Network pharmacology: a crucial approach in traditional Chinese medicine research.

Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research. Network pharmacology enables researchers to construct multilayered networks that systematically elucidate TCM's multi-component, multi-target mechanisms of action. This review summarizes key databases commonly used in network pharmacology, including those focused on herbs, components, diseases, and dedicated platforms for network pharmacology analysis.

Digital recombinase polymerase amplification chip based on asymmetric contact angle composite interface.

Background: Digital recombinase polymerase amplification (dRPA) is an effective tool for the absolute quantification of nucleic acids and the detection of rare mutations. Due to the high viscosity or other physical properties of the reagent, this can compromise the accuracy and reproducibility of detection results, which limits the broader adoption and practical application of this technology. In this study, we developed an asymmetric contact angle digital isothermal detection (ACA-DID) chip and optimized the ACA-DID chip structure to achieve rapid digital recombinase polymerase amplification.

Cyclopamine inhibits corneal neovascularization and fibrosis by alleviating inflammatory macrophage recruitment and endothelial cell activation.

Purpose: To explore the function of cyclopamine in corneal neovascularization and subsequent fibrosis after cornea alkali-burn injury.

Methods: In vivo, mice cornea were injured by NaOH, and then treated with cyclopamine, clodronate liposomes (CLO-LPS), and vehicle of cyclopamine separately by subconjunctival injections. Clinical features were observed and pathological characteristics were examined.

Electrocatalytic methane conversion via in-situ generated superoxide radicals in an aprotic ionic liquid.

The electrochemical activation and partial oxidation of methane are highly attractive to enable the direct conversion in a sustainable and decentralized way. Herein, we report an electrochemical system in a non-diaphragm electrochemical bath to convert CH to CHOH and CHCHOH at room temperature, in which VO·HO as the anodic catalyst to activate CH and an aprotic ionic liquid [BMIM]BF as supporting electrolyte to control superoxide radicals (O) as the main active oxygen species generated on cathode. As a result, methanol and ethanol were identified as the liquid products, and the superior methanol Faraday efficiency (FE) of 32.

Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis.

Background: Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method.

Methods: We obtained data from genome-wide association studies (GWASs) in European individuals for IBD and its main subtypes, Crohn's disease (CD) and ulcerative colitis (UC) (31,665 IBD cases, 13,768 UC cases, 17,897 CD cases and 33,977 controls).

Generation of a PDK-1 knockout human embryonic stem cell line by CRISPR/(WAe009-A-2K) Cas9 editing.

Pyruvate Dehydrogenase Kinase1 (PDK1) belongs to the family of kinases, regulates diverse metabolic processes. PDK1 is a susceptibility locus for heart failure via thinning of ventricle walls, and enlarged atria and ventricles. We successfully developed a PDK1 knockout (PDK1/) human embryonic stem cell (hESC) line using an episomal vector-based CRISPR/Cas9 system explore the role of PDK in human heart development.

Review of Short-Wavelength Infrared Flip-Chip Bump Bonding Process Technology.

Short-wave infrared (SWIR) imaging has a wide range of applications in civil and military fields. Over the past two decades, significant efforts have been devoted to developing high-resolution, high-sensitivity, and cost-effective SWIR sensors covering the spectral range from 0.9 μm to 3 μm.

FITA-Containing 2,4-Dinitrophenyl Alkylthioether-Based Probe for Detection and Imaging of GSH.

Glutathione (GSH) plays a crucial role in various physiological processes and its imbalances are closely related to various pathological conditions. Probes for detection and imaging of GSH are not only useful for understanding GSH chemical biology but are also important for exploring potential theranostic agents. Herein, we report a fast intramolecular thiol-activated arylselenoamides ()-based fluorescent probe using 2,4-dinitrophenyl alkylthioether as a sulfydryl-selective receptor for the first time.

Mechanical Properties and Microstructure of Geopolymer-Based PFSS Synthesized from Excavated Loess.

Pre-mixed fluidized solidified soil (PFSS) has the advantages of pumpability, convenient construction, and a short setting time. This paper took the excavated loess in Fuzhou as the research object and used cement-fly-ash-ground granulated blast furnace slag-carbide slag as a composite geopolymer system (CFGC) to synthesize PFSS. This study investigated the fluidity and mechanical strength of PFSS under different water-solid ratios and curing agent dosages; finally, the microstructure of the composite geopolymer system-pre-mixed fluidized solidified soil (CFGC-PFSS) was characterized.

Study on the Aging Effects of Relative Humidity on the Primary Chemical Components of Palm Leaf Manuscripts.

Palm Leaf Manuscripts represent a significant component of the world's cultural heritage. Investigating their primary chemical components and understanding the transformations these materials undergo under environmental influences are crucial for elucidating their material characteristics and aging mechanisms and developing effective strategies for preventive conservation. This study utilized infrared absorption spectroscopy and X-ray diffraction analysis to examine changes in the primary chemical components of Palm Leaf Manuscripts under varying relative humidity conditions over extended periods.

Analysis of the risk factors of delayed extubation after surgery for Ebstein's anomaly.

Objective: In this study, we aimed to screen the risk factors for delayed extubation after surgery for Ebstein's anomaly (EA), determine the diagnostic cut-off values, and develop a prediction equation to accurately encourage rapid recovery after surgery.

Methods: The perioperative data of 76 pediatric patients undergoing EA surgery in the Surgical Department of the Pediatric Heart Center of Anzhen Hospital from September 2013 to September 2021 were retrospectively analyzed.

Results: Among these cases, 37 (48.

