A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma.

Background: Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). This study aimed to develop a robust predictive model, FLIPI-C, using a machine learning approach to identify FL patients at high risk of POD24.

Methods: A cohort of 1,938 FL patients (FL1-3a) from seventeen centers nationwide in China was randomly divided into training and internal validation sets (2:1 ratio).

Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells.

Background: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is a common, yet highly efficient, cellular immunotherapy for lymphoma. However, many recent studies have reported on its cardiovascular (CV) toxicity. This study analyzes the cardiotoxicity of CD19 CAR T cell therapy in the treatment of lymphoma for providing a more valuable reference for clinicians.

CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD/NADH ratio.

Background: Glioblastoma multiforme (GBM) exhibits a cellular hierarchy with a subpopulation of stem-like cells known as glioblastoma stem cells (GSCs) that drive tumor growth and contribute to treatment resistance. NAD(H) emerges as a crucial factor influencing GSC maintenance through its involvement in diverse biological processes, including mitochondrial fitness and DNA damage repair. However, how GSCs leverage metabolic adaptation to obtain survival advantage remains elusive.

Identification of a pathogenic SDHD mutation in a Chinese family with hereditary head and neck paraganglioma: implications for genetic counseling and management.

Background: This study aims to identify a pathogenic SDHD mutation associated with hereditary head and neck paraganglioma (HNPGL) in a Chinese family and to explore its implications for genetic counseling.

Methods: The study involved a family with 15 members spanning three generations. A 31-year-old patient (II-4) was diagnosed with a left parotid gland tumor and a right carotid body tumor, while both the father and elder sister had right carotid body tumors, and the third sister had bilateral carotid body tumors.

The mediating role of aging attitudes between social isolation and self-neglect: a cross-sectional study of older adults living alone in rural China.

Background: Self-neglect is a significant global public health issue, compromising the health, safety, and well-being of older adults. Despite extensive research on the prevalence and risk factors of self-neglect, the underlying psychosocial mechanisms remain underexplored. Social isolation and aging attitudes have been identified as important correlates of self-neglect; however, the precise interplay between these variables, particularly the mediating role of aging attitudes, has yet to be fully examined in the context of rural older adults.

Myelitis associated with glial fibrillary acidic protein IgG: characterization and comparison with aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG myelitis.

Background: Awareness of the characteristics of glial fibrillary acidic protein autoantibody (GFAP-IgG) associated myelitis facilitates early diagnosis and treatment. We explored features in GFAP-IgG myelitis and compared them with those in myelitis associated with aquaporin-4 IgG (AQP4-IgG) and myelin oligodendrocyte glycoprotein IgG (MOG-IgG).

Methods: We retrospectively reviewed data from patients with GFAP-IgG myelitis at the First Affiliated Hospital of Zhengzhou University and Henan Children's Hospital from May 2018 to May 2023.

Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers.

Background: To analyze the demographic characteristics of retinopathy of prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates to the ROP guideline.

Methods: A multicenter, retrospective-cohort study was conducted. The study included infants born between January 1, 2018, and July 31, 2023, who underwent ROP screening and were diagnosed with ROP at seven screening centers in China.

Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer.

Background: Pancreatic cancer is a highly aggressive neoplasm characterized by poor diagnosis. Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulators of cellular metabolism. Understanding the interplay between pancreatic cancer and amino acid metabolism offers potential avenues for improving patient clinical outcomes.

Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects.

Purpose Of Review: Review the latest data regarding the intersection of adipose tissue (AT) and iron to meet the needs of AT metabolism and the progression of related diseases.

Recent Findings: Iron is involved in fundamental biological metabolic processes and is precisely fine-tuned within the body to maintain cellular, tissue and even systemic iron homeostasis. AT not only serves as an energy storage depot but also represents the largest endocrine organ in the human body, maintaining systemic metabolic homeostasis.

Integrated Mendelian Randomization and Single-Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in Epilepsy.

Background: Epilepsy has a genetic predisposition, yet causal factors and the dynamics of the immune environment in epilepsy are not fully understood.

