43 results match your criteria: "Barts Health NHS Trust and Queen Mary University[Affiliation]"
Trials
July 2024
Centre for Rehabilitation & Ageing Research (CRAR), Injury, Recovery Sciences and Inflammation (IRIS), School of Medicine, Medical School, University of Nottingham, Nottingham, NG7 2UH, UK.
Background: Moderately severe or major trauma (injury severity score (ISS) > 8) is common, often resulting in physical and psychological problems and leading to difficulties in returning to work. Vocational rehabilitation (VR) can improve return to work/education in some injuries (e.g.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2024
Barts Health NHS Trust and Queen Mary University, London, United Kingdom.
Prurigo nodularis (PN) is a skin disease characterized by intensely itchy skin nodules and is associated with a significant healthcare resource utilization (HCRU). This study aimed to estimate the HCRU of patients in England with PN overall and moderate-to-severe PN (MSPN) in particular. This retrospective cohort study used data from the Clinical Practice Research Datalink and Hospital Episode Statistics in England.
View Article and Find Full Text PDFHeart Rhythm
December 2024
Imperial College Healthcare NHS Trust and Imperial College London, London, United Kingdom. Electronic address:
Background: Recurrent ventricular tachycardia (VT) can be treated by substrate modification of the myocardial scar by catheter ablation during sinus rhythm without VT induction. Better defining this arrhythmic substrate could help improve outcome and reduce ablation burden.
Objective: The study aimed to limit ablation within postinfarction scar to conduction channels within the scar to reduce VT recurrence.
Dermatol Ther (Heidelb)
April 2024
Barts Health NHS Trust and Queen Mary University, London, UK.
Introduction: Alopecia areata (AA) is an autoimmune condition that causes non-scarring hair loss and can impose a high psychosocial burden on patients. The presence of comorbid conditions may impact the management of AA in clinical practice. This analysis aims to describe disease characteristics and management of AA in patients with concomitant atopic, autoimmune, and psychiatric comorbid conditions.
View Article and Find Full Text PDFAcne can create a significant burden for people of all ages. However, the psychological consequences might often be overlooked. This review comments on recent evidence in the field of psychodermatology, to highlight the importance of considering a person's mental health in the treatment of acne.
View Article and Find Full Text PDFERJ Open Res
January 2023
Usher Institute, University of Edinburgh, Edinburgh, UK.
Background: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.
Methods: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19.
J Obstet Gynaecol
December 2023
Lipidomic and Nutrition Research Centre, School of Health Sciences, London Metropolitan University, London, UK.
Total testosterone (TT), sex hormone-binding globulin (SHBG), dehydroepiandrosterone (DHEA) levels, and cervical length (CL) were investigated in pregnant Egyptian women with polycystic ovary syndrome (PCOS, = 38), history of miscarriages (RM, = 40) and without the conditions (HC, = 40). At week 8, the RM had lower levels of TT ( 0.000) and free androgen index (FAI) ( = 0.
View Article and Find Full Text PDFAnn Neurol
February 2023
Department of Infectious and Tropical Diseases, Toulouse University Hospital, Toulouse, France.
Objective: Our aim was to assess the real-world effectiveness of immune checkpoint inhibitors for treatment of patients with progressive multifocal leukoencephalopathy (PML).
Methods: We conducted a multicenter survey compiling retrospective data from 79 PML patients, including 38 published cases and 41 unpublished cases, who received immune checkpoint inhibitors as add-on to standard of care. One-year follow-up data were analyzed to determine clinical outcomes and safety profile.
Clin Cosmet Investig Dermatol
May 2022
Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
Psoriasis is a well-known chronic disease characterized by the development of erythematous, indurated, scaly, pruritic plaques on the skin with cycles of remission and symptom flare-ups. The management of patients with chronic plaque psoriasis has been more challenging since the Covid-19 pandemic as health care professionals have had to adapt to remote consultations for some patients, and patients have had to adapt to the changing health landscape. The rapid resolution of psoriasis symptoms especially those with a substantial impact on quality of life can improve patient satisfaction and adherence, making it an important factor in successful treatment.
View Article and Find Full Text PDFCurr Opin Pulm Med
May 2022
Usher Institute, University of Edinburgh, Edinburgh.
Purpose Of Review: Persistence of symptoms after acute coronavirus disease 2019 (COVID-19), often described as long- COVID, is common and debilitating. In this article, we review the epidemiology, clinical features, and research priorities for long-COVID focusing on the respiratory system.
Recent Findings: Breathlessness, cough and chest pain were the most commonly reported respiratory symptoms associated with long-COVID.
Transfus Apher Sci
June 2022
NHS Blood and Transplant, Barts Health NHS Trust and Queen Mary University of London, UK.
Sickle cell disease results in systemic inflammation even at steady state and this is accentuated during acute crises. The plasma of affected patients contains several proinflammatory cytokines as well as adhesion molecules and prothrombotic factors. This environment promotes further red cell sickling while many of these substances can cause direct tissue toxicity and end-organ damage.
View Article and Find Full Text PDFBr J Dermatol
March 2022
British Association of Dermatologists, Willan House, 4 Fitzroy Square, London, W1T 5HQ, UK.
