13,057 results match your criteria: "Bar-Ilan University; galit.ophir@biu.ac.il.[Affiliation]"

Coffee leaf rust is a prevalent botanical disease that causes a worldwide reduction in coffee supply and its quality, leading to immense economic losses. While several pandemic intervention policies (PIPs) for tackling this rust pandemic are commercially available, they seem to provide only partial epidemiological relief for farmers. In this work, we develop a high-resolution spatiotemporal economical-epidemiological model, extending the Susceptible-Infected-Removed model, that captures the rust pandemic's spread in coffee tree farms and its associated economic impact.

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  • Gastroesophageal reflux disease (GERD) is a chronic condition divided into two types: erosive reflux disease (ERD) and non-erosive reflux disease (NERD), primarily influenced by acid secretion and managed with various acid-suppressant medications.
  • Since the 1970s, treatments have evolved from histamine-H-receptor antagonists to proton pump inhibitors (PPIs), and recently, potassium-competitive acid blockers (p-CABs) like Vonoprazan have emerged, offering improved efficacy and safety.
  • Vonoprazan has demonstrated effectiveness in managing ERD and related symptoms, showing potential advantages over older PPIs, with ongoing research expected to explore its long-term benefits in treating other acid-related
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IgG4-related disease (IgG4-RD) is a rare illness with inflammatory and fibrotic changes in affected organs such as pancreas, thyroid, salivary or lacrimal glands, and retroperitoneal space; rarely other organs may be involved. IgG4-related breast disease (IgG4-BD) is very rare and generally presents as a lump or mastitis. IgG4-BD as a presenting feature of IgG4-RD is extremely rare.

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Background: While clinical practice guidelines advocate for multidisciplinary heart team (MDHT) discussions in coronary revascularization, variability in implementation across health care settings remains a challenge. This variability could potentially be addressed by language learning models like ChatGPT, offering decision-making support in diverse health care environments. Our study aims to critically evaluate the concordance between recommendations made by MDHT and those generated by language learning models in coronary revascularization decision-making.

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The role of childhood trauma and attachment state of mind in mothers' birth experiences.

Attach Hum Dev

December 2024

Clinical Child and Family Studies, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Negative birth experiences are common. It is yet unclear which women may be most at risk already before pregnancy. Childhood trauma and non-autonoumous/unresolved attachment state of mind may affect how women experience giving birth.

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  • KSHV (Kaposi's sarcoma-associated herpesvirus) relies on lytic replication for persistent infection, with its proteins hijacking cellular pathways for this process.
  • The study identifies that the proteins FoxK1 and FoxK2 bind with the KSHV protein ORF45, playing a crucial role in late viral gene expression and virion production.
  • The interaction between ORF45 and FoxK1/FoxK2 enhances transcriptional activity at late viral promoters, facilitating KSHV lytic replication and revealing their new roles in KSHV pathogenesis.
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An unbiased comparison of immunoglobulin sequence aligners.

Brief Bioinform

September 2024

Faculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.

Article Synopsis
  • Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is essential for studying the adaptive immune system, but analyzing the data requires accurate immunoglobulin (Ig) sequence alignments.
  • Currently, there's no standardized method for comparing different Ig sequence aligners, making it difficult to know which is best for specific tasks.
  • The introduction of GenAIRR, a simulation framework, allows for realistic modeling of Ig sequences and their complexities, providing a way to fairly evaluate various alignment tools and improve our understanding of adaptive immunity.
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  • The study analyzed the long-term safety of dupilumab, a drug for atopic dermatitis (AD), compared to conventional systemic treatments like azathioprine and methotrexate using electronic health records.
  • Findings showed that dupilumab had a lower risk of various adverse effects, including infections and type 2 inflammatory diseases, compared to other treatments.
  • However, the risk of conjunctivitis was higher in patients treated with dupilumab compared to those on mycophenolate mofetil and methotrexate, prompting the need for further research to confirm these results.
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Suppression of magnetic vortex losses in submicron NbN coplanar waveguide resonators.

Sci Rep

November 2024

Institute of Superconductivity and Institute of Nanotechnology, Department of Physics, Bar-Ilan University, Ramat-Gan, 5290002, Israel.

We present a method for improving the performance of microwave coplanar resonators in magnetic fields, by using narrow superconducting strips of width close to the London penetration depth. In a range of low fields, the narrow strips inhibit the presence of magnetic vortices, thus preventing the generation of losses caused by their motion, leading to enhanced resistance to magnetic fields. Our method provides a more straightforward solution compared to previously proposed techniques designed to restrict vortex motion, holding potential for the development of improved devices based on microwave resonators.

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Conventional vaginal approach vs. transvaginal natural orifice transluminal endoscopic surgery for treating apical prolapse, a randomized controlled study.

Eur J Obstet Gynecol Reprod Biol

December 2024

Dept. of Obstetrics and Gynecology, Imelda Hospital, Bonheiden, Belgium; Department of Development and Regeneration in Abdominal, Plastic and Urogenital Surgery, KU Leuven University, Leuven, Belgium.

Objective: Vaginal hysterectomy combined with uterosacral suspension (USLS) is a technique for treating pelvic organ prolapse. Vaginal natural orifice transluminal endoscopic surgery (vNOTES) has been described as an alternative minimal invasive approachfor treating various gynecological and non-gynecological pathologies. The aim was to compare the surgical time between conventional vaginal hysterectomy combined with USLS and vNOTES hysterectomy combined with USLS.

