114 results match your criteria: "Basildon and Thurrock University Hospitals NHS[Affiliation]"
Liver Int
May 2019
Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Background And Aims: The long-term outcomes of patients with hepatitis B virus-related acute on chronic liver failure (HBV-ACLF) remain unclear. The main aim of the study was to compare the 5-year survival rate and incidence rate of hepatocellular carcinoma (HCC) between patients with HBV-ACLF and HBV-cirrhosis.
Methods: Clinical data of patients with ACLF, compensated cirrhosis and decompensated cirrhosis who survived more than 3 months after diagnosis were collected.
Thorax
April 2019
Department of Respiratory, Queen Alexandra Hospital, Portsmouth, Hampshire, UK.
Purpose: Malignant pleural mesothelioma (MPM) has a high symptom burden and poor survival. Evidence from other cancer types suggests some benefit in health-related quality of life (HRQoL) with early specialist palliative care (SPC) integrated with oncological services, but the certainty of evidence is low.
Methods: We performed a multicentre, randomised, parallel group controlled trial comparing early referral to SPC versus standard care across 19 hospital sites in the UK and one large site in Western Australia.
Ther Hypothermia Temp Manag
March 2019
5 Basildon and Thurrock University Hospital FT, Basildon, United Kingdom .
BMC Infect Dis
December 2018
Department of Liver Research Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, No. 20, Chazhong Road, Taijiang District, Fuzhou, 350001, Fujian, China.
Background: Previous studies have suggested that Toxoplasma gondii (T. gondii) infection might be associated with fatty liver disease. However, the relationship between non-alcoholic fatty liver disease (NAFLD) and T.
View Article and Find Full Text PDFTher Hypothermia Temp Manag
December 2018
Departments of Neurology, Neurosurgery and Emergency Medicine, Kings County Hospital/SUNY Downstate College of Medicine, Brooklyn, New York.
Oxf Med Case Reports
November 2018
Department of Radiology, Basildon and Thurrock University Hospitals NHS Foundation Trust, Nethermayne, Basildon, UK.
Biliary ascariasis is a tropical infectious disease, endemic in regions such as the Far East, Indian subcontinent and parts of the Middle East. The responsible organism is the worm. This case study presents a 54-year-old British Caucasian female patient, admitted with a 1-week history of generalized abdominal pain.
View Article and Find Full Text PDFJ Clin Exp Hepatol
September 2018
Institute for Liver and Digestive Health, Royal Free Campus, UCL, London, UK.
Background: Cirrhosis and acute-on-chronic liver failure (ACLF) are associated with systemic inflammation, and caspase-mediated hepatocyte cell death. Emricasan is a novel, pan-caspase inhibitor. Aims of this study were to assess the pharmacokinetics, pharmacodynamics, safety and clinical outcomes of emricasan in acute decompensation (AD) of cirrhosis.
View Article and Find Full Text PDFBMC Musculoskelet Disord
July 2018
Basildon and Thurrock University Hospitals NHS Trust, Nethermayne, Basildon, SS16 5NL, UK.
Background: The shoulder is the least constrained of all joints of the body and is more susceptible to injury including dislocation. The rate of recurrent instability following primary stabilization procedure at 10 years of follow-up ranged from 3.4 to 20%.
View Article and Find Full Text PDFAnn R Coll Surg Engl
September 2018
Royal Free London NHS Foundation Trust , UK.
Introduction The use of embedded peritoneal dialysis (PD) catheters is purported to offer numerous benefits over standard placement. However, the optimum period of embedment and the effect of prolonged embedment on subsequent catheter function remain unclear. Methods This retrospective observational study looked at adult patients undergoing embedded PD catheter insertion in a large tertiary referral centre in the UK.
View Article and Find Full Text PDFTher Hypothermia Temp Manag
September 2018
1 The Essex Cardiothoracic Centre, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, United Kingdom .
Mild therapeutic hypothermia (MTH 33°C) post out-of-hospital cardiac arrest (OHCA) is widely accepted as standard of care. However, uncertainty remains around the dose and therapy duration. OHCA patients are usually kept sedated±paralyzed and ventilated for the first 24-36 hours, which allows for targeted temperature management, but makes neurological prognostication challenging.
View Article and Find Full Text PDFHealth Technol Assess
December 2017
Pain and Anaesthesia Research Centre, Barts Health NHS Trust, London, UK.
Background: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum.
View Article and Find Full Text PDFNeuromodulation
January 2018
Research and Development, Boston Scientific Neuromodulation, Valencia, CA, USA.
Objective: The PROCO RCT is a multicenter, double-blind, crossover, randomized controlled trial (RCT) that investigated the effects of rate on analgesia in kilohertz frequency (1-10 kHz) spinal cord stimulation (SCS).
Materials And Methods: Patients were implanted with SCS systems and underwent an eight-week search to identify the best location ("sweet spot") of stimulation at 10 kHz within the searched region (T8-T11). An electronic diary (e-diary) prompted patients for pain scores three times per day.
BMJ Case Rep
November 2017
Foundation Training, Whittington Hospital, London, UK.
Int J Surg Case Rep
October 2017
Department of Oral and Maxillofacial Surgery, Basildon and Thurrock University Hospitals NHS Foundation Trust, Nethermayne, Basildon, Essex, SS16 5NL, United Kingdom.
