Aggregation-induced emission(AIE)for next-generation biosensing and imaging: A review.

Luminescence technology is a powerful analytical tool for biomedical research as well as for marker detection. Luminescent materials with aggregation-induced emission (AIE) properties have attracted extensive research interest, and their unique luminescence characteristics, biocompatibility, and sensitivity make them useful for the development of fluorescence-turn-on biosensors with superior sensitivity. While numerous reviews have focused on the design of AIEgens, comprehensive summaries on the strategies for biosensor preparation and application fields remain limited.

Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.

Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.

Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.

The RNA-binding protein CMSS1 promotes the progression of non-small cell lung cancer by regulating the telomerase protein subunit hTERT.

Aims: High telomerase activity has been detected in over 85 % of tumors, with the activation of hTERT being the most crucial mechanism for re-establishing telomerase activity. Activation of hTERT maintains telomere length in cells, enabling cancer cells to proliferate indefinitely. Nevertheless, the specific mechanism of telomerase activation in non-small cell lung cancer (NSCLC) remains unclear, and post-transcriptional regulation of hTERT could be a potential activation mechanism.

NUF2 is associated with cancer stem cell characteristics and a potential drug target for prostate cancer.

Background: Cancer stem cells are characterized by self-renewal, clonal tumor initiation capacity, and treatment resistance, which play essential roles in the tumor progression of prostate cancer (PCa). In this study, we aim to explore the features of cancer stemness and characterize the expression of stem cell-related genes for PCa.

Methods: We downloaded RNA-seq data and related clinical information from The Cancer Genome Atlas (TCGA) database.

Investigation of Gray Matter Changes Using Voxel-Based Morphometry in HIV-Negative Patients with General Paresis of the Insane.

Purpose: To investigate whole-brain gray matter volume (GMV) changes in human immunodeficiency (HIV)-negative patients with general paresis of the insane (GPI) using voxel-based morphometry (VBM).

Patients And Methods: A total of 18 HIV-negative individuals with GPI and 24 healthy control volunteers matched for sex, age, and education were enrolled in this study. 3 D T1-weighted imaging (3D T1WI) structural images of GPI patients and healthy controls were preprocessed using VBM.

Impact of different antiretroviral therapy regimens on bone mineral density in people living with HIV: a retrospective and longitudinal study in China.

Background: HIV infection and antiretroviral therapy (ART) are associated with bone loss of people living with HIV (PLWH), but limited studies exist on the impacts of ART regimens on bone mineral density (BMD) in China. This study evaluated BMD changes with three common ART regimens: tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) + efavirenz (EFV), tenofovir alafenamide (TAF)-containing, and dolutegravir (DTG)-containing (non-TDF/non-TAF) therapies.

Methods: In this retrospective study, the prevalence of low BMD was analyzed in PLWH who underwent dual-energy X-ray absorptiometry (DXA) before ART initiation.

Evaluating the capacity of tertiary general hospitals in Beijing to prevent and treat respiratory infectious diseases: a delphi study.

Background: The capacity of tertiary general hospitals to prevent and treat respiratory infectious diseases plays a key role in effectively containing the spread of major epidemics within hospitals and ensuring early treatment for patients. This, in turn, helps control the transmission of diseases at the societal level and safeguard public health. However, there is a lack of detailed indicators for assessing hospitals' capacity in this area, which makes it difficult to evaluate and manage practices.

A nomogram model for predicting advanced liver fibrosis in patients with hepatitis B: A multicenter study.

Background: Biopsy is the gold standard method for diagnosing liver fibrosis. FibroScan is a non-invasive method of diagnosing liver fibrosis, but it still faces some limitations. This study aimed to establish a nomogram model and identify patients at high risk of advanced liver fibrosis associated with hepatitis B infection.

Association between CD4 count, CD4/CD8 ratio, and fragility fractures in people living with HIV: a retrospective cohort study in China.

Background: People living with HIV (PLHIV) often exhibit reduced CD4+ T cell counts and altered CD4/CD8 ratios, but their impact on fragility fractures remains underexplored. This study investigated the association between CD4 count, CD4/CD8 ratio, and fragility fractures in PLHIV in China.

Methods: A retrospective cohort study was conducted on PLHIV treated at Beijing Ditan Hospital from January 2011 to September 2023.

Immunological characteristics in elderly COVID-19 patients: a post-COVID era analysis.

Background: Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, the elderly remain particularly susceptible, highlighting the need for intensified focus on immune health management.

Methods: A total of 281 elderly patients were enrolled in this study and categorized based on their clinical status at the time of admission into three groups: non-severe (n = 212), severe survivors (n = 49), and severe non-survivors (n = 20).

Efficacy of nintedanib as a host-directed therapy candidate in the treatment of tuberculosis.

Background: The lengthy duration and high frequency of drug resistance associated with currently used antimycobacterial drug treatments have intensified the need for alternative therapies against Mycobacterium tuberculosis, the causative agent of TB.

Methods: MICs and intracellular macrophage cfu counts were tested to evaluate the antibacterial activity of nintedanib and pirfenidone against drug-susceptible and -resistant M. tuberculosis.

Prognostic value of the neutrophil-to-lymphocyte ratio and prognostic nutritional index in unresectable hepatocellular carcinoma patients treated with tyrosine kinase inhibitors and immune checkpoint inhibitors.

