures may affect body growth trajectory and increase obesity risk. We conducted a population-based prospective cohort study of preconception women and their newborn children followed until 2 years old from metropolitan Shanghai, China to investigate the impact of preconception air pollution on childhood weight and body mass index (BMI) growth trajectories.