89 results match your criteria: "Basic Excisional Surgery"
Mesenchymal Stem Cells Engineered by Multicomponent Coassembled DNA Nanofibers for Enhanced Wound Healing.
Nano Lett
November 2024
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China.
A major challenge for stem cell therapies, such as using mesenchymal stem cells to treat skin injuries, is the stable engraftment of exogenous cells and the maintenance of their regenerative capacities in the wound areas. DNA-based self-assembly strategies can be used for artificial and multifunctional cell surface engineering to stabilize and enhance their functions for therapeutic applications. Here, we developed DNA nanofiber-decorated stem cells, in which DNA-based, multivalent fiber-like structures were self-assembled in situ on the cell surfaces.
View Article and Find Full Text PDFSelf-Assembled DNA Composite-Engineered Mesenchymal Stem Cells for Improved Skin-Wound Repair.
Small
August 2024
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Article Synopsis
- * Researchers developed DNA-based self-assembled composites that help MSCs stick to wounds, improve their survival, and promote faster healing.
- * In animal studies, these engineered MSCs showed increased blood vessel formation and better wound closure, highlighting their potential as a new approach for treating skin damage.
Standardized Pre-clinical Surgical Animal Model Protocol to Investigate the Cellular and Molecular Mechanisms of Ischemic Flap Healing.
Biol Proced Online
January 2024
Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut St., 6Th floor, Philadelphia, PA, 19107, USA.
Background: Some of the most complex surgical interventions to treat trauma and cancer include the use of locoregional pedicled and free autologous tissue transfer flaps. While the techniques used for these reconstructive surgery procedures have improved over time, flap complications and even failure remain a significant clinical challenge. Animal models are useful in studying the pathophysiology of ischemic flaps, but when repeatability is a primary focus of a study, conventional in-vivo designs, where one randomized subset of animals serves as a treatment group while a second subset serves as a control, are at a disadvantage instigated by greater subject-to-subject variability.
View Article and Find Full Text PDFMultifocal cutaneous phaeohyphomycosis caused by with clinical resolution in an immunocompromised cat.
JFMS Open Rep
April 2023
Department of Clinical Sciences, University of Toulouse, ENVT, Toulouse, France.
Article Synopsis
- A 3-year-old cat with a history of immune-related blood disorders developed a pigmented skin nodule on its foreleg, which was later found to contain fungal elements.
- After surgery to remove the nodule and discovering another lesion, the cat was diagnosed with phaeohyphomycosis, a fungal skin infection.
- The treatment involved surgery and the antifungal medication itraconazole, leading to recovery despite the cat being on immunosuppressive drugs.
Desmoid Tumor and Implant-Based Breast Reconstruction.
Case Rep Oncol
February 2023
Department of Plastic and Reconstructive Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Article Synopsis
- Desmoid tumors are rare, locally aggressive tumors often found in the abdomen, making up 0.2% of breast tumors, with specific risk factors like previous surgeries, high estrogen levels, and genetic conditions influencing their occurrence.
- A case is presented of a patient with a past breast cancer diagnosis, who discovered a desmoid tumor during evaluation for heart issues, initially mistaken for recurrent cancer due to complications from implant surgery.
- Treatment for breast desmoid tumors typically involves surgical excision with negative margins and reconstruction, but emerging strategies like "watchful waiting" and medical management are also being considered as viable options.
Short-Term Surgical Mission in Sub-Saharan Country, Experience of a Breast-Dedicated Team: Reviewing the Past and Stepping Toward the Last Mission.
JCO Glob Oncol
January 2023
Breast Unit, Hospital São Francisco Xavier, CHLO, Lisbon, Portugal.
Purpose: The present article aims to present the data of a Breast Cancer Team Short-Term Surgical Mission in Guinea-Bissau in the setting of the National Bissau Hospital, Hospital Nacional Simão Mendes, level A referral health structure.
Patients And Methods: Patients with breast disease have been presented to our team for in loco consultation during the total of three missions in 1 year. We have observed a total of 97 female patients with age ranging from 12 to 70 years.
Rectal Artery Embolization for Hemorrhoidal Disease: Anatomy, Evaluation, and Treatment Techniques.
