Navigating parental decision-making: Intersex surgeries in Italy.

Decision-making dynamics in Italian paediatric care for Intersex and Variations of Sex Characteristics (VSC) involve a complex interplay between medical practices, parental perspectives, and socio-cultural factors. This article explores how medical professionals and parents make decisions amid cultural debates on gender, the body, and autonomy. It addresses aspects of why surgical intervention, with limited child involvement, is often seen as the 'only option' in the 'conservative' culture of Italy.

High yield seedless synthesis of mini gold nanorods: partial silver decoupling allows effective nanorod elongation with tunable surface plasmon resonance beyond 1000 nm and CTAB-free functional coating for THPC conjugation.

Gold nanorods with small dimensions demonstrate better cellular uptake and absorption efficiency. The ability to synthesize gold nanorods while maintaining a tunable high aspect ratio is challenging as it requires careful control of reaction conditions, often employing additional steps such as pH modification or the use of polymeric additives. We demonstrate a seedless approach for the synthesis of mini (width < 10 nm) gold nanorods with tunable longitudinal surface plasmon resonance from ∼700 nm to >1000 nm and aspect ratios ranging from ∼3 to ∼7 without the use of any polymeric additives or pH modification.

The melon resistance gene pair: Correlated spatial expression and interaction with a viral protein.

The head-to-head oriented pair of melon resistance genes, and , control resistance to races 0 and 2 and papaya ringspot virus (PRSV), respectively. They encode, via several RNA splice variants, TIR-NBS-LRR proteins, and Prv has a C-terminal extra domain with a second NBS homologous sequence. In other systems, paired R-proteins were shown to operate by "labor division," with one protein having an extra integrated domain that directly binds the pathogen's Avr factor, and the second protein executing the defense response.

Pain management in zebrafish : Report from a FELASA Working Group.

Empirical evidence suggests fishes meet the criteria for experiencing pain beyond a reasonable doubt and zebrafish are being increasingly used in studies of pain and nociception. Zebrafish are adopted across a wide range of experimental fields and their use is growing particularly in biomedical studies. Many laboratory procedures in zebrafish involve tissue damage and this may give rise to pain.

Delocalization quantitatively mapped for prototypic organic nitroanions as well as azidoform anions.

Delocalization of occupied orbitals impacts the chemical bonding in the simplest known pernitroanions [(NO)C] (1) and [(NO)N] (2) as well as other functionalized organic anions. By quantitatively mapping it onto molecular backbones of 1, 2, [CHNO] (3), [CHNNO] (4) and [C(N)] (6) anions (all modeled by QM calculations), the Weinhold's NBO analysis refines their chemical structure, enabling to explain and even predict their essential chemical behaviour. In detail, the HOMO of 1 and 2 is associated with the central atom to the degree of 70.

Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.

Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells.

Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction.

Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based on various chiral amino acid derivatives and characterized by dynamic light scattering and scanning electron microscopy.

As long as it circulates, we've got to keep fighting: COVID-19 and the motivation to get vaccinated.

Objective: The first purpose of this research was to explore the relationship between goal-directed motivation and vaccination behavior. The second purpose was to find ways to motivate people to get vaccinated against COVID-19 and infectious diseases in general.

Rationale: According to regulatory focus theory, goal-directed behavior is regulated by two motivational systems - prevention and promotion.

Metaphase Cells Enrichment for Efficient Use in the Dicentric Chromosome Assay.

The dicentric chromosome assay (DCA), is considered the 'gold standard' for radiation biodosimetry. Yet, DCA, as currently implemented, may be impractical for emergency response applications, especially when time is of the essence, owing to its labor-intensive and time-consuming nature. The growth of a primary lymphocyte culture for 48 h in vitro is required for DCA, and manual scoring of dicentric chromosomes (DCs) requires an additional 24-48 h, resulting in an overall processing time of 72-96 h for dose estimation.

Tailor made magnetic nanolights: fabrication to cancer theranostics applications.

Nanoparticles having magnetic and fluorescent properties could be considered as a gift to materials scientists due to their unique magneto-optical qualities. Multiple component particles can overcome challenges related with a single component and unveil bifunctional/multifunctional features that can enlarge their applications in diagnostic imaging agents and therapeutic delivery vehicles. Bifunctional nanoparticles that have both luminescent and magnetic features are termed as magnetic nanolights.

A multi-variable model for explaining long-term commitment to volunteering among COVID-19 volunteers.

The aim of the study was to test variables that explain long-term commitment to volunteering among volunteers in the first wave of the COVID-19 pandemic in Israel. Long-term commitment to volunteering was tested by the participants' evaluation of the stability, consistency, and intensity of their volunteering over time. Two theoretical frameworks served for explaining commitment to volunteering: the social-structural approach and the psychological characteristics approach.

Decreasing pH impairs sexual reproduction in a Mediterranean coral transplanted at a CO vent.

