1,684 results match your criteria: "Barcelona Institute for Global Health[Affiliation]"
Mol Psychiatry
October 2024
Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased risk of developing AD. We included 397 participants from the ALFA+ cohort with CSF Aβ, p-tau, sTREM2, YKL40, and GFAP, magnetic resonance imaging-based hippocampal volume (n = 299), and amyloid burden (centiloids) measured with [F] flutemetamol positron emission tomography (n = 341).
View Article and Find Full Text PDFArtif Intell Med
November 2024
Barcelona Institute for Global Health (ISGlobal), C/ del Dr. Aiguader, 88, Barcelona 08003, Catalonia, Spain. Electronic address:
JAMA
December 2024
Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil.
Importance: Despite its implementation in several countries, there has not been a randomized clinical trial to assess whether telemedicine in intensive care units (ICUs) could improve clinical outcomes of critically ill patients.
Objective: To determine whether an intervention comprising daily multidisciplinary rounds and monthly audit and feedback meetings performed by a remote board-certified intensivist reduces ICU length of stay (LOS) compared with usual care.
Design, Setting, And Participants: A parallel cluster randomized clinical trial with a baseline period in 30 general ICUs in Brazil in which daily multidisciplinary rounds performed by board-certified intensivists were not routinely available.
BMC Geriatr
October 2024
Department of General Practice and Primary Health Care, University of Helsinki, PO Box 20, 00014, Helsinki, Finland.
Semin Liver Dis
November 2024
The Global NASH Council, Washington, District of Columbia.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and can progress to serious complications, including metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Predisposing risk factors for MASH include obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. Patients with MASH often experience significant impairments in their health-related quality of life and other patient-reported outcomes (PROs), particularly in physical functioning domains, fatigue, and vitality.
View Article and Find Full Text PDFCurr Top Membr
October 2024
ISGlobal, Barcelona Institute for Global Health, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; IGTP Institut d'Investigació Germans Trias I Pujol, Badalona, Barcelona, Spain; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
Parasitic diseases constitute a major global health problem, affecting millions of people worldwide. Recent advances in the study of extracellular vesicles (EVs) have opened up new strategies for biomarker discovery in protozoan and helminth infections. Analyses of EVs in cultures and biological fluids have identified numerous potential biomarkers that could be useful for early and differential diagnosis, monitoring therapeutic responses, and the overall management and control of these diseases.
View Article and Find Full Text PDFInt J Hyg Environ Health
January 2025
Department of Infectious Disease Epidemiology & International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centro de Integração de Dados e Conhecimentos para Saúde (CIDACS), Oswaldo Cruz Foundation, Salvador, Brazil.
Background: Pregnancy represents a critical window of vulnerability to the harmful effects of air pollution on health. However, long-term consequences such as risk of having lower respiratory tract infections (LRTIs) are less explored. This systematic review aims to synthesize previous research on prenatal exposure to ambient (outdoor) air pollution and LRTIs in childhood and adolescence.
View Article and Find Full Text PDFSci Total Environ
December 2024
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Background: Air pollution is the leading environmental risk factor for health. Assessing outdoor air pollution exposure with detailed spatial and temporal variability in urban areas is crucial for evaluating its health effects.
Aim: We developed and compared Land Use Regression (LUR), dispersion (DM), and hybrid (HM) models to estimate outdoor concentrations for NO, PM, black carbon (BC), and PM (Fe, Cu, Zn) in Barcelona.
J Mol Diagn
December 2024
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres" (INGEBI)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address:
Cities
December 2024
Barcelona Institute for Global Health (ISGlobal), Doctor Aiguader 88, 08003 Barcelona, Spain.
Recent advances in data science and urban environmental health research utilise large-scale databases (100s-1000s of cities) to explore the complex interplay of urban characteristics such as city form and size, climate, mobility, exposure, and environmental health impacts. Cities are still hotspots of air pollution and noise, suffer urban heat island effects and lack of green space, which leads to disease and mortality burdens preventable with better knowledge. Better understanding through harmonising and analysing data in large numbers of cities is essential to identifying the most effective means of disease prevention and understanding context dependencies important for policy.
View Article and Find Full Text PDFTrials
September 2024
Barcelona Institute for Global Health, Hospital Clinic-University of Barcelona, Barcelona, Spain.
