How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Previous studies found that post-stroke motor impairments are associated with damage to the lesioned corticospinal tract and a maladaptive increase in indirect contralesional motor pathways. How the somatosensory system adapts to the change in the use of motor pathways and the role of adaptive sensory feedback to the abnormal movement control of the paretic arm remains largely unknown. We hypothesize that following a unilateral stroke, there is an adaptive hemispheric shift of somatosensory processing toward the contralesional sensorimotor areas to provide sensory feedback support to the contralesional indirect motor pathways.

Isoleucine gate blocks K conduction in C-type inactivation.

Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter toward a non-conductive state. Recently, a high-resolution structure of a strongly inactivated triple-mutant channel kv1.2-kv2.

Repeatability of diffusion kurtosis tensor parameters in muscles of the lower legs.

Purpose: The aim of this study was to provide measurements from and investigate the repeatability of diffusion kurtosis tensor parameters in the muscles of the lower legs.

Methods: Test-retest acquisition of a kurtosis tensor sequence was performed in 13 healthy volunteers. Quantitative kurtosis tensor parameters were derived, and repeatability of each parameter was evaluated by muscle group and over the whole muscle through intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wsCV).

Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures.

We present a physics-based, temperature and state-dependent electrical conductivity model for soft biological tissue under thermal therapies with a quantified damage parameter that represents the state of soft biological tissue (degree of denaturation). Most existing models consider electrical conductivity to be only temperature-dependent and evaluate tissue damage during post-processing after temperature calculation. Our model allows tissue damage to be coupled into the thermal model for a more accurate description of both RF ablation and electrosurgery.

Single-molecule dynamic structural biology with vertically arranged DNA on a fluorescence microscope.

The intricate interplay between DNA and proteins is key for biological functions such as DNA replication, transcription and repair. Dynamic nanoscale observations of DNA structural features are necessary for understanding these interactions. Here we introduce graphene energy transfer with vertical nucleic acids (GETvNA), a method to investigate DNA-protein interactions that exploits the vertical orientation adopted by double-stranded DNA on graphene.

How Likely Is it that I Would Act the Same Way: Modeling Moral Judgment During Uncertainty.

Moral rules come with exceptions, and moral judgments come with uncertainty. For instance, stealing is wrong and generally punished. Yet, it could be the case that the thief is stealing food for their family.

Mother-infant interactive processes and infant behavioral and vagal stress recovery: Associations at 3, 6, and 9 months of age.

Mother-infant interactive processes, including matching social behaviors and repairing interactive ruptures, are proposed to foster infant stress functioning. However, little is known about the extent to which the concurrent relations between these dyadic processes and infant behavioral and vagal stress recovery change over the first year of life. In this study, 116 mother-infant dyads (55 girls) from a midwestern city in the United States completed the still-face paradigm at 3, 6, and 9 months.

Validation of the CRAVE-C scale in Chinese adults: a four-study examination of competing motivations for physical activity versus rest.

Background: The study aimed to validate the Cravings for Rest and Volitional Energy Expenditure (CRAVE) scale among Chinese adults with different health conditions (healthy control, chronic illnesses, and psychiatric disorders) and skill levels (athletes vs. non-athletes).

Methods: In Study 1, a confirmatory factor analysis (CFA) using the Maximum Likelihood Method (MLM) was performed on a Chinese sample of emerging adults ( = 481) to evaluate the structural validity of the Cravings for Rest and Volitional Energy Expenditure-Chinese version (CRAVE-C).

Learning ballet technique modulates the stretch reflex in students with cerebral palsy: case series.

Background: Cerebral palsy (CP) is considered the most prevalent developmental motor disorder in children. There is a need for training programs that enhance motor abilities and normalize function from an early age. Previous studies report improved motor outcomes in dance interventions for CP.

The Restoring Force Triangle: A Mnemonic Device for Polymer Mechanochemistry.

In polymer mechanochemistry, mechanophores are specific molecular units within the macromolecular backbone that are particularly sensitive to tension. To facilitate understanding of this selective responsiveness, we introduce the restoring force triangle (RFT). The RFT is a mnemonic device intended to provide intuitive insight into how external tensile forces (i.

Expanded Functionality and Portability for the Colvars Library.

Colvars is an open-source C++ library that provides a modular toolkit for collective-variable-based molecular simulations. It allows practitioners to easily create and implement descriptors that best fit a process of interest and to apply a wide range of biasing algorithms in collective variable space. This paper reviews several features and improvements to Colvars that were added since its original introduction.

Beta-Band Cortico-Muscular Phase Coherence in Hemiparetic Stroke.

Following a stroke, compensation for the loss of ipsilesional corticospinal and corticobulbar projections, results in increased reliance on contralesional motor pathways during paretic arm movement. Better understanding outcomes of post-stroke contralesional cortical adaptation outcomes may benefit more targeted post-stroke motor rehabilitation interventions. This proof-of-concept study involves eight healthy controls and ten post-stroke participants.

