Clinical Management Strategies of Cardiologists in Heart Failure with Reduced Ejection Fraction in Türkiye.

Objective: Integrating heart failure (HF) guideline recommendations into clinical practice takes time and is often suboptimal in real-life settings. Physician-related factors may be significant barriers to the adoption of these guidelines. This survey aims to assess the current opinions of cardiologists practicing in Türkiye regarding the management of heart failure with reduced ejection fraction (HFrEF).

Factors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry.

Current guidelines recommend adding long-acting muscarinic antagonists (LAMAs) in patients with uncontrolled asthma, despite the use of moderate to high doses of inhaled steroid-long-acting beta agonists (ICS/LABA). This study aims to analyze the factors related to the prescription of add-on LAMA in clinical practice for asthma patients, shedding light on physicians' preferences. This study included adult asthma patients on add-on LAMA and ICS/LABA monitored for at least one year in a national registry comprising 2053 asthmatics.

The effect of the menstrual cycle on the vestibular system in healthy adult women.

Aim: The purpose of this study was to evaluate the effect of menstrual cycle phases on the vestibular system in healthy adult women.

Materials And Methods: A total of 40 healthy adult women aged 18-40 years without hearing or balance complaints were included in the study. The participants were administered the Vestibular Evoked Myogenic Potentials (VEMP) test, the Video Head Impulse Test (vHIT), the Dizziness Handicap Inventory (DHI), and the Hospital Anxiety and Depression Scale (HADS).

The impact of dentofacial characteristics and malocclusions on dissatisfaction with dentofacial appearance.

Objectives: To assess how, and to what extent, dentofacial features and malocclusions affect the perceived dissatisfaction with the appearance of dentofacial region in different age groups.

Materials And Methods: Dissatisfaction with dental appearance (DDA) and facial appearance (DFA) of 430 patients were assessed using self-reported 5-point Likert scores (1: very satisfied - 5:very dissatisfied). Number of decayed, filled, and missing teeth, oral hygiene status, crowding in the upper/lower arches, molar relationship, overjet, overbite, posterior-crossbite, upper/lower midline deviations, face type, profile, nasal tip and chin deviations were assessed by an experienced orthodontist.

Hearing and balance functions in adults with ıron deficiency.

Background: Because the inner ear requires high-energy metabolism and because of the iron content of some cochlear enzymes, iron deficiency-related hypoxia can affect hearing and the balance system.

Objectives: To evaluate the hearing and balance functions in adults with iron deficiency (ID) and iron deficiency anemia (IDA).

Material And Methods: 22 ID patients, 22 IDA patients and 22 healthy controls underwent pure tone audiometry (0.

Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study.

: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their strong therapeutic activity and excellent safety profiles, azole antifungals are currently the most extensively used systemic antifungal drugs. Antibacterial properties of various topical antifungals, such as oxiconazole, which features oxime ether functionality, were discovered, indicating an exciting prospect in antimicrobial chemotherapy.

Caring Under Pressure: Investigating Parental Attitudes in Mother-Child Chronic Illness Dynamics.

Background: The presence of chronic illnesses in both a mother and a child poses a significant challenge for mothers in managing these conditions, yet how maternal attitudes adapt to dual illness remains poorly understood. This study aims to explore parenting styles in families dealing with mother-child chronic illnesses.

Methods: Mothers of children aged 2-6 were recruited from three pediatric clinics and categorized based on the health status of both the mother and the child.

Temporal Lobe Epilepsy Focus Detection Based on the Correlation Between Brain MR Images and EEG Recordings with a Decision Tree.

Background/objectives: In this study, a medical decision support system is presented to assist physicians in epileptic focus detection by correlating MRI and EEG data of temporal lobe epilepsy patients.

Methods: By exploiting the asymmetry in the hippocampus in MRI images and using voxel-based morphometry analysis, gray matter reduction in the temporal and limbic lobes is detected, and epileptic focus prediction is realized. In addition, an epileptic focus is also determined by calculating the asymmetry score from EEG channels.

Recurrent Immune Thrombocytopenia After Liver Transplantation in a Pediatric Patient: Successful Bridging Treatment With Eltrombopag Before Partial Splenic Embolization and Review of the Literature.

Although thrombocytopenia is a frequent complication that develops after liver transplantation, immune thrombocytopenia rarely occurs post-transplant. We present an 8-year-old boy who experienced 2 immune thrombocytopenia episodes that occurred 72 and 93 months after liver transplant while the patient was on tacrolimus therapy. The patient, who had primary diagnosis being deoxyguanosine kinase deficiency, received a liver transplant from his father at 1 year of age.

Impact of Preoperative Right Ventricular Function on Acute Renal Failure Development in Patients With Ventricular Assist Devices.

Background Acute kidney injury (AKI) and acute renal failure contribute significantly to the high mortality and morbidity seen in patients with left ventricular assist devices (LVADs). The role of preoperative right ventricular function in the onset of acute renal failure remains an area of active investigation. This study aims to explore the correlation between preoperative right ventricular function and the development of AKI in patients undergoing LVAD implantation.

Anterior Pituitary Hormones are Important in Growth, but does their Deficiency Cause Skeletal Deformity? A Case Report.

Hypopituitarism is a clinical syndrome that occurs when the anterior pituitary gland fails to secrete one or more hormones. Developmental delay is frequently seen in these patients. However, skeletal deformities and postural instability are unexceptional.

Adaptation of the Shirom-Melamed Burnout Measure in Parents of Turkish Pediatric Oncology Patients.

Objectives: This study was conducted to adapt the Shirom-Melamed Burnout Measure (SMBM) in parents of Turkish pediatric oncology patients.

Methods: This methodological and descriptive study was conducted with 184 parents of pediatric oncology patients from December 2023 to July 2024. Data was collected face to face interviews via an information form and the SMBM.

Development of Cyclosporine A Nanosuspension Using an Experimental Design Based on Response Surface Methodology: Evaluations.

Objectives: This study aimed to develop nanosuspensions (NSs) of cyclosporine A (CycA) using a top-down technology [high-pressure homogenization-(HPH)] for oral administration.

Materials And Methods: Formulas were prepared using different ratios of hydroxypropyl methylcellulose (HPMC) (1% and 0.5%) and sodium dodecyl sulfate (SDS) (1%) to improve the solubility of CycA.

Real-time physiological environment emulation for the Istanbul heart ventricular assist device via acausal cardiovascular modeling.

Background And Objectives: The cost and complexity associated with animal testing are significantly reduced by using mock circulatory loops prior. Novel mock circulatory loops allow us to test biomedical devices preclinically due to their flexibility, scalability, and cost-effectiveness. The presented work describes the development of a hardware-in-the-loop platform to emulate human physiology for the Istanbul Heart (iHeart-II) LVAD.

Bibliometric analysis of the Acta Orthopaedica et Traumatologica Turcica from 2013 to 2022.

Objective: This study aimed to analyze the original articles published in Acta Orthopaedica et Traumatologica Turcica (AOTT) between 2013 and 2022 using bibliometric methods to identify their characteristics and examine the changing trends over the last 10 years.

Methods: The articles were analyzed in terms of publication year, authors, countries, affiliations, citations, study design, subspecialty of orthopedics, sample size, study outcome, presence of statistical methods, time elapsed from submission date to acceptance date, and presence of funding. Periods (2003-2012 and 2013-2022) were compared for trend analysis in the journal.