The reliability and validity of the Chinese version of premenstrual dysphoric disorder questionnaire for DSM-5.

Objective: Premenstrual dysphoric disorder (PMDD) seriously affects women's work and life, and early screening and diagnosis of PMDD can improve the quality of life of potential PMDD patients. The Premenstrual Dysphoric Disorder Questionnaire for DSM-5 (CTDP-DSM-5) is a validated screening tool for PMDD based on the DSM-5. This study intends to conduct reliability testing and validity evaluation of the scale after translation and revision in Chinese women.

Developmental origins and evolution of pallial cell types and structures in birds.

Innovations in the pallium likely facilitated the evolution of advanced cognitive abilities in birds. We therefore scrutinized its cellular composition and evolution using cell type atlases from chicken, mouse, and nonavian reptiles. We found that the avian pallium shares most inhibitory neuron types with other amniotes.

Evolutionary convergence of sensory circuits in the pallium of amniotes.

The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits' stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons.

Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis.

Background: Recent studies hint at mitochondrial genes influencing UC patient response to anti-TNF treatment. We evaluated this hypothesis by following a targeted strategy to identify gene expression that captures the relationship between mitochondrial dysregulation and response to treatment. Our objective was to initially examine this relationship in colon samples and subsequently assess whether the resulting signal persists in the bloodstream.

Area per Player in Small-Sided Games to Estimate the External Load in Elite Youth Soccer Players.

Small-sided games (SSGs) refer to game formats where there are variations in the pitch size, the number of players, and rules as compared to official soccer matches. The purpose of this study was to assess the relationship between GPS-derived external loads and the SSGs' area per player (ApP) in elite youth soccer players to identify whether the ApP influenced GPS-derived external load measures to estimate external load variables from SSGs with different densities (i.e.

Exploring the Impact of Social Relationship Modification on Young Female Soccer Players' Performance in Small-Sided Games.

This study compared young female soccer players' tactical, conditional, and emotional responses during two small-sided games (SSGs), without restrictions (SSG), and introducing an additional rule (SSG: if a player touches an opponent just before she receives the ball, her team wins the ball back with an indirect free kick). Fourteen developmental U14 players participated in two 4 × 6-min seven-a-side games (six each, plus goalkeepers) on a 50-m long × 30-m wide field. Players' positional data were collected using a GPS to assess their tactical performance (central tendency and entropy measures of the surface area, distance between players and to the nearest opponent, and stretch and spatial exploration indices) and conditional performance (total and low-moderate, high, very high speed, sprinting distance covered, and the number of accelerations and decelerations).

Electrode Setup for Electromyography-Based Silent Speech Interfaces: A Pilot Study.

This paper describes a series of pilot experiments developed to define the electrode setup in order to record a novel parallel electromyography (EMG)-audio database. The main purpose of the database is to provide data useful for the development of an EMG-based silent speech interface for Spanish laryngectomized speakers. Motivated by the scarcity of information in related studies regarding this important decision-making process, we decided to carry out a set of experiments with multiple recording sessions and different setups.

Potential Transformation of Food Resveratrol: Mechanisms and Biological Impact.

Resveratrol is a naturally occurring phenolic compound found in foods like grapes, berries, and peanuts. It has attracted substantial interest for its potential human health benefits, including antioxidant and anti-inflammatory effects. Research indicates that resveratrol may contribute to cardiovascular health, protect cognitive function, and exhibit anticancer properties.

Comparative safety analysis of Hedgehog inhibitor preparations: insights from the FAERS database.

Background: Vismodegib and sonidegib are currently the only Hedgehog inhibitors (HHIs) approved by the U.S. Food and Drug Administration (FDA) for the treatment of locally advanced BCC (laBCC).

Pediatric complex chronic and life-limiting conditions in the Basque public health system: cross-sectional prevalence study.

Background: The survival of children and adolescents with complex chronic conditions (CCCs) and/or life-limiting or life-threatening conditions (LLCs) is increasing, while estimating their prevalence is complex and limited. This study aims to describe the prevalence of CCCs and/or LLC in children and adolescents and their profile in a European public health system.

Methods: This was a descriptive cross-sectional study of the whole pediatric population (< 19 years) registered in the Basque Public Health System (BPHS) in May 2022.

Long-term validation of intra-cystic biomarkers for pancreatic cysts.

Background: Pancreatic Cyst Lesions (PCLs) are frequently diagnosed in radiologic imaging tests and can be classified as benign, premalignant and malignant. Their correct stratification is essential and has significant implications for the patient. The objective of the study was to determine the clinical and analytical characteristics that can help in their differential diagnosis.

Cluster sets and traditional sets elicit similar muscular hypertrophy: a volume and effort-matched study in resistance-trained individuals.

Background And Objective: Previous studies examining the effects of cluster sets (CS) compared to traditional sets (TS) protocols on muscle hypertrophy have primarily equated to volume load. This inevitably has resulted in a lower number of repetitions performed in TS compared to CS, thereby leading to a suboptimal hypertrophic stimulus. The present study aimed to compare the impact of CS and TS protocols, both performed with the same number of sets and repetitions, but with loads adjusted to the same range of repetitions in reserve (RIR) on muscle hypertrophy.

Targeting protein hyperSUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma crosstalk.