Alkyl Quinolone Response is dampened by .

The bacterium is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While is known to exhibit a robust competitive response towards other bacterial species, this bacterium is frequently identified in polymicrobial infections where multiple species survive. For example, in prosthetic joint infections (PJIs), can be identified along with other pathogenic bacteria including and Here we have explored the survival and behavior of such microbes and find that readily survives culturing with while other tested species do not.

Sex differences in elite track and field performances and inferences about steroid doping.

Females likely experience larger performance benefits from androgenic-anabolic steroids than males. We set out to determine if there were temporal differences in select athletics (track and field) records between females and males. Exploratory aims included: (1) evaluating the improvements in female and male world records over time, and (2) investigating the influence of doping programs on male and female world records before and after 1990, when sports governing bodies began to implement random out-of-competition and systematic in-competition drug testing.

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Carboxysomes are protein microcompartments found in cyanobacteria, whose shell encapsulates rubisco at the heart of carbon fixation in the Calvin cycle. Carboxysomes are thought to locally concentrate CO in the shell interior to improve rubisco efficiency through selective metabolite permeability, creating a concentrated catalytic center. However, permeability coefficients have not previously been determined for these gases, or for Calvin-cycle intermediates such as bicarbonate ([Formula: see text]), 3-phosphoglycerate, or ribulose-1,5-bisphosphate.

Release from same-talker speech-in-speech masking: Effects of masker intelligibility and other contributing factorsa).

Human speech perception declines in the presence of masking speech, particularly when the masker is intelligible and acoustically similar to the target. A prior investigation demonstrated a substantial reduction in masking when the intelligibility of competing speech was reduced by corrupting voiced segments with noise [Huo, Sun, Fogerty, and Tang (2023), "Quantifying informational masking due to masker intelligibility in same-talker speech-in-speech perception," in Interspeech 2023, pp. 1783-1787].

Kidney toxicology of a novel compound Lithium Bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) used in energy applications: An epigenetic perspective.

Exposure to emerging energy-based environmental contaminants such as lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, trade name HQ-115), poses a significant threat to human health, yet its impact on kidney function and epigenetic regulation remains poorly understood. Here, we investigated the effects of LiTFSI exposure on kidney-related biochemical indicators, renal injuries, and epigenetic alterations in male CD-1 mice under both 14-day and 30-day exposure durations. Our study revealed that LiTFSI exposure led to changes in kidney-related markers, notably affecting serum bicarbonate levels, while relative kidney weight remained unaffected.

Modulation of ABCG2 Transporter Activity by Ko143 Derivatives.

ABCG2 is a multidrug transporter that protects tissues from xenobiotics, affects drug pharmacokinetics, and contributes to multidrug resistance of cancer cells. Here, we present tetracyclic fumitremorgin C analog Ko143 derivatives, evaluate their modulation of purified ABCG2, and report four high-resolution cryo-EM structures and computational analyses to elucidate their interactions with ABCG2. We found that Ko143 derivatives that are based on a ring-opened scaffold no longer inhibit ABCG2-mediated transport activity.

Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium.

Introduction: Organophosphate esters (OPEs) are increasing in use as flame retardants and plasticizers and concerns have been raised given their endocrine-disrupting activities and possible obesogenic consequences. However, longitudinal studies on gestational OPE exposure and childhood obesity are scarce. This study examined whether OPE levels in maternal urine during pregnancy were associated with the risk of childhood obesity.

Exploring diet as a source of plasticizers in pregnancy and implications for maternal second-trimester metabolic health.

Background And Objectives: Diet plays critical roles in modulating maternal metabolic health in pregnancy, but is also a source of metabolic-disrupting phthalates and their replacements. We aimed to evaluate whether the effects of better diet quality on favorable maternal metabolic outcomes could be partially explained by lower exposure to phthalates/replacements.

Methods: At 13 weeks gestation, 295 Illinois women (enrolled 2015-2018) completed a three-month food frequency questionnaire that we used to calculate the Alternative Healthy Eating Index (AHEI)-2010 to assess diet quality.

Using precision approaches to improve brain-behavior prediction.

Predicting individual behavioral traits from brain idiosyncrasies has broad practical implications, yet predictions vary widely. This constraint may be driven by a combination of signal and noise in both brain and behavioral variables. Here, we expand on this idea, highlighting the potential of extended sampling 'precision' studies.

An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization.

The mesoscope has emerged as a powerful imaging tool in biomedical research, yet its high cost and low resolution have limited its broader application. Here, we introduce the Omni-Mesoscope, a high-spatial-temporal and multimodal mesoscopic imaging platform built from cost-efficient off-the-shelf components. This system uniquely merges the capabilities of label-free quantitative phase microscopy to capture live-cell morphodynamics across thousands of cells with highly multiplexed fluorescence imaging for comprehensive molecular characterization.