2 results match your criteria: "Baylor College of Medicine cMichael E. DeBakey Veterans Affairs Medical Center; Houston[Affiliation]"
Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.
Psychiatr Genet
October 2017
aThe Menninger Clinic bThe Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine cMichael E. DeBakey Veterans Affairs Medical Center; Houston, Texas dStatistical and Genetic Consulting LLC, Daren, Connecticut, USA.
Objective: This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine.
Methods: Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration of saline or cocaine (-15 min) to up to 20 min after infusion.
Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders.
Pharmacogenet Genomics
June 2015
aDepartment of Pharmacology bMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine cMichael E. DeBakey Veterans Affairs Medical Center, Houston, Texas dLaboratory of Statistical Genetics, The Rockefeller University, New York, New York, USA.
Objective: The aim of this study was to identify gene variants of DAT1 (SLC6A3) that modulate subjective responses to acute cocaine exposure.
Methods: Non-treatment-seeking volunteers (n=66) with cocaine use disorders received a single bolus infusion of saline and cocaine (40 mg, intravenous) in a randomized order. Subjective effects were assessed with visual analog scales administered before (-15 min) and up to 20 min after infusion.