Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia.

Schizophrenia is one of the most debilitating mental illnesses affecting any age group. The mechanism and etiology of schizophrenia are extremely complex and multiple signaling pathways recruit genes implicated in the etiology of this disease. While the role of Wnt/β-catenin signaling in this disorder has been verified, the impact of long noncoding RNAs (lncRNAs) associated with this pathway has not been studied in schizophrenia.

Spectrum of ARSA mutations in Iranian patients with metachromatic leukodystrophy.

Metachromatic leukodystrophy (MLD) is an autosomal recessive disorder caused by mutations in the arylsulfatase A (ARSA) gene. Few studies have assessed the spectrum of ARSA mutations among Iranian patients. Here, we report eight Iranian patients with clinical features of MLD.

The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021.

Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer.

Mesenchymal stem cell-derived exosome and liposome hybrids as transfection nanocarriers of Cas9-GFP plasmid to HEK293T cells.

Exosomes are natural membrane-enclosed nanovesicles (30-150 nm) involved in cell-cell communication. Recently, they have garnered considerable interest as nanocarriers for the controlled transfer of therapeutic agents to cells. Here, exosomes were derived from bone marrow mesenchymal stem cells using three different isolation methods.

Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing.

Dermatologists have been interested in recent advancements in regenerative therapy. Current research is actively investigating the possibility of placental tissue derivatives to decelerate the skin aging process, enhance skin regeneration, reduce scarring, and prevent hair loss. Amniotic membranes (AM) play a crucial role in regenerative medicine as they serve as a suitable means of transporting stem cells, growth hormones, cytokines, and other essential compounds.

Unlocking the Potential: How Flavonoids Affect Angiogenesis, Oxidative Stress, Inflammation, Proliferation, Invasion, and Alter Receptor Interactions in Endometriosis.

Endometriosis, though not classified as a carcinogenic condition, shares features such as oxidative stress, migration, invasion, angiogenesis, and inflammation with tumor cells. This study aims to review the effects of flavonoids on these processes and their molecular mechanisms in preventing and treating endometriosis. A comprehensive review was conducted, involving a literature search in online databases using keywords like "endometriosis," "endometrioma," and "flavonoid.

Influence of Low-Level Laser Irradiation of the Red and Infrared Spectral Range for Treating Chronic Testicular Pain: A Randomized Clinical Trial.

The treatment of chronic testicular pain is a complex condition that will be encountered by most practicing clinicians. In this study, the influence of low-level laser irradiation of the red and infrared spectral range for treating chronic testicular pain was evaluated and compared. In this double-blind, placebo-controlled randomized clinical trial study, 60 patients were randomly divided into three groups of 20: (1) low-level laser group with red (650 nm, 50 mW), (2) low-level laser group with infrared (820 nm, 100 mW) and (3) laser placebo group.

Reduction of by Chlorella-Mediated Antimicrobial Photodynamic Therapy.

Nowadays, antimicrobial photodynamic therapy (aPDT) has been introduced as one of the minimally invasive methods for disinfection of the surfaces of dental implants. Being derived from seaweed, Chlorella has been used as a photosensitizer in this study. This study aimed to investigate the impacts of aPDT with Chlorella on the rate of reduction of in vitro.

Extramedullary Plasmacytoma of the Oral Cavity: A Rare Case in the Buccal Mucosa.

Extramedullary plasmacytomas (EMP) are uncommon solitary tumors composed of neoplastic plasma cells occurring outside the bone. These lesions are of clinical significance due to their potential progression to multiple myeloma (MM), a more systemic and serious plasma cell malignancy. Although EMPs primarily arise in the head and neck region, cases involving the oral cavity are particularly rare.

Grade III of Blunt Thoracic Aortic Injury and Duodenal Perforation due to Multiple Trauma; Which Is Priority? A Case Report.

Perforation of the duodenum after trauma has a low incidence and its coincidence with BTAI is very rare. The clinical condition of the patient is very important for deciding the treatment priority. In this patient, considering the stable condition and degree of aorta injury, we chose TEVAR before laparotomy.

Managing Large Perforated Internal Root Resorption With Partial Pulpectomy: A Case Report.

Internal root resorption (IRR) is a complex and often asymptomatic dental condition that can severely compromise tooth vitality and function. This case report presents the successful management of a perforated large IRR lesion in a 49-year-old female using an ultraconservative approach involving partial pulpectomy (PP) using calcium-enriched mixture (CEM) cement. The patient, initially presenting with an asymptomatic resorptive lesion in her left first premolar, underwent ultraconservative PP following diagnosis via conventional radiography and cone beam computed tomography.

Prevalence of macro-vascular complications among type 2 diabetic adults aged 50 and over: results from Ardakan cohort study on aging (ACSA).