Radiographics
October 2022
From the Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone, Assistance Publique Hopitaux de Marseille, 264 Rue Saint-Pierre, 13385 Marseille, France (J.P., M.D.B., P.H., A.B., V.V., F.T.); Laboratory of Experimental Interventional Imaging (LIIE) and European Centre for Research in Medical Imaging (CERIMED) (J.P., M.D.B., P.H., V.V., F.T.), and Department of Visceral Surgery, Hôpital de la Timone (D.M., J.D.), Aix-Marseille University, Marseille, France.
Article Synopsis
- Chronic hemorrhoidal disease affects millions globally, leading to symptoms like rectal bleeding and impacting quality of life; pain is less common but can occur with complications.
- Treatment typically includes lifestyle changes, medications, and nonsurgical options like infrared photocoagulation, while surgical options such as hemorrhoidectomy are standard for severe cases.
- A new method called hemorrhoid embolization offers an effective alternative, involving minimal risks and a same-day procedure with positive results in symptom improvement and technical success rates.
[IgG4-related disease with nasopharyngeal malignancy-like manifestations].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
April 2022
Article Synopsis
- The article aims to highlight the clinical features and imaging characteristics of IgG4-related disease (IgG4-RD) to facilitate early diagnosis, particularly in cases involving the nasopharynx.
- Patient data were collected through electronic records, including demographics, symptoms, and lab tests such as nasal endoscopy and IgG4 levels, and all patients underwent partial excisional biopsy for further analysis.
- The findings showed that patients with IgG4-RD often present similarly to nasopharyngeal carcinoma, making timely diagnosis crucial to avoid potential damage to other organs. Treatment resulted in significant symptom improvement for those diagnosed.
Thermal Ablation Treatment for Cervical Precancer (Cervical Intraepithelial Neoplasia Grade 2 or Higher [CIN2+]).
Methods Mol Biol
March 2022
Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
Article Synopsis
- * Treatment options include excisional procedures, which are often impractical in low-resource settings, and cryotherapy, which faces logistical issues due to gas requirements.
- * The World Health Organization now recommends thermal ablation using heat for treatment, outlining the use and protocols for three thermal ablation devices with detailed instructions.
Therapeutic downregulation of () promotes surgical skin wound healing.
Elife
January 2022
Regenerative Bioengineering and Repair Laboratory, Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, Los Angeles, United States.
Article Synopsis
- Surgeons face significant challenges in minimizing scarring despite advancements in wound closure techniques.
- A study was conducted on a compound named Dwn1, which was found to suppress circadian activity, enhance fibroblast cell migration, and reduce collagen synthesis in laboratory settings.
- In mouse models, Dwn1 application led to quicker wound healing, improved strength, and reduced scarring, indicating its potential as a therapeutic target for better surgical wound management.
Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury.
Biomolecules
October 2021
Department of Dentistry, Orthodontics and Craniofacial Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6525EX Nijmegen, The Netherlands.
Article Synopsis
- The study investigated the effects of fibrin constructs enhanced with laminin-nidogen on wound healing in the soft palate of rats.
- Results showed that both types of fibrin constructs led to smaller collagen areas at 56 days post-implantation compared to empty wounds, suggesting reduced fibrosis.
- Additionally, the group with laminin-nidogen exhibited better muscle regeneration, indicating this method could improve healing in cleft soft palate repairs and significant muscle injuries.
Paediatric neck masses in Zaria: A review of clinical profile and treatment outcome.
Afr J Paediatr Surg
August 2021
Department of Pathology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Article Synopsis
- The study focuses on analyzing neck masses in children treated at a hospital in Northwestern Nigeria over seven years, highlighting their prevalence as a common reason for surgical consultations.* -
- A total of 99 cases were reviewed, with a slight majority of males (52.5%) and an average age of 4.4 years; most neck masses were found to be congenital, particularly thyroglossal duct cysts.* -
- The majority of patients underwent excisional biopsy, with a low complication rate of surgical site infections (7.1%), indicating that timely diagnosis and treatment generally lead to positive outcomes.*
Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor.
ACS Biomater Sci Eng
June 2021
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, California 95616, United States.
Article Synopsis
- - Re-epithelialization is essential for wound healing, but conventional topical methods of delivering growth factors, like ointments, have limited effectiveness due to their short duration on wounds.
- - The study shows that covalently immobilizing epidermal growth factor (EGF) onto the wound surfaces of genetically diabetic mice allows for sustained release and improved healing outcomes.
- - This method resulted in a 20% increase in wound closure compared to topical treatment and required significantly less EGF, with no observed adverse effects, highlighting its potential for treating difficult wounds.
Unusual Case of a Caruncular Oncocytoma.
