Role of different examination methods in colorectal cancer screening: Insights and future directions.

Colorectal cancer is a malignant tumor with the third and second highest incidence and mortality rates worldwide, and its mortality rate is increasing annually. Colorectal cancer evolves gradually over a long period of time. The evolving process from colorectal adenoma to colorectal cancer takes approximately 10-15 years, providing a sufficiently long "window period" for early screening and diagnosis of colorectal cancer.

Modified Zuojin pill alleviates gastric precancerous lesions by inhibiting glycolysis through the HIF-1α pathway.

Background: Gastric precancerous lesions (GPL) typically originates from chronic gastritis (CG), and the changes in glycolysis mediated by the HIF-1α pathway during the progression from CG to GPL are unclear. Modified Zuojin pill (SQQT) is a traditional Chinese herbal formula used for treating GPL. However, the underlying mechanism has not been fully elucidated.

Newly Synthesized Citral Derivatives Serve as Novel Inhibitor in HepG2 Cells.

2H-pyran compound 1 synthesized from 6-methylpyridine-2,4-diol and citral, has been used for Cu-catalyzed N-arylation with a range of arylboric acids to obtain arylated pyranopyridine core structure derivatives (yield up to 77 %). Among them, compound 3 h exhibited a much better inhibitory effect on HepG2 liver cancer cells compared to citral, and the IC value was 5.3 μM following exposure with the newly synthesized derivatives (herein named 3 h for short in this paper), which was lower than that of the cisplatin (6.

Research Progress on Applying Intelligent Sensors in Sports Science.

Smart sensors represent a significant advancement in modern sports science, and their effective use enhances the ability to monitor and analyze athlete performance in real time. The integration of these sensors has enhanced the accuracy of data collection related to physical activity, biomechanics, and physiological responses, thus providing valuable insights for performance optimization, injury prevention, and rehabilitation. This paper provides an overview of the research progress in the application of smart sensors in the field of sports science; highlights the current advances, challenges, and future directions in the deployment of smart sensor technologies; and anticipates their transformative impact on sports science and athlete development.

A burden-sharing model shaping the embodied carbon emission and considering regions' efforts to reduce emissions in China's power sector.

To achieve "carbon peaking and carbon neutrality", reasonable burden-sharing for emission reductions among key players is critical. And reasonable burden-sharing requires scientific clarification of their actual emissions and responsibilities, and full accounting of efforts to reduce emissions. Therefore, this paper focuses on China's power industry and proposes a burden-sharing model that reflects regions' embodied carbon emissions and mitigation efforts.

Open-window MSR Design with Active Magnetic Compensation Coil based on COMSOL Multiphysics.

Magnetic shielding room (MSR) is one of the necessary equipment for measuring magnetocardiography (MCG) and magnetoencephalography (MEG). The traditional closed MSR only focuses on the indicators of the shielded magnetic field, and ignores the patient's feelings within the MSR. In this paper, an open-window MSR is proposed to solve the problem that patients have difficulty in communicating with the outside of closed MSR and have closed fear.

A New Genus Gen. Nov and Description of Sp. Nov. (Phyllotopsidaceae, Agaricales) from Northwestern China Based on Phylogeny, Morphology, and Divergence Time.

While investigating macrofungi diversity in Gansu province, northwestern China, five fresh and fleshy specimens were collected, which are characterized by nearly white to buff hemispherical pileus with waved margins, a disc depressed with coral to brownish red fibrillose scales, adnate to sub-decurrent lamellae with four relatively regular rows of lamellulae, a stipe that is central, hollow, frequently straight to curved; basidiospores that are globose to subglobose, 5.0-6.0 × (3.

Effects of Gene Knockdown in SKM-1 Cells on Apoptosis, Erythroid Differentiation and Inflammations.

Protein tyrosine phosphatase non-receptor type 6 ( is a cytoplasmic phosphatase that acts as a key regulatory protein in cell signaling to control inflammation and cell death. In order to investigate the role of in hematologic tumor myelodysplastic syndrome (MDS), this study infected SKM-1 cell line (MDS cell line) with packaged H_-shRNA lentivirus to obtain H_-shRNA SKM-1 stable strain. The effect of knockdown on apoptosis, erythroid differentiation, and inflammations in SKM-1 cell line was examined.

Lignin as a bioderived modular surfactant and intercalant for TiCT MXene stabilization and tunable functions.

Controlled tailoring of atomically thin MXene interlayer spacings by surfactant/intercalants (e.g., polymers, ligands, small molecules) is important to maximize their potential for application.

Melatonin improves cadmium tolerance in Salix viminalis by enhancing amino acid and saccharide metabolism, and increasing polyphenols.

As a short-rotation woody plant, Salix viminalis has the potential for phytoremediation of cadmium (Cd), but it has poor tolerance to high Cd concentrations. Melatonin (MEL), a candidate bio-promoter, was considered to play an active role in plant responses to Cd. However, the molecular mechanism by which MEL regulates metabolic processes in plants to defend against Cd stress remain unclear.

An emergency operation strategy and motion planning method for autonomous vehicle in emergency scenarios.

Ensuring driving operational safety in emergency scenarios is paramount for autonomous vehicles to prevent accidents, particularly when vehicle motion completely depends on autonomous systems. Numerous factors must be evaluated when designing emergency collision avoidance strategies for critical situations, such as trajectory feasibility, vehicle motion stability, and driver comfort. Therefore, this study proposes a framework for emergency operation that uses collision-free area calculations to inform maneuver decisions and facilitate collision avoidance trajectory planning, preventing vehicle collisions.

Prognostic effectiveness of interactive vs. non-interactive mobile app interventions in type 2 diabetes: a systematic review and meta-analysis.

Background: Mobile app interventions are emerging as significant tools in managing the prognosis of type 2 diabetes, demonstrating progressively greater impacts. The effectiveness of these interventions needs further evidence-based support.

Objective: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the effectiveness of mobile app interventions in improving prognosis for patients with type 2 diabetes.

Integrative pharmacological analysis of modified Zuojin formula: Inhibiting the HIF-1α-mediated glycolytic pathway in chronic atrophic gastritis.

Ethnopharmacological Relevance: Zuojin formula (ZJF) is a well-known herbal medicine in Pharmacopoeia of China, which is widely used for gastritis. Modified Zuojin formula (MZJF) was adapted based on traditional Chinese medicine (TCM) theories concerning gastric atrophy and dysplasia, along with extensive clinical experience, has been clinically employed to treat chronic atrophic gastritis (CAG). However, the underlying mechanisms by which MZJF intervenes in CAG remain to be fully elucidated.

Protoplast transient transformation facilitates subcellular localization and functional analysis of walnut proteins.

Walnut (Juglans regia), an important contributor to oil production among woody plants, encounters research constraints due to difficulties in the subcellular localization and functional analysis of its proteins. These limitations arise from the protracted fruiting cycle and the absence of a reliable transient gene transformation system and organelle markers. In this study, we established a transient expression system using walnut protoplasts and generated fluorescent-tagged organelle markers, whose localization was validated against Arabidopsis (Arabidopsis thaliana) organelle markers.

Organophosphorus flame retardants in infant's diets from Beijing, China: Detection and risk assessment.

As a group of widely used flame retardants, organophosphate esters (OPEs) and their metabolites, organophosphate diesters (di-OPEs), have been widely detected in various environmental media and human samples. However, the information on dietary exposure to OPEs for lactating infants is still limited. Here, 38 OPEs and 10 di-OPEs were monitored in 110 infant formula samples and 122 breast milk samples collected in Beijing, China.