SEROTONIN AND AMYOTROPHIC LATERAL SCLEROSIS.

Selective degeneration of motoneurons is the pathological hallmark of amyotrophic lateral sclerosis (ALS). Does serotonin (5-HT) play a role in progression or development of disease is under the research. The topic of the present paper is pressing as there is no data available regarding the spread of amyotrophic lateral sclerosis.

Optimization of the method of ultrasonic extraction of lycopene with a green extract from the fruit of , common in Western Georgia.

The study determined the content of lycopene in the fruits of the (35.25-60.21 mg/100 g), common at different heights above sea level in Western Georgia.

Analysis of repeat expansions in Georgian patients with Amyotrophic lateral sclerosis (ALS).

Background: Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder that affects the upper and lower motor neurons. Several genetic risk factors have been identified in the past decade with a hexanucleotide repeat expansion in the gene being the most significant. However, the presence of repeat expansion has not been examined in the Transcaucasian region, therefore we aimed to analyse its frequency in Georgian patients with ALS.

Incidence and Risk Factor of Hepatocellular Carcinoma Recurrence After Liver Transplant: Results From a Single Clinic.

Objectives: Although liver transplant is highly effective for early-stage hepatocellular carcinoma, guidance on tailored posttransplant management to optimize outcomes is lacking. We examined the incidence and pretransplant radiological scans and indicators of tumor marker associated with posttransplant hepatocellular carcinoma recurrence.

Materials And Methods: We reviewed outcomes of 34 hepatocellular carcinoma candidates aged ≥18 years who underwent living-donor liver transplant between January 2016 and January 2023.

The Effect of Metabolic Control on Diabetes Complication Rates and the Need for Medical Care During COVID-19 Social Isolation in Adjara, Georgia.

Introduction: Social isolation or distancing during the COVID-19 pandemic was associated with poor metabolic control in patients with diabetes mellitus. It might have contributed to the high mortality rate of those with diabetes who became infected. This study aims to determine the degree or level of metabolic control in patients with diabetes mellitus, the progression of its complications, and the need for emergency care during social isolation caused by the COVID-19 pandemic.

EVALUATION OF SOME LABORATORY PARAMETERS IN PATIENTS WITH MORBID OBESITY AFTER BARIATRIC SURGERY.

Obesity is a global challenge of the 21st century, both in terms of morbidity and mortality worldwide. In this article, we studied the effect of surgical treatment on glycemic indicators within morbid obesity patients, therefore assessing the glucose and glycosylated hemoglobin in blood serum. Also, we evaluated the hormonal background associated with Obesity - by measuring the insulin level in patients.

THE STUDY OF LIVER AND KIDNEY FUNCTION WITHIN COVID-19 PATIENTS.

Goal -the existing data on the coronavirus disease 2019 (COVID-19) revealed the impact of the disease on different organs such as the liver, the heart, the kidneys, etc. In our study, we evaluated the clinical characteristics of COVID-19 in patients with abnormal liver and kidney test results in recovered and dead patients. The number of the covid-19 patients was - 289.

ANALYSIS OF RISK FACTORS FOR MAJOR DENTAL DISEASES IN THE STUDENT POPULATION.

Nowadays, the reduction of widespread dental diseases (caries and periodontitis) is still crucial and appears to be both a medical and social concern. The aim of this study was an investigation of dental health status, determination of leading risk factors, and determination of preventive measures among the students of the Adjara region. Clinical studies were conducted on 392 students aged 18-25 years.

DNA methylation status of interspersed repetitive sequences in patients with migraine.

Objective: To analyse the methylation status of the Long Interspersed Nuclear Element-1 (LINE-1) and Short Interspersed Nuclear Element Alu (Alu) of peripheral blood mononuclear cells (PBMCs) from patients with migraine compared with healthy control subjects.

Methods: This case-control study recruited patients with migraine without aura and age-matched healthy control subjects. PBMCs were purified from peripheral blood samples.

Heuristic Optimization of a New Type of Prestressed Arched Truss.

This paper represents new approaches for calculating, designing, and optimizing prestressed arched trusses with a tie member. Structural systems with long spans, such as trusses, beams, frames, etc., are subjected to a considerable/substantial risk of losing load-carrying capacity because of the different types of loads used.

Study of the Electrical Conductivity of Ion-Exchange Resins and Membranes in Equilibrium Solutions of Inorganic Electrolytes.

The study of the electrical conductivity of ion-exchange membranes in equilibrium electrolyte solutions is of great importance for the theory of membrane processes, in particular for practical electrodialysis. The purpose of the work is to determine the electrical conductivity of industrial ion-exchange membranes MK-40 and MA-40, as well as their basis-granules of a bulk layer of industrial ion exchangers KU-2-8 and EDE-10p, by differential and modified contact methods in electrolyte solutions and the development of a new methodology that will give the values that are closest to the true ones; determination of the dependence of electrical membrane conductivity depending on the type of counterion and concentration equilibrium solution and granules of a bulk layer of ion exchangers on the volume fraction of a dry ion exchanger with different degrees of compaction. It is shown that the dependence of the electrical conductivity of diaphragms on the electrolyte concentration, according to theoretical ideas, disappears under compression.

