The relationship between tumor budding and survival of patients with breast cancer: A meta-analysis.

Tumor budding has been proposed as a potential prognostic marker in various cancers, but its association with survival outcomes in breast cancer (BC) remains unclear. This meta-analysis aimed to clarify the relationship between tumor budding and survival outcomes in patients with BC. A comprehensive literature search was conducted in PubMed, EMBASE, and Web of Science.

Schisandrol A Alleviates Allergic Asthma in Mice via Regulating the NF-κB/IκBα and Nrf2/HO-1 Signaling Pathways.

(Turcz) Baill () is the key traditional Chinese medicine for the treatment of asthma used by ancient and modern medical practitioners. However, the material basis and the main mechanism of its antiasthmatic effect remain unclear. Our preliminary results showed that schisandrol A (SCA), a representative monomer of lignans, had the best relaxation effect on tracheal rings in isolated rats.

Zinc finger domain of p62/SQSTM1 is involved in the necroptosis of human cisplatin‑resistant ovarian cancer cells treated with sulfasalazine.

Cisplatin resistance in ovarian cancer cells is mainly apoptosis resistant. Although other types of programmed cell death are highly involved in chemoresistance, which type can overcome cisplatin resistance remains unclear. The present study observed that cisplatin-sensitive SKOV3 cells and cisplatin-resistant SKOV3/DDP cells had different levels of sensitivity to sulfasalazine (SAS).

Anthocyanin modified by chondroitin sulphate and tannic acid improved the quality-indicating properties of gelatin-based intelligent film.

A highly pH-responsive gelatin film incorporating purple cabbage anthocyanin (PCA) and chondroitin sulphate (CS)/tannic acid (TA) was developed. Co-pigmentation of PCA via CS/TA improved its photothermal stability and visibility of color change in gelatin film. The morphological and structural properties of CS-PCA and TA-PCA films revealed that a more stable network was formed as new hydrogen bonds were generated by the co-pigmentation.

Straw Tar Epoxy Resin for Carbon Fiber-Reinforced Plastic: A Review.

The massive consumption of fossil fuels has led to the serious accumulation of carbon dioxide gas in the atmosphere and global warming. Bioconversion technologies that utilize biomass resources to produce chemical products are becoming widely accepted and highly recognized. The world is heavily dependent on petroleum-based products, which may raise serious concerns about future environmental security.

The Fungal Transcription Factor BcTbs1 from Promotes Pathogenicity via Host Cellulose Degradation.

Zn(II)2Cys6 proteins constitute the largest group of fungal-specific transcription factors. However, little is known about their functions in the crop killer . In this work, a T-DNA insertion strain M13448 was identified which was inserted into the Zn(II)2Cys6 TF-encoding gene .

Chlorbenzuron downregulated HcLCP-17 expression by depressing two 20E-responsive transcription factors Br-C and βFTZ-F1 in Hyphantria cunea (Lepidoptera: Erebidae) larvae.

Background: Cuticular proteins (CPs) play essential roles in forming cuticular structures in insects. However, the specific functions and regulatory mechanisms of CPs remain largely unexplored. In this study, the Larval cuticular protein 17 (HcLCP-17) gene was identified from Hyphantria cunea, a highly destructive and polyphagous forest pest.

Fragmentation Characteristics of Bubbles in a Throttling Hole Pipe.

To enhance the performance of tubular microbubble generators, the Volume of Fluid (VOF) multiphase flow model in COMSOL Multiphysics was used to simulate the bubble fragmentation characteristics within a throttling hole microbubble generator. The effects of the inlet speed of the throttling hole pipe, the diameter of the throttling hole, and the length of the expansion section on bubble fragmentation performance were analyzed. The results indicated that an increase in the inlet speed of the throttling hole pipe gradually improved the bubble fragmentation performance.

Acyl-CoA thioesterase 13 () attenuates the progression of autosomal dominant polycystic kidney disease via triggering mitochondrial-related cell apoptosis.

Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common cause of end-stage kidney disease. It has been shown that Acyl-CoA thioesterase 13 () level was reduced in renal cystic tissues from ADPKD patients. However, the role of in ADPKD remains largely elusive.

polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.

Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between intestine and liver plays an important role in ALI, and natural polysaccharides can participate in the regulation of ALI by regulating the composition of intestinal flora. In this study, polysaccharide was used as the research object, and ICR mice were used to construct an acute liver injury model induced by carbon tetrachloride (CCl).

Multi-active photocatalysts of biochar-doped g-CN incorporated with polyoxometalates for the high-efficient degradation of sulfamethoxazole.

Sulfamethoxazole (SMX) is one of major antibiotic contaminants in current aqueous environment. In this paper, waste loofah and melamine were co-carbonized to prepare biochar-doped g-CN (CCN) by a one-pot method and then combined with CoPMoVO (CoPMoV) using a binder to obtain the novel polyoxometalates (POMs) photocatalytic composites (CCN/CoPMoV). The incorporation of CoPMoV dramatically reduced the photogenerated carrier recombination and led to a small band gap.

