A point of care sensor for detection of alcohols, aldehydes and esters in urinary metabolites of war veterans injured by sulfur mustard.

To discriminate between different alcoholic, aldehyde, and ester species of urine samples, a colorimetric sensor array consisting of dopamine-capped copper-silver bimetallic nanoparticles (Ag@Cu BMNPs) combined with 12 organic dyes is introduced. Based on the sensing mechanism, the nanozyme catalyzed the reactions of oxidation, dehydrogenation, and hydrolysis of volatile organic compounds. The products could alter the amount of hydronium ions in the detection media, making a variation in the color intensity of pH-sensitive indicators.

New portable smartphone-based PDMS microfluidic kit for the simultaneous colorimetric detection of arsenic and mercury.

A smartphone-based microfluidic platform was developed for point-of-care (POC) detection using surface plasmon resonance (SPR) of gold nanoparticles (GNPs). The simultaneous colorimetric detection of trace arsenic and mercury ions (As and Hg) was performed using a new image processing application (app). To achieve this goal, a microfluidic kit was fabricated using a polydimethylsiloxane (PDMS) substrate with the configuration of two separated sensing regions for the quantitative measurement of the color changes in GNPs to blue/gray.