Ocean acidification, due to the increase of carbon dioxide (CO) concentration in the atmosphere and its absorption by the oceans, affects many aspects of marine calcifying organisms' biology, including reproduction. Most of the available studies on low pH effects on coral reproduction have been conducted on tropical species under controlled conditions, while little information is reported for either tropical or temperate species in the field. This study describes the influence of decreasing pH on sexual reproduction of the temperate non-zooxanthellate colonial scleractinian , transplanted in four sites along a natural pH gradient at the underwater volcanic crater of Panarea Island (Tyrrhenian Sea, Italy).

Frontline love: Romantic partners of frontline doctors and nurses during the New York City COVID-19 outbreak.

Objective: This qualitative study's aim was to learn how the spouses and romantic partners of frontline doctors and nurses dealt with the acute stress of the outbreak; the kinds of support they provided when the frontliners had to navigate COVID-19 at their hospitals; and, according to their perceptions, how this crisis impacted their relationship.

Background: This study focused on the partners of frontliners working in hospitals during the crisis of the coronavirus outbreak in New York City (NYC)-one of the earliest epicenters of the COVID-19 pandemic in the United States. This study expanded upon the Family Stress Model-which examines how economic problems can affect marital quality and stability.

Application of a conversion electrode based on decomposition derivatives of Ag[Fe(CN)] for aqueous electrolyte batteries.

The lack of stable electrode materials for water-based electrolytes due to the intercalation and conversion reaction mechanisms encourage scientists to design new or renovate existing materials with better cyclability, capacity, and cost-effectiveness. Ag[Fe(CN)] is a material belonging to the Prussian blue family that can be used, as its other family members, as an electrode material with the intercalation/deintercalation reaction or conversion-type mechanism through Ag oxidation/reduction. However, due to the instability of this material in its dry state, it decomposes to AgCN and a Prussian blue residual complex.

Combined nanofiltration and advanced oxidation processes with bifunctional carbon nanomembranes.

Wastewater reclamation is becoming a top global interest as population growth and rapid industrialization pose a major challenge that requires development of sustainable cost-effective technologies and strategies for wastewater treatment. Carbon nanomembranes (CNMs)-synthetic 2D carbon sheets-can be tailored chemically with specific surface functions and/or physically with nanopores of well-defined size as a strategy for multifunctional membrane design. Here, we explore a bifunctional design for combined secondary wastewater effluent treatment with dual action of membrane separation and advanced oxidation processes (AOP), exploiting dissolved oxygen.

Cu(ii)-based DNA labeling identifies the structural link between transcriptional activation and termination in a metalloregulator.

Understanding the structural and mechanistic details of protein-DNA interactions that lead to cellular defence against toxic metal ions in pathogenic bacteria can lead to new ways of combating their virulence. Herein, we examine the Copper Efflux Regulator (CueR) protein, a transcription factor which interacts with DNA to generate proteins that ameliorate excess free Cu(i). We exploit site directed Cu(ii) labeling to measure the conformational changes in DNA as a function of protein and Cu(i) concentration.

Thicker macula in asymptomatic Ɛ4 middle-aged adults at high AD risk.

Introduction: We compared retinal layers' thickness between apolipoprotein E () Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk.

Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between groups.

Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk.

Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history.

Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history.

Parenthood in the shadow of COVID-19: The contribution of gender, personal resources and anxiety to first time parents' perceptions of the infant.

We sought to examine new parents' perceptions of their infant during the worldwide spread of COVID-19, exploring the contribution of gender, personal resources (attachment orientation, presence of meaning in life and intolerance of uncertainty) and COVID-19-related anxieties. A convenience sample of 606 Israeli first-time parents (137 fathers and 469 mothers), whose child was 3-12 months old, was recruited through social media during April 2020. Findings indicate that being a woman, younger age, lower education, better physical health, older infant's age, lower attachment anxiety, higher presence of meaning in life and greater COVID-19-related anxiety over the infant's health contributed significantly to a greater perception of infant's warmth; being a father, higher education and economic status, poorer physical health, higher attachment anxiety and intolerance of uncertainty and less presence of meaning in life contributed significantly to a greater perception of infant's invasiveness.

[AUTOPHAGY AND DIABETIC NEPHROPATHY].

Diabetes mellitus (DM) is the leading cause of end stage renal disease; 40% of the patients worldwide will require replacement therapy after 20 years of DM. Early-stage diabetic nephropathy is characterized by hyper filtration with micro-and macro albuminuria. Later on end-stage renal disease (ESRD) can appear; 40% of diabetic patients develop micro-and macrovascular complications, with increased risk among patients with genetic predisposition, such as Haptoglobin 2-2 phenotype.

Nanopatterning of oxide 2-dimensional electron systems using low-temperature ion milling.

We present a 'top-down' patterning technique based on ion milling performed at low-temperature, for the realization of oxide two-dimensional electron system devices with dimensions down to 160 nm. Using electrical transport and scanning Superconducting QUantum Interference Device measurements we demonstrate that the low-temperature ion milling process does not damage the 2DES properties nor creates oxygen vacancies-related conducting paths in the STO substrate. As opposed to other procedures used to realize oxide 2DES devices, the one we propose gives lateral access to the 2DES along the in-plane directions, finally opening the way to coupling with other materials, including superconductors.