Hormonal interventions in skin wounds - a mini review.

The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried out by coordinated actions of various cells, cytokines, and hormones. Incoordination of these steps may impede complete and efficient reconstruction and functional recovery of wounds or even lead to worsened outcomes.

Silencing the lncRNA EBLN3P Improves Prognosis in Patients with Invasive Breast Cancer by Directly Targeting miR-144-3p.

The incidence of breast cancer, a malignant tumor that causes more harm to women, is increasing year by year, affecting women at a younger age. This paper describes the possible practical significance of lncRNA EBLN3P (EBLN3P) in predicting the prognosis of invasive breast cancer. EBLN3P and miR-144-3p levels in tissues and cells were detected by real-time quantitative PCR (RT-qPCR).

Upcycling Waste Polyethylene Terephthalate to Produce Nitrogen-Doped Porous Carbon for Enhanced Capacitive Deionization.

Porous carbon with a high surface area and controllable pore size is needed for energy storage. It is still a significant challenge to produce porous carbon in an economical way. Nitrogen-doped porous carbon (N-PC) was prepared through carbonization of a mixture of waste PET-derived metal-organic frameworks (MOFs) and ammonium.

MUF-n-Octadecane Phase-Change Microcapsules: Effects of Core pH and Core-Wall Ratio on Morphology and Thermal Properties of Microcapsules.

Phase change energy storage microcapsules were synthesized in situ by using melamine-formaldehyde-urea co-condensation resin (MUF) as wall material, n-octadecane (C18) as core material and styryl-maleic anhydride copolymer (SMA) as emulsifier. Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and thermogravimetric analysis were used to study the effects of emulsifier type, emulsifier dosage, core-wall ratio and pH on the morphology and thermal properties of microcapsules. The results show that the pH of core material and the ratio of core to wall have a great influence on the performance of microcapsules.

The Interaction Mechanism Between C14-Polyacetylene Compounds and the Rat TRPA1 Receptor: An In Silico Study.

Polyacetylene (PA) compounds, as natural products, exhibit remarkable properties and distinctive chemical activities. Three structurally similar C14-PA compounds-Echinophorin D, Echinophorin B, and Echinophorin A-extracted from plants demonstrate varying biological activities on the Transient Receptor Potential Channel A1 (TRPA1) protein, which belongs to the TRP (Transient Receptor Potential) family. In the current study, we investigated the binding modes of these three PA compounds with TRPA1 using molecular dynamics (MD), molecular docking, binding free energy calculations, and quantum mechanics/molecular mechanics (QM/MM) methods.

Ischemic stroke and sarcopenia have an asymmetric bidirectional relationship based on a two-sample Mendelian randomization study.

Background: We investigated the potential relationship between age-related conditions, particularly sarcopenia and ischemic stroke (IS), through a two-sample Mendelian randomization (MR) study.

Methods: We conducted a two-sample bidirectional MR study to investigate the relationship between sarcopenia and stroke. Genetic instruments for sarcopenia were derived from the UK Biobank, while data on IS and its subtypes were obtained from the MEGASTROKE consortium.

Four new species and four newly recorded species of Haliday (Hymenoptera, Eulophidae) from China, with a key to Chinese species.

In this paper, four species of Haliday, Li & Li, , Li & Li, , Li & Li, , and Li & Li, , are described as new to science; four species, Szelényi, Graham, Yefremova & Kriskovich, and (Förster) are reported from China for the first time; and the male of is reported for the first time in the world. A key to all known species of the genus in China is provided.

Insights about exosomal circular RNAs as novel biomarkers and therapeutic targets for hepatocellular carcinoma.

One of the most prevalent pathological types of Primary Liver Cancer (PLC) is the Hepatocellular Carcinoma (HCC) poses a global health issue. The high recurrence and metastasis rate of HCC, coupled with a low 5-year survival rate, result in a bleak prognosis. Exosomes, small extracellular vesicles released by various cells, contain diverse non-coding RNA molecules, including circular RNAs (circRNAs), which play a significant role in intercellular communication and can impact HCC progression.

Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.

Tuberculosis (TB) is a chronic infectious disease caused by (), which threatens human health and safety all over the world. Hundreds of thousands of people die from TB every year. Timely early diagnosis and treatment of patients is the most important measure to control the source of infection and curb the epidemic of tuberculosis.

Clinical application of 3D-printed fusion cage implantation in treating cervical spondylotic myelopathy.

Objective: To investigate the clinical efficacy of 3D-printed fusion cage implantation in treating cervical spondylotic myelopathy.

Methods: A retrospective analysis was performed on 52 patients with single-segment cervical spondylotic myelopathy who received anterior cervical discectomy and fusion in Affiliated Hospital of Beihua University from July 2019 to July 2022. They were divided into the 3D group and the control group.

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.

Hyperuricemia is a known risk factor for chronic kidney disease (CKD) and subsequent renal fibrosis. N6-methyladenosine (m6A) is the most prevalent chemical modification in eukaryotic mRNAs and has been implicated in various diseases. However, its role in hyperuricemic nephropathy (HN) remains unclear.

Highly specific screening of aspirin resistance-related single-nucleotide polymorphisms using ligase chain reaction strategy.

Aspirin (ASP) is currently the drug of choice for antiplatelet therapy. However, approximately 5%-45 % of patients are resistant to ASP and do not achieve the expected result. At present, a few studies have investigated the correlation between ASP resistance (AR) and single-nucleotide polymorphism (SNP).

Retinal fundus image super-resolution based on generative adversarial network guided with vascular structure prior.

Many ophthalmic and systemic diseases can be screened by analyzing retinal fundus images. The clarity and resolution of retinal fundus images directly determine the effectiveness of clinical diagnosis. Deep learning methods based on generative adversarial networks are used in various research fields due to their powerful generative capabilities, especially image super-resolution.

[Interpretation of a clinical practice guideline on the management of chronic pain associated with temporomandibular joint disorders].

Temporomandibular disorders (TMD) are a heterogeneous group of diseases that affect the temporomandibular joint, chewing muscle system, dental occlusion, and even various structures throughout the body, with significant characteristics of biological-psychological-social pattern. TMD related chronic pain, as the most important clinical symptom, can result in negative emotions seriously affecting patients' quality of life and physical and mental health. Although a variety of therapies have been previously reported to treat TMD related chronic pain, there is a lack of widely recognized therapies.

Multidimensional frailty as a predictor of mortality among older adults: a systematic review and meta-analysis.

Objective: This systematic review examined studies that assessed the relationship between mortality risk and multidimensional frailty. The pooled risk of mortality was estimated via a meta-analysis.

Design: A systematic review and meta-analysis.

Estimation Model for Maize Multi-Components Based on Hyperspectral Data.

Assessing the quality of corn seeds necessitates evaluating their water, fat, protein, and starch content. This study integrates hyperspectral imaging technology with chemometric analysis techniques to achieve non-invasive and rapid detection of multiple key components in corn seeds. Hyperspectral images of the embryo surface of maize seeds were collected within the wavelength range of 1100~2498 nm.

The Effect of Elevation Gradient on Distribution and Body Size of Carabid Beetles in the Changbaishan Nature Reserve in Northeast Asia.

The environment of mountain ecosystems can change greatly in short distances as elevation increases. The effects of elevation change on the distribution and body size of carabid beetles were investigated at elevations of 750-2600 m in the Changbaishan Nature Reserve (Northeast China). The richness and abundance of carabid species decreased significantly as elevation increased.