Background And Rationale: Cholangiocarcinoma (CCA) includes a diverse group of biliary malignancies with poor prognosis. Alterations in post-translational modifications contribute to disrupted protein dynamics, cellular disturbances, and disease. This study investigates the role of protein SUMOylation in cholangiocarcinogenesis and its potential as a therapeutic target.

Rehabilitation Strategies and Occlusal Vertical Dimension Considerations in the Management of Worn Dentitions: Consensus Statement From SSRD, SEPES, and PROSEC Conference on Minimally Invasive Restorations.

Objective: The Joint SSRD, SEPES, and PROSEC Consensus Conference aimed to provide clinical statements and recommendations for the rehabilitation of worn dentition and to evaluate the necessity of an evaluation phase when increasing the occlusal vertical dimension (OVD) during full-mouth rehabilitation.

Materials And Methods: Two systematic reviews were conducted before the conference. The findings of the reviews were analyzed, discussed in working group 2, and debated in plenary sessions until a consensus was reached.

Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens.

Tuberculosis (TB) in goats is a chronic infectious disease caused by complex (MTBC) organisms that pose a great health and economic challenge for the caprine industry in some European and developing countries. It is also a zoonotic disease posing a risk for public health. The control programs of the disease are based on a test-and-slaughter strategy, and vaccination is not feasible with available vaccines due to its interferences with the current TB immunodiagnosis.

Evaluation of the efficacy and safety of a novel xanthine oxidase inhibitor, tigulixostat, in gout patients with hyperuricemia: Design of the EURELIA 1 and EURELIA 2 studies.

Background: Gout is a chronic disease of monosodium urate crystal deposition caused by elevated serum urate (SU). Gout may progress from acute episodic attacks to a disabling chronic deforming arthropathy. Allopurinol and febuxostat are the most widely prescribed urate-lowering drugs, however, these agents have potential adverse events and are seldom titrated to achieve a target SU level.

Exploring N activation using novel Lewis acid/base pairs: computational insight into frustrated Lewis pair reactivity.

The activation of dinitrogen (N) is a crucial step in synthesizing nitrogen-based compounds and remains a significant challenge due to its strong triple bond. Currently, industrial N conversion relies on the Haber-Bosch process, a highly energy-intensive method that utilizes transition metal-based catalysts. Frustrated Lewis pairs (FLPs) have emerged as a promising alternative for N activation without the need for transition metals.

Is more data always better? On alternative policies to mitigate bias in Artificial Intelligence health systems.

The development and implementation of Artificial Intelligence (AI) health systems represent a great power that comes with great responsibility. Their capacity to improve and transform healthcare involves inevitable risks. A major risk in this regard is the propagation of bias throughout the life cycle of the AI system, leading to harmful or discriminatory outcomes.

Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT-BD Study.

Introduction: Bipolar disorder (BD) is associated with considerable morbidity and premature mortality, mainly due to somatic causes. This study aims to determine some physical, exercise capacity-related physiological variables and biochemical markers of health status in adults (45.4 ± 13.

Simplified vs extended in vitro methods for the evaluation of bioaccessibility of metals and metalloids present in urban recreational soils.

Urban soils may contain different metals and metalloids and they can enter the human body by direct inhalation, ingestion or dermic absorption. According to USEPA, 200 mg·day is the average daily ingested dose of soil for children aged from 1 to 12 years of age. In vitro bioaccessibility tests which are based on human physiology, have been used for the determination of the element fraction in soils that can be absorbed by human digestion.

Integrating "nature" in the water-energy-food Nexus: Current perspectives and future directions.

Integrated approaches for managing natural resources are said to meet increasing demand for water, energy, and food, while maintaining the integrity of ecosystems, and ensuring equitable access to resources. The Water-Energy-Food (WEF) Nexus has been proposed as a cross-sectoral approach to manage trade-offs and exploit synergies that arise among these sectors. Although not initially included as a component of the Nexus, the role of nature in sustaining the water, energy, and food sectors and in regulating their interrelationships is increasingly recognised by Nexus researchers and practitioners.

A scientific approach to hemorrhage risk assessment of SSRIs/SNRIs utilizing the FAERS database.

Objectives: Hemorrhage represents a notable adverse event (AE) associated with the utilization of SSRIs and SNRIs. This study aimed to provide valuable insights for clinical practice by providing a comprehensive understanding of hemorrhage events associated with SSRIs/SNRIs.

Methods: Ten-year data on the main SSRIs/SNRIs were extracted from the FAERS database for the period spanning from 2014 to 2023.

Characterization of visual cognition in pre-manifest, manifest and reduced penetrance Huntington's disease.

Cognitive and visual impairment are common in Huntington's Disease (HD) and may precede motor diagnosis. We investigate the early presence of visual cognitive deficits in 181 participants, including HD carriers (40 pre-manifest, 30 early manifest, 27 manifest, and 6 reduced penetrance) and 78 healthy controls (HC). Significant differences in visual memory were observed between reduced penetrance and pre-manifest groups (p = .

Semi-supervised learning for multi-view and non-graph data using Graph Convolutional Networks.

Semi-supervised learning with a graph-based approach has become increasingly popular in machine learning, particularly when dealing with situations where labeling data is a costly process. Graph Convolution Networks (GCNs) have been widely employed in semi-supervised learning, primarily on graph-structured data like citations and social networks. However, there exists a significant gap in applying these methods to non-graph multi-view data, such as collections of images.