Am J Dermatopathol
December 2021
Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA.
Article Synopsis
- A case study details a 68-year-old man with a 1mm papule, experiencing discomfort, which was diagnosed through biopsy revealing unique cell characteristics and the need to rule out a potentially similar but malignant condition.
- Complete surgical excision is the preferred treatment, emphasizing the importance of understanding the rare occurrence of ocular oncocytomas for dermatologists and pathologists.
Characterization of high risk human papilloma virus genotypes associated with oropharyngeal cancers in a Nigerian population.
Pan Afr Med J
April 2021
Department of OBGYN, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Plateau State, Nigeria.
Article Synopsis
- Recent studies show a rising incidence of head and neck cancers in young people, particularly linked to high-risk human papilloma virus (hrHPV) infections, prompting this study to investigate hrHPV-related oropharyngeal carcinoma in Nigerian adults.
- The study analyzed data from 41 patients over two years, identifying a 17.1% HPV prevalence, with genotypes 16, 33, 35, and 52 being prevalent, while noting that HPV was absent in HIV-positive individuals.
- The findings highlight the association of specific hrHPV genotypes with oropharyngeal cancer in Nigeria, emphasizing the need for preventive measures, including vaccination and public awareness to combat these cancers.
Surgical training tools for dermatology trainees: porcine vs. synthetic skin for excision and repair.
Arch Dermatol Res
November 2021
Departments of Dermatology, Otolaryngology and Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair Suite 1600, Chicago, IL, 60611, USA.
Article Synopsis
- Dermatology trainees need strong skills in excisional surgery and suturing, making effective training mediums essential.
- A study compared silicone-based synthetic skin to porcine skin for surgical practice among dermatology residents, with findings showing a preference for pig skin in most areas.
- Although many residents successfully completed surgical tasks on the synthetic skin, improvements are needed for it to better mimic the feel and usability of animal skin.
Prevalence of Deep Endometriosis and Rectouterine Pouch Obliteration in the Presence of Normal Ovaries.
J Obstet Gynaecol Can
October 2020
Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Hospital, Kingswood, Australia; Sydney Medical School Nepean, University of Sydney, Sydney, Australia; OMNI Gynaecological Ultrasound and Care, St. Leonards, Australia.
Article Synopsis
- The study investigates the prevalence of deep endometriosis (DE) and rectouterine pouch (RP) obliteration in women with normal ovaries compared to those with ovarian endometriomas (OE).
- Conducted across multiple hospitals from 2009 to 2017, it found that 25.4% of women with normal ovaries had DE, while 68.1% with OE had DE, indicating a significant difference.
- The findings suggest that even in patients without OE, there is a notable prevalence of DE and RP obliteration, emphasizing the need for better diagnostic methods for endometriosis beyond just pelvic ultrasounds.
Breast cancer early detection and diagnostic capacity in Uganda.
Cancer
May 2020
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Article Synopsis
- * A situational analysis was conducted using guidelines from the Breast Health Global Initiative, leading to recommendations aimed at improving early detection through better clinical practices and referral processes.
- * To enhance early diagnosis of breast cancer, the study suggests educational programs for primary health providers and increasing diagnostic testing capacity at secondary facilities via task shifting and remote specialist oversight.
A case of secretory breast cancer in a 6 year-old girl: is it possible to make a correct preoperative diagnosis?
Breast Cancer
July 2020
Department of Pathology, Saitama Medical University, Iruma-gun, Japan.
Article Synopsis
- Secretory breast carcinoma is the most common type of breast cancer found in children under 20, emphasizing the need for careful noninvasive diagnostic methods.
- A case study of a 6-year-old girl revealed an invasive secretory breast carcinoma detected through a palpable mass, which led to a successful excision biopsy.
- The study highlights the use of elastography as a noninvasive tool to assess tumor stiffness, suggesting that a high stiffness score (above 4) warrants further invasive diagnostic procedures to ensure accurate diagnosis of breast tumors in pediatric patients.
Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes via Akt/GSK-3β/β-Catenin Pathway.
Aesthetic Plast Surg
June 2020
Department of Plastic Surgery, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200031, People's Republic of China.
Article Synopsis
- The study explores the role of Aldehyde dehydrogenase 2 (ALDH2) activation in wound healing, specifically looking at Alda-1 as a potential enhancer of this process, which has been previously overlooked.