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  • Cardiac amyloidosis (CA) is an often overlooked cause of heart failure (HF), highlighting the importance of early detection and timely therapy for better patient outcomes.
  • A global survey with 1,460 physicians revealed that while many have experience diagnosing CA in patients with preserved ejection fraction (HFpEF), systematic screening is not widely practiced, with only 10% conducting routine checks.
  • There is significant variability in screening and management strategies for CA, indicating a need for better education and access to disease-modifying therapies within the HF community.
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Major amendments in neonatal care have been introduced in recent decades. It is important to understand whether these amendments improved the cognitive sequelae of preterm children. Through a large-scale meta-analysis, we explored the association between prematurity-related complications, neonatal care quality, and cognitive development from birth until 7 years.

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  • Metastatic disease is a major cause of cancer-related deaths, yet its tumor microenvironment is not well understood due to technical challenges in studying it.
  • This research created a comprehensive map of 67 tumor biopsies from 60 metastatic breast cancer patients, using advanced techniques like single-cell RNA sequencing and various spatial expression assays to analyze tumor characteristics.
  • Key findings included identifying different macrophage spatial patterns, three phenotypes of epithelial-to-mesenchymal transition, and gene expression linked to T cell presence or absence, highlighting the study's potential for clinical insights.
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Marine plastic pollution poses a growing environmental threat, with microplastics accumulating in the global oceans. This study profiles the seasonal dynamics and taxonomic composition of the plastisphere, the microplastic ecosystem, in the Eastern Mediterranean Sea. Using long-read 16 S and 18 S metabarcoding, we analyzed offshore microplastic and whole seawater samples across each season over a two-year period.

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Postoperative Antibiotics May Be Unnecessary in Pediatric Patients Hospitalized With Minor Odontogenic Infections.

J Oral Maxillofac Surg

January 2025

Department of Oral and Maxillofacial Surgery, The Baruch Padeh "Tzafon" Medical Center, Poriya, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Background: Antibiotic overuse is a growing concern in health care. For pediatric odontogenic infections, the necessity of postoperative antibiotics lacks clear, evidence-based guidelines.

Purpose: The purpose of this study was to compare treatment outcomes between pediatric patients hospitalized with vestibular space odontogenic infections who received postoperative antibiotics and those who did not.

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Background: Primary hyperoxaluria type 3 (PH3) is a rare autosomal recessive disorder caused by bi-allelic genetic variants in the 4 hydroxy-2 oxoglutarate aldolase (HOGA-1) gene. We report the natural history of PH3 in a 16-patient cohort, 15 from a unique genetically isolated population.

Methods: This retrospective single-center study followed PH3 patients between 2003 and 2023 with demographic, clinical, radiographic, genetic, and biochemical parameters.

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Zebrafish and other small laboratory fishes are emerging as important animal models for investigating human skeletal development and diseases. In recent years, there has been a notable increase in research publications employing X-ray radiography and micro-computed tomography to analyze the skeletal structures of these animals. However, evaluating bone morphology and mineral density in small laboratory fish poses unique challenges compared to well-established small rodent models.

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This review, focused on hybrid drugs, is the third in a series of reviews, where the first two reviews dealt with a) dimeric drugs, b) mutual prodrugs - codrugs. The compounds designated as hybrids are comprised of two (and sometimes three) biologically active entities, linked by metabolically stable bridges. In some cases, one of the two components of the hybrids serves as a carrier for the second component, and most frequently, the components elicit their individual biological properties, which are commonly synergistic or complementary.

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  • The study updates findings from the CREST study on the 8-week treatment of glecaprevir/pibrentasvir (GLE/PIB) for patients with chronic hepatitis C and compensated cirrhosis.
  • It analyzes 437 patients, showing a high sustained virologic response (SVR12) of 98.9%, especially among those with certain comorbidities and those on other medications.
  • The research highlights safety aspects, noting only a small percentage experienced adverse events, and emphasizes variations in healthcare resource use based on patients' employment status and drug use history.
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  • Finding the global minimum in complex networks is tough, especially in human networks that must adapt to various disturbances like conflicts and climate change.
  • Our study on violin players showed that human networks use unique methods, like changing coupling strength and tempo, to avoid local minima, making them more resilient than non-human networks.
  • The research highlights phenomena like high-order vortex states and oscillation death, and it may inform various fields such as politics, economics, and AI-driven decision-making.
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  • The original publication discusses key themes and findings that are essential to understanding the subject matter.
  • It outlines the methodology used in the research, highlighting the importance of data collection and analysis.
  • The text also emphasizes the implications of the findings for future studies and their relevance in the broader context of the field.
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This research explores how the availability of substrates affects the regulation of soil microbial communities and the taxonomical composition of bacteria. The goal is to understand the impact of organic matter and substrate availability and quality on the diversity of soil bacteria. The study observed gradual changes in bacterial diversity in response to the addition of different substrate-induced respiration (SIR) substrates.

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  • Autoimmune hepatitis (AIH) is a chronic liver disease where the immune system attacks liver cells, treated primarily with glucocorticoids and immunosuppressive drugs like azathioprine or MMF.
  • A study investigated the risk of developing non-Hodgkin lymphoma (NHL) in a large cohort of AIH patients over two decades, finding that NHL incidence was significantly higher than in the general population.
  • The study revealed that older patients (45 and up) were more affected, especially within the first seven years post-AIH diagnosis, but no link was found between NHL risk and the specific treatment drug used.
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Multimodal technology is poised to revolutionize clinical practice by integrating artificial intelligence with traditional diagnostic modalities. This evolution traces its roots from Hippocrates' humoral theory to the use of sophisticated AI-driven platforms that synthesize data across multiple sensory channels. The interplay between historical medical practices and modern technology challenges conventional patient-clinician interactions and redefines diagnostic accuracy.

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