Objective: Type 2 diabetes mellitus (T2DM) is a common condition that can lead to adverse macrovascular complications. This study aims to determine the prevalence of macrovascular complications in adults aged ≥ 50 with T2DM in Ardakan city, using data from the Ardakan Cohort Study on Aging (ACSA).

Methods: A cross-sectional investigation involved 5933 participants from the ACSA; of those assessed, 2340 had T2DM.

Health indicators in the management of diabetes in Primary health care: Iran-package of Essential Non-communicable diseases (IraPEN) program.

Objectives: This study evaluated the effectiveness of the IraPEN program, an adapted version of the WHO Package of Essential Non-communicable Disease (PEN) intervention, in managing diabetes from September 2020 to September 2021 using the Input-Process-Output-Outcome framework.

Methods: In this Cross-sectional/Ecological study, aggregated data was collected from IraPEN facilities by medical universities using the electronic health system. The data was presented as numbers and proportions, for urban and rural healthcare facilities separately.

Lactulose Versus Naloxone for Opioid-Induced Constipation in Intensive Care.

Objectives: Constipation caused by opioid-induced constipation (OIC) is prevalent among critically poisoned patients and can result in complications that prolong hospitalization and, in rare cases, cause bowel perforatio This research aimed to evaluate the safety and efficacy of lactulose and naloxone in the treatment of OIC in the intensive care unit for poisoning.

Materials And Methods: This was a randomized, double-blind, clinical trial of patients with opioid poisoning who experienced constipation for 14 months. Patients were divided into two groups: one receiving lactulose (30 cc daily) and the other receiving naloxone (8 mg three times a day).

Characteristics and recovery trends of severe TBI patients with a favorable functional outcome at 6-month follow-up.

Traumatic Brain Injury (TBI) is a devastating cause of death and disability. Outcomes following TBI have been extensively studied; however, less attention has been given to identifying characteristics of individuals who have a favorable outcome following severe TBI. We conducted a retrospective analysis of a database containing information on TBI patients admitted to a level 1 trauma center between 2015 and 2021.

Dual Checkpoint Inhibition in M2 Macrophages via Anti-PD-L1 and siRNA-Loaded M1-Exosomes: Enhancing Tumor Immunity through RNA-Targeting Strategies.

The interaction between a cluster of differentiation 47 (CD47) on cancer cells and signal regulatory protein alpha (SIRPα) on macrophages is thought to hinder macrophage phagocytic activity, which can be blocked by combining siRNAs targeting SIRPα (siSIRPα) with simultaneous involvement of activating receptors like FcRs (Fc receptors) anti-programmed death-ligand 1 (anti-PD-L1). For this study, M1 macrophage-derived exosomes were used to deliver the siRNAs, isolated from lipopolysaccharide (LPS)-stimulated RAW264.7 cells and electroporated with siSIRPα.

Lifestyle and Pharmacologic Approaches to Prevention of MASLD-related HCC.

Hepatocellular carcinoma (HCC) is a major concern for public health. Fatty liver disease, related to alcohol misuse or metabolic syndrome, has become the leading cause of chronic liver disease and HCC. The strong association between type 2 diabetes mellitus and HCC can be partly attributed to the development of metabolic dysfunction associated steatotic liver disease (MASLD).

Systematic Review and Meta-Analysis on the Accuracy of Artificial Intelligence Algorithms in Individuals Gender Detection Using Orthopantomograms.

The integration of artificial intelligence (AI) into dental imaging has led to significant advancements, particularly in the analysis of panoramic radiographs, also known as orthopantomograms (OPGs). One emerging application of AI is in determining gender from these radiographs, a task traditionally performed by forensic experts using manual methods. This systematic review and meta-analysis aim to evaluate the accuracy of AI algorithms in gender determination using OPGs, focusing on the reliability and potential clinical and forensic applications of these technologies.

The relationship between dietary branched-chain and aromatic amino acids with the regulation of leptin and FTO genes in adipose tissue of patients undergoing abdominal surgery.

Recent studies have suggested that the interaction between diet and an individual's genetic predisposition can determine the likelihood of obesity and various metabolic disorders. The current study aimed to examine the association of dietary branched-chain amino acids(BCAAs) and aromatic amino acids(AAAs) with the expression of the leptin and FTO genes in the visceral and subcutaneous adipose tissues of individuals undergoing surgery. This cross-sectional study was conducted on 136 Iranian adults, both men and women, aged ≥18 years.

Harnessing IL-27: challenges and potential in cancer immunotherapy.

IL-27 is structurally an immune-enhancing and pleiotropic two-chain cytokine associated with IL-12 and IL-6 families. IL-27 contains two subunits, namely IL-27p28 and EBI3. A heterodimer receptor of IL-27, composed of IL27Rα (WSX1) and IL6ST (gp130) chains, mediates the IL-27 function following the activation of STAT1 and STAT3 signaling pathways.