Background: Azithromycin has been shown to be beneficial in preventing infectious diseases, including malaria, infectious diarrhoea and pneumonia. A cluster randomised control trial on azithromycin MDA in children in Niger, Malawi and Tanzania found a reduction in all-cause under-five (U5) mortality in communities who received azithromycin compared to placebo. However, the reduction was largest and statistically significant only in Niger.
View Article and Find Full Text PDFAnn Work Expo Health
November 2024
Barcelona Institute for Global Health (ISGlobal), C/ del Rosselló, 132, L'Eixample, 08036, Barcelona, Spain.
Cochrane Database Syst Rev
September 2024
Maternal, Child and Reproductive Health Initiative, Barcelona Institute for Global Health (ISGlobal), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Background: Malaria and HIV infection overlap geographically in sub-Saharan Africa and share risk factors. HIV infection increases malaria's severity, especially in pregnant women. The World Health Organization (WHO) recommends intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) for pregnant women living in areas of stable malaria transmission.
View Article and Find Full Text PDFClin Transl Allergy
September 2024
Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Matern Child Health J
November 2024
Department of Community and Behavioral Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ann Am Thorac Soc
September 2024
KU Leuven, Leuven, Flanders, Belgium;
Scand J Work Environ Health
October 2024
Barcelona Institute for Global Health (ISGlobal), Doctor Aiguader, 88, Barcelona, Spain, 08003.
Objective: In this discussion paper, we provide a narrative review of past and present occupational cancer studies in the journal with a viewpoint towards future occupational cancer research.
Method: We reviewed all references in the journal that mentioned cancer according to relevance to etiology, cancer type, agent type, study design, and study population.
Results: The Scandinavian Journal of Work, Environment & Health has published over 300 manuscripts on occupational cancer over the 50 past years.
JHEP Rep
October 2024
Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Front Immunol
September 2024
Institute of Physiology, University of Zurich, Zurich, Switzerland.
Breast milk is a vital source of nutrients, prebiotics, probiotics, and protective factors, including antibodies, immune cells and antimicrobial proteins. Using bacterial lipopolysaccharide arrays, we investigated the reactivity and specificity of breast milk antibodies towards microbial antigens, comparing samples from rural Kenya and urban Switzerland. Results showed considerable variability in antibody reactivity both within and between these locations.
View Article and Find Full Text PDFClin Pharmacol Ther
January 2025
Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
Int J Cancer
February 2025
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Radiofrequency electromagnetic fields (RF-EMF, 100 kHz to 300 GHz) are classified by IARC as possibly carcinogenic to humans (Group 2B). This study evaluates the potential association between occupational RF-EMF exposure and brain tumor risk, utilizing for the first time, a RF-EMF job-exposure matrix (RF-JEM) developed in the multi-country INTEROCC case-control study. Cumulative and time-weighted average (TWA) occupational RF-EMF exposures were estimated for study participants based on lifetime job histories linked to the RF-JEM using three different methods: (1) by considering RF-EMF intensity among all exposed jobs, (2) by considering RF-EMF intensity among jobs with an exposure prevalence ≥ the median exposure prevalence of all exposed jobs, and (3) by considering RF-EMF intensity of jobs of participants who reported RF-EMF source use.
View Article and Find Full Text PDFAm J Trop Med Hyg
December 2024
ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Int J Radiat Biol
October 2024
Unitat d'Antropologia Biològica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain.
Purpose: Exposure to low doses (LD) of ionizing radiation (IR), such as the ones employed in computed tomography (CT) examination, can be associated with cancer risk. However, cancer development could depend on individual radiosensitivity. In the present study, we evaluated the differences in the response to a CT-scan radiation dose of 20 mGy in two lymphoblastoid cell lines with different radiosensitivity.
View Article and Find Full Text PDFParasit Vectors
September 2024
Barcelona Institute for Global Health, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
Soil-transmitted helminth (STH) infections account for a significant global health burden, necessitating mass drug administration with benzimidazole-class anthelmintics, such as albendazole (ALB), for morbidity control. However, ALB efficacy shows substantial variability, presenting challenges for achieving consistent treatment outcomes. We have explored the potential impact of the baseline gut microbiota on ALB efficacy in hookworm-infected individuals through microbiota profiling and machine learning (ML) techniques.
View Article and Find Full Text PDF