4 results match your criteria: "Bart's and the London Queen Mary School of Medicine and Dentistry[Affiliation]"
Autistic enterocolitis; is it a histopathological entity?
Histopathology
February 2007
Institute of Cell and Molecular Science and Health Sciences Education, Bart's and the London Queen Mary School of Medicine and Dentistry, London, UK.
Aims: To review the literature on the histopathological diagnosis of the condition termed 'autistic enterocolitis'.
Methods And Results: We have reviewed all published works where mucosal biopsy specimens from autistic children have been examined histopathologically. Abstracts were excluded.
Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo.
Microcirculation
March 2005
The William Harvey Research Institute, Bart's and the London Queen Mary School of Medicine and Dentistry, London, UK.
Article Synopsis
- The study explored the role of the anti-inflammatory protein TSG-6 and its Link module (Link_TSG6) in influencing how leukocytes interact with endothelial cells during inflammation.
- Researchers induced inflammation in mouse mesenteries and measured leukocyte behavior, finding that Link_TSG6 effectively reduced the movement and adhesion of these immune cells.
- The findings suggest that TSG-6 and Link_TSG6 primarily exert their anti-inflammatory effects in the localized tissue environment where leukocytes exit the bloodstream, rather than affecting broader neutrophil activity or endothelial activation.
The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects.
Tumour Biol
July 2004
Williamson Laboratory, Department of Obstetrics and Gynecology, Bart's and the London Queen Mary School of Medicine and Dentistry, Queen Mary University of London, London, UK.
The ectopic production of free hCG beta is a common phenomenon in epithelial tumours, a phenomenon originally believed to have no biological significance. However, it is now apparent that hCG beta may significantly effect tumour development by increasing cell populations through inhibition of apoptosis. The recently identified hCG beta beta homodimer, with topological similarities to cystine knot growth factors, has been suggested to be the responsible mediator of these novel tumourigenic responses.
View Article and Find Full Text PDFAnnexin 1 and the biology of the neutrophil.
J Leukoc Biol
July 2004
Bart's and the London Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
This overview will focus on one aspect of neutrophil biology, which is the selective activation of the annexin 1 system in relation to the process of cell extravasation. Besides the current view about the biochemistry of annexin 1 and annexin 1 receptor(s) up-regulation within the microenvironment of the adherent neutrophils, we will also comment on the final result achieved by activation of the system, which is inhibition of neutrophil recruitment. In view of the historical link between annexin 1 and glucocorticoids, the potential for the annexin 1 system in mediating at least some of the anti-inflammatory actions of these powerful drugs is also discussed.
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