- Using a wound model in mice, the researchers compared the effects of Alda-1 with a control substance (DMSO) over a week, measuring various indicators of healing like wound rate, ALDH2 activity, and tissue characteristics.
- Results showed that Alda-1 significantly improved wound healing rates and restored ALDH2 activity, suggesting that activating this enzyme could be a promising strategy to enhance wound repair in plastic surgery settings.
Limited Tissue Biopsies and Hematolymphoid Neoplasms.
Am J Clin Pathol
November 2019
Department of Pathology, Duke University Hospital, Durham, NC.
Article Synopsis
- - The study analyzed 152 cases using fine-needle aspiration/needle core biopsy (FNA/CNB) to evaluate blood-related diseases, finding that 81.6% of cases resulted in a definitive diagnosis without needing further invasive procedures.
- - The diagnostic accuracy was notably high in cases of suspected lymphoma relapse (95.4%) and in patients with immunodeficiency (100%), highlighting the effectiveness of FNA/CNB in these specific scenarios.
- - Although FNA/CNB was generally effective, some cases required follow-up excisional biopsies, with a small number experiencing diagnostic discrepancies, indicating that while FNA/CNB is useful, it has limitations in complex pathological situations.
Matrix Metalloproteinases Are Differentially Regulated and Responsive to Compression Therapy in a Red Duroc Model of Hypertrophic Scar.
Eplasty
January 2018
The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC.
Article Synopsis
- Matrix metalloproteinases (MMPs) are important for maintaining the extracellular matrix and tissue health, but their response to compression therapy is not well understood.
- In a study using swine models, researchers analyzed how compression therapy affected the transcription of 26 MMPs in hypertrophic scars formed from excisional wounds.
- Results showed that while most MMPs increased during early healing, compression therapy helped maintain elevated levels of 10 specific MMPs, including MMP7, throughout the healing process.
Evaluation of the use of recombinant human basic fibroblast growth factor in combination with negative pressure wound therapy with instillation and dwell time in porcine full-thickness wound model.
Wound Repair Regen
November 2017
Department of Plastic Surgery, Wound Repair and Regeneration, Fukuoka University, School of Medicine, Fukuoka, Japan.
Article Synopsis
- This study investigates the effectiveness of combining NPWT with instillation and dwell time (NPWTi-d) and recombinant human basic fibroblast growth factor (rh-bFGF) for wound treatment.
- Six pigs were used to create 12 skin wounds, which were treated with various methods, including NPWTi-d, NPWT, and advanced wound care, with and without rh-bFGF.
- Results on day 6 showed that the combined treatment led to significantly better granulation tissue formation and blood vessel development compared to the control group, suggesting it can enhance wound healing.
Radioguided Occult Lesion Localization: Technical Procedures and Clinical Applications.
Clin Nucl Med
December 2017
From the *Regional Center of Nuclear Medicine, Hospital University of Pisa, Pisa; †Department of Nuclear Medicine, Radiology and Clinical Pathology, "S. Maria della Misericordia" Hospital, Rovigo, Italy; ‡Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Madrid, Spain; §Unit of Senology Hospital University of Pisa, Pisa, Italy; ∥Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria; and ¶Department of Radiology, University of Southern California, Los Angeles, CA.
Article Synopsis
- The concept of "radioguided occult lesion localization" (ROLL) combines preoperative imaging and intraoperative detection to assist surgeons in finding hidden cancerous lesions during surgery.
- The technique injects Tc-macroaggregated human albumin into the lesion, where particles remain to guide the excisional biopsy during the operation.
- ROLL has evolved to cover other types of tumors and is now part of the broader GOSTT framework, which incorporates advanced technologies like hybrid tracers and mixed-reality navigation systems for surgical guidance.
Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and pro-angiogenic property.
Cell Mol Life Sci
February 2018
The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, L406A, Tsinghua Campus, The University Town, Shenzhen, 518055, China.
Article Synopsis
- Mesenchymal stem cells (MSCs) have different subpopulations, and this study focuses on isolating a specific group with better wound healing properties, namely those expressing the PDGF receptor (PDGFR)-β.
- The PDGFR-β MSCs exhibited higher growth rates and produced more colony-forming units compared to non-PDGFR-β MSCs, and they also released more factors that encourage blood vessel formation.
- When these PDGFR-β MSCs were applied to wounds in mice, they integrated more effectively into the wound tissue and improved healing, also leading to greater blood vessel development compared to other cell types, suggesting their potential for treating various conditions.