This study aimed to investigate the role of the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in unresectable hepatocellular carcinoma (HCC) patients treated with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The optical cutoff values of the NLR and PNI were determined via time-dependent receiver operating characteristic curve analysis. The associations between overall survival (OS) and various potential risk factors were analyzed.

Effect of Narrative Nursing Intervention on Patients with Specific Digestive Tract Malignancies (Esophageal, Gastric, and Intestinal Cancers): A Retrospective Study.

Objective: To explore the effect of narrative nursing intervention on patients with esophageal, gastric, and intestinal cancers.

Methods: A retrospective analysis was conducted on the clinical data of 103 patients with digestive tract malignant tumors admitted to our hospital from January 2022 to January 2024. According to the nursing intervention received by the patients, they were divided into a control group (n=51) and an observation group (n=52).

The Imbalance of Homeostasis in Neutrophil Extracellular Traps is Associated with Portal Vein Thrombosis in Patients with Decompensated Cirrhosis.

Background And Aims: Portal vein thrombosis (PVT) is a challenging complication in liver cirrhosis, with no currently available sensitive diagnostic markers. This study aimed to investigate the potential of neutrophil extracellular traps (NETs) and Deoxyribonuclease (DNase) as diagnostic indicators for PVT in chronic hepatitis B (CHB)-related decompensated cirrhosis.

Methods: We analyzed 145 CHB-related decompensated cirrhosis patients from the Ditan study and 33 from the Changgung validation study, categorizing them based on PVT occurrence.

Outcome and management of patients with hepatocellular carcinoma who achieved a complete response to immunotherapy-based systemic therapy.

Background And Aims: The outcome of patients with HCC who achieved complete response (CR) to immune-checkpoint inhibitor (ICI)-based systemic therapies is unclear.

Approach And Results: Retrospective study of patients with HCC who had CR according to modified Response Evaluation Criteria in Solid Tumors (CR-mRECIST) to ICI-based systemic therapies from 28 centers in Asia, Europe, and the United States. Of 3933 patients with HCC treated with ICI-based noncurative systemic therapies, 174 (4.

Nanozymes featuring a mesoporous silica shell for rapid enrichment and ultrasensitive lateral flow immunoassay of influenza A.

Background: Respiratory illnesses stemming from influenza A viruses represent a significant worldwide health concern. There is an immediate need for a rapid and sensitive method to detect influenza A viruses early, without requiring extra equipment.

Results: Here, we established a lateral flow immunoassay (LFIA) for the detection of influenza A (Flu A) using a "three-in-one" multifunctional mesoporous FeO@SiO@Pt nanozymes (FeO@MSiO@Pt NZs) with excellent magnetic separation properties, colorimetric, and peroxidase-like (POD-like) activities.

Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants.

Nonalcoholic fatty liver disease (NAFLD) is recognized as a significant public health problem worldwide. Several clinical studies have investigated the associations between Per- and poly-fluoroalkyl substances (PFAS) compounds with the risk of NAFLD in general adults, but the mediating effect of triglycerides (TG) was remained unexplored. In this study, 6990 individuals from the National Health and Nutrition Examination Survey (NHANES, 2003-2018) database were enrolled.

Global trends in the application of droplet digital PCR technology in the field of infectious disease pathogen diagnosis: A bibliometric analysis from 2012 to 2023.

Background: This study discusses the development trends and current applications of digital droplet PCR technology in pathogen diagnostics.

Methods: A bibliometric analysis was conducted by retrieving droplet digital pcr related articles published between January 1,2012 to December31, 2023, from the Web of Science Core Collection.

Results: A total of 3,513 authors from 66 countries published 508 research papers across 203 academic institutions.

Insulin resistance has closer correlation with the occurrence of metabolic dysfunction associated steatotic liver disease diagnosed by liver biopsy.

Objective: To explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).

Methods: Data from all MASLD patients, diagnosed by liver biopsy, were enrolled and divided into MASLD alone group and MASLD with MS group. They were subdivided into hyperuricemia group and normal SU group to find correlation between SU/IR and MASLD in patients with MS and independent risk factors for MASLD.

Artemether Ameliorates Non-Alcoholic Steatohepatitis by Restraining Cross-Talk Between Lipotoxicity-Induced Hepatic Hepatocytes and Macrophages.

Non-alcoholic steatohepatitis (NASH) has no effective treatment drug. Our previous study initially found that artemether (Art) treatment significantly attenuates NSAH by regulating liver lipid metabolism. This study further elucidates new mechanisms of Art in improving liver inflammation and provides evidence for drug repurposing.

Elimination of hepatitis B as a public health threat: Addressing the challenge and taking action.

Despite the significant efforts made in recent years, the latest data from the World Health Organization indicates that there are substantial challenges in achieving the elimination of hepatitis B virus (HBV) infection by 2030. The article in the by Ismael highlighted the limited accessibility to screening and antiviral treatment for HBV infection in eastern Ethiopia. Therefore, the editorial comments on this article will focus on the current challenges and recent efforts in the prevention and treatment of chronic hepatitis B, particularly emphasizing the expansion of screening and antiviral therapy, as well as feasible strategies to improve accessibility for HBV testing, antiviral therapy, and adherence enhancement.