Investigating the effectiveness of ailurophobia treatment using virtual reality technique compared to metacognitive therapy: a randomized clinical trial.

Background: Fear of cats as a specific phobia disorder can cause disruption in some aspects of the affected people's lives. On the other hand, due to the fact that the two approaches of metacognitive treatment and behavioral therapy methods such as virtual reality are considered common treatment methods in anxiety disorders; It seems that it is necessary to examine the two approaches based on the effectiveness, durability and cost-benefit issue to present and introduce to therapists.

Methods: The present study was a Randomized Clinical Trial study that was conducted on 28 patients with Ailurophobia.

Evaluation of the relationship between worry and anxiety with the general health status of pregnant women at risk of diagnosing abnormalities.

Background: Today, the screening of fetal abnormalities during pregnancy is used as one of the components of the prenatal care worldwide, and many abnormalities are detected by ultrasound during pregnancy. On the other hand, the possibility of an abnormality in the fetus causes worry and anxiety in pregnant women. Therefore, the present study was conducted with the aim of determining the relationship between worry and anxiety with the general health status of pregnant women at risk of diagnosing fetal abnormalities.

Understanding the neurobiological mechanisms of LPS‑induced memory impairment.

In recent years, growing evidence suggests that lipopolysaccharide (LPS), a bacterial endotoxin found in the outer membrane of gram‑negative bacteria, can influence cognitive functions, particularly memory formation and retrieval. However, the underlying mechanisms through which LPS exerts its effects on memory remain incompletely understood. This review used various electronic databases, including PubMed, Scopus, and Web of Science, to identify relevant studies published between 2000 and 2024.

Misuse of the Term Retrospective Cohort. Comment on Alsayouf et al. Atomoxetine Treatment of Attention Deficit/Hyperactivity Disorder Symptoms in 3-6-Year-Old Children with Autism Spectrum Disorder: A Retrospective Cohort Study. 2024, , 163.

Recently, an article entitled "Atomoxetine Treatment of Attention Deficit/Hyperactivity Disorder Symptoms in 3-6-Year-Old Children with Autism Spectrum Disorder: A Retrospective Cohort Study" was published in the journal . In this letter, the methodology of the mentioned study is discussed.

Association between latent toxoplasmosis and bipolar disorder: a case-control seroprevalence study.

Background: Toxoplasma gondii (T. gondii) is the most successful obligate protozoan that can infect warm-blooded vertebrate hosts. Some researchers suggest that the presence of Toxoplasma cysts in the brain can lead to mental disorders.

Translation, Validity, and Reliability of Depression Literacy Questionnaire in Iranian Young Adults.

Background: Depression literacy has notable advantages in the early identification and treatment of depression. The current study was conducted with the aim of translating and investigating the validity and reliability of the Depression Literacy Questionnaire (D-Lit) in Iranian young adults.

Methods: The current study entailed a descriptive-analytical study in which the translation, validation, and preparation of the Persian version of D-Lit were conducted.

Effectiveness of Extended-Release Bupropion and Duloxetine on Pelvic Pain and Sexual Function among Patients with Chronic Prostatitis/Chronic Pelvic Pain.

Background: This study aimed to compare the efficacy of the two antidepressants, duloxetine and bupropion, on pelvic pain in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Materials And Methods: This single-blind clinical trial was conducted on 68 CP/CPPS patients. The patients with CP/CPPS received either an extended-release formulation of 150 mg/day bupropion (bupropion group) or duloxetine 30 mg/day for 12 weeks (duloxetine group).

A randomized, controlled trial study of the effectiveness of mindfulness-based stress reduction program on depression and physical problems in depressed elderly individuals.

The aim of this study was to investigate the effectiveness of mindfulness-based stress reduction (MBSR) program on depression and physical problems in depressed elderly individuals. This randomized controlled trial was conducted on two groups of 30 depressed elderly individuals over 60 years old using purposive sampling. The GDS and the PE-PSI questionnaires were administered to both groups before and after the intervention.

Expression of miR-155 and CEA and VEGF Proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer in Peripheral Blood.

Background: Cancer is a disease caused by manifestation and abnormal gene expression. Many of the genes that inhibit cancer by the microRNAs. The aim of this study was to investigate the Expression of miR155 gene and CEA and VEGF proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer (NSCLC).

Coronary artery calcification score as the determinant of coronary artery disease in chronic kidney disease patients: A preliminary study.

Background: Coronary computed tomography angiography (CCTA) is a noninvasive cardiovascular imaging procedure that visualizes coronary artery calcifications (CAC), a marker of subclinical atherosclerosis. Due to different calcification patterns in patients with chronic kidney disease (CKD) compared to the general population, this study aims to present diagnostic cut-off values for CAC to detect early coronary artery disease (CAD) in CKD patients.

