124 results match your criteria: "Basaloid Follicular Hamartoma"
Re-evaluation of the concept of basaloid follicular hamartoma associated with naevoid basal cell carcinoma syndrome: a morphological, immunohistochemical and molecular study.
Pathology
September 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; CARADERM Network, France; 'Biologie des infections à polyomavirus' Team, UMR INRA ISP 1282, Université de Tours, Tours, France.
Article Synopsis
- - Naevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic condition caused by mutations in the Sonic Hedgehog (SHH) pathway, leading to early development of multiple basal cell carcinomas (BCCs) and related skin tumors like basaloid follicular hamartoma (BFH).
- - A study analyzed 140 skin tumors from NBCCS patients and 140 control BCC tumors to compare their morphological characteristics, finding that BFH was exclusively present in NBCCS patients and had distinct histopathological features.
- - The research indicates that BFH could represent precursors to BCC, as it was identified in up to 24% of the tumors in NBCCS patients, with possible
Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants.
JAMA Dermatol
November 2024
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Article Synopsis
- This study investigates the range of skin conditions in patients with germline SUFU pathogenic variants (PVs), focusing on their clinical and histopathologic features.* -
- Conducted across U.S. dermatology and genetics clinics over eight years, the study analyzed skin biopsy samples from five female patients aged 31-68, identifying several types of skin tumors.* -
- Findings reveal that alongside typical basal cell carcinomas, these patients exhibit various indolent skin lesions, indicating a broader range of cutaneous manifestations associated with SUFU PVs.*
Basaloid Follicular Hamartoma: A Histologic Clue for Diagnosis of Nevoid Basal Cell Carcinoma Syndrome.
Dermatol Surg
January 2025
Department of Dermatology, MedStar Washington Hospital Center, Washington, District of Columbia.
Solitary Basaloid Follicular Hamartoma: A Report of Two Cases.
Acta Dermatovenerol Croat
March 2024
Prof. Danica Tiodorović, MD, PhD, Clinic of Dermatovenereology University Clinical Center of Nis, Niš, Serbia;
Article Synopsis
- Basaloid follicular hamartoma (BFH) is a rare and benign skin condition that is often misdiagnosed due to its varied clinical manifestations.
- It can occur as a familial, congenital, or acquired condition and may present in localized or generalized forms, with different clinical variants linked to a range of abnormalities.
- The text discusses two documented cases of solitary BFH in pediatric patients, both observed through dermoscopy.
Follicular Basaloid Hamartoma and Associated Cutaneous Tumors: Clinical, Histopathological and Dermoscopic Aspects.
J Clin Aesthet Dermatol
November 2023
Drs. Rekik, Hammami, Bahloul, K. Sellami, Masmoudi, Amouri, Mseddi, and Turki are with the Dermatology Department at Hedi Chaker Hospital University in Sfax, Tunisia.
Article Synopsis
- Basaloid follicular hamartoma is a rare, benign tumor of hair follicles, which can sometimes be linked to basal cell carcinoma, as demonstrated in a patient with congenital lesions developing multiple carcinomas.
- A 76-year-old man presented with erythematous papules that evolved into nodules, which were analyzed using various dermatological assessments and histopathology.
- The study concluded that while some dermoscopic features of basaloid follicular hamartoma have been identified, more research is needed to confirm consistent diagnostic indicators.
Basaloid follicular hamartoma syndrome: acquired sporadic variant with hypothyroidism, hypohidrosis and alopecia, a rare case.
J Pak Med Assoc
June 2023
Department of Histopathology, PNS Shifa Hospital, Karachi, Pakistan.
Article Synopsis
- Basaloid follicular hamartoma is a rare, benign hair follicle malformation, appearing as multiple brown papules primarily on the face, scalp, and trunk.
- It can either be congenital or acquired and may occur with or without other diseases, making it clinically significant as it can resemble basal cell carcinoma.
- The case reported involves a 51-year-old woman with acquired basaloid follicular hamartomas linked to alopecia, hypothyroidism, and hypohidrosis, highlighting its rarity.
Happle-Tinschert syndrome variable phenotype as part of the mosaic hedgehog spectrum: Report of three cases.
Pediatr Dermatol
July 2023
Department of Dermatology, Hospital Alemán, Buenos Aires, Argentina.
Article Synopsis
- Happle-Tinschert syndrome is a rare genetic skin condition caused by a mutation in the SMO gene that occurs after fertilization.
- Key symptoms include skin growths (hamartomas), abnormal hair growth, and skin color changes that follow specific lines on the body, along with potential issues in bones, teeth, and brain.
- The report details three new cases of the syndrome, highlighting new skin features and noting that two cases did not show the typical skin growths associated with the condition.