Methods: We analyzed peripheral blood samples from epilepsy patients, identifying key genes associated with epilepsy risk through Mendelian randomization, using eQTLGen and genome-wide association studies. The peripheral immune environment's composition in epilepsy was explored using CIBERSORT.

The prognostic impact of 1q21 gain/amplification in newly diagnosed multiple myeloma: a retrospective study based on a single center in China.

1q21gain/amp is the most common in patients with multiple myeloma. However, there is limited research on the prognostic heterogeneity of 1q21+, and the prognostic of the 1q21 copy remains controversial. In this study, we primarily conducted a retrospective analysis of the prognostic significance of 1q21 gain/amp in 375 newly diagnosed multiple myeloma patients.

Decoupled peak property learning for efficient and interpretable electronic circular dichroism spectrum prediction.

Electronic circular dichroism (ECD) spectra contain key information about molecular chirality by discriminating the absolute configurations of chiral molecules, which is crucial in asymmetric organic synthesis and the drug industry. However, existing predictive approaches lack the consideration of ECD spectra owing to the data scarcity and the limited interpretability to achieve trustworthy prediction. Here we establish a large-scale dataset for chiral molecular ECD spectra and propose ECDFormer for accurate and interpretable ECD spectrum prediction.

Faces of different socio-cultural identities impact emotional meaning learning for L2 words.

This study investigated how exposure to Caucasian and Chinese faces influences native Mandarin-Chinese speakers' learning of emotional meanings for English L2 words. Participants were presented with English pseudowords repeatedly paired with either Caucasian faces or Chinese faces showing emotions of disgust, sadness, or neutrality as a control baseline. Participants' learning was evaluated through both within-modality (i.

Downscaling of ERA5 reanalysis land surface temperature based on attention mechanism and Google Earth Engine.

Land Surface Temperature (LST) is widely recognized as a sensitive indicator of climate change, and it plays a significant role in ecological research. The ERA5-Land LST dataset, developed and managed by the European Centre for Medium-Range Weather Forecasts (ECMWF), is extensively used for global or regional LST studies. However, its fine-scale application is limited by its low spatial resolution.

Unconventional hexagonal open Prussian blue analog structures.

Prussian blue analogs (PBAs), as a classical kind of microporous materials, have attracted substantial interests considering their well-defined framework structures, unique physicochemical properties and low cost. However, PBAs typically adopt cubic structure that features small pore size and low specific surface area, which greatly limits their practical applications in various fields ranging from gas adsorption/separation to energy conversion/storage and biomedical treatments. Here we report the facile and general synthesis of unconventional hexagonal open PBA structures.

Lignin alkali regulated interfacial polymerization towards ultra-selective and highly permeable nanofiltration membrane.

Thin-film composite polyamide (TFC PA) membranes hold promise for energy-efficient liquid separation, but achieving high permeance and precise separation membrane via a facile approach that is compatible with present manufacturing line remains a great challenge. Herein, we demonstrate the use of lignin alkali (LA) derived from waste of paper pulp as an aqueous phase additive to regulate interfacial polymerization (IP) process for achieving high performance nanofiltration (NF) membrane. Various characterizations and molecular dynamics simulations revealed that LA can promote the diffusion and partition of aqueous phase monomer piperazine (PIP) molecules into organic phase and their uniform dispersion on substrate, accelerating the IP reaction and promoting greater interfacial instabilities, thus endowing formation of TFC NF membrane with an ultrathin, highly cross-linked, and crumpled PA layer.

Skillful seasonal predictions of continental East-Asian summer rainfall by integrating its spatio-temporal evolution.

Skillful seasonal climate prediction is critical for food and water security over the world's heavily populated regions, such as in continental East Asia. Current models, however, face significant difficulties in predicting the summer mean rainfall anomaly over continental East Asia, and forecasting rainfall spatiotemporal evolution presents an even greater challenge. Here, we benefit from integrating the spatiotemporal evolution of rainfall to identify the most crucial patterns intrinsic to continental East-Asian rainfall anomalies.

