2,057 results match your criteria: "Beijing Ditan Hospital[Affiliation]"
Prevalence and risk factors of significant fibrosis in chronic hepatitis B patients with concurrent metabolic dysfunction-associated steatotic liver disease.
Ann Hepatol
September 2024
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, PR China. Electronic address:
Article Synopsis
- The study investigates the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on significant fibrosis in patients with chronic hepatitis B (CHB), aiming to determine if those with both conditions face a higher risk.
- A total of 1818 patients were analyzed, revealing that those with CHB and MASLD exhibited significant fibrosis at rates of 35.5%, compared to 23.5% in those with just CHB.
- The findings suggest that MASLD is linked to increased fibrosis in CHB patients, especially for those with three or more cardiometabolic risk factors, highlighting the importance of early detection and intervention.
Occupational exposure protection and perioperative management of sudden infectious diseases from the perspective of COVID-19.
J Int Med Res
September 2024
Department of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
The coronavirus disease (COVID-19) SARS-CoV-2 virus epidemic continues to exhibit a sporadic onset trend due to the continuous variation of the novel coronavirus. However, the psychological impact of the pandemic persists. It is crucial to reflect on our experiences to better prepare for future large-scale infectious diseases.
View Article and Find Full Text PDFA chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants.
PLoS Pathog
September 2024
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Article Synopsis
- Influenza and COVID-19 are two major respiratory diseases that have led to significant health challenges worldwide, prompting the need for an effective combined vaccine to avoid multiple doses.
- Researchers created a chimeric protein subunit vaccine combining parts of the influenza virus and the SARS-CoV-2 virus, demonstrating effectiveness in mouse models against various strains.
- An mRNA vaccine candidate was developed from this chimeric antigen, showing strong immune responses and complete protection in mice against both influenza and different strains of SARS-CoV-2, with the potential for easy adaptation to new variants.
Diagnostic model for spontaneous bacterial peritonitis in cirrhotic patients with ascites: a multicenter cohort study.
Eur J Gastroenterol Hepatol
November 2024
Department of Critical Care Medicine of Liver Disease, Beijing You-An Hospital, Capital Medical University.
Article Synopsis
- - The study focuses on spontaneous bacterial peritonitis (SBP), a serious complication of liver disease, aiming to improve early diagnosis and treatment to enhance patient survival rates.
- - Researchers analyzed data from 1,618 patients with liver-related fluid buildup to identify key predictors of SBP, creating a nomogram for diagnosis based on various clinical parameters.
- - The diagnostic model proved to be effective, showing strong accuracy in both training and validation cohorts, and includes an easy-to-use Excel tool for clinical adoption.
Distinctive features and prognostic utility of neutrophil in severe patients with infection.
Front Cell Infect Microbiol
September 2024
Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Background: Neutrophil plays a pivotal role in the management of infection. Delineate the clinical characteristics and prognostic utility of neutrophil in severe patients with infection are crucial for clinical management and prognostic assessment.
Methods: patients with different infection sites were enrolled from Medical Information Mart for Intensive Care IV and eICU Collaborative Research Database.
Serum metabolomics profile identifies patients with community-acquired pneumonia infected by bacteria, fungi, and viruses.
Ann Med
December 2024
Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing, China.
Article Synopsis
- The study aimed to analyze the metabolic profiles of patients with bacterial, viral, and fungal community-acquired pneumonia (CAP) to understand how these infections differ from each other and from healthy individuals.
- Researchers used advanced technologies to screen respiratory samples and found significant metabolic differences among patients with different types of CAP, identifying specific metabolites unique to each infection type.
- The findings suggest that serum metabolomic techniques can help early detection of the type of pathogen causing pneumonia, potentially leading to faster and more effective treatment.
Effect of Low-Dose Aspirin Use After Thermal Ablation in Patients with Hepatocellular Carcinoma: A Retrospective Study.
J Hepatocell Carcinoma
September 2024
Cancer Center, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Purpose: To determine the effect of aspirin on hepatocellular carcinoma (HCC) recurrence and survival after thermal ablation.
Methods: A retrospective analysis was performed to evaluate the efficacy and safety of aspirin in combination with thermal ablation. The clinical data were collected for the enrolled patients.
Corrigendum to "Knowledge fused latent representation from lung ultrasound examination for COVID-19 pneumonia severity assessment" [Ultrasonics 143 (2024) 107409].
Ultrasonics
January 2025
School of Biomedical Engineering, Tsinghua University, Beijing 100084, China. Electronic address:
Clinical and laboratory characteristics of asymptomatic and symptomatic neurosyphilis in HIV-infected patients: A retrospective study in China.
Medicine (Baltimore)
September 2024
Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- High rates of HIV and Treponema pallidum coinfection exist, and HIV can worsen the incidence of neurosyphilis, but risk factors for symptomatic neurosyphilis (SNS) are not well understood.
- A study reviewed the medical records of 60 male inpatients with syphilis and HIV, finding that 75% were diagnosed with SNS, with meningo-vascular neurosyphilis being most common.