Dermatol Ther (Heidelb)
October 2021
Department of Dermatology, Psoriasis Center, University Medical Center, Erlangen, Germany.
Introduction: There are clear treatment options for mild psoriasis where topical therapies are the mainstay, and for severe psoriasis where systemic therapy (biologic or non-biologic) is necessary. However, there is less clarity in the 'grey zone' of patients in the moderate or so-called 'beyond-mild' segment. There are frequent delays to the initiation, discontinuation, switching and dose change in treatment, and many patients fail to continue treatment because of concerns about safety or lack of efficacy.
View Article and Find Full Text PDFLancet Respir Med
December 2021
Population Health Science Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle, UK. Electronic address:
Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas.
View Article and Find Full Text PDFClin Exp Dermatol
January 2022
South Wales Clinical Psychology Training Programme, School of Psychology, Cardiff University and Cardiff and Vale University Health Board, Cardiff, UK.
Background: Skin conditions have a large emotional, psychological and psychiatric impact on the individual. The All-Party Parliamentary Group on Skin (APPGS) commissioned a qualitative survey to further explore this relationship alongside the experiences of those accessing services in relation to these difficulties in the UK.
Aim: To examine the experiences of UK individuals living with a skin condition, and their views of seeking and receiving psychological treatment.
Orphanet J Rare Dis
April 2021
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Background: Idiopathic Ketotic hypoglycemia (IKH) is a diagnosis of exclusion. Although considered as the most frequent cause of hypoglycemia in childhood, little progress has been made to advance the understanding of IKH since the medical term was coined in 1964. We aimed to review the literature on ketotic hypoglycemia (KH) and introduce a novel patient organization, Ketotic Hypoglycemia International (KHI).
View Article and Find Full Text PDFDermatol Ther (Heidelb)
April 2021
Dermatology Department, Barts Health NHS Trust and Queen Mary University, London, UK.
Introduction: Determining optimal treatment for moderate plaque psoriasis can be challenging. Recent studies have demonstrated the effectiveness of calcipotriol and betamethasone dipropionate (Cal/BD) foam in patients with moderate-to-severe plaque psoriasis.
Methods: This research explored the use of Cal/BD foam in patients with beyond-mild psoriasis (defined as patients eligible for topical treatment, systemic treatment, or combined topical/systemic treatments) using an online questionnaire, retrospective medical-record review, and by capturing the attitudes and treatment approaches of dermatology specialists.
J Allergy Clin Immunol Pract
April 2021
Observational and Pragmatic Research Institute, Singapore, Singapore; Optimum Patient Care, Cambridge, United Kingdom; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address:
Br J Dermatol
May 2021
Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK.
Background: Evidence for the effectiveness of vitiligo treatments is limited.
Objectives: To determine the effectiveness of (i) handheld narrowband UVB (NB-UVB) and (ii) a combination of potent topical corticosteroid (TCS) and NB-UVB, compared with TCS alone, for localized vitiligo.
Methods: A pragmatic, three-arm, placebo-controlled randomized controlled trial (9-month treatment, 12-month follow-up).
BMC Med Res Methodol
August 2020
Optimum Patient Care, Cambridge, UK.
Background: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour.
View Article and Find Full Text PDFClin Exp Dermatol
October 2020
Centre for Dermatology Research, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.
J Dermatolog Treat
November 2021
LEO Pharma A/S, Ballerup, Denmark.
Purpose: To compare the short-term cost and effectiveness of calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam against nonbiologic systemics in psoriasis patients for whom oral systemic or topical therapy is considered appropriate in seven European countries.
Methods: Matching-adjusted indirect comparisons of four-week PASI-75 responses of Cal/BD foam were performed versus 12-week responses of methotrexate, acitretin, fumaric acid esters (FAE) and 16-week responses of apremilast. Analyses took a payer perspective and included drug, physician visit and monitoring costs.
Chest
April 2020
Optimum Patient Care Global Ltd, Cambridge, England; Observational and Pragmatic Research Institute, Singapore, Republic of Singapore; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address:
Background: Clinical characteristics of the international population with severe asthma are unknown. Intercountry comparisons are hindered by variable data collection within regional and national severe asthma registries. We aimed to describe demographic and clinical characteristics of patients treated in severe asthma services in the United States, Europe, and the Asia-Pacific region.
View Article and Find Full Text PDFBr J Hosp Med (Lond)
April 2019
Consultant Cardiologist, Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London EC1A 7BE and Senior Clinical Lecturer, NIHR Biomedical Research Centre at Barts, Barts Health NHS Trust and Queen Mary University of London, London.
Cardiogenic shock remains a major problem affecting a large proportion of patients with acute coronary syndromes, with a persistent high mortality rate. Although mechanical reperfusion with percutaneous coronary intervention has improved outcomes following acute coronary syndromes, there is limited evidence supporting the other current treatments used to manage patients with cardiogenic shock (intra-aortic balloon pumps, percutaneous left ventricular assist devices and extracorporeal membrane oxygenation). This article looks at these options, assessing current evidence and recent advances.
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