Basaloid follicular hamartoma following Blaschko's lines.
An Bras Dermatol
October 2022
Universidade Potiguar, Natal, RN, Brazil.
Segmental basaloid follicular hamartomas derive from a post-zygotic SMO p.L412F pathogenic variant and express hair follicle development-related proteins in a pattern that distinguish them from basal cell carcinomas.
Am J Med Genet A
December 2022
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Article Synopsis
- Basaloid follicular hamartomas (BFH) are benign skin tumors that can occur alone or in groups, and some cases have a congenital, segmented pattern indicative of a mutation occurring after fertilization.
- The study analyzes two patients with isolated segmental BFH and finds a specific mutation (SMO c.1234 C>T, p.L412F) present only in the BFH tissue, which is linked to previous syndromes involving BFH.
- The research shows that segmental BFH has a lower cell proliferation index and distinct protein expression patterns compared to basal cell carcinomas (BCCs), indicating that the somatic SMO variant drives the development of BFH and highlights differences that could help differentiate between BF
PTCH1 inactivation is sufficient to cause basaloid follicular hamartoma in paediatric Nevoid basal cell carcinoma syndrome.
J Eur Acad Dermatol Venereol
November 2022
Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
"Kissing" basaloid follicular hamartomas of the eyelid.
J Cutan Pathol
October 2022
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Article Synopsis
- Basaloid follicular hamartomas (BFHs) are rare, non-cancerous skin tumors made up of basaloid cells arranged in a loose fibrous environment, often appearing as skin-colored bumps.
- They can be linked to diseases like alopecia and myasthenia gravis, and BFHs are particularly uncommon on the eyelids, with only five documented cases.
- A new case is reported involving congenital "kissing" BFHs on both eyelids, where the examination showed specific cellular features characteristic of BFH, including reticulated strands and unique cell expressions.
Multiple follicular abnormalities in a 1-year old cat consistent with basaloid follicular hamartomas.
Vet Dermatol
June 2022
Small Animal Clinic, Université de Toulouse, ENVT, Toulouse, France.
Article Synopsis
- Basaloid follicular hamartomas are benign tumors in humans that may be inherited; this study examines similar abnormalities in a young cat.
- The young cat showed clinical signs like hair loss and abnormal skin thickening, with skin samples revealing irregularities in hair follicles and abnormal keratin production.
- This case report is significant as it presents the first evidence of basaloid follicular hamartomas in cats, highlighting the condition's clinical and histopathological features.
Basaloid Follicular Hamartoma of the Eyelid: A Case Report and Literature Review about an Unusual Lesion in the Ocular Region.
Diagnostics (Basel)
January 2022
Anatomic Pathology Service, Pathology Department, Centro Hospitalar e Universitário do Porto, Largo Professor Abel Salazar, 4099-001 Porto, Portugal.
Article Synopsis
- Basaloid follicular hamartoma (BFH) is a rare benign skin lesion, particularly challenging to differentiate from other tumors like basal cell carcinoma due to similarities in appearance.
- A case study is presented involving a 53-year-old male with a mass on his eyelid, who has a history of familial adenomatous polyposis and a mutation in the APC gene.
- The histological analysis of the lesion showed distinctive features indicating BFH, which was confirmed after surgical removal, and the patient has remained healthy without recurrence for nine months post-surgery.
Basaloid follicular hamartoma associated with follicular mucinosis and inflammation.
An Bras Dermatol
January 2022
Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.
Article Synopsis
- * It is associated with a mutation in the PTCH-1 gene, which is linked to Gorlin-Goltz syndrome, a genetic condition.
- * A case study of a 9-year-old showed an expanding lesion on the forehead, diagnosed as basaloid follicular hamartoma with additional features, but Gorlin-Goltz syndrome was excluded through examination.
Familial multiple basaloid follicular hamartoma.
Dermatol Online J
June 2021
Department of Dermatology and Venereology, Centro Hospitalar São João, EPE Porto.
Article Synopsis
- Basaloid follicular hamartoma (BFH) is a rare, benign skin condition that can resemble basal cell carcinoma, making accurate diagnosis important.
- Familial multiple BFH (FMBFH) is a hereditary form that often shows up early, causing multiple small, skin-colored bumps on the face, which may not be painful but can affect appearance.
- Treatment options include surgery and various therapies like cryotherapy and lasers, but there's no established standard; a case study is presented where CO2 laser treatment successfully addressed FMBFH in adulthood.
Basaloid Follicular Hamartoma: An Additional Criterion of Nevoid Basal Cell Carcinoma Syndrome.
Am J Dermatopathol
January 2022
Dermatology and Dermatopathology, and.