STUDY OF THE BIOACTIVE COMPOUNDS CONTENT IN THE FLOWERS OF POLIANTHES TUBEROSA L. INTRODUCED BY GREEN TECHNOLOGIES.

The content of bioactive compounds of perennial, fragrant species of tuberose or Polianthes tuberosa L. representing the genus Polianthes L., asparagus (Asparagaceae Juss) family, highly decorative and widely accepted in the perfumery industry and extremely sensitive to environmental conditions, native to Mexico, was studied based on of raw materials of the flowers of the said plant introduced to five different locations of the BBG with various exposition and soil content by green technologies.

ABO system combination with Rh, Kell and MN group in Georgian blood donors.

Unlabelled: There are numerous scientific data about the study of the prevalence of blood group antigens in the different donor population. Several studies showed that the profile of major blood group antigens is not similar in blood donors from different local areas.

Research Objective: Our scientific goal was to study of the prevalence blood group antigens in the Georgian blood donor population.

The Genetic Polymorphisms in Colon Cancer.

Colon cancer (CC) belongs to a widespread malignant progression from the digestive tract. Moreover, CC is the leading cause of cancer-related mortality worldwide. It was suggested that there are several causative risk factors, among which are genetic factors that play an important role in the predisposition and development of CC.

Neutralization of Industrial Water by Electrodialysis.

The process of non-reagent adjustment of the pH of a NaCl solution (0.5 g/L) of different acidity was investigated by the method of bipolar electrodialysis on a device operating according to the K-system (concentration). The experiments were carried out in the range pH = 2.

Breast Cancer Response to Therapy: Can microRNAs Lead the Way?

Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment.

[STUDY OF ANTIVIRAL AND IMMUNECORRECTIVE EFFECTS OF LAZOLEX IN PATIENTS WITH RECURRENT HERPETIC STOMATITIS].

At present, our country continues intensive research to find and introduce into practice new natural medicinal preparations made from ecologically clean endemic plants of Georgia. An example of such studies in the Iveria-Pharma company is the domestic drug Lazolex (extract of the pericarpium of an unripe walnut), which has passed the necessary preclinical tests and began to be used in the clinic as an antiherpetic agent. On healthy volunteers, we found positive immunotropic effects of Lazolex.

; INTRODUCTION OF AROMATIC PLANTS IN THE BATUMI BOTANICAL GARDEN AND THEIR RESEARCH FOR THE CONTENT OF BIOLOGICALLY ACTIVE COMPOUNDS.

The research objectives were to study the introduction process of different aromatic and spice plants in the Batumi Botanical Garden and the content of bioactive compounds in aromatic plants introduced and grown in the soil and climatic conditions of the garden.; Among the aromatic plants introduced to the BBG by the authors, the following species are having full vegetative and generative development in the open ground:Cuminum cyminum L.; Polianthes tuberosa L.

Specific Combinations of Erythrocyte Group Antigens in Blood Donors.

Blood groups are inherited biological characteristics that do not change throughout life only in healthy people. Blood group antigens determine the adaptation of a human, as a biological species, to the surrounding environment. Our goal was to study the combination and frequency characteristics of three group systems (ABO, RH, KELL) in blood donors.

The Caucasian flora: a still-to-be-discovered rich source of antioxidants.

Cellular redox homeostasis is a state of balance between the formation of Usually Reactive Oxygen and / or Nitrogen Species (ROS/RNS), endogenous antioxidant defence systems, and exogenous dietary antioxidants. The disturbance of redox homeostasis, by the overproduction of endogenous ROS/RNS, may increase the risk of development of so-called civilisation diseases. The solution seems to be either the increased production of endogenous or consumption of exogenous antioxidants.

Presence of a Sexual Population of f. sp. in Georgia Provides a Hotspot for Genotypic and Phenotypic Diversity.

Wheat stem rust, caused by f. sp. , is a re-emerging disease exemplified by recent epidemics caused by new virulent races.

MATERNAL STRESS AND ENVIRONMENTAL RISK FACTORS OF CHILDHOOD ASTHMA.

Asthma is a common disease with increasing prevalence both in children and adults. WHO estimates that annually 15 million disability-adjusted life-years are lost and 250,000 asthma deaths are reported worldwide. Approximately 500,000 annual hospitalizations are due to asthma.

Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability.

Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent.

[EPIDEMIOLOGY OF DENTAL CARIES, DENTAL STATUS AND CORRECTION PROSPECTS IN SCHOOL CHILDREN OF ADJARA REGION KOBULETI AND KHELVACHAURI MUNICIPALITIES].

The epidemiological research was conducted among school children of 6-7, 12, 15 ages (According to the WHO nomenclature) in the municipalities of Kobuleti and Khelvachauri of Ajara region in order to study the spread of major dental diseases and determine further prophylactic measures. The research involved 246 children, of whom 129 were residents of Kobuleti and 117 residents of Khelvachauri. Studies have shown that in all age groups the level of caries distribution is high; the median intensity index is also high in all age groups compared to the median indexes established for residents of Georgia.