Introduction: Tumours of the parapharyngeal space are rare. Only 0.5% of head and neck tumours occur in this space.
View Article and Find Full Text PDFBMJ Case Rep
July 2017
Department of Radiology, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
The aim of this report is to discuss with high-quality images, a case of a caecal volvulus herniating through the foramen of Winslow with signs of perforation.
View Article and Find Full Text PDFJ Card Fail
July 2017
St Georges' Hospital, London, UK.
Aims: To investigate the effect of the different eligibility criteria used by phase III clinical studies in heart failure with preserved ejection fraction (HFpEF) on patient selection, phenotype, and survival.
Methods And Results: We applied the key eligibility criteria of 7 phase III HFpEF studies (Digitalis Investigation Group Ancillary, Candesartan in Patients With Chronic Heart Failure and Preserved Left-Ventricular Ejection Fraction, Perindopril in Elderly People With Chronic Heart Failure, Irbesartan in Heart Failure With Preserved Systolic Function, Japanese Diastolic Heart Failure, Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist, and Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [PARAGON-HF; ongoing]) to a typical and well-characterized HFpEF population (n = 557) seen in modern European cardiological practice. Follow-up was available for a minimum of 24 months in each patient.
BMJ Qual Improv Rep
March 2017
Basildon and Thurrock University Hospitals NHS Trust, United Kingdom.
The role of a junior doctor involves preparing for the morning ward round. At a time when there are gaps on rotas and doctors' time is more stretched, this can be a source of significant delay and thus a loss of working time. We therefore looked at ways in which we could make the ward round a more efficient place by introducing specific electronic, printed ward round proformas.
View Article and Find Full Text PDFCurr Opin Anaesthesiol
June 2017
aDepartment of Anesthesiology, Queen's Hospital, BHR University Hospital NHS Trust, Romford bQueen Mary University of London, London cDepartment of Anesthesiology, Princess Royal Hospital, King's College Hospital NHS Trust, Farnborough dDepartment of Obstetrics and Gynecology, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
Purpose Of Review: The current review outlines the challenges in managing pregnant women with sickle-cell anemia, who are at risk of becoming critically ill during pregnancy.
Recent Findings: Sickle obstetric patients pose unique challenges to the anesthetist and intensivist. We discuss the role of prophylactic transfusions for specific indications like acute anemia and twin pregnancies.
Urologia
February 2017
Department of Urology, Royal Free London NHS Foundation Trust, London - UK.
Nonmodifiable factors including pre-operative renal function and amount of healthy renal tissue preserved are the most important predictive factors that determine renal function after partial nephrectomy. Ischaemia time is an important modifiable risk factor and cold ischaemia time should be used if longer ischaemia time is anticipated. New techniques may have a role in maximising postoperative kidney function, but more robust studies are required to understand their potential benefits and risks.
View Article and Find Full Text PDFClin Exp Dermatol
March 2017
Department of Dermatology, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with suprabasal acantholysis and hyperkeratosis, and no evidence of viral infection, dysplasia or malignancy.
View Article and Find Full Text PDFJ Cardiovasc Surg (Torino)
April 2017
Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
Identification and treatment of arterial pathologies in athletes can present a significant challenge because symptoms may be nonspecific and standard examination is often unremarkable. Sportspeople frequently experience long delays to diagnosis, during which time their ability to exercise and their quality of life may be severely impacted. Though the conditions that affect this young patient group may not be widely seen in the general population, knowledge of their existence and recognition of the need for specialist referral can aid early identification and appropriate management.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
November 2016
Center for Public Policy and Administration, University of Utah, Salt Lake City, UT, 84112, USA.
Background: Digitized (scanned) medical records have been seen as a means for hospitals to reduce costs and improve access to records. However, clinical usability of digitized records can potentially have negative effects on productivity.
Methods: Data were collected during follow-up outpatient consultations in two NHS hospitals by non-clinical observers using a work sampling approach in which pre-defined categories of clinician time usage were specified.
BMJ Qual Improv Rep
August 2016
Basildon and Thurrock University Hospitals NHS Trust, United Kingdom.
Ischaemic stroke can result in approximately 2 million brain neurones being damaged for each minute that it is left untreated. Various trials and studies such as the National Institute of Neurologic Disorders (NINDS) trial, the European Cooperative Acute Stroke Study (ECASS), ECASS II, and the Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke (ATLANTIS) study have clearly demonstrated the beneficial effects of intravenous tissue plasminogen activator (tPA) for treatment of acute stroke. Therefore to minimise damage and improve clinical outcome, we need to identify patients who present within 4.
View Article and Find Full Text PDFStrategies Trauma Limb Reconstr
April 2016
Basildon and Thurrock University Hospitals NHS Foundation Trust, Nethermayne, Essex, SS16 5NL, UK.
We report the case of a Brodie's abscess presenting five and a half years following closed reduction and percutaneous pinning of a distal radius fracture. The index surgery was complicated by a pin site infection that was treated successfully with antibiotics. The patient represented with forearm pain years later, and radiological investigations revealed a Brodie's abscess in the distal radius at the site of the previous Kirschner wires.
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