Article Synopsis
- Basaloid follicular hamartoma (BFH) is a rare, non-cancerous skin growth that appears as brown to skin-colored bumps on areas like the face, scalp, and trunk.* -
- BFH is characterized by clusters of basaloid cells with cystic structures and needs to be differentiated from more aggressive conditions like infundibulocystic basal cell carcinoma to ensure proper treatment.* -
- A specific case is discussed involving a 13-year-old with nevoid basal cell carcinoma syndrome (NBCCS) who had multiple BFHs, suggesting that BFH should be considered part of the diagnostic criteria for NBCCS.*
Basaloid follicular hamartomas in pediatric Basal Cell Nevus Syndrome: A diagnostic challenge.
J Dermatol
July 2021
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Article Synopsis
- Basal Cell Nevus Syndrome (BCNS) is an inherited condition linked to mutations in the PTCH1 gene, leading to skin issues and a higher risk of skin cancer.
- Key skin features include thickened skin on palms and soles, small pits on these areas, and a tendency to develop multiple basal cell carcinomas (BCCs).
- The study discusses three pediatric cases involving both BCCs and basaloid follicular hamartomas (BFHs), using various diagnostic tools for evaluation.
Happle-Tinschert Syndrome: A Case Report of Unilateral Segmentally Arranged Basaloid Follicular Hamartoma with Scoliosis and Review of Literature.
Ann Dermatol
April 2020
Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Happle-Tinschert syndrome is a rare condition marked by unique skin growths called basaloid follicular hamartomas, along with various bone, dental, and brain abnormalities.
- A case study of a 26-year-old woman highlighted symptoms such as brownish skin changes, nail problems, scoliosis, and other physical anomalies, all linked to this syndrome.
- Genetic testing did not find any mutations, emphasizing the unknown genetic basis of Happle-Tinschert syndrome, with only 14 cases reported so far.
Treatment of basal cell carcinomas and basaloid follicular hamartomas in basal cell nevus syndrome children and adolescents.
J Dermatolog Treat
May 2022
GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Basaloid follicular hamartoma of the eyelid in a pediatric patient.
Am J Ophthalmol Case Rep
September 2020
Edward S. Harkness Eye Institute Columbia University College of Physicians and Surgeons, New York, NY, USA.
Article Synopsis
- A six-year-old girl with juvenile diabetes had an eyelid lesion that was diagnosed as a basaloid follicular hamartoma.
- This type of lesion is benign and comes from hair follicles, but it can look like a more serious condition called basal cell carcinoma.
- Complete removal of the lesion is necessary to prevent any complications or misdiagnosis.
Basaloid follicular proliferations, brain tumours and SUFU.
Br J Dermatol
November 2020
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions.
Dermatol Online J
February 2020
School of Medicine, University of California San Diego, La Jolla, CA.
Article Synopsis
- - Nevus sebaceus is a harmless skin growth that typically emerges at birth and enlarges during puberty, with the potential to develop both non-cancerous and cancerous tumors later in life.
- - Common benign tumors associated with nevus sebaceus include syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma.
- - Accurate diagnosis often requires multiple biopsies to identify any secondary tumors, and it’s crucial to carefully choose the biopsy location and size.
Clinicopathological and Dermoscopic Features in a Case of Linear and Unilateral Basaloid Follicular Hamartoma.
Indian Dermatol Online J
November 2019
Department of Dermatology, Venereology and Leprosy, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India.
Article Synopsis
- Linear and unilateral basaloid follicular hamartoma (BFH) is a rare skin condition characterized by papules and plaques that appear along specific lines on the skin.
- Although it has a benign nature, there is a potential long-term risk of developing basal cell carcinoma (BCC).
- A detailed examination of a case revealed typical dermoscopic features of BFH, some of which resembled those of BCC, but crucial distinguishing features of BCC were absent.
Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?
J Cutan Pathol
March 2020
Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
Article Synopsis
- Basaloid tumors linked to seborrheic keratosis (SK) are rare and can resemble basal cell carcinoma (BCC) while showing traits similar to trichoblastoma or basaloid follicular hamartoma.
- A study conducted from 2001 to 2017 analyzed cases of SK with basaloid tumors and compared them with control groups, assessing various tumor-associated antigens and mitotic activity.
- The findings revealed that the basaloid tumors were generally benign and not BCC, with characteristics consistent with follicular hamartomas rather than malignant forms.
Dermoscopy of Linear Basaloid Follicular Hamartoma.
Indian Dermatol Online J
August 2019
Department of Dermatology, Venereology and Leprosy, Shri B M Patil Medical College, Hospital and Research Center, BLDE (Deemed to be University), Vijayapur, Karnataka, India.