Development and validation of a risk prediction model for acute kidney injury in coronary artery disease.

Background: Acute Kidney Injury (AKI) is a sudden and often reversible condition characterized by rapid kidney function reduction, posing significant risks to coronary artery disease (CAD) patients. This study focuses on developing accurate predictive models to improve the early detection and prognosis of AKI in CAD patients.

Methods: We used Electronic Health Records (EHRs) from a nationwide CAD registry including 54 429 patients.

Spatial distribution, sediment‒water partitioning, risk assessment and source apportionment of heavy metals in the Golmud River-Dabson Salt Lake ecosystem.

The occurrence of heavy metals is important for understanding their behavior in the sediments of river-salt lake ecosystems due to dramatically changes in salinity and flow velocity at the confluence area. Sediments and surface water samples were collected from the Golmud River-Dabson Salt Lake ecosystem, northwest China, to investigate the spatial distribution, sediment-water partitioning, risk assessment and source apportionment of heavy metals. Higher concentrations of heavy metals were observed in surface water from Dabson Salt Lake than in other regions.

Magnetic molecularly imprinted polymers coupled with UPLC-MS/MS for simultaneous detection of 19 steroid hormones in human plasma.

Steroid hormones constitute a group of hormones with molecular weights ranging from 200 to 400 daltons, characterized by their highly similar chemical structures. Each hormone within this group holds significant value for the diagnosis of various diseases. Accurate clinical measurement of the levels of each hormone is crucial for the diagnosis in clinical settings.

Activity determination of Lu using TDCR-Čerenkov method.

The accuracy of measuring the activity of Lu is crucial for calibrating the instruments employed in clinical applications. To support the measurements of Lu solution, the existing TDCR-Čerenkov method has been extended for this nuclide. The contribution of β and γ transitions from Lu was taken into account in the extended method.

Ubiquitination of TFEB increased intestinal permeability to aggravate metabolic dysfunction-associated steatohepatitis.

Background And Aims: Increased intestinal permeability exacerbates the development of metabolic dysfunction associated steatohepatitis (MASH), but the underlying mechanisms remain unclear. Autophagy is important for maintaining normal intestinal permeability. Here, we investigated the impact of intestinal transcription factor EB (TFEB), a key regulator of autophagy, in intestinal permeability and MASH progression.

MOF-derived Carbon-Based Materials for Energy-Related Applications.

New carbon-based materials (CMs) are recommended as attractively active materials due to their diverse nanostructures and unique electron transport pathways, demonstrating great potential for highly efficient energy storage applications, electrocatalysis, and beyond. Among these newly reported CMs, metal-organic framework (MOF)-derived CMs have achieved impressive development momentum based on their high specific surface areas, tunable porosity, and flexible structural-functional integration. However, obstacles regarding the integrity of porous structures, the complexity of preparation processes, and the precise control of active components hinder the regulation of precise interface engineering in CMs.

Unraveling the Synergistic Neuroprotective Mechanism of Natural Drug Candidates Targeting TRPV1 and TRPM8 on an Ischemic Stroke.

The development of multitargeted drugs is urgent for ischemic stroke. TRPV1 and TRPM8 are important targets of ischemic stroke. Previous drug candidate screening has identified that muscone, l-borneol, and ferulic acid may target TRPV1 and TRPM8 for ischemic stroke.

Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association.

Identifying dependable prognostic indicators is essential for the efficient management of metabolic dysfunction-associated steatotic liver disease (MASLD). The index of hemoglobin glycation (HGI) has been demonstrated to be closely linked to the onset and advancement of MASLD. Currently, no studies have investigated the relationship between HGI and mortality rates among MASLD patients.

Development of deep-underground engineering structures via 2D and 3D RQD prediction using non-invasive CSAMT.

The stability criterion based on the characterization of rock masses can be used to advance deep underground engineering projects. A key geomechanical criterion in geotechnical engineering is rock quality designation (RQD), which assesses risk for engineering design success criteria. Time, cost, and credibility constraints make it difficult to accurately estimate RQD.

Spatiotemporal distribution of global peatland area during the Holocene.

Peatlands are a key component of terrestrial ecosystems, and their development has an important impact on global carbon cycle and climate change. However, the long-term evolution of global peatlands remains uncertain, particularly their spatial distribution. We compiled 4700 basal peatland data during Holocene, and 669 pollen data of Sphagnum with basal and end ages, to allow a more robust reconstruction of the spatial distribution of peatlands.

Rapid and dual-mode nitrite detection with improved sensitivity by nanointerface-regulated ultrafast Griess assay.

Background: The rapid and sensitive detection of nitrite is important to human health protection due to its carcinogenic and teratogenic risks with excessive intake. The Griess assay is widely applied for the design of nitrite detection system. However, its relatively slow reaction kinetics and sole colorimetry mode might limit it's the sensitivity and practical application.

Temperature-Controlled Gas Hydrate Nucleation in the Heterogeneous Environment.

Nucleation of multicomponent systems is a pervasive phenomenon in nature and is pertinent to a diverse array of scientific and industrial challenges. The nucleation mechanisms of immiscible multicomponent systems remain unclear. Here, gas hydrate is employed as a model system to study the nucleation of multicomponent systems.

Mastering the Copolymerization Behavior of Ethyl Cyanoacrylate as Gel Polymer Electrolyte for Lithium-metal Battery Application.

Polymers with strong electron-withdrawing groups (e.g., cyano-containing polymers) are attractive for a wide range of applications due to their high dielectric constant and outstanding electrochemical stability.