Carbon-metal metal-metal synergistic mechanism of ethylene electro-oxidation electrolysis of water on TMN sites in graphene.

Acetaldehyde (AA) and ethylene oxide (EO) are important fine chemicals, and are also substrates with wide applications for high-value chemical products. Direct electrocatalytic oxidation of ethylene to AA and EO can avoid the untoward effects from harmful byproducts and high energy emissions. The most central intermediate state is the co-adsorption and coupling of ethylene and active oxygen intermediates (*O) at the active site(s), which is restricted by two factors: the stability of the *O intermediate generated during the electrolysis of water on the active site at a certain applied potential and pH range; and the lower kinetic energy barriers of the oxidation process based on the thermo-migration barrier from the *O intermediate to produce AA/EO.

Engineered P2Y-Overexpressing Cell-Membrane-Wrapped Nanoparticles for the Functional Reversal of Ticagrelor and Clopidogrel.

Antiplatelet agents, particularly P2Y receptor inhibitors, are critical medicines in the prevention and treatment of thrombotic diseases in the clinic. However, their long-term use introduces a significant risk of bleeding in patients with cardiovascular diseases. Whether the bleeding is caused by the drug itself or due to surgical procedures or trauma, the need to rapidly reverse the effects of antiplatelet agents in the circulation is essential; however, no such agents are currently available.

Novel Zn(II)Cys Transcription Factor BcFtg1 Enhances the Virulence of the Gray Mold Fungus by Promoting Organic Acid Secretion and Carbon Source Utilization.

The Zn(II)Cys zinc cluster protein family comprises a subclass of zinc-finger proteins that serve as transcriptional regulators involved in a diverse array of fugal biological processes. However, the roles and mechanisms of the Zn(II)Cys transcription factors in mediating , a necrotrophic fungus that causes gray mold in over 1000 plant species, development and virulence remain obscure. Here, we demonstrate that a novel pathogenicity-associated factor (ungal ranscription factor containing the AL4 domain), identified from a virulence-attenuated mutant M20162 from a T-DNA insertion mutant library, plays an important role in oxalic acid (OA) secretion, carbon source absorption and cell wall integrity.

Myocardium-targeted liposomal delivery of the antioxidant peptide 8P against doxorubicin-induced myocardial injury.

Doxorubicin (Dox) is a broad-spectrum antineoplastic chemotherapeutic agent used in clinical settings, yet it exhibits significant cardiotoxicity, which in severe cases can lead to heart failure. Research indicates that oxidative stress plays a pivotal role in Dox -induced cardiomyocyte injury. Therefore, the application of antioxidants represents an effective strategy to mitigate the cardiotoxic effects of doxorubicin.

Application and evaluation of the hybrid "Problem-Based Learning" model based on "Rain Classroom" in experimental courses of medical molecular biology.

Background: With the advancement of society, the cultivation of medical professionals equipped with solid theoretical knowledge, a strong sense of innovation, and critical thinking has become a crucial goal in the reform of medical higher education. Over recent years, the hybrid Problem-Based Learning (hPBL) model, a blend of Problem-Based Learning (PBL) and Lecture-Based Learning (LBL), has emerged as a novel approach in the medical education reform landscape of China. The application and efficacy of the hPBL model in medical experimental courses have piqued the interest of medical educators.

Expression and immune infiltration studies of IL-33-ST2-NF-κB signaling pathway in prostate cancer.

Background: To analyze the expression of interleukin-33 (IL-33), growth-stimulated expression gene 2 (ST2), nuclear factor-kappaB (NF-κB) and immune cell infiltration in prostate cancer, this study aims to provide an experimental basis for the clinical prevention and treatment of prostate cancer.

Methods: The expression of IL-33 in PCa tissues was analyzed using TCGA, TIMER and HPA databases. Using the UALCAN database, the systematic exploration of the relationship between IL-33 and various clinicopathological parameters was conducted.

Specnuezhenide ameliorates hepatic fibrosis via regulating SIRT6-Mediated inflammatory signaling cascades.

Ethnopharmacological Relevance: Ligustrum lucidum W.T. Aiton is a traditional Chinese medicine that has long been used with high hepatoprotective therapeutic and condition value.

Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease.

Neurodegenerative diseases are the main causes of death and morbidity among elderly people worldwide. From the pathological point of view, oxidative stress, neuroinflammation, mitochondrial damage and apoptosis are the causes of neuronal diseases, and play a harmful role in the process of neuronal cell death and neurodegeneration. The most common neurodegenerative diseases are Alzheimer's disease(AD) and Parkinson's disease(PD), and there is no effective treatment.

Understanding the factors of wearable devices among the patients with thyroid cancer: A modified UTAUT2 model.

Wearable devices hold promising prospects on a global scale, including in China. Thyroid cancer prevalence is notably high in China.This purpose of this researchwas to provide an updated theoretical model for assessing Chinese thyroid cancer patients' intentions towards wearable devices, based on the UTAUT2 framework, and to ascertain the factors that have an impact on these intents.