- Significant factors linked to SNS include the absence of early syphilis treatment and a higher cerebrospinal fluid (CSF) white blood cell count, suggesting that closer monitoring and treatment are crucial, especially regarding young patients with unexplained strokes.
Five miRNAs identified in fucosylated extracellular vesicles as non-invasive diagnostic signatures for hepatocellular carcinoma.
Cell Rep Med
September 2024
Beijing Key Laboratory of POCT for Bioemergency and Clinic (No. BZ0329), Beijing, China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address:
Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer that presents significant challenges for early detection. This study introduces the GlyExo-Capture method for isolating fucosylated extracellular vesicles (Fu-EVs) from serum. We analyze microRNA (miRNA) profiles from Fu-EVs in 88 HCC patients and 179 non-HCC controls using next-generation sequencing (NGS) and identify five miRNAs (hsa-let-7a, hsa-miR-21, hsa-miR-125a, hsa-miR-200a, and hsa-miR-150) as biomarkers for HCC diagnosis.
View Article and Find Full Text PDFSerotonergic transmission plays differentiated roles in the rapid and sustained antidepressant-like effects of ketamine.
Br J Pharmacol
December 2024
Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing, China.
Article Synopsis
- Ketamine shows promising rapid and sustained antidepressant effects, linked to increased serotonin (5-HT) levels in the brain.
- Experimental methods involved inducing depression-like behaviors in mice and measuring changes in 5-HT using various tests and techniques.
- The study indicates that targeting serotonin transmission is crucial for maintaining ketamine's antidepressant effects, highlighting the role of AMPA receptors in the process.
Editorial: Immune cell development and differentiation in liver diseases.
Front Cell Dev Biol
August 2024
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Evaluation of the effectiveness of a segmented alternating shift pattern based on wearable vital signs monitoring devices during COVID-19: a cross-sectional study.
BMC Nurs
September 2024
National Center for Infectious Disease, Beijing Ditan Hospital Capital Medical University, Beijing, China.
Aim: To explore the feasibility and effectiveness of an alternating shift pattern in two-hour segments in the state of emergency management of public health events.
Methods: A cross-sectional research design was conducted in our study. The nursing staff working in the admission ward of suspected or confirmed patients with COVID-19 in December 2022 were selected as subjects by the whole-group sampling method.
CuPCA: a web server for pan-cancer association analysis of large-scale cuproptosis-related genes.
Database (Oxford)
September 2024
College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China.
Copper-induced cell death is a novel mechanism of cell death, which is defined as cuproptosis. The increasing level of copper can produce toxicity in cells and may cause the occurrence of cell death. Several previous studies have proved that cuproptosis has a tight association with various cancers.
View Article and Find Full Text PDFPotential Contributions of Human Endogenous Retroviruses in Innate Immune Memory.
J Immunol
October 2024
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Trained immunity refers to the long-term changes in innate immune cells that enhance their ability to fight infections, influenced by transcriptional and epigenetic reprogramming.
- This study examined extensive omics data to investigate the role of human endogenous retroviruses (HERVs) in shaping trained immunity in macrophages, identifying specific HERVs linked to gene expression and inflammatory responses.
- Findings indicated that 15.3% of HERVs were actively transcribed in a nonrandom manner and were associated with key genes involved in the immune response, suggesting a significant role of HERVs in the training of immune cells.
Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas.
Cell Biosci
September 2024
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Adamantinomatous craniopharyngioma (ACP) is a clinically aggressive tumor without effective treatment method. Previous studies proposed a paracrine tumorigenesis model, in which oncogenic β-catenin induces senescence in pituitary stem cells and the senescent cells lead the formation of paracrine tumors through secretion of pro-tumorigenic factors. However, there lacks characterization on senescent cells in ACPs.
View Article and Find Full Text PDFSARS-CoV-2 Evolution: Immune Dynamics, Omicron Specificity, and Predictive Modeling in Vaccinated Populations.
Adv Sci (Weinh)
October 2024
State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, 102206, China.
Article Synopsis
- Host immunity, influenced by vaccination and prior infections, plays a key role in how SARS-CoV-2 spreads, with a study analyzing the interactions between the virus's mutations and immune responses in vaccinated humans and mice.
- A new model called the Prevalence Score (P-Score) outperforms previous methods in predicting how new variants could spread in vaccinated groups, emphasizing the importance of vaccine type and timing.
- The results suggest that combining a wild-type inactivated vaccine with an Omicron mRNA vaccine could offer broader protection against various strains, though specific variants like EG.5.1 still present challenges, informing future vaccine strategies and public health planning.
Prognostic Value of High-Density Lipoprotein Cholesterol in Patients with Overt Hepatic Encephalopathy.
Biomedicines
August 2024
Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Overt hepatic encephalopathy (OHE), a serious complication of liver cirrhosis, is associated with alterations in lipid and lipoprotein metabolism. We evaluated the correlation between high-density lipoprotein cholesterol (HDL-C) levels and transplant-free (TF) mortality in patients with OHE. Patients with OHE admitted to Beijing Ditan Hospital between January 2010 and August 2016 (n = 821) and between September 2016 and December 2020 (n = 480) were included in the training and validation sets, respectively.