Mechanistic evaluation of enhanced graphene toxicity to Bacillus induced by humic acid adsorption.

The extensive application of graphene nanosheets (GNSs) has raised concerns over risks to sensitive species in the aquatic environment. The humic acid (HA) corona is traditionally considered to reduce GNSs toxicity. Here, we evaluate the effect of sorbed HA (GNSs-HA) on the toxicity of GNSs to Gram positive Bacillus tropicus.

Analysis of the Clinical Characteristics and Ultrasonographic Features in 141 Cases of Cystic Neutrophilic Granulomatous Mastitis.

Rationale And Objectives: To summarize the clinical features and ultrasonic characteristics of patients with cystic neutrophilic granulomatous mastitis (CNGM), and to enhance the understanding of CNGM in clinical practice.

Materials And Methods: This study retrospectively analyzed the demographic data, clinical symptoms, and ultrasonic characteristics of 141 patients diagnosed with CNGM through pathological examination. This study was approved by the Medical Ethical Committee of Beijing Hospital of Traditional Chinese Medicine (2023BL02-054-01).

Cognitive impairments in chronic pain: a brain aging framework.

Chronic pain (CP) not only causes physical discomfort but also significantly affects cognition. This review first summarizes emerging findings that reveal complex associations between CP and cognitive impairments, and then presents neuroimaging evidence showing aging-related brain alterations in CP and proposes a framework where accelerated brain aging links CP to cognitive impairments. This framework explains how CP-related multi-level factors, which either contribute to the onset of CP or arise as a result of CP, influence brain aging in linear and nonlinear ways, leading to cognitive impairments and increased dementia risk.

Experimental investigation and finite element analysis on the durability of root-filled teeth treated with multisonic irrigation.

Objective: This study compared the fracture load, stress distribution, and survival probability under cyclic loading of extensively restored teeth treated with multisonic irrigation with those treated with conventional instrumentation, with or without a post.

Methods: Mesial-occlusal-distal cavities were prepared in 30 human mandibular premolars. The teeth were randomly divided into 3 groups of 10 based on the endodontic and restorative procedures: (1) Root canal treatment (RCT) followed by resin composite restoration (control group), (2) RCT followed by a glass fiber post restoration (conventional group), and (3) minimal instrumentation plus multisonic irrigation followed by resin composite restoration (GW group).

Predictive value of cough peak flow for successful extubation in mechanically ventilated patients after craniotomy: a single-centre prospective diagnostic study.

Objectives: The purpose of this study was to evaluate the predictive value of the cough peak flow (CPF) for successful extubation in postcraniotomy critically ill patients.

Design: This was a single-centre prospective diagnostic study.

Setting: The study was conducted in three intensive care units (ICUs) of a teaching hospital.

Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study.

Background: Chronic respiratory diseases (CRDs) have been shown to be associated with frailty, but these findings have not yet reached a consensus. The aim of this study was to investigate the association between CRDs and frailty in the elderly using a nationally representative data from China.

Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) were analysed, including 3309 frailty-free participants followed for three waves from 2011.

The 2-aminoadipic acid (2-AAA) regulates Grass carp ULK2 to inhibit GCRV replication.

Grass carp is an important commercial fish in China that is plagued by various diseases, especially the hemorrhagic disease induced by grass carp reovirus (GCRV). Autophagy, a highly conserved biological process among eukaryotes, is pivotal in maintaining cellular homeostasis and managing various stressors, including viral infections. Uncoordinated (Unc) 51-like kinase 2 (ULK2) is considered an initiator of the autophagic process.

The time-stamped effects of screen exposure on food intake in adults: A meta-analysis of experimental studies.

Objective: The purpose of this study was to examine time-stamped impacts of screen exposure on food intake among healthy adults.

Methods: Four electronic databases were searched up to August 31, 2024, including ProQuest, PubMed, Web of Science and Embase. A meta-analysis of inverse variance was used to calculate the standardized mean difference (SMD) in food intake between watching and not watching screen groups, and groups with different screen contents (e.