Methods: This cross-sectional study included 807 patients: 407 with CKD and 400 controls with normal kidney function who underwent CCTA during 2019-2021.

Electrochemical biosensors for depression: Diagnosis and therapeutic monitoring.

Electrochemical biosensors have revolutionized the detection of biomarkers related to depression and the quantification of antidepressant drugs. These biosensors leverage nanomaterials and advanced assay designs to achieve high sensitivity and selectivity for clinically relevant analytes. Key neurotransmitters implicated in depression, such as serotonin, dopamine, and glutamate, can be accurately measured via biosensors, providing insights into the effects of antidepressant treatments on neurotransmission.

Effect of hypnosis on anxiety and blood pressure of pregnant women with preeclampsia: A double-blind controlled clinical trial study.

Background: The risk is on the level of blood pressure, and blood pressure is one of the prominent characteristics of preeclampsia. The aim of this study is to assess the effect of hypnosis on the pressure and blood pressure of pregnant women with preeclampsia.

Materials And Methods: In this controlled clinical trial study, 44 pregnant women from 20 to 32 weeks referred to Shahid Akbarabadi Hospital in Tehran in 2022 were randomly assigned to two intervention and control groups.

Health anxiety during a global pandemic: a comparison of medical and non-medical students in Mashhad, Iran.

Background: The COVID-19 pandemic has negatively impacted mental health worldwide, especially among healthcare professionals, including medical students, who were more exposed to pandemic-related stressors. However, health anxiety within this vulnerable group remains understudied.

Objective: This study aimed to assess and compare health anxiety and COVID-19 anxiety between medical and non-medical students during the COVID-19 pandemic and to identify factors associated with these forms of anxiety.

Seasonal Trends and Emergency Admissions for Obstetric Hemorrhage and Trauma among Pregnant Women in Iran.

Objective: Globally, obstetric hemorrhage and trauma are the leading causes of maternal and fetal morbidity and mortality during pregnancy. Delivering high-quality medical care to these patients is therefore imperative.This study aims to examine the relationship between month of referral and the severity of emergency admissions among pregnant women referred for obstetric hemorrhage and trauma.

Multivariate linear regression to predict association of non-invasive arterial stiffness with cardiovascular events.

Background: Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.

Methods: Out of the original 9704 participants in the Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study, we randomly selected 363 healthy participants, 226 normal subjects (who reported symptoms of CVD but were not confirmed) and 292 individuals who had experienced a major cardiovascular event.

Men in Marital Relationships with Women Undergoing Breast Cancer Treatment: A Qualitative Study.

Objective: Sexual health is an essential part of overall health and well-being. Breast cancer affects the marital relationships and sexual activity of patients and their sexual partners. The present qualitative study was conducted to discover the experiences of women undergoing breast cancer treatment and their husbands regarding marital relationships after breast cancer.

Altered expression of Csnk1a1p in Autism Spectrum Disorder in Iranian population: case-control study.

Over the past decade, substantial scientific evidence has showed that long non-coding RNAs (lncRNAs) are extensively expressed and play a crucial role in gene modulation through a diverse range of transcriptional, and post-transcriptional mechanisms. Recent discoveries have emphasized the involvement of lncRNAs in maintaining cellular homeostasis and neurogenesis in the brain. Accumulating reports identified dysregulated lncRNAs associated with psychiatric disorders, including autism.

Obsessive-compulsive disorder, major depressive disorder, and addiction: the vicious relationship.

Obsessive-Compulsive Disorder (OCD) and Major Depressive Disorder (MDD) are prevalent psychiatric conditions, each affecting a substantial portion of the global population. When these conditions coexist with a Substance Use Disorder (SUD), the complexity of the clinical presentation is heightened. Herein, we describe two cases of individuals who have comorbid OCD and/or MDD and substance use disorder that highlight the importance of addressing the coexisting psychiatric illness when treating the SUD.

Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats.

Clavulanic acid (ClvA), a beta-lactamase inhibitor, is being explored for its significant neuroprotective potential. The effects of ClvA were assessed both individually and in combination with crocin (Cr), an antioxidant derived from saffron, in the context of tardive dyskinesia (TD). In rat haloperidol (Hp)-induced-TD (1 mg/kg, i.

Development and validation of the Fall Risk Assessment Scale for patients in rehabilitation hospitals: A methodological study.

Background And Aims: Falling is a serious threat for patient safety in hospitals. This study aimed to identify the risk factors of fall amongst rehabilitation patients and to use them for developing and validating the Persian version of Fall Risk Assessment Scale (FRAS).

Methods: The current methodological study was conducted in two phases.