View Article and Find Full Text PDFSymptom network connectivity and interaction among people with HIV in China: secondary analysis based on a cross-sectional survey.
BMC Public Health
August 2024
Department of Medical Records and Statistics, Beijing Ditan Hospital Capital Medical University, Beijing, China.
Background: The symptom burden in people with HIV (PWH) is considerable. Nonetheless, the identification of a central symptom, or bridge symptom, among the myriad symptoms experienced by PWH remains unclear. This study seeks to establish networks of symptom experiences within different clusters and investigate the relationships and interconnectedness between these symptoms in PWH.
View Article and Find Full Text PDFTrends and Patterns of HIV Transmitted Drug Resistance in China From 2018 to 2023.
J Infect Dis
December 2024
Institute for HIV/AIDS and STD Prevention and Control, Beijing Center for Disease Prevention and Control (CDC), Beijing Academy of Preventive Medicine, Beijing.
Article Synopsis
- The study examined drug resistance in HIV among newly diagnosed individuals in China from 2018 to 2023 to adapt treatment guidelines.
- Out of over 22,000 individuals, 4.36% had at least one transmitted drug resistance (TDR) mutation, with the most common being linked to nonnucleoside reverse transcriptase inhibitors.
- The prevalence of TDR mutations notably increased from 4.05% to 5.39% over the study years, supporting the ongoing use of NNRTI-based treatment regimens for HIV.
Improvement in the 95-95-95 Targets Is Accompanied by a Reduction in Both the Human Immunodeficiency Virus Transmission Rate and Incidence in China.
J Infect Dis
November 2024
Institute for HIV/AIDS and STD Prevention and Control, Beijing Center for Disease Control and Prevention (CDC), Beijing Academy of Preventive Medicine, Beijing.
Article Synopsis
- China adopted the WHO's "treat all" policy in 2016, aiming to improve HIV care through the 95-95-95 targets, which include diagnosing 95% of HIV positive individuals, getting 95% of those diagnosed on treatment, and achieving viral suppression in 95% of treated individuals.
- Data from 2004 to 2023 showed significant advancements in these targets, correlating with a drop in new HIV infections, as evidenced by a dip in clustering frequency and a peak in cases documented in 2014.
- The study concludes that while progress has been made, China needs to focus on increasing efforts in the first "95" target to further reduce HIV transmission rates and improve overall outcomes.
Feasibility and Safety of the Clinical Outcomes of TACE Combined with Lenvatinib and PD-1 Blockades in the Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective Exploratory Study.
Int J Gen Med
August 2024
Department of Oncology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People's Republic of China.
Objective: This study aimed to investigate the feasibility of the efficacy and safety of TACE combined with Lenvatinib and PD-1 blockade in HCC with portal vein tumor thrombus (PVTT).
Methods: Patients with HCC and PVTT who underwent TACE combined with Lenvatinib and PD-1 blockade as first-line therapy in clinical practice were retrospectively included. All subjects were followed-up regularly to obtain prognostic outcomes.
Clinical application of a novel three-dimensional printed template for osteoporotic vertebral compression fracture.
Asian J Surg
August 2024
Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address:
Role of Early On-Treatment Serum HBV RNA Declines in Predicting Hepatocellular Carcinoma Risk in Patients With Chronic Hepatitis B.
Clin Gastroenterol Hepatol
August 2024
Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China; State Key Laboratory of Organ Failure Research, Guangzhou, China; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China; Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases, Guangzhou, China; Guangdong Provincial Clinical Research Center for Viral Hepatitis, Guangzhou, China. Electronic address:
Article Synopsis
- The study focuses on predicting the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B receiving nucleos(t)ide analogues (NAs), emphasizing the importance of serum hepatitis B virus (HBV) RNA as a novel biomarker.
- Researchers analyzed data from 1,374 NA-treated patients, tracking HBV RNA levels over three years and using a Cox proportional-hazard model to assess the link between HBV RNA declines and HCC risk, finding significant associations.
- The findings suggest that patients with lower declines in HBV RNA at one and two years have a higher risk of developing HCC, and incorporating these declines into existing risk prediction models can improve their accuracy and help guide patient monitoring strategies
Development and validation of a prognostic nomogram to predict the recurrence of AFP-negative and DCP-positive hepatocellular carcinoma after curative resection.
Front Oncol
August 2024
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- - Approximately one-third of hepatocellular carcinoma (HCC) cases are alpha-fetoprotein negative (AFP-NHCC), with 60% of these patients testing positive for des-gamma-carboxyprothrombin (DCP), which correlates with a worse prognosis.
- - A study of 540 patients at Beijing You'an Hospital identified key risk factors for HCC recurrence post-surgery, including age, tumor number, tumor size, γ-glutamyl transpeptidase (γ-GT), and prothrombin time (PT).
- - A novel nomogram was created and validated to predict recurrence-free survival for DCP-positive AFP-NHCC